PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Research identifies how cancer cells cheat death

2011-06-09
(Press-News.org) Research led by David Litchfield of The University of Western Ontario has identified how biochemical pathways can be "rewired" in cancer cells to allow these cells to ignore signals that should normally trigger their death. It's one way that cancer cells may become resistant to therapy. The findings are now published in Science Signaling (http://stke.sciencemag.org/cgi/content/full/sigtrans;4/172/ra30 ).

"This work focused on understanding how cancer cells acquire a selective survival advantage, allowing them to avoid apoptosis, the process required for normal cell turnover and chemically-induced cell death" says Litchfield, Chair of the Department of Biochemistry and Professor in the Department of Oncology at the Schulich School of Medicine & Dentistry. "Our work also provides encouragement for the development of novel therapeutic approaches that would prevent - or neutralize - this 'rewiring' to make sure that cancer cells respond to treatment."

### The study was funded by the Canadian Institutes of Health Research. Its multi-disciplinary approach included computational studies enabled by Greg Gloor, proteomics and systems biology approaches made possible by Shawn Li, both at Western, and a collaboration with Bernhard Luscher from the RWTH Aachen University in Germany. Two PhD students, James Duncan who is now in postdoctoral training at the University of North Carolina and Jacob Turowec are the lead authors on this investigation.


ELSE PRESS RELEASES FROM THIS DATE:

Scientists create humanized mouse model for hepatitis C

2011-06-09
Scientists at Rockefeller University and The Scripps Research Institute have developed the first genetically humanized mouse model for hepatitis C, an achievement that will enable researchers to test molecules that block entry of the hepatitis C virus into cells as well as potential vaccine candidates. The finding is reported in the June 9 issue of the journal Nature. While the hepatitis C virus can infect chimpanzees and humans, scientists have been unable to study the progression of the virus' life cycle or possible treatments in small animal models. The new mouse model ...

THE VELUX Group Wins Design Award for Sun Tunnel Skylight by Lovegrove; Partnership Between VELUX & Green Design Proponent Wins Sought-After 'Red Dot' Label

2011-06-09
A very unusual partnership between the VELUX Group and the internationally acknowledged proponent of Green Design, Ross Lovegrove, wins this year's attractive red dot award "best of the best" for pioneering design. The sun tunnel by Lovegrove is a contemporary and smooth new product that spreads natural light through the roof to otherwise electrically lit rooms and is a supplement to the ordinary VELUX sun tunnel. The new design represents yet another innovative way to bring daylight into buildings. The "red dot" is a sought-after quality label worldwide. ...

Connection discovered between the nervous system and the vascular system

2011-06-09
Montréal, June 8, 2011 – Dr. Frédéric Charron, researcher at the Institut de recherches cliniques de Montréal (IRCM), and his team have shown for the first time that a key molecule of the vascular system directs axons during the formation of neural circuits. This connection between the nervous system and the vascular system could be a good starting point for the development of therapies for neurodegenerative diseases. The discovery will be published tomorrow by Neuron, a scientific journal of the Cell Press group. "To properly form neural circuits, developing axons (long ...

Competition between females leads to infanticide in some primates

Competition between females leads to infanticide in some primates
2011-06-09
An international team of scientists, with Spanish participation, has shed light on cannibalism and infanticide carried out by primates, documenting these acts for the first time in the moustached tamarin (Saguinus mystax). The mothers, which cannot raise their infants without help from male group members, commit infanticide in order to prevent the subsequent death of their offspring if they are stressed and in competition with other females. "Infanticide is an extreme behaviour, and in most species is used by males to eliminate competitors and make females become sexually ...

VELUX Introduces the Sun Tunnel Skylight Shade

2011-06-09
VELUX America is introducing a manual blackout shade for its Sun Tunnel tubular skylights. The new accessory utilizes magnets on the top, or non-visible side, of the ceiling diffuser trim ring. When the magnets are in place and the trim ring is reinstalled, a white, fabric-covered disk with a metal outer ring is attached to the diffuser trim ring. The center of the disk has a fitting that connects to a two-piece, 26.5" rod, which is inserted into the fitting and used to attach and remove the accessory shade disk. The accessory kit (ZTB designation) is available ...

Mountain pine beetle activity may impact snow accumulation and melt, says CU-Boulder study

Mountain pine beetle activity may impact snow accumulation and melt, says CU-Boulder study
2011-06-09
A new University of Colorado Boulder study indicates the infestation of trees by mountain pine beetles in the high country across the West could potentially trigger earlier snowmelt and increase water yields from snowpack that accumulates beneath affected trees. Led by CU-Boulder geological sciences department doctoral student Evan Pugh, the study was undertaken near Grand Lake, Colo., adjacent to Rocky Mountain National Park, an area that has been devastated by mountain pine beetle attacks in recent years. Mountain pine beetles have killed more than 4 million acres ...

Bureau of Prescription Health Gives The Whole Truth (and Nothing But) About Free Medicine at FreeMedicine.com

2011-06-09
Located in Doniphan, MO the Bureau of Prescription Health provides options for people of all ages in the USA who cannot afford to pay for their prescriptions out-of-pocket. During this time of economic uncertainty, too many Americans live with the fear that they or a family member will not have access to medicines they need because they lack insurance or a drug benefit. Members of "Big Pharma" have collectively pledged, "No one in need of medications will do without them." The Bureau of Prescription Health, along with drug companies in the USA, are ...

The deVere Group Extends Global Presence with a New License Granted in Miami, USA

2011-06-09
This latest addition is the fifteenth office that the deVere Group has opened worldwide in the last two years, however it is the first established presence in the continent. Nigel Green, CEO of the deVere Group, said: "The deVere Group is already successful in every continent around the world. We are delighted to have been granted a license in this highly-regulated market. The USA has massive potential and we are very excited as a company to provide our services to clients there." deVere's global presence now extends to nearly 60 offices worldwide. With ...

Tut, tut: Microbial growth in pharaoh's tomb suggests burial was a rush job

Tut, tut: Microbial growth in pharaohs tomb suggests burial was a rush job
2011-06-09
Cambridge, Mass, June 8, 2011 - In the tomb of King Tutankhamen, the elaborately painted walls are covered with dark brown spots that mar the face of the goddess Hathor, the silvery-coated baboons—in fact, almost every surface. Despite almost a century of scientific investigation, the precise identity of these spots remains a mystery, but Harvard microbiologist Ralph Mitchell thinks they have a tale to tell. Nobody knows why Tutankhamen, the famed "boy king" of the 18th Egyptian dynasty, died in his late teens. Various investigations have attributed his early demise ...

Is root grafting a positive, cooperative behavior in trees?

Is root grafting a positive, cooperative behavior in trees?
2011-06-09
Trees are often viewed as individuals that compete with one another for access to limited resources. But could trees in stressed environments actually benefit from positive, facultative interactions? The authors of a new paper suggest that might be the case for certain tree species—and that it may take the form of root grafting. Natural root grafting between individuals has been observed in over 150 species of plants around the world. However, while much is known about benefits of merging stem tissues (primarily from horticultural practices), little is known about ...

LAST 30 PRESS RELEASES:

Study finds one-year change on CT scans linked to future outcomes in fibrotic lung disease

Discovery of a novel intracellular trafficking pathway in plant cells

New tool helps forecast volcano slope collapses and tsunamis

Molecular coating cleans up noisy quantum light

From Parkinson's to rare diseases, discovered a key switch for cellular health

Tiny sugars in the brain disrupt emotional circuits, fueling depression

Mini-organs reveal how the cervix defends itself

Africa, climate, and food: How to feed a continent without increasing its carbon footprint

Researchers demonstrates substrate design principles for scalable superconducting quantum materials

How better software choices could cut US health care costs

Concussion history in NCAA athletes yields mixed health outcomes

Counting plastic reveals hidden waste and sparks action

Warming oceans may pose a serious threat to American lobsters

Deaths from drug-induced unintentional injury rise across the US

In car crashes with pedestrians, age and zip code may predict extent of traumatic injuries

AI optimizes evacuation, diagnosis, and treatment of wounded soldiers in Ukraine

Mastectomy linked to worsened sexual health, body image after surgery

Drop in credit score after cancer diagnosis linked to increased mortality, study shows

Use of weight loss drugs before bariatric surgery has soared in recent years, study finds

EMS call times in rural areas take at least 20 minutes longer than national average

Rectal bleeding in young adults linked to 8.5 times higher risk of colorectal cancer

Hospital closures disproportionately affect socioeconomically disadvantaged communities

Global disparities in premature mortality

Keck Medicine of USC expands world-class care in Pasadena

Untreated depression makes surgical outcomes worse in cancer patients

Standardizing frailty indexes to improve preclinical aging research

Hanbat National University researchers present new technique to boost solid oxide fuel cell performance

Even short school breaks affect student learning unevenly across socioeconomic backgrounds

When words matter: Language and culture shape early childhood outcomes

UBC enzyme technology clears first human test toward universal donor organs for transplantation

[Press-News.org] Research identifies how cancer cells cheat death