Girls with family history of breast disease should avoid alcohol

(Press-News.org) Adding to research linking alcohol to breast cancer risk, a new study from Washington University School of Medicine in St. Louis shows that adolescent girls with a family history of breast disease — either cancer or the benign lesions that can become cancer – have a higher risk of developing benign breast disease as young women than other girls. And unlike girls without a family history, this already-elevated risk rises with increasing alcohol consumption.

"The most common question we hear from women with a family history of breast disease is how can we prevent breast cancer in our daughters," says epidemiologist Graham A. Colditz, MD, PhD, the Niess-Gain Professor of Surgery and senior author on the study published online Nov. 14 in the journal Cancer. "This points to a strategy to lower risk — or avoid increasing risk — by limiting alcohol intake."

This study is one of the first to look at alcohol consumption in adolescents and the risk of breast disease. Most studies linking alcohol to the risk of developing breast cancer focus on women in their 40s, 50s and 60s and on their risk of invasive breast cancer, not the risk of early, benign lesions that may lead to invasive breast cancer.

One such study published Nov. 2 in the Journal of the American Medical Association, in which Colditz was a co-author, found a moderate increase in breast cancer risk with as few as three to six drinks per week for any adult women, regardless of family history.

"In the current study, we have tried to disentangle the effects of alcohol in women with a family history that includes both breast cancer and benign breast disease, compared to women with no family history," Colditz says. "And we're seeing the strongest effect of alcohol in women with breast disease in the family."

The new study of younger women began in 1996 with more than 9,000 girls from all 50 states who are daughters of participants in the Nurses' Health Study II. The girls were ages nine to 15 when they completed baseline questionnaires. Follow-up questionnaires over the next five years and surveys in 2003, 2005 and 2007 tracked family history, alcoholic beverage intake, height, weight, waist circumference and age of first menstrual period, among other factors that influence breast cancer risk.

The 2005 and 2007 surveys, conducted when the participants were ages 18 to 27, asked whether they had ever been diagnosed with benign breast disease, a large class of conditions that can cause breast lumps or pain and are a known risk factor for breast cancer. Sixty-seven of the young women reported a diagnosis of benign breast disease that was confirmed by biopsy, and 6,741 reported no such diagnosis.

The researchers first looked at the effects of family history, independent of alcohol. They found that when a young woman's mother or aunt had breast cancer, she was more than twice as likely to be diagnosed with benign breast disease than a young woman with no family history. Similarly, daughters of mothers with benign breast disease were almost twice as likely to develop benign breast disease themselves.

And alcohol heightened a young girl's risk further if she had a family history. Girls whose mothers, aunts or grandmothers had breast cancer were more likely to develop benign breast disease, and their risk increased with the amount of alcohol they consumed. The same was true of the daughters of women with benign breast disease.

In an interesting finding, young women with no family history of breast disease saw no elevated risk of benign breast lesions with alcohol consumption. Instead, their risk appeared to be related to increased body mass index in childhood, waist circumference in adolescence and height in adulthood. Such findings suggest that risk factors differ between those women with a family history of breast cancer and those without.

"Increasing height is related to breast cancer risk," Colditz says. "And some data point to faster growth spurts leading to a higher risk of subsequent cancer. Obviously, that's not something we can control. But if we can understand what is going on in terms of hormones and processes in the body and the role of physical activity and diet, we may be able to modify some of that accumulation of breast cancer risk through the early years."

### Berkey CS, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Young women with family history of breast cancer and their risk factors for benign breast disease. Cancer. Nov. 14, 2011.

Chen WY, Rosner B, Hankinson SE, Colditz GA, Willett WC. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. Journal of the American Medical Association. Nov. 2, 2011.

Funding for this study was provided by grants from the National Institutes of Health (NIH), the Breast Cancer Research Foundation, the American Institute for Cancer Research and by an American Cancer Society Clinical Research Professorship.

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked fourth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.