(Press-News.org) New analysis casts doubt on results of tobacco industry studies into safety of cigarette additives
Published tobacco industry scientific research on the safety of cigarette additives cannot be taken at face value, according to an analysis led by Stanton Glantz from the Center for Tobacco Control Research and Education at the University of California in San Francisco, and published in this week's PLoS Medicine.
In the PLoS Medicine study, the authors reanalyzed data from "Project MIX" in which chemical analyses of smoke, and the potential toxicity of 333 cigarette additives were conducted by scientists from the tobacco company Philip Morris. The results of these analyses were published in Food and Chemical Toxicology in 2002.
The authors of the independent analysis used documents made public as a result of litigation against the tobacco industry to investigate the origins and design of Project MIX, and to conduct their own analyses of the results. Internal documents revealed post-hoc changes in analytical protocols after the industry scientists found that the additives increased cigarette toxicity by increasing the number of particles in the cigarette smoke. Crucially, the authors also found that in the original Project MIX analysis, the published papers obscured findings of toxicity by adjusting the data by Total Particulate Matter concentration: when the authors conducted their own analysis by studying additives per cigarette, they found that 15 carcinogenic chemicals increased by 20% or more. The authors also found that the failure to identify many toxic biological effects was because the studies Philip Morris carried out were too small to reliably detect toxic effects.
The authors conclude that their independent analysis provides evidence for the elimination of the use of the studied additives (including menthol) from cigarettes on public health grounds.
The authors say: "The results demonstrate that toxins in cigarette smoke increase substantially when additives are put in cigarettes, including the level of [Total Particulate Matter]. In particular, regulatory authorities, including the [Food and Drug Administration] and similar agencies elsewhere, could use the Project MIX data to eliminate the use of these 333 additives (including menthol) from cigarettes."
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Funding: This work was supported by National Cancer Institute Grant CA-87472. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors do not consider these competing interests, but in the interest of full transparency Dr. Glantz declares the following: Dr. Glantz holds two research grants related to tobacco from the National Cancer Institute (one of which, CA-87472, supported this work), an endowed chair as American Legacy Distinguished Professor in Tobacco Control, and, during the time some of the work on this project was completed, an unrelated grant from University of California Tobacco Related Diseases Research Program. Dr. Glantz also administers an endowment from the American Legacy Foundation, which supports the UCSF Center for Tobacco Control Research and Education, which Dr. Glantz directs, and the Legacy Tobacco Documents Library. He also has the William Cahan Endowment provided by the Flight Attendant Medical Research Institute. None of these organizations played any role in the preparation of this paper or the decision to submit it for publication. All other authors have declared that no competing interests exist.
Citation: Wertz MS, Kyriss T, Paranjape S, Glantz SA (2011) The Toxic Effects of Cigarette Additives. Philip Morris' Project Mix Reconsidered: An Analysis of Documents Released through Litigation. PLoS Med 8(12): e1001145. doi:10.1371/journal.pmed.1001145
CONTACT:
Professor Stanton Glantz
Center for Tobacco Control Research and Education
University of California San Francisco
530 Parnassus Suite 366
San Francisco, CA 94143-1390
United States of America
415-476-3893
glantz@medicine.ucsf.edu
New analysis casts doubt on results of tobacco industry studies into safety of cigarette additives
2011-12-21
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