PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Beneficial or not beneficial: that is the question for IL-1 inhibition in atherosclerosis

2011-12-29
(Press-News.org) Atherosclerosis is a disease of the major arterial blood vessels. It is one of the major causes of heart attack and stroke. The proinflammatory molecule IL-1 has been linked to atherosclerosis and a clinical trial has been launched in which an antibody specific for IL-1-beta is being studied for its effects on the severe clinical complications of atherosclerosis (i.e., heart attack and stroke). However, a team of researchers led by Gary Owens, at the University of Virginia, Charlottesville, has now generated data in mice that raise potential concerns about this clinical trial — Owens and colleagues find that IL-1 limits the features of advanced atherosclerosis that are linked to the severe complications of the disease in humans.

### TITLE: Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

AUTHOR CONTACT:
Gary Owens
University of Virginia, Charlottesville, VA, USA
Phone: 434.924.2652; E-mail: gko@virginia.edu.


ELSE PRESS RELEASES FROM THIS DATE:

JCI online early table of contents: Dec. 27, 2011

2011-12-29
EDITOR'S PICK Another potential obstacle to developing an HIV vaccine A clinical trial testing a candidate HIV vaccine known as the STEP study was halted in September 2007 after interim analysis indicated that the vaccine did not work. Moreover, subsequent analyses indicated that the vaccine made some individuals more susceptible to HIV, in particular individuals who had pre-existing immune effectors (antibodies) that recognized a component of the vaccine (adenovirus serotype 5 [Ad5]). A team of researchers led by Juliana McElrath, at the Fred Hutchinson Cancer Research ...

Tests for biomarker may help determine diagnosis of heart attack within hours

2011-12-29
CHICAGO – For patients admitted to an emergency department with chest pain, use of a contemporary or highly sensitive test for levels of troponin I (a protein in muscle tissue) may help rule-out a diagnosis of heart attack, while changes in the measured levels of this biomarker at 3 hours after admission may be useful to confirm a diagnosis of heart attack, according to a study in the December 28 issue of JAMA. One of the most common reasons patients seek care in an emergency department is for acute chest pain. "Early identification of individuals at high and intermediate ...

Perception of inappropriate care frequent among ICU workers

2011-12-29
CHICAGO – A survey of nurses and physicians in intensive care units (ICUs) in Europe and Israel indicated that the perception of inappropriate care, such as excess intensity of care for a patient, was common, and that these perceptions were associated with inadequate decision sharing, communication and job autonomy, according to a study in the December 28 issue of JAMA. "Clinicians perceive the care they provide as inappropriate when they feel that it clashes with their personal beliefs and/or professional knowledge. Intensive care unit workers who provide care perceived ...

Analysis does not support genetic test before use of anti-clotting drug

2011-12-29
CHICAGO – Although the U.S. Food and Drug Administration (FDA) has recommended that a certain type of genetic testing (for the genotype CYP2C19) be considered before prescribing the drug clopidogrel to identify individuals who may be less responsive to the medication, a review and analysis of previous studies did not find an overall significant association between the CYP2C19 genotype and cardiovascular events, according to a study in the December 28 issue of JAMA. Clopidogrel is an antiplatelet drug used by approximately 40 million patients worldwide to treat or prevent ...

Possible Defenses To A DUI Charge

2011-12-29
You are sitting in your car, watching the red lights in your rearview mirror. The officer exits their vehicle and begins walking toward your car. The next thing you know, you have been charged with a DUI. What do you do now? You may think you have no chance, that even though you did not feel intoxicated or impaired, the blood alcohol content reading of the breathalyzer showed you were over the limit, and you are as good as convicted. Machines don't make mistakes, do they? Challenging A DWI Charge While it may seem an open and shut case, there may be multiple ...

Oxidative DNA damage repair

2011-12-29
Oxidative stress is the cause of many serious diseases such as cancer, Alzheimer's, arteriosclerosis and diabetes. It occurs when the body is exposed to excessive amounts of electrically charged, aggressive oxygen compounds. These are normally produced during breathing and other metabolic processes, but also in the case of ongoing stress, exposure to UV light or X-rays. If the oxidative stress is too high, it overwhelms the body's natural defences. The aggressive oxygen compounds destroy genetic material, resulting in what are referred to as harmful 8-oxo-guanine base mutations ...

Irikaitz archaeological site -- host to a 25,000-year-old pendant

2011-12-29
The recent discovery of a pendant at the Irikaitz archaeological site in Zestoa (in the Basque province of Gipuzkoa) has given rise to intense debate: it may be as old as 25,000 years, which would make it the oldest found to date at open-air excavations throughout the whole of the Iberian Peninsula. This stone is nine centimetres long and has a hole for hanging it from the neck although it would seem that, apart from being adornment, it was used to sharpen tools. The discovery has had great repercussion, but it is not by any means the only one uncovered here by the team ...

Whistleblowing Remedies in New Jersey

2011-12-29
Recent decisions by the New Jersey Supreme Court and the Appellate Division clarify the definition of "adverse employment action" that triggers New Jersey's "whistleblower law," known as the Conscientious Employee Protection Act (CEPA). Adverse Employment Action John Seddon had worked for Dupont 30 years when he filed a complaint with OSHA, the federal office for occupational safety and health. Seddon's complaint involved DuPont's practice of inspecting employee vehicles at the gate of the plant. Employees had to stand by the side of a busy ...

Targeted blocking of cell death prevents fatal condition septic shock

2011-12-29
Ghent, Belgium 27 December 2011 - Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. In sepsis, acute inflammation is attended by low blood pressure and blood clots, causing the organs to stop working. Only recently, the Brazilian football legend Socrates, died of the consequences of this condition. In a new study in the top journal Immunity, Peter Vandenabeele and colleagues of VIB-UGent described ...

Toasting the chemistry of champagne: New Year's Eve video from the American Chemical Society

Toasting the chemistry of champagne: New Years Eve video from the American Chemical Society
2011-12-29
WASHINGTON, Dec. 27, 2011 — Just in time for those New Year's Eve toasts, which might include a farewell to the International Year of Chemistry, the world's largest scientific society today posted online a video on the chemistry of champagne. The latest addition to the award-winning Bytesize Science series from the American Chemical Society (ACS) is available at www.BytesizeScience.com. It explains that champagne, unlike other wines, undergoes a second fermentation in the bottle to trap carbon dioxide gas, which dissolves into the wine and forms the fabled bubbles in ...

LAST 30 PRESS RELEASES:

The most effective diabetes drugs don't reach enough patients yet

Breast cancer risk in younger women may be influenced by hormone therapy

Strategies for staying smoke-free after rehab

Commentary questions the potential benefit of levothyroxine treatment of mild hypothyroidism during pregnancy

Study projects over 14 million preventable deaths by 2030 if USAID defunding continues

New study reveals 33% gap in transplant access for UK’s poorest children

Dysregulated epigenetic memory in early embryos offers new clues to the inheritance of polycystic ovary syndrome (PCOS)

IVF and IUI pregnancy rates remain stable across Europe, despite an increasing uptake of single embryo transfer

It takes a village: Chimpanzee babies do better when their moms have social connections

From lab to market: how renewable polymers could transform medicine

Striking increase in obesity observed among youth between 2011 and 2023

No evidence that medications trigger microscopic colitis in older adults

NYUAD researchers find link between brain growth and mental health disorders

Aging-related inflammation is not universal across human populations, new study finds

University of Oregon to create national children’s mental health center with $11 million federal grant

Rare achievement: UTA undergrad publishes research

Fact or fiction? The ADHD info dilemma

Genetic ancestry linked to risk of severe dengue

Genomes reveal the Norwegian lemming as one of the youngest mammal species

Early birds get the burn: Monash study finds early bedtimes associated with more physical activity

Groundbreaking analysis provides day-by-day insight into prehistoric plankton’s capacity for change

Southern Ocean saltier, hotter and losing ice fast as decades-long trend unexpectedly reverses

Human fishing reshaped Caribbean reef food webs, 7000-year old exposed fossilized reefs reveal

Killer whales, kind gestures: Orcas offer food to humans in the wild

Hurricane ecology research reveals critical vulnerabilities of coastal ecosystems

Montana State geologist’s Antarctic research focuses on accumulations of rare earth elements

Groundbreaking cancer therapy clinical trial with US Department of Energy’s accelerator-produced actinium-225 set to begin this summer

Tens of thousands of heart attacks and strokes could be avoided each year if cholesterol-lowering drugs were used according to guidelines

Leading cancer and metabolic disease expert Michael Karin joins Sanford Burnham Prebys

Low-intensity brain stimulation may restore neuron health in Alzheimer's disease

[Press-News.org] Beneficial or not beneficial: that is the question for IL-1 inhibition in atherosclerosis