(Press-News.org) A gluten-free, casein-free diet may lead to improvements in behavior and physiological symptoms in some children diagnosed with an autism spectrum disorder (ASD), according to researchers at Penn State. The research is the first to use survey data from parents to document the effectiveness of a gluten-free, casein-free diet on children with ASD.
"Research has shown that children with ASD commonly have GI [gastrointestinal] symptoms," said Christine Pennesi, medical student at Penn State College of Medicine. "Notably, a greater proportion of our study population reported GI and allergy symptoms than what is seen in the general pediatric population. Some experts have suggested that gluten- and casein-derived peptides cause an immune response in children with ASD, and others have proposed that the peptides could trigger GI symptoms and behavioral problems."
The team -- which included Laura Cousino Klein, associate professor of biobehavioral health and human development and family studies -- asked 387 parents or primary caregivers of children with ASD to complete a 90-item online survey about their children's GI symptoms, food allergy diagnoses, and suspected food sensitivities, as well as their children's degree of adherence to a gluten-free, casein-free diet. The team's results appeared online this month in the journal Nutritional Neuroscience.
Pennesi and Klein and their team found that a gluten-free, casein-free diet was more effective in improving ASD behaviors, physiological symptoms and social behaviors for those children with GI symptoms and with allergy symptoms compared to those without these symptoms. Specifically, parents noted improved GI symptoms in their children as well as increases in their children's social behaviors, such as language production, eye contact, engagement, attention span, requesting behavior and social responsiveness, when they strictly followed a gluten-free, casein-free diet.
According to Klein, autism may be more than a neurological disease -- it may involve the GI tract and the immune system.
"There are strong connections between the immune system and the brain, which are mediated through multiple physiological symptoms," Klein said. "A majority of the pain receptors in the body are located in the gut, so by adhering to a gluten-free, casein-free diet, you're reducing inflammation and discomfort that may alter brain processing, making the body more receptive to ASD therapies."
The team found that parents who eliminated all gluten and casein from their children's diets reported that a greater number of their children's ASD behaviors, physiological symptoms and social behaviors improved after starting the diet compared to children whose parents did not eliminate all gluten and casein. The team also found that parents who implemented the diet for six months or less reported that the diet was less effective in reducing their child's ASD behaviors.
According to the researchers, some of the parents who filled out the surveys had eliminated only gluten or only casein from their children's diets, but survey results suggested that parents who completely eliminated both gluten and casein from their child's diet reported the most benefit.
"While more rigorous research is needed, our findings suggest that a gluten-free, casein-free diet might be beneficial for some children on the autism spectrum," Pennesi said. "It is also possible that there are other proteins, such as soy, that are problematic for these children."
The reason Klein and Pennesi examined gluten and casein is because they are two of the most common "diet offenders."
"Gluten and casein seem to be the most immunoreactive," Klein said. "A child's skin and blood tests for gluten and casein allergies can be negative, but the child still can have a localized immune response in the gut that can lead to behavioral and psychological symptoms. When you add that in with autism you can get an exacerbation of effects."
Klein's advice to parents of children with ASD?
"If parents are going to try a gluten-free, casein-free diet with their children, they really need to stick to it in order to receive the possible benefits," she said.
"It might give parents an opportunity to talk with their physicians about starting a gluten-free, casein-free diet with their children with ASD."
INFORMATION:
END
Already a prominent oil and gas state, Texas can expect its contribution to the nation's energy resources to keep growing. Take the Barnett Shale formation, for instance, near Fort Worth. The Barnett Shale already produces six percent of all natural gas produced in the entire 48 contiguous states, with more production expected.
Texas Shale Formations & Hydraulic Fracturing
Extracting trapped natural gas from the reservoirs of layered shale rock has, for the first time in just the last several years, become practical and profitable.
Conventional drilling equipment ...
DURHAM, N.C. -- Using exotic man-made materials, scientists from Duke University and Boston College believe they can greatly enhance the forces of electromagnetism (EM), one of the four fundamental forces of nature, without harming living beings or damaging electrical equipment.
This theoretical finding could have broad implications for such applications as magnetic levitation trains, which ride inches above the tracks without touching and are propelled by electro-magnets.
As the term indicates, EM is made up of two types of fields – electric and magnetic. Alternating ...
Researchers at Drexel University have found that a majority of women with bulimia nervosa reach their highest-ever body weight after developing their eating disorder, despite the fact that the development of the illness is characterized by significant weight loss. Their new study, published online last month in the International Journal of Eating Disorders, adds to a body of recent work that casts new light on the importance of weight history in understanding and treating bulimia.
"Most patients lose a lot of weight as part of developing this disorder, and all dedicate ...
Experts say at least $20 million to $30 million in government research is needed over the next decade to adequately identify and address the possible ecological risks of synthetic biology, an emerging area of research focused on the design and construction of new biological parts and systems, or modification of existing ones, to create new applications in areas ranging from energy to chemicals and pharmaceuticals.
Without key research into these risks and appropriate federal oversight, certain synthetic organisms might survive and flourish in natural environments, wreaking ...
If you want big muscles without working out, there's hope. In the March 2012 print issue of the FASEB Journal, scientists from the University of Florida report that a family of protein transcription factors, called "Forkhead (Fox0)" plays a significant role in the regulation of skeletal muscle mass. Specifically, they found that interfering with the activity of these transcription factors prevents muscle wasting associated with cancer and sepsis, and even promotes muscle growth. This discovery is likely to be relevant to any disease, condition or lifestyle that leads to ...
WASHINGTON — Federal laws that motivate or require drug and biologic developers to conduct pediatric studies have yielded beneficial information to guide the use of medications in children, says a new report by the Institute of Medicine. Still, studies involving children continue to be limited, especially in certain areas such as medications' use in newborns and long-term safety and effectiveness in children. The report identifies ways that Congress and the U.S. Food and Drug Administration could further improve the utility of clinical information obtained from pediatric ...
Though tax fraud schemes are common, the indictment of 55 people in a single case is not. In early October 2011, a federal grand jury indicted 55 business owners and customers of two southern California businesses, as well as the attorneys, tax preparers and other professionals working with them, in one of the largest tax fraud cases ever seen.
Through two companies, Old Quest Foundation and De la Fuente and Ramirez and Associates, the defendants are accused of fraud against the government, seeking around $270 million in fraudulent tax returns. De la Fuente and Ramirez ...
NEW YORK, February 29, 2012 – A new method for creating nanofibers made of proteins, developed by researchers at Polytechnic Institute of New York University (NYU-Poly), promises to greatly improve drug delivery methods for the treatment of cancers, heart disorders and Alzheimer's disease, as well as aid in the regeneration of human tissue, bone and cartilage.
In addition, applied differently, this same development could point the way to even tinier and more powerful microprocessors for future generations of computers and consumer electronics devices.
The details are ...
NEW YORK (Feb. 29, 2012)—Exposure to lead wreaks havoc in the brain, with consequences that include lower IQ and reduced potential for learning. But the precise mechanism by which lead alters nerve cells in the brain has largely remained unknown.
New research led by Tomás R. Guilarte, PhD, Leon Hess Professor and Chair of Environmental Health Sciences at Columbia University Mailman School of Public Health, and post-doctoral research scientist Kirstie H. Stansfield, PhD, used high-powered fluorescent microscopy and other advanced techniques to painstakingly chart the varied ...
COLUMBUS, Ohio – In this world, there are winners and losers – and, for your own safety, it is best to fear the winners.
A new study found that winners – those who outperformed others on a competitive task – acted more aggressively against the people they beat than the losers did against the victors.
"It seems that people have a tendency to stomp down on those they have defeated, to really rub it in," said Brad Bushman, co-author of the study and professor of communication and psychology at Ohio State University.
"Losers, on the other hand, don't really act any more ...
