PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Patients suffering from pre-diabetes at potential future risk of stroke

Research: Effect of pre-diabetes on future risk of stroke: meta-analysis editorial: Pre-diabetes as a contributor to stroke

2012-06-08
(Press-News.org) Millions of people suffering from pre-diabetes may be at a higher risk of stroke, a study published on bmj.com today suggests.

Pre-diabetes is characterised by higher than normal blood glucose levels that, if left untreated, develops into type 2 diabetes. The scale of the problem is enormous and growing, with an estimated 79 million people in the US and 7 million people in the UK affected.

People with pre-diabetes also harbour the same vascular risk factors as people with type 2 diabetes, such as high blood pressure, high cholesterol and obesity, but its effect on future stroke risk has not been established.

So a team of researchers from the University of California looked at the relationship between pre-diabetes and risk of stroke whilst taking into consideration other cardiovascular risk factors such as an unhealthy weight and lifestyle. The authors analysed the results of 15 studies involving 760,925 participants.

They show that the relationship between pre-diabetes and risk of stroke appears to depend on the definition of pre-diabetes.

Pre-diabetes is generally defined as impaired fasting glucose (raised blood glucose levels after a 12-hour fast). A range of 70.2 to 100 mg/dl is normal, while a level of 100 to 126 mg/dl is considered a sign of pre-diabetes.

The researchers found that pre-diabetes based on the 1997 American Diabetes Association (ADA) definition of 110 to 125 mg/dl carried a 21% higher chance of stroke.

However, in 2003 the ADA redefined pre-diabetes as an impaired fasting glucose of 100 to 125mg/dl and no risk was found in studies using this current, less stringent definition.

This suggests that there may be a 'threshold effect' with regard to the relationship between impaired fasting glucose and future stroke risk to the extent that the risk of a stroke only begins to rise at or above a fasting glucose level of 110 mg/dL.

The authors stress the possibility that some other unmeasured (confounding) factor may explain these results and it is important to note that the quality of evidence was variable.

The authors conclude that people with pre-diabetes (with a fasting glucose 110 to 125 mg/dl) were at a "modestly higher risk of future stroke". They do add however that those with the 2003 ADA's definition (100 to 125 mg/dl) do not have an increased risk of stroke.

The authors suggest that those with pre-diabetes "should be aware that they are at increased risk of future stroke" and that the condition is associated with the presence of one or more other cardiovascular risk factors. They recommend that weight be kept under control and that healthy lifestyle changes should be adopted to decrease this risk.

In an accompanying editorial, Dr Jonathan Treadwell, from the ECRI Institute in Philadelphia, suggests that due to unmeasured factors such as age, obesity and hypertension, it is impossible to know the exact size of the association between pre-diabetes and stroke. He also argues that Lee's study only takes into consideration two of the overall four categories that define pre-diabetes. He concludes that it is "too simple" to categorise whether someone has diabetes, pre-diabetes and not diabetes but commends Lee's study for thinking "outside of the box of what meta-analysis can achieve" adding that the "clinical question must drive the research methods".

### END


ELSE PRESS RELEASES FROM THIS DATE:

By adding VSL#3 probiotic to traditional therapies UC patients can improve remission rates

2012-06-08
GAITHERSBURG, MD, June 7 – As one of the few probiotics with medical food designation for specific illnesses, VSL#3® has been the subject of a collection of more than 80 studies that have demonstrated its use in the dietary management of IBS, ulcerative colitis, and an ileal pouch. Ulcerative colitis patients, in particular, have been shown to benefit from adding VSL#3 medical food to their prescription drug regimen. One particular study shows that the combination of VSL#3 and traditional drug therapy can improve remission rates over drug therapy alone by 10 to 17 percent, ...

Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients

2012-06-08
Berlin, Germany, June 7 2012: Initial results from an international, investigator-initiated, open label phase III trial were presented at EULAR 2012, the Annual Congress of the European League Against Rheumatism. Data indicate that haematopoietic stem cell transplantation (HSCT) results in better long term survival than conventional treatment for patients with poor prognosis early diffuse cutaneous systemic sclerosis. The ASTIS (Autologous Stem Cell Transplantation International Scleroderma) trial enrolled more than 150 patients between 2001 and 2009, and randomised ...

Mapping genes: Mayo Clinic finds new risk factors for neurodegenerative diseases

2012-06-08
JACKSONVILLE, Fla. — Using a new and powerful approach to understand the origins of neurodegenerative disorders such as Alzheimer's disease, researchers at Mayo Clinic in Florida are building the case that these diseases are primarily caused by genes that are too active or not active enough, rather than by harmful gene mutations. In the June 7 online issue of PLoS Genetics, they report that several hundred genes within almost 800 brain samples of patients with Alzheimer's disease or other disorders had altered expression levels that did not result from neurodegeneration. ...

Surgeon experience affects complication rate of spinal stenosis surgery

2012-06-08
Philadelphia, Pa. (June 7, 2012) - For patients undergoing surgery for spinal stenosis, the risk of complications is higher when the surgeon performs very few such procedures—less than four per year, suggests a study in the June issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. In contrast, the complication rate is not significantly affected by the volume of spinal stenosis surgeries performed at the hospital, according to the new research. The senior ...

Meditation practice may decrease risk for cardiovascular disease in teens

Meditation practice may decrease risk for cardiovascular disease in teens
2012-06-08
AUGUSTA, Ga. – Regular meditation could decrease the risk of developing cardiovascular disease in teens who are most at risk, according to Georgia Health Sciences University researchers. In a study of 62 black teens with high blood pressure, those who meditated twice a day for 15 minutes had lower left ventricular mass, an indicator of future cardiovascular disease, than a control group, said Dr. Vernon Barnes, a physiologist in the Medical College of Georgia and the Georgia Health Sciences University Institute of Public and Preventive Health. Barnes, Dr. Gaston Kapuku, ...

Armored caterpillar could inspire new body armor

2012-06-08
RIVERSIDE, Calif. (www.ucr.edu) — Military body armor and vehicle and aircraft frames could be transformed by incorporating the unique structure of the club-like arm of a crustacean that looks like an armored caterpillar, according to findings by a team of researchers at the University of California, Riverside's Bourns College of Engineering and elsewhere published online today, June 7, in the journal Science. The bright orange fist-like club of the mantis shrimp, or stomatopod, a 4-inch long crustacean found in tropical waters, accelerates underwater faster than a 22-caliber ...

Caribbean wins the seaweed Olympics

2012-06-08
A new study finds that Caribbean seaweeds are far better competitors than their equivalents in the Indian and Pacific Oceans. But this triumph is bad news for Caribbean coral reefs. The picture-postcard beauty of Caribbean reefs owes much to the living corals that build reefs and contribute startling white sand to beaches. Coral reefs might seem to be tranquil environment but in fact a battle is constantly waged between corals and seaweeds that fight over space. Scientists have known for some time that seaweeds can gain the upper hand if corals are damaged by hurricanes ...

How does dolomite form?

2012-06-08
Not only in the Dolomites, but throughout the world dolomite is quite common. More than 90 percent of dolomite is made up of the mineral dolomite. It was first described scientifically in the 18th century. But who would have thought that the formation of this mineral is still not fully understood, although geologists are aware of large deposits of directly formed (primary) dolomite from the past 600 million years. The process of recent primary dolomite formation is restricted to extreme ecosystems such as bacterial mats in highly saline lakes and lagoons. "As these systems ...

Breaking the limits of classical physics

Breaking the limits of classical physics
2012-06-08
With simple arguments, researchers show that nature is complicated! Researchers from the Niels Bohr Institute have made a simple experiment that demonstrates that nature violates common sense – the world is different than most people believe. The experiment illustrates that light does not behave according to the principles of classical physics, but that light has quantum mechanical properties. The new method could be used to study whether other systems behave quantum mechanically. The results have been published in the scientific journal, Physical Review Letters. In physics ...

Financial mania: Why bankers and politicians failed to heed warnings of the credit crisis

2012-06-08
Western economies displayed the same kind of manic behaviour as psychologically disturbed individuals in the run up to the 2008 credit crisis -- and it could happen again, according to a new study. Bankers, economists and politicians shared a "manic culture" of denial, omnipotence and triumphalism as they threw caution to the wind, says Professor Mark Stein, the award-winning academic from the University of Leicester School of Management. Observing - but not heeding - the warning signs from the collapse of the Japanese economy in 1991 and the 1998 crisis in south-east ...

LAST 30 PRESS RELEASES:

Plant doctor: An AI system that watches over urban trees without touching a leaf

Study tracks chromium chemistry in irradiated molten salts

Scientists: the beautiful game is a silver bullet for global health

Being physically active, even just a couple of days a week, may be key to better health

High-fat diet promote breast cancer metastasis in animal models

A router for photons

Nurses and AI collaborate to save lives, reduce hospital stays

Multi-resistance in bacteria predicted by AI model

Tinker Tots: A citizen science project to explore ethical dilemmas in embryo selection

Sensing sickness

Cost to build multifamily housing in California more than twice as high as in Texas

Program takes aim at drinking, unsafe sex, and sexual assault on college campuses

Inability to pay for healthcare reaches record high in U.S.

Science ‘storytelling’ urgently needed amid climate and biodiversity crisis

KAIST Develops Retinal Therapy to Restore Lost Vision​

Adipocyte-hepatocyte signaling mechanism uncovered in endoplasmic reticulum stress response

Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid

Low LDL cholesterol levels linked to reduced risk of dementia

Thickening of the eye’s retina associated with greater risk and severity of postoperative delirium in older patients

Almost one in ten people surveyed report having been harmed by the NHS in the last three years

Enhancing light control with complex frequency excitations

New research finds novel drug target for acute myeloid leukemia, bringing hope for cancer patients

New insight into factors associated with a common disease among dogs and humans

Illuminating single atoms for sustainable propylene production

New study finds Rocky Mountain snow contamination

Study examines lactation in critically ill patients

UVA Engineering Dean Jennifer West earns AIMBE’s 2025 Pierre Galletti Award

Doubling down on metasurfaces

New Cedars-Sinai study shows how specialized diet can improve gut disorders

Making moves and hitting the breaks: Owl journeys surprise researchers in western Montana

[Press-News.org] Patients suffering from pre-diabetes at potential future risk of stroke
Research: Effect of pre-diabetes on future risk of stroke: meta-analysis editorial: Pre-diabetes as a contributor to stroke