(Press-News.org) VIDEO:
Harry Ostrer, M.D., discusses how his research into a new genetic analysis focusing on Jews from North Africa has provided an overall genetic map of the Jewish Diasporas. Dr....
Click here for more information.
August 6, 2012 — (Bronx, NY) — A new genetic analysis focusing on Jews from North Africa has provided an overall genetic map of the Jewish Diasporas. The findings support the historical record of Middle Eastern Jews settling in North Africa during Classical Antiquity, proselytizing and marrying local populations, and, in the process, forming distinct populations that stayed largely intact for more than 2,000 years. The study, led by researchers at Albert Einstein College of Medicine of Yeshiva University, was published online today in the Proceedings of the National Academy of Sciences.
"Our new findings define North African Jews, complete the overall population structure for the various groups of the Jewish Diaspora, and enhance the case for a biological basis for Jewishness," said study leader Harry Ostrer, M.D. , professor of pathology, of genetics and of pediatrics at Einstein and director of genetic and genomic testing for the division of clinical pathology at Montefiore Medical Center. Dr. Ostrer noted that obtaining a comprehensive genetic fingerprint of various Jewish subpopulations can help reveal genetic links to heart disease, cancer, diabetes and other common diseases.
In a previous genetic analysis, the researchers showed that modern-day Sephardic (Greek and Turkish), Ashkenazi (Eastern European) and Mizrahi (Iranian, Iraqi and Syrian) Jews that originated in Europe and the Middle East are more related to each other than to their contemporary non-Jewish neighbors, with each group forming its own cluster within the larger Jewish population. Further, each group demonstrated Middle-Eastern ancestry and varying degrees of mixing with surrounding populations. Two of the major Jewish populations—Middle Eastern and European Jews—were found to have diverged from each other approximately 2,500 years ago.
The current study extends that analysis to North African Jews—the second largest Jewish Diaspora group. Their relatedness to each other, to other Jewish Diaspora groups, and to their non-Jewish North African neighbors had not been well defined. The study also included members of Jewish communities in Ethiopia, Yemen and Georgia. In all, the researchers analyzed the genetic make-up of 509 Jews from 15 populations along with genetic data on 114 individuals from seven North African non-Jewish populations.
North African Jews exhibited a high degree of endogamy, or marriage within their own religious and cultural group in accordance with custom. Two major subgroups within this overall population were identified: Moroccan/Algerian Jews and Djerban (Tunisian)/Libyan Jews. The two subgroups varied in their degree of European mixture, with Moroccan/Algerian Jews tending to be more related to Europeans—most likely stemming from the expulsion of Sephardic Jews from Spain during the Inquisition, starting in 1492. Ethiopian and Yemenite Jewish populations also formed distinctive genetically linked clusters, as did Georgian Jews .
###Dr. Ostrer's paper is titled, "North African Jewish and non-Jewish populations form distinctive, orthogonal clusters." Additional Einstein contributors include: Christopher Campbell, Gil Atzmon, Ph.D., Carole Oddoux, Ph.D., Alexander Pearlman, Ph.D., and Edward R. Burns, M.D. Other contributors include: Pier Francesco Palamara and Itsik Pe'er, Ph.D. (Columbia University, New York, NY); Laura Rodríguez-Botigué and David Comas Martínez (Universitat Pompeu Fabra, Barcelona, Spain); Marc Fellous, M.D., Ph.D. (Cochin Institute, Inserm, Paris, France); Li Hao, Ph.D. (University of Medicine and Dentistry of New Jersey, Newark, NJ); Brenna Henn, Ph.D., and Carlos Bustamante (Stanford School of Medicine, Stanford, CA); Maya Dubrovsky and Eitan Friedman, M.D., Ph.D (Tel-Aviv University, Tel Aviv, Israel).
The research was supported by grants from the Lewis and Rachel Rudin Foundation; the Iranian-American Jewish Federation of New York; the U.S.-Israel Binational Science Foundation; National Cancer Institute (CA121852) of the National Institutes of Health; and Ruth and Sidney Lapidus.
About Albert Einstein College of Medicine of Yeshiva University
Albert Einstein College of Medicine of Yeshiva University is one of the nation's premier centers for research, medical education and clinical investigation. During the 2009-2010 academic year, Einstein is home to 724 M.D. students, 248 Ph.D.students, 117 students in the combined M.D./Ph.D. program, and 368 postdoctoral research fellows.
The College of Medicine has 2,522 fulltime faculty members located on the main campus and at its clinical affiliates. 2011, Einstein received nearly $170 million in awards from the NIH. This includes the funding of major research centers at Einstein in diabetes, cancer, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities.
Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients.
Through its extensive affiliation network involving Montefiore, Jacobi Medical Center – Einstein's founding hospital, and five other hospital systems in the Bronx, Manhattan, Long Island and Brooklyn, Einstein runs one of the largest post-graduate medical training programs in the United States, offering approximately 155 residency programs to more than 2,200 physicians in training. For more information, please visit http://www.einstein.yu.edu/home/default.asp and follow us on Twitter @EinsteinMed.
Specially designed comprehensive behavioral therapy is more effective than sessions offering patient support and education in helping adults with Tourette syndrome manage their tics – sudden, repetitive motions or vocalizations – according to a study in the August issue of Archives of General Psychiatry. The findings come from a team of investigators at Massachusetts General Hospital (MGH)/Harvard Medical School, Yale University, the University of Texas Health Science Center at San Antonio, and other institutions.
"The program we tested, which teaches patients new ways ...
CHICAGO – Weight training was linked with a reduced risk of type 2 diabetes in a study of male health professionals, and those men who engaged in weight training and aerobic exercise for at least 150 minutes a week had the greatest reduction in risk, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.
Regular physical activity is a cornerstone in the prevention and management of type 2 diabetes mellitus (T2DM), but the role of weight training in the primary prevention of the disease is largely unknown, according to ...
CHICAGO – Higher levels of physical activity were related to lower risk of death in patients with diabetes, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.
Increased physical activity (PA) has long been considered a key element in diabetes management. Patients with diabetes are at higher risk for cardiovascular disease (CVD) and premature death, so researchers note it is important to determine whether PA can produce similar beneficial effects in this high-risk population. While other studies have suggested that ...
Boston, MA – Men who do weight training regularly—for example, for 30 minutes per day, five days per week—may be able to reduce their risk of type 2 diabetes by up to 34%, according to a new study by Harvard School of Public Health (HSPH) and University of Southern Denmark researchers. And if they combine weight training and aerobic exercise, such as brisk walking or running, they may be able to reduce their risk even further—up to 59%.
This is the first study to examine the role of weight training in the prevention of type 2 diabetes. The results suggest that, because ...
CHICAGO – The odds of undergoing cranial computed tomography (CT) among children with minor blunt head trauma who were at higher risk for clinically important traumatic brain injury did not appear to differ by race/ethnicity in a secondary analysis of a study of injured children, according to a report in the August issue of Archives of Pediatrics & Adolescent Medicine, a JAMA Network publication. However, there may have been differences for children at intermediate or lowest risk.
Traumatic brain injury (TBI) is a leading cause of pediatric illness and death in the U.S., ...
CHICAGO – Treatment with growth hormone-releasing hormone appears to be associated with favorable cognitive effects among both adults with mild cognitive impairment and healthy older adults, according to a randomized clinical trial published Online First by Archives of Neurology, a JAMA Network publication.
"Growth hormone-releasing hormone (GHRH), growth hormone and insulinlike growth factor 1 have potent effects on brain function, their levels decrease with advancing age, and they likely play a role in the pathogenesis of Alzheimer disease," the authors write as background ...
CHICAGO – Patients with hoarding disorder exhibited abnormal activity in regions of the brain that was stimulus dependent when deciding what to do with objects that did or did not belong to them, according to a report in the August issue of Archives of General Psychiatry, a JAMA Network publication.
Hoarding disorder (HD) is defined as the excessive collection of objects and an inability to discard them. It is characterized by marked avoidance of decisions about possessions, according to the study background.
David F. Tolin, Ph.D., of the Institute of Living, Hartford, ...
White children are more likely to receive cranial (head) CT scans in an emergency department following minor head trauma, compared with African-American or Hispanic children, a study published by researchers at UC Davis has found.
The study findings do not indicate that CT (computed tomography) scans are underused in African-American and Hispanic children. Rather, the researchers suggested that white children may receive too many CT scans and thus may be exposed to unnecessary radiation.
The results are online and appear in the August issue of the Archives of Pediatrics ...
Just as differences in song can be used to distinguish one bird species from another, the pips and squeaks bats use to find prey can be used to identify different species of bat. Now, for the first time, ecologists have developed a Europe-wide tool capable of identifying bats from their echolocation calls.
The new free online tool – iBatsID – will be a major boost to conserving bats, whose numbers have declined significantly across Europe over the past 50 years. Details are published today in the British Ecological Society's Journal of Applied Ecology.
Working with ...
LEXINGTON, Ky. (Aug. 6 , 2012) — University of Kentucky researchers, led by Dr. Jayakrishna Ambati, have made an exciting finding in the "dry" form of age-related macular degeneration known as geographic atrophy (GA). GA is an untreatable condition that causes blindness in millions of individuals due to death of retinal pigmented epithelial cells. The paper, "ERK1/2 Activation is a Therapeutic Target in Age-Related Macular Degeneration" appears in the current online issue of the premier journal Proceedings of the National Academy of Sciences.
Ambati, professor of physiology, ...
