Study finds gene that predicts happiness in women

New finding may help explain the gender difference in happiness

2012-08-29

(Press-News.org) Tampa, FL (Aug. 28, 2012) -- A new study has found a gene that appears to make women happy, but it doesn't work for men. The finding may help explain why women are often happier than men, the research team said.

Scientists at the University of South Florida (USF), the National Institutes of Health (NIH), Columbia University and the New York State Psychiatric Institute reported that the low activity form of the gene monoamine oxidase A (MAOA) is associated with higher self-reported happiness in women. No such association was found in men.

The findings appear online in the journal Progress in Neuro-Psychopharmacology & Biological Psychiatry.

"This is the first happiness gene for women," said lead author Henian Chen, MD, PhD, associate professor in the Department of Epidemiology and Biostatistics, USF College of Public Health.

"I was surprised by the result, because low expression of MAOA has been related to some negative outcomes like alcoholism, aggressiveness and antisocial behavior," said Chen, who directs the Biostatistics Core at the USF Health Morsani College of Medicine's Clinical and Translational Sciences Institute. "It's even called the warrior gene by some scientists, but, at least for women, our study points to a brighter side of this gene."

While they experience higher rates of mood and anxiety disorders, women tend to report greater overall life happiness than do men. The reason for this remains unclear, Chen said. "This new finding may help us to explain the gender difference and provide more insight into the link between specific genes and human happiness."

The MAOA gene regulates the activity of an enzyme that breaks down serontin, dopamine and other neurotransmitters in the brain -- the same "feel-good" chemicals targeted by many antidepressants. The low-expression version of the MAOA gene promotes higher levels of monoamine, which allows larger amounts of these neurotransmitters to stay in the brain and boost mood.

The researchers analyzed data from a population-based sample of 345 individuals – 193 women and 152 men – participating in Children in the Community, a longitudinal mental health study. The DNA of study subjects had been analyzed for MAOA gene variation and their self-reported happiness was scored by a widely used and validated scale.

After controlling for various factors, ranging from age and education to income, the researchers found that women with the low-expression type of MAOA were significantly happier than others. Compared to women with no copies of the low-expression version of the MAOA gene, women with one copy scored higher on the happiness scale and those with two copies increased their score even more.

While a substantial number of men carried a copy of the "happy" version of the MAOA gene, they reported no more happiness than those without it.

So, why the genetic gender gap in feeling good?

The researchers suspect the difference may be explained in part by the hormone testosterone, found in much smaller amounts in women than in men. Chen and his co-authors suggest that testosterone may cancel out the positive effect of MAOA on happiness in men.

The potential benefit of MAOA in boys could wane as testosterone levels rise with puberty, Chen said. "Maybe men are happier before adolescence because their testosterone levels are lower."

Chen emphasizes that more research is needed to identify which specific genes influence resilience and subjective well-being, especially since studies of twins estimate genetic factors account for 35 to 50 percent of the variance in human happiness.

While happiness is not determined by a single gene, there is likely a set of genes that, along with life experiences, shape our individual happiness levels, Chen said. "I think the time is right for more genetic studies that focus on well-being and happiness."

"Certainly it could be argued that how well-being is enhanced deserves at least as much attention as how (mental) disorders arise; however, such knowledge remains limited."

###The study by Chen and colleagues was supported by the National Institutes of Health and a USF proposal enhancement grant.

Article citation: Henian Chen, Daniel S. Pine, Monique Ernst, Elena Gorodetsky, Stephanie Kasen, Kathy Gordon, David Goldman, Patricia Cohen; The MAOA gene predicts happiness in women; Progress in Neuro-Psychopharmacology & Biological Psychiatry, online in advance of print Aug. 4, 2012; http://dx.doi.org/10.1016/j.pnpbp.2012.07.018

USF Health's mission is to envision and implement the future of health. It is the partnership of the USF Health Morsani College of Medicine, the College of Nursing, the College of Public Health, the College of Pharmacy, the School of Biomedical Sciences and the School of Physical Therapy and Rehabilitation Sciences; and the USF Physician's Group. The University of South Florida is a global research university ranked 50th in the nation by the National Science Foundation for both federal and total research expenditures among all U.S. universities.

ELSE PRESS RELEASES FROM THIS DATE:

Can branding improve school lunches?

2012-08-29

A popular marketing ploy with junk foods and other indulgent table fare can be an equally effective tool for promoting healthier eating in school cafeterias. "Nutritionists and school lunch planners can turn the tables on children's poor eating habits by adopting the same 'branding' tactic used by junk food marketers," said Brian Wansink, an expert on the subtle cues that affect people's eating habits and professor of marketing at the Dyson School of Applied Economics and Management at Cornell University. Food marketers have associated particular foods with mascots, ...

The beat goes in the brain

2012-08-29

URBANA, Ill. — Like a melody that keeps playing in your head even after the music stops, researchers at the University of Illinois's Beckman Institute have shown that the beat goes on when it comes to the human visual system. In an experiment designed to test their theory about a brain mechanism involved in visual processing, the researchers used periodic visual stimuli and electroencephalogram (EEG) recordings and found, one, that they could precisely time the brain's natural oscillations to future repetitions of the event, and, two, that the effect occurred even after ...

Not all lung cancer patients who could benefit from crizotinib are identified by FDA-approved test

2012-08-29

Break apart a couple worm-like chromosomes and they may reconnect with mismatched tips and tails – such is the case of the EML4-ALK fusion gene that creates 2-7 percent of lung cancers. Almost exactly a year ago, the FDA approved the drug crizotinib to treat these ALK+ lung cancer patients, who were likely never smokers. Informed doctors use the test called a FISH assay to check for the EML4-ALK fusion gene, and then if the test is positive, ALK+ patients benefit greatly from crizotinib. A recent University of Colorado Cancer Center case study published in the Journal ...

Metabolism in the brain fluctuates with circadian rhythm

2012-08-29

CHAMPAIGN, lll. — The rhythm of life is driven by the cycles of day and night, and most organisms carry in their cells a common, (roughly) 24-hour beat. In animals, this rhythm emerges from a tiny brain structure called the suprachiasmatic nucleus (SCN) in the hypothalamus. Take it out of the brain and keep it alive in a lab dish and this "brain clock" will keep on ticking, ramping up or gearing down production of certain proteins at specific times of the day, day after day. A new study reveals that the brain clock itself is driven, in part, by metabolism, the production ...

Mayo study: Exercise can help cancer patients, but few oncologists suggest it

2012-08-29

ROCHESTER, Minn. -- Numerous studies have shown the powerful effect that exercise can have on cancer care and recovery. For patients who have gone through breast or colon cancer treatment, regular exercise has been found to reduce recurrence of the disease by up to 50 percent. But many cancer patients are reluctant to exercise, and few discuss it with their oncologists, according to a Mayo Clinic study published in the Journal of Pain and Symptom Management. "As doctors, we often tell patients that exercise is important, but to this point, nobody had studied what patients ...

Why retire later?

2012-08-29

ANN ARBOR, Mich.---What if every U.S. worker got an automatic 10 percent pay raise at age 55? According to a new University of Michigan study, most people would work quite a bit longer to enjoy the extra income before they retired. By eliminating social security payroll taxes starting when workers are 55-years old, the study shows that take-home pay would jump by 10.6 percent and they would work 1.5 years longer on average, paying more income taxes and helping to reduce the Federal deficit. "People are living longer, healthier lives, and so far have opted to take most ...

Evaluate children's stress after natural disasters

2012-08-29

CORAL GABLES, FL (August 28, 2012) -- As Hurricane Isaac nears the Gulf Coast, one may wonder what the impact of natural disasters are on children. Who is most at risk for persistent stress reactions? How can such youth be identified and assisted in the aftermath of a destructive storm? Dr. Annette M. La Greca, a professor of psychology and pediatrics at the University of Miami, and her colleagues, have been studying children's disaster reactions following Hurricanes Andrew (1992), Charley (2004) and Ike (2008). Recent findings from Hurricane Ike shed light on these questions ...

Kindergarten readiness: Are shy kids at an academic disadvantage?

2012-08-29

CORAL GABLES, FL (August 28, 2012)—Parents of young children hope for a successful kindergarten experience that will set their youngsters on the right path of their educational journey. Some worry about their kids not adapting to the school environment, particularly when the children are talkative and overactive. Yet, a new study by the University of Miami (UM) shows that overly shy preschool children are at greater academic risk than their chatty and boisterous peers. The study is one of the first to follow the social and academic progress of children throughout the preschool ...

Pretend play may not be as crucial to child development as believed, new study shows

2012-08-29

Pretend play can be fun for preschool children, but a new University of Virginia study, published in a recent online edition of the journal Psychological Bulletin, finds that it is not as crucial to a child's development as currently believed. Pretend play is any play a child engages in, alone, with playmates, or with adults, that involves uses of the imagination to create a fantasy world or situation, such as making toy cars go "vrrooooom" or making dolls talk. Based on a number of key studies over four decades, pretend play is widely considered by psychologists – and ...

URMC researchers connect new genetic signature to leukemia

2012-08-29

University of Rochester Medical Center scientists believe they are the first to identify genes that underlie the growth of primitive leukemia stem cells, and then to use the new genetic signature to identify currently available drugs that selectively target the rogue cells. Although it is too early to attach significance to the drug candidates, two possible matches popped up: A drug in development for breast cancer (not approved by the Food and Drug Administration), and another experimental agent that, coincidentally, had been identified earlier by a URMC laboratory as ...

Study finds gene that predicts happiness in women

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: