Inner city infants have different patterns of viral respiratory illness than infants in the suburbs

(Press-News.org) Children living in low-income urban areas appear especially prone to developing asthma, possibly related to infections they acquire early in life. In a new study in The Journal of Infectious Diseases, available online, researchers from the University of Wisconsin in Madison investigated viral respiratory illnesses and their possible role in the development of asthma in urban versus suburban babies. The differences in viral illness patterns they found provide insights that could help guide the development of new asthma treatments in children.

Viral respiratory illnesses have been linked previously to the development of asthma in childhood. Early studies investigated the association of respiratory syncytial virus (RSV) and the onset of asthma. More recent studies have shown that children with human rhinovirus (HRV) infections have a greater chance of developing asthma by age 6 than children with RSV infections. Additionally, it has been suggested that particular virus strains may be more likely than others to promote asthma development. Because children living in urban inner cities have different environmental exposures than children in suburban areas, the authors of this latest study hypothesized that the types of viral respiratory infections would also be unique to each environment.

To document patterns of respiratory viruses in infants living in urban and suburban locations, James E. Gern, MD, and his team of investigators collected nasal secretions from 500 infants from four inner-city areas in the U.S. (Boston, Baltimore, New York City, and St. Louis) and 285 infants from suburban Madison, Wis. Nasal secretions were sampled during periods when the babies had respiratory illnesses and when they were healthy.

The inner-city infants had lower rates of viral detection overall. This may suggest that other factors, such as bacteria or allergic reactions to pollutions or toxic exposures, contribute significantly to respiratory illness. Sick urban infants had lower rates of two kinds of viruses, HRV and RSV, and higher rates of adenovirus infections, compared to suburban infants. In the urban babies, 4.8 percent of nasal washes tested positive for only adenovirus, while just 0.7 percent of samples from suburban babies were positive for only adenovirus. "Adenovirus infections, either as a single pathogen or when detected in concert with other viruses, were significantly more common in the urban population, and this held true for each of the four urban locations where our study was conducted," the authors wrote.

This is of particular interest, the researchers noted, because adenovirus can cause persistent infections. The study authors believe this may suggest that development of the lungs or airways could be altered by adenovirus infections in early life.

In an accompanying editorial, Peter W. Heymann, MD, and Thomas A.E. Platts-Mills, MD, PhD, of the University of Virginia in Charlottesville, noted that the findings are of interest given the pervasiveness and the morbidity and mortality of asthma in poor urban areas. "The results clearly show differences in the detection of viral infections during the first year of life," they wrote, "and this approach is likely to provide novel insights that will serve to guide the development of treatment interventions to decrease the prevalence and severity of asthma during childhood."

In an effort to better understand the origins of non-viral respiratory illnesses, Dr. Gern and colleagues are planning experiments to evaluate other pathogens and microbes in the airways. They also plan to follow the urban children in this study for at least 10 years to "test the hypothesis that infections with adenoviruses might be associated later on in childhood with an increased rate of asthma and perhaps lower levels of lung function."

### Fast Facts: 1) Researchers investigated viral respiratory illnesses and their possible role in the development of asthma in urban versus suburban babies. They found differences in viral illness patterns that may help guide the development of new asthma treatment interventions. 2) Urban infants in the study had lower rates of human rhinovirus (HRV) and respiratory syncytial virus (RSV) infections than suburban infants. 3) Among urban babies in the study, 4.8 percent of samples tested positive for only adenovirus, while just 0.7 percent of those from suburban babies tested positive for only adenovirus. 4) The authors plan to follow the urban infants in the study for at least 10 years to determine whether adenovirus infections are associated with an increased rate of asthma and lower levels of lung function.

The study and the accompanying editorial are available online. They are embargoed until 12:01 a.m. EDT on Wednesday, Sept. 26, 2012:

Etiology of Viral Respiratory Illnesses in Inner City vs. Suburban Infants

Deciphering the Importance of Host and Environmental Factors that Influence the Genesis of Asthma During Childhood

Published continuously since 1904, The Journal of Infectious Diseases is the premier global journal for original research on infectious diseases. The editors welcome major articles and brief reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. The journal is an official publication of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing nearly 10,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org.