(Press-News.org) Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% of the world's population. A group of inflammatory molecules known as interleukins activate an immune response that causes itchy skin, but it is unclear how the skin cells and immune cells communicate. In a study published in the Journal of Clinical Investigation, researchers led by Manfred Kopf at the Swiss Federal Institute of Technology in Zürich, Switzerland found that mice lacking interleukin-36 (IL-36) were protected from immune-mediated skin inflammation. These results indicate that IL-36 might be a useful therapeutic target in the treatment of psoriasis.
###TITLE:
Psoriasiform dermatitis is driven by interleukin-36-mediated dendritic cell-keratinocyte crosstalk
AUTHOR CONTACT:
Manfred Kopf
Swiss Federal Institute of Technology, Zurich, , CHE
Phone: +41 44 633 6470; E-mail: Manfred.Kopf@ethz.ch
View this article at: http://www.jci.org/articles/view/63451?key=94c50375c771888cd255
Scratching the surface of psoriasis
2012-10-15
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JCI early table of contents for Oct. 15, 2012
2012-10-15
Scratching the surface of psoriasis
Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% of the world's population. A group of inflammatory molecules known as interleukins activate an immune response that causes itchy skin, but it is unclear how the skin cells and immune cells communicate. In a study published in the Journal of Clinical Investigation, researchers led by Manfred Kopf at the Swiss Federal Institute of Technology in Zürich, Switzerland found that mice lacking interleukin-36 (IL-36) were protected from immune-mediated skin inflammation. ...
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2012-10-15
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LA BioMed's Dr. Virender Rehan studies maternal nicotine's effects on unborn children and asthma
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Urgent need for tuberculosis vaccines; experts report progress, obstacles in growing drug resistance
As World Health Organization prepares to release report on global TB incidence, researchers say UK at forefront of efforts to develop critical medical tools
London (October 15, 2012) – Drawing on recent findings of a significant rise in cases of drug-resistant tuberculosis in the UK and globally, top TB researchers ...
Cell growth protein Ras forms a 'pair' on the cell membrane
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