(Press-News.org) In a study presented at the 35th Congress of the European Society for Medical Oncology (ESMO), Dr Giovanni Bernardo from Fondazione Maugeri in Pavia, Italy, presented results that suggested it may be possible to identify subsets of metastatic breast cancer patients who are likely to respond to subsequent lines of chemotherapy.
Dr Bernardo's group analysed data from 980 women treated with chemotherapy for metastatic breast cancer in their centre between 1992 and 2006.
They found that the median overall survival grew progressively smaller for each successive chemotherapy regimen the patients were given. The time to treatment failure also shortened as each new regimen was tried, from a median of 9.2 months for first-line therapy, to 7.8 and 6.4 months for the second and third-line drugs. Beyond the third line, there was no significant decrease in the medial time to treatment failure for each successive therapy.
The researchers found that only one factor they analysed affected a patient's overall survival time. That factor was the time to treatment failure for each line of chemotherapy. In other words, the more benefit one type of therapy offered, the more benefit the subsequent therapy was likely to offer.
"The implications of our analysis for clinical practice concern the possibility of deciding which patients should be offered a third- or successive chemotherapy line, considering that there are multiple treatment options available today for metastatic disease, and increasing numbers of patients ask for more options when a particular treatment fails," said Dr Bernardo.
###Notes to Editors
Contact the ESMO Press Office at media@esmo.org to find out:
How to follow press briefings remotely via toll-free dial-in
How to schedule one-on-one interviews with top speakers, presenters of the studies and ESMO key opinion leaders
The Congress full program is available at http://www.esmo.org/events/milan-2010-congress/program.html
Media registration
On-site registration is possible at the Press Registration Desk. You will be asked for your press card and a letter of assignment.
About the European Society for Medical Oncology
The European Society for Medical Oncology (ESMO) is the leading European professional organization committed to advancing the specialty of medical oncology and promoting a multidisciplinary approach to cancer treatment and care.
ESMO's mission is to advance cancer care and cure through fostering and disseminating good science that leads to better medicine and determines best practice. In this way ESMO fulfils its goal to support oncology professionals in providing people with cancer with the most effective treatments available and the high-quality care they deserve.
The ESMO community is a powerful alliance of more than 6,000 committed oncology professionals from over 100 countries. As a trusted organization with 35 years of experience and over 500 expert officers, ESMO serves its members and the oncology community through: a brand of excellence in post-graduate oncology education and training; leadership in transforming evidence-based research into standards of cancer care in Europe; dedicated efforts to foster a more favorable environment for scientific research; innovative international platforms to share expertise, best practices and disseminate the most up-to-date scientific research to as wide an audience as possible.
ESMO's scientific journal, Annals of Oncology, ranks among the top clinical oncology journals worldwide. ESMO events are the meeting place in Europe for medical oncologists to update their knowledge, to network and to exchange ideas.
To find our more about our Society, please visit: www.esmo.org
END
For the first time, UK scientists have reported direct evidence that taking up smoking results in epigenetic changes associated with the development of cancer.
The results were reported at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy.
The link between smoking and cancer has been established for decades, explained Dr Yuk Ting Ma from the Cancer Research UK Institute of Cancer Studies, Birmingham, who presented the results. Smoking is the single biggest cause of cancer in the world, and years of research have confirmed that carcinogenic ...
A drug being developed as a treatment for ovarian cancer has shown single agent activity with durable disease control in some patients in a Phase-II clinical trial, an international research group has reported.
Dr Ursula Matulonis from Dana-Farber Cancer Institute in the USA reported the results of the single-agent trial of the drug, called MLN8237, in a poster at the 35th Congress of the European Society for Medical Oncology (ESMO).
MLN8237 selectively inhibits an enzyme known as Aurora A kinase, which is a member of a family of kinase enzymes involved in normal ...
Ameripro Appliance Repair is the leading home, business and commercial appliance repair company in Los Angeles. Air conditioning is a wonderful thing for some people to use when the summer heat strikes. However, some people may not think about getting some of the regular maintenance carried out of the machine. Then when they go to use the machine they discover that it does not function. That is when they will want to know about the positives of Los Angeles air conditioning repair information and how it can help a person in determining the issue and knowing which service ...
MyVideoTalk was founded in 2004 and is a division of Team Effort International, LLC, a privately held, debt-free company founded in 2002 with global offices in Northern California, USA. Their mission is "Bring the World Closer Together" by utilizing cutting-edge Internet communication technologies and bringing them to the global marketplace. Their products are state-of-the-art, user-friendly, and continually enhanced for better and more functionality. The products are simple enough for anyone to use and sophisticated enough for businesses to greatly improve their marketing ...
Charlotte Reid has recently joined doTERRA International.
"I chose doTERRA over several other companies because of the leadership, experience, team focus, and exceptional products. I have seen miracles both in the health and wealth in my own life and the lives of my family thanks to doTERRA." Charlotte emphatically stated.
Charlotte, although new to serious network marketing, shows amazing potential as a dynamic leader and online network marketing superstar. For the past 8 months Charlotte's study in online network marketing has yielded amazing results.
"It's ...
The corporate and business law division of the Mesriani Law Group - a leading law firm in Los Angeles and Southern California - has successfully recovered for its client $153,618 as payment for unpaid goods.
Records show that the client, a company engaged in selling fabric and linings, had entered into both an oral and written contract with another company, the buyer, which purchased the goods and paid it later as agreed.
The transactions between the two companies continued for seven years. And as arranged, the client, which is the seller, shipped the order to the ...
Fashion Group International of Los Angeles, Inc. (FGI LA) is celebrating 75 years of support for Los Angeles fashion businesses with the industry's most recognizable faces. On October 20, 2010, prominent members of LA's fashion industry will gather at the Cabana Club in Hollywood from 6 to 10 p.m. for hors d'oeuvres, cocktails and a special performance from Grammy Award winning R&B artist, Faith Evans.
The 75th anniversary gala will serve as a multi-media preview for FGI LA's book. FACES is a documentation of the individuals that influence the Los Angeles fashion community ...
Moore Pressure Cleaning, in partnership with Harland Clarke, recently participated in a United Way event benefiting the Children's Bereavement Center of South Texas. The Moore Pressure Cleaning employees completed pressure washing the center's parking lot, drive ways, sidewalks, and patios. Upon completion of an afternoon of working for the center, Glen Boehm, Moore Pressure Cleaning Owner/President, was quoted, "the Children's Bereavement Center of South Texas is one of those organizations that fulfills a very important mission in our community. Our hearts go out to the ...
Dreyer Group Smiles is a program dedicated to giving to facilities that provide safe and transitional housing to children and youth in the Fraser Valley of British Columbia. By providing funds to these programs, Dreyer Group Mortgages will make a meaningful difference to kids who otherwise may not have a roof over their heads, or hope for a bright future. Dreyer Group is working closely with the Salvation Army to allocate these funds to the children and shelters.
Stuffies for Safe Housing
At our event, Partners were offered to purchase from a selection of cuddly stuffies ...
The Resolutions Firm helped host a charity Wiffle Ball Tournament on Sunday, Sept. 26 at Kate Sessions Park, in their efforts to help raise money for Operation Smile: Adopt-a-Smile.
The Resolutions Firm started working with Operation Smile after a colleague spent time at an Operation Smile mission site in South America. The company plans to take part in helping fund an entire mission with plans to raise over $2000 by 2011.
Operation Smile provides free surgeries for children to repair cleft lip, cleft palate and other facial deformities that hinder a child's ability ...
