PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Implanting medication to treat opioid dependence appears beneficial in decreasing opioid usage

2010-10-13
(Press-News.org) Helping to address the issue of medication adherence, persons with opioid dependence who had the medication buprenorphine implanted had less opioid use over 16 weeks, according to a study in the October 13 issue of JAMA.

Dependence on opioids, in the form of heroin or prescription pain medications, is a significant health concern. A treatment that has been increasing in usage is the medication buprenorphine, with numerous studies supporting the efficacy of sublingually (beneath the tongue) administered buprenorphine. However, poor treatment adherence, resulting in craving and withdrawal symptoms that increase the likelihood of relapse, is a concern, according to background information in the article. To address these problems with adherence and nonmedical use, an implantable formulation of buprenorphine was developed that delivers a constant and low level of buprenorphine. A preliminary open-label phase 2 study reported favorable results with this implant in opioid-dependent patients.

Walter Ling, M.D., of the University of California, Los Angeles, and colleagues conducted a phase 3 study of buprenorphine implants for treatment of opioid dependence at 18 sites in the United States between April 2007 and June 2008. The study included 163 adults, ages 18 to 65 years, diagnosed with opioid dependence. One hundred eight were randomized to receive buprenorphine implants and 55 to receive placebo implants. The implants were placed below the skin in the inner side of the nondominant arm. The 4 buprenorphine implants, each of which gradually released 80 mg of buprenorphine, and the 4 placebo implants, were removed after 6 months. Standardized individual drug counseling was provided to all patients. Opioid use was gauged via urine samples.

During the course of the study, the buprenorphine implant group had significantly more urine samples negative for illicit opioids during weeks 1 through 16. Patients with buprenorphine implants had an average percentage of urine samples that tested negative for illicit opioids of 40.4 percent and a median (midpoint) of 40.7 percent; those in the placebo group had an average of 28.3 percent and a median of 20.8 percent.

Treatment group differences were also evident on additional efficacy measures, with 65.7 percent of patients in the buprenorphine implant group remaining in the study for the full 24-week study period compared to 30.9 percent of patients in the placebo group. No patients in the buprenorphine implant group met the definition of treatment failure; 30.9 percent of placebo patients were classified as treatment failures.

"Those who received buprenorphine implants also had fewer clinician-rated and patient-rated withdrawal symptoms, had lower patient ratings of craving, and experienced a greater change on clinician global ratings of severity of opioid dependence and on the clinician global ratings of improvement than those who received placebo implants," the researchers write.

"In summary, this study found that the use of buprenorphine implants compared with placebo resulted in less opioid use over 16 weeks and also across the full 24 weeks."

(JAMA. 2010;304[14]:1576-1583. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Advances in the Treatment of Opioid Dependence - Continued Progress and Ongoing Challenges

Patrick G. O'Connor, M.D., M.P.H., of the Yale University School of Medicine, New Haven, Conn., writes in an accompanying editorial that the study by Ling et al represents a potentially important step forward in the effort to improve and expand the treatment options for opioid dependence.

"Further research is needed to assess how this treatment compares with current opioid maintenance treatment prior to the widespread use of implant buprenorphine in clinical practice. If further research suggests that this buprenorphine implant is as good as or better than current treatment approaches, then the study by Ling et al would represent a major advance in the substantial and continued progress that has occurred in the treatment of opioid dependence since methadone maintenance began in the 1960s."

(JAMA. 2010;304[14]:1612-1614. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including financial disclosures, funding and support, etc.

INFORMATION:

END



ELSE PRESS RELEASES FROM THIS DATE:

Restrictive use of blood transfusions during cardiac surgery shows comparable outcomes

2010-10-13
Use of stricter guidelines for the use of red blood cell transfusions for patients undergoing cardiac surgery was associated similar rates of death and severe illness compared to patients who received more transfusions, according to a study in the October 13 issue of JAMA. Another study in this issue of JAMA examines the variation in the use of blood transfusions for patients undergoing cardiac surgery. Cardiac surgery is associated with a high rate of blood transfusion. The rationale for red blood cell (RBC) transfusion is based on the observation that anemia is an independent ...

Rates of blood transfusions for CABG surgery varies widely among US hospitals

2010-10-13
A study that includes data on more than 100,000 patients who underwent coronary artery bypass graft surgery finds that there is wide variability among hospitals in the U.S. on the use of blood transfusions, without a large difference in the rate of death, suggesting that many transfusions may be unnecessary, according to a study in the October 13 issue of JAMA. Another study in this issue of JAMA examines the effect of a restrictive transfusion strategy on outcomes after cardiac surgery. "Patients who undergo cardiac surgery receive a significant proportion of the 14 ...

Considerable proportion of patients with advanced cancer continue to undergo common cancer screening

2010-10-13
A sizeable proportion of patients with advanced cancer and a life expectancy of only a few years continue to undergo common cancer screening tests that are unlikely to provide meaningful benefit, according to a study in the October 13 issue of JAMA. Cancer screening programs, such as mammography, Papanicolaou test, prostate-specific antigen (PSA) and colonoscopy, evaluate asymptomatic patients for the detection of early forms of cancer and have contributed substantially to the decline in deaths from cancer. "Although the benefits of cancer screening are compelling for ...

Transfusion rates vary extremely in cardiac bypass surgery

2010-10-13
DURHAM, NC – Transfusion rates for blood products used in a common heart surgery range from no patients to nearly all patients, and vary by hospital, according to findings from a group of researchers from Duke University Medical Center. The study, which looked at data from 102,470 patients in 798 hospitals, examined the variation in transfusion rates for red blood cells (RBCs), plasma and platelets, but the team didn't reach conclusions about how well patients fared if they did or didn't get a transfusion. "We don't know whether the variability is potentially harming ...

IOF campaign puts spotlight on vastly under-diagnosed and under-treated spinal fractures

2010-10-13
At a press conference held in Brussels today, the International Osteoporosis Foundation (IOF), the Belgian Bone Club and the European Parliament Osteoporosis Interest Group called on health care professionals and health policy officials in Europe to take action to prevent spinal fractures. The call to action was made at the launch of a unique photographic essay, 'snap! the breaking spine', leading up to World Osteoporosis Day on October 20, 2010. Taking viewers across the globe to Brazil, Canada, India, Jordan and Switzerland, the photographic essay captures a typical ...

Peer-based outreach services for sex workers assist entry into detox and drug treatment

2010-10-13
A mobile outreach program staffed by current and former sex workers is associated with increased entry to detoxification and residential drug treatment among women in street-based sex work, according to an evaluation led by the BC Centre for Excellence in HIV/AIDS (BC-CfE) and the University of British Columbia (UBC). The study, recently published in the peer-reviewed medical journal Drug and Alcohol Dependence, examined the link between accessing Vancouver's Mobile Access Project, or "the MAP van," and uptake of addiction treatment services by women engaged in street-based ...

No quick fix for peripheral artery disease -- repeat hospitalizations

2010-10-13
Even after initial procedures to clear blockages in leg arteries, hospitalizations and associated costs in patients with peripheral artery disease increase as the condition progresses, according to research reported in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. "We are dealing with clinically and economically severe consequences of PAD, a disease which is truly preventable," said Elizabeth Mahoney, Sc.D., the study's lead author. "Our prior research estimated that vascular-related hospitalizations for PAD patients cost the ...

Titan Pharma announces JAMA publication highlighting phase 3 opioid dependence data

2010-10-13
South San Francisco, CA – October 12, 2010 – Titan Pharmaceuticals, Inc. (TTNP.OB) today announced that data from its previously completed and announced Phase 3 randomized, placebo-controlled clinical trial of Probuphine were published in the Journal of the American Medical Association (JAMA). The article highlights data from the 163-patient trial, which showed that patients receiving Titan's Probuphine implant had significantly less illicit opioid use, experienced fewer symptoms of withdrawal and craving, stayed in treatment longer and had greater overall improvement ...

Despite brain damage, working memory functions -- within limits

2010-10-13
Researchers at the University of California, San Diego School of Medicine, led by Larry R. Squire, PhD, professor of psychiatry, psychology and neurosciences at UC San Diego and a scientist at the VA San Diego Healthcare System, report that working memory of relational information – where an object is located, for example – remains intact even if key brain structures like the hippocampus are damaged. The findings, published in the October 13, 2010 issue of The Journal of Neuroscience, run contrary to previous research that suggested spatial information, especially if ...

Diagnosing autism with MRI is 1 step closer

2010-10-13
SALT LAKE CITY—University of Utah (U of U) medical researchers have made an important step in diagnosing autism through using MRI, an advance that eventually could help health care providers indentify the problem much earlier in children and lead to improved treatment and outcomes for those with the disorder. In a study published on October 15, 2010 in Cerebral Cortex online, researchers led by neuroradiologist Jeffery S. Anderson, M.D., Ph.D., U of U assistant professor of radiology, used MRI to identify areas where the left and right hemispheres of the brains of people ...

LAST 30 PRESS RELEASES:

Political elites take advantage of anti-partisan protests to disrupt politics

Tiny target discovered on RNA to short-circuit inflammation, UC Santa Cruz researchers find

Charge your laptop in a minute? Supercapacitors can help; new research offers clues

Scientists discover CO2 and CO ices in outskirts of solar system

Theory and experiment combine to shine a new light on proton spin

PKMYT1, a potential ‘Achilles heel’ of treatment resistant ER+ breast cancers with the poorest prognosis

PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors (PARs)

Virginia Tech researcher creates new tool to move tiny bioparticles

On repeat: Biologists observe recurring evolutionary changes, over time, in stick insects

Understanding a broken heart

Genetic cause of rare childhood immune disorders discovered

With wobbling stars, astronomers gauge mass of 126 exoplanets and find 15 new ones

High H5N1 influenza levels found in mice given raw milk from infected dairy cows

Study finds discreet shipping used to sell e-cigarettes to minors

African scientists call for equitable research partnerships to advance microbiome research

How COVID-19 'breakthrough' infections alter your immune cells

Virginia Tech entomologist sheds light on 250-year-old mystery of the German cockroach

Advancing skin science: explore Skin Ageing & Challenges 2024 Strategic Topics in Malta this November

Controlling water, transforming greenhouse gases

MSK Research Highlights, May 24, 2024

ASCO: Large precision oncology study identifies differences in prostate cancer genomics among a racially and ethnically diverse cohort of U.S. veterans

ASCO: Combination therapy significantly improves outcomes for patients with metastatic colorectal cancer

Euclid space mission releases first scientific results and new images of the cosmos

Sociodemographic heterogeneity in the associations of social isolation with mortality

COVID-19 admission rates and changes in care quality in us hospitals

Preterm and early-term delivery after heat waves in 50 US metropolitan areas

Research spotlight: Virtual scribes reduced physicians’ time spent on electronic health records

Duke-NUS researchers develop new light-controlled ‘off switch’ for brain cells

Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients

Update on the STING signaling pathway in developing nonalcoholic fatty liver disease

[Press-News.org] Implanting medication to treat opioid dependence appears beneficial in decreasing opioid usage