Mayo Clinic identifies promising treatment for inherited form of kidney disease
2012-11-03
(Press-News.org) SAN DIEGO -- A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say. The medication, tolvaptan, slowed the pace of kidney cyst growth over the three years of the study. The phase three clinical trial results were being presented today at the American Society of Nephrology annual meeting and published online in the New England Journal of Medicine.
The multicenter study found tolvaptan demonstrated a nearly 50 percent reduction in the rate of increase in total kidney volume (a measurement of kidney cyst growth) in ADPKD patients over the study period, compared to placebo.
"ADPKD is the most common inherited and the fourth most common overall cause of kidney failure worldwide," says lead author Vicente Torres, M.D., Ph.D., Mayo Clinic nephrologist.
"In most patients with this disease, relentless cyst growth within the kidneys destroys the tissue, causes hypertension and painful complications, and negatively impacts the quality of life," Dr. Torres says. "The results of this study reveal a potential treatment that blunts kidney growth, lessens associated symptoms and slows kidney function decline when given over three years."
While the trial findings are encouraging, tolvaptan has not yet been approved for this indication, Dr. Torres notes.
INFORMATION:
The study was funded by Otsuka Pharmaceuticals.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and www.mayoclinic.org/news.
MULTIMEDIA ALERT: A video interview with Dr. Torres is available for journalists to download on the Mayo Clinic News Network.
END
ELSE PRESS RELEASES FROM THIS DATE:
2012-11-03
It is a fact that planning for one's demise is not a popular pastime for most people nationwide. However, if you fail to prepare your estate plan properly, it can bring serious hardships on your loved ones. Unfortunately, estate planning is an area of law where there is widespread confusion among the public. As you are considering your estate plan, it is important to be aware of some of the most common myths.
Estate Planning Is Just For the Rich
Many individuals think that estate planning is not needed if the estate is not big enough to be subject to estate taxes ...
2012-11-03
Recently, a dangerous combination of factors -- distracted driving and drunk driving --caused a two-car accident in Phoenixville, Pennsylvania.
The woman who allegedly caused the accident was both under the influence of alcohol and distracted at the time of the crash. Reportedly, a law enforcement official who arrived at the scene detected alcohol on the motorist's breath. She agreed to a field sobriety test, which indicated she was under the influence of alcohol. While she would not state how many drinks she had consumed that evening, she told officers that she had ...
2012-11-03
While motor vehicle accidents involving all types of vehicles can prove deadly, those involving large trucks are often the most dangerous. The severity of these accidents is generally due to the size difference between the large commercial motor vehicle and, often, the much smaller passenger car with which it collides. As a result of the seriousness of these accidents, researchers in India have begun examining truck accident crash data to identify the typical causes of these accidents. By understanding the common causes, trucking companies will be able to educate their ...
2012-11-03
In the summer of 2011, former North Dakota Attorney General Nicholas Spaeth filed a dramatic age discrimination suit against six U.S. law schools, including Michigan State University College of Law. Spaeth alleged that the schools passed over his applications for employment, instead hiring younger, less qualified candidates as law professors in violation of the federal Age Discrimination in Employment Act, known as the ADEA.
Spaeth, who is in his early 60s, has a long, distinguished legal career that includes a law degree from Stanford, a stint as a law clerk at the ...
2012-11-03
Limited liability corporations and limited liability partnerships are useful entity types that can accomplish a variety of purposes for a business. Which entity type is appropriate for a business depends upon the type of business, the number of owners, the financial situation of the business and how the owners want to run the business. Only certain types of California businesses are allowed to form an LLP or LLC.
Under California law, only professionals such as architects, attorneys or accountants can form an LLP. LLCs, on the other hand, cast a wider net and can involve ...
2012-11-03
New commercial construction increasingly uses "green" technology such as wind turbines, fuel cells and even vegetative roofs in an attempt to lower energy costs and be more environmentally responsible. Commercial enterprises use green buildings to cultivate an image of corporate responsibility that will appeal to consumers. In addition, studies have shown that green buildings, which tend to have natural light and fresh air, can improve employee concentration and boost productivity.
It is no surprise, then, that green commercial building construction is on the ...
2012-11-03
Pennsylvania Small Claims Court
The Pennsylvania State Court system is comprised of five courts: the Minor Judiciary/Magisterial District Court (small claims court), Common Pleas, Commonwealth Court, Superior Court and Supreme Court. This article will provide to the consumer a brief overview of civil lawsuits in small claims court.
Small Claims Actions
Magisterial district justices (also known as MDJs) hear a wide variety of cases involving criminal complaints and prosecutions, landlord-tenant disputes, and general civil complaints, such as collection matters and ...
2012-11-03
Construction Defects Increase as Contractors Work Outside of Expertise
The economy has forced many builders and contractors in Colorado and elsewhere in the country to take on projects outside of their expertise in order to stay afloat or gain new business. However, the consequence of builders and contractors taking on projects outside of their wheelhouses may lead to a rise in construction defects detrimentally affecting commercial and residential clients. When a builder takes on a project outside of an area of expertise, the builder remains responsible for any negligence ...
2012-11-03
Social Media and Divorce
Along with social media comes many positives and negatives. Facebook and Twitter provide great ways to stay in touch with loved ones and transmit information in a quick and efficient way. Recently however, social media is having a larger role in divorce proceedings in the United States, and often, the consequences of using social media in this setting are not positive.
How Social Media Can Affect a Divorce Case
The American Academy of Matrimonial Lawyers reports that social media postings are increasingly being used in divorce proceedings. ...
2012-11-03
Beware of Hidden Assets in Divorce
Couples going through a divorce in Texas must usually undergo a thorough lifestyle analysis to determine the couple's marital property and what an individual's budget may look like after the divorce. An accurate inventory of all the assets is an essential part of the analysis and is vital to achieving a fair division of property in a Texas divorce.
Unfortunately, some spouses try to cheat by hiding assets, then reclaiming them some time after the property division is finalized, ending up with an unfair share of the marital property. ...
LAST 30 PRESS RELEASES:
[Press-News.org] Mayo Clinic identifies promising treatment for inherited form of kidney disease
