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JCI early table of contents for Jan. 9, 2013

2013-01-09
(Press-News.org) Small peptide ameliorates autoimmune skin blistering disease in mice Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, report on a small peptide that blocked antibody recognition of desmogleins. Importantly, the peptide could prevent antibody-mediated skin blistering when applied topically to mice. At the cellular level, the peptide improved cell-cell adhesion and attenuated signaling pathways that are activated by antibody binding. These results suggest that this peptide could serve as a treatment option for pemphigus vulgaris. TITLE:
Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering AUTHOR CONTACT:
Jens Waschke
Ludwig-Maximilians-University Munich, Munich, , DEU
Phone: 0049-89-5160-4811; Fax: 0049-89-5160-4802; E-mail: jens.waschke@med.uni-muenchen.de View this article at: http://www.jci.org/articles/view/60139?key=b333192372ea9937c9be A new treatment for kidney disease-associated heart failure? Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice. In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tübingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced vascular calcification in klotho hypomorphic mice and increased their life span. In a companion Attending Physician article, Darryl Quarles of the University of Tennessee discusses the implications of these findings for the treatment of CKD patients. TITLE:
Spironolactone-sensitive vascular calcification and Pit-1-dependent osteoblastic differentiation in klotho-hypomorphic mice AUTHOR CONTACT:
Florian Lang
Dept. of Physiology, Tuebingen, NULL, DEU
Phone: +4970712972194; Fax: +497071295618; E-mail: florian.lang@uni-tuebingen.de View this article at: http://www.jci.org/articles/view/64093?key=3010c850d2f970ad6617 ACCOMPANYING THE ATTENDING PHYSICIAN TITLE:
Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new AUTHOR CONTACT:
Darryl Quarles
University of Tennessee Health Science Center, memphis, TN, USA
Phone: 901-448-1459; Fax: 901-448-1188; E-mail: dquarles@uthsc.edu View this article at: http://www.jci.org/articles/view/67203?key=054ae63743c930253936 New fusion gene contributes to glioblastoma progression Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice. In this issue of the Journal of Clinical Investigation, researchers led by Matti Annala at Tampere University of Technology in Finland identified a fusion between the FGFR3 and TACC3 genes in human glioblastoma samples. The protein produced by this fusion gene promoted tumor growth and progression in a mouse model of glioblastoma, while increased expression of either of the normal genes did not alter tumor progression. Ivan Babic and Paul Mischel of the University of California, San Diego, explain in the accompanying commentary that it remains unclear how this fusion protein mediates tumorigenesis. TITLE:
The tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma AUTHOR CONTACT:
Matti Annala
Tampere University of Technology, Tampere, FIN
Phone: +358415079885; E-mail: matti.annala@tut.fi View this article at: http://www.jci.org/articles/view/67144?key=b644a26bcc8a516cd41d ACCOMPANYING COMMENTARY TITLE:
Multiple functions of a glioblastoma fusion oncogene AUTHOR CONTACT:
Paul Mischel
UCSD, La Jolla, CA, USA
Phone: (858) 534-6080; Fax: ; E-mail: pmischel@ucsd.edu View this article at: http://www.jci.org/articles/view/67658?key=0186fce1cd2ddde6082f ALSO IN THIS ISSUE TITLE:
Type 1 diabetes patients exhibit altered cerebral metabolism during hypoglycemia AUTHOR CONTACT:
Bastiaan de Galan
Radboud University Nijmegen Medical Centre, Nijmegen, UNK, NLD
Phone: +31243618819; Fax: +31243541734; E-mail: b.degalan@aig.umcn.nl View this article at: http://www.jci.org/articles/view/62742?key=9b86666385df6bd2593b TITLE:
Regulation of dendritic cell activation by microRNA let-7c and BLIMP1 AUTHOR CONTACT:
Betty Diamond
The Feinstein Institute for Medical Research, Manhasset, NY, USA
Phone: 516-562-3830; Fax: 516-562-2953; E-mail: bdiamond@nshs.edu View this article at: http://www.jci.org/articles/view/64712?key=6599e97537112226049c TITLE:
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer AUTHOR CONTACT:
Yosuke Osawa
Gifu University Graduate School of Medicine, Gifu, JPN
Phone: 81-58-230-6217; Fax: 81-58-230-6218; E-mail: osawa-gif@umin.ac.jp View this article at: http://www.jci.org/articles/view/65188?key=4dc45a19d2e16fb3b7c9 TITLE:
Specialized role of migratory dendritic cells in peripheral tolerance induction AUTHOR CONTACT:
Juliana Idoyaga
The Rockefeller University, New York, NY, USA
Phone: 212-327-7863; Fax: 212-327-8875; E-mail: ijuliana@rockefeller.edu View this article at: http://www.jci.org/articles/view/65260?key=843f605de298ce5048b3 ### END


ELSE PRESS RELEASES FROM THIS DATE:

Small peptide ameliorates autoimmune skin blistering disease in mice

2013-01-09
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, ...

Newly found 'volume control' in the brain promotes learning, memory

2013-01-09
WASHINGTON — Scientists have long wondered how nerve cell activity in the brain's hippocampus, the epicenter for learning and memory, is controlled — too much synaptic communication between neurons can trigger a seizure, and too little impairs information processing, promoting neurodegeneration. Researchers at Georgetown University Medical Center say they now have an answer. In the January 10 issue of Neuron, they report that synapses that link two different groups of nerve cells in the hippocampus serve as a kind of "volume control," keeping neuronal activity throughout ...

A new treatment for kidney disease-associated heart failure?

2013-01-09
Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice. In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tübingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced vascular calcification ...

Fusion gene contributes to glioblastoma progression

2013-01-09
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice. In this issue of the Journal of Clinical Investigation, researchers led by Matti Annala at Tampere University of Technology in Finland identified a fusion between the FGFR3 and TACC3 genes in human glioblastoma samples. The protein produced by this fusion gene promoted tumor growth and progression in a mouse model of glioblastoma, while increased expression of either of the normal genes did not alter tumor progression. Ivan Babic ...

Regeneration of sound sensing cells recovers hearing in mice with noise-induced deafness

Regeneration of sound sensing cells recovers hearing in mice with noise-induced deafness
2013-01-09
Extremely loud noise can cause irreversible hearing loss by damaging sound sensing cells in the inner ear that are not replaced. But researchers reporting in the January 9 issue of the Cell Press journal Neuron have successfully regenerated these cells in mice with noise-induced deafness, partially reversing their hearing loss. The investigators hope the technique may lead to development of treatments to help individuals who suffer from acute hearing loss. While birds and fish are capable of regenerating sound sensing hair cells in the inner ear, mammals are not. Scientists ...

Mathematics and weather and climate research

2013-01-09
San Diego, California – January 9, 2013 – How does mathematics improve our understanding of weather and climate? Can mathematicians determine whether an extreme meteorological event is an anomaly or part of a general trend? Presentations touching on these questions will be given at the annual national mathematics conference in San Diego, California. New results will also be presented on the MJO (pronounced "mojo"), a tropical atmospheric wave which governs monsoons and also impacts rainfall in North America, and yet does not fit into any current computer models of the ...

BPA linked to potential adverse effects on heart and kidneys

2013-01-09
NEW YORK (January 9, 2013) – Exposure to a chemical once used widely in plastic bottles and still found in aluminum cans appears to be associated with a biomarker for higher risk of heart and kidney disease in children and adolescents, according to an analysis of national survey data by NYU School of Medicine researchers published in the January 9, 2013, online issue of Kidney International, a Nature publication. Laboratory studies suggest that even low levels of bisphenol A (BPA) like the ones identified in this national survey of children and adolescents increase oxidative ...

E-games boost physical activity in children; might be a weapon in the battle against obesity

2013-01-09
WASHINGTON—Video games have been blamed for contributing to the epidemic of childhood obesity in the United States. But a new study by researchers at the George Washington University School of Public Health and Health Services (SPHHS) suggests that certain blood-pumping video games can actually boost energy expenditures among inner city children, a group that is at high risk for unhealthy weight gain. The study, "Can E-gaming be Useful for Achieving Recommended Levels of Moderate to Vigorous-Intensity Physical Activity in Inner-City Children," will appear January 9 in ...

Study finds routine tests done on patients with microscopic blood in urine can be avoided

2013-01-09
PASADENA, Calif., January 9, 2013 – The presence of microscopic hematuria – blood found in urine that can't be seen by the naked eye – does not necessarily indicate the presence of cancer, according to a Kaiser Permanente Southern California study published in the journal Mayo Clinic Proceedings. The study suggests that tests routinely done on patients with this condition could be avoided and has led to the creation of a screening tool to better diagnose certain types of cancers. The observational study examined the electronic health records of more than 4,000 patients ...

Networking ability a family trait in monkeys

2013-01-09
DURHAM, N.C. -- Two years of painstaking observation on the social interactions of a troop of free-ranging monkeys and an analysis of their family trees has found signs of natural selection affecting the behavior of the descendants. Rhesus macaques who had large, strong networks tended to be descendants of similarly social macaques, according to a Duke University team of researchers. And their ability to recognize relationships and play nice with others also won them more reproductive success. "If you are a more social monkey, then you're going to have greater reproductive ...

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[Press-News.org] JCI early table of contents for Jan. 9, 2013