Comparable patterns of failure between SBRT, lobectomy or pneumonectomy for stage I NSCLC

Researchers support need to enroll patients in randomized trials

2013-01-15

(Press-News.org) DENVER – For patients with medically operable clinical stage I non–small-cell lung cancer (NSCLC), lobectomy or pneumonectomy is the standard approach. For patients with medically inoperable stage I NSCLC, stereotactic body radiotherapy (SBRT) has become a standard of care. Researchers from the Washington University School of Medicine wanted to compare the patterns of failure (primary tumor control, local control, regional control, and distant control) between each method.

A recent study published in the February 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes that there are comparable patterns of failure between treatments.

Researchers looked at 454 patients (336 surgery, 118 SBRT) treated at Washington University in St. Louis between January 2004 and January 2008. The results demonstrate that patterns of failure between optimal surgery (lobar resection) and optimally dosed SBRT are similar. However, their results also highlight the difficulties in making such comparisons, given the inherent imbalance in both patient and tumor-related factors. For example, lobar resection patients were younger, healthier, and had superior pulmonary function, while more patients in the SBRT group had smaller tumors.

While researchers were unable to control for factors predictive of overall survival, they were able to match 76 patients in each group based on tumor size. Researchers noted, "In a T-stage matched comparison of 152 patients, there was no significant difference in patterns of failure or cancer-specific survival"

They conclude that, "In this retrospective comparison, overall survival was superior for surgery, though cancer-specific survival was similar. Randomized trials are necessary to control for fundamental differences in co-morbidity that impact interpretation of both tumor control and survival."

### The lead author of this work is Dr. Cliff Robinson. Co-authors include IASLC members Dr. Bryan Meyers and Dr. Jeffrey Bradley.

About the IASLC: The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit www.iaslc.org. END

ELSE PRESS RELEASES FROM THIS DATE:

When wanting is more important than having: Will that new car really make you happy?

2013-01-15

Materialistic consumers may derive more pleasure from desiring products than they do from actually owning them, and are willing to overspend and go into debt because they believe that future purchases will transform their lives, according to a new study in the Journal of Consumer Research. "Thinking about acquisition provides momentary happiness boosts to materialistic people, and because they tend to think about acquisition a lot, such thoughts have the potential to provide frequent mood boosts. But the positive emotions associated with acquisition are short-lived. Although ...

The housing market: Consumers struggle to get the price right

2013-01-15

Consumers systematically mispredict both the selling and purchase prices of other consumers due to a lack of cognitive and emotional connection, according to a new study in the Journal of Consumer Research. "As sellers, consumers fail to appreciate the extent to which endowment and the prospect of giving up an object and not getting to enjoy its benefits influence other owner valuations. On the other hand, as buyers, consumers fail to realize the extent to which lack of ownership and the prospect of giving up money to purchase an object impact other buyer valuations," ...

Fashion blogs: How do ordinary consumers harness social media to become style leaders?

2013-01-15

The Internet has given consumers the unprecedented opportunity to reach a mass audience and thereby advance their social position through displays of good taste, according to a new study in the Journal of Consumer Research. "Ordinary consumers were previously limited to sharing their views and tastes within their circle of friends and acquaintances, and only media professionals and others in powerful positions could reach a mass audience. But the Internet has made it possible for ordinary consumers to reach a mass audience or 'grab hold of the megaphone' through blogs, ...

Are consumers with fewer friends more likely to take financial risks?

2013-01-15

Feeling socially isolated causes consumers to pursue riskier but potentially more profitable financial opportunities, according to a new study in the Journal of Consumer Research. "Seeking social acceptance and maintaining close relationships are among the most fundamental and universal human needs. Consumers are often willing to invest or sacrifice important resources to secure social bonds. In the absence of social support, consumers seek significantly more money to secure what they want out of the social system surrounding them. Feeling socially rejected triggers riskier ...

How does family life influence consumer response to television advertising?

2013-01-15

Family interaction and everyday activity strongly influence how television advertisements are experienced and interpreted at home, according to a new study in the Journal of Consumer Research. "It is common to link advertising viewing at home to increased levels of materialism and domestic tension stemming from 'pester power' (children getting parents to buy something by asking for it repeatedly until they get it). While these are serious issues, we have found that creative and skilled viewers of television advertising in the family living room can overturn and personalize ...

Don't read my lips! Body language trumps the face for conveying intense emotions

2013-01-15

Be it triumph or crushing defeat, exhilaration or agony, body language more accurately conveys intense emotions, according to recent research that challenges the predominance of facial expressions as an indicator of how a person feels. Princeton University researchers report in the journal Science that facial expressions can be ambiguous and subjective when viewed independently. The researchers asked study participants to determine from photographs if people were experiencing feelings such as loss, victory or pain from facial expressions or body language alone, or from ...

Major step toward an Alzheimer's vaccine

2013-01-15

This press release is available in French. Quebec City, January 15, 2013—A team of researchers from Université Laval, CHU de Québec, and pharmaceutical firm GlaxoSmithKline (GSK) has discovered a way to stimulate the brain's natural defense mechanisms in people with Alzheimer's disease. This major breakthrough, details of which are presented today in an early online edition of the Proceedings of the National Academy of Sciences (PNAS), opens the door to the development of a treatment for Alzheimer's disease and a vaccine to prevent the illness. One of the main characteristics ...

Youth mentoring linked to many positive effects, new CAMH and Big Brothers Big Sisters study shows

2013-01-15

Toronto, January 15, 2013 –The Centre for Addiction and Mental Health (CAMH) and Big Brothers Big Sisters Canada (BBBSC) are releasing the first results of one of the largest mentoring studies ever conducted. The five-year study, which tracks the experiences of almost 1,000 children and teenagers registered with Big Brothers Big Sisters agencies across Canada, found that those with a mentor are significantly more confident in their academic abilities and considerably less likely to display behavioural problems. One stand out finding is that girls in the study with ...

Claims of 'post-racial' society and other denials of racism may reflect ignorance of history

2013-01-15

New research suggests that commonly observed differences in how groups perceive racism may be explained by ignorance about — and even denial of — the extent of racism over the course of history. The research, conducted by psychological scientists at the University of Kansas and Texas A&M University, indicates that African Americans had more accurate knowledge of historically documented racism compared to European Americans. This difference in historical knowledge partially accounted for group differences in perceptions of racism, both at a systemic and an incident-specific ...

Salmon runs boom, go bust over centuries

2013-01-15

Salmon runs are notoriously variable: strong one year, and weak the next. New research shows that the same may be true from one century to the next. Scientists in the past 20 years have recognized that salmon stocks vary not only year to year, but also on decades-long time cycles. One example is the 30-year to 80-year booms and busts in salmon runs in Alaska and on the West Coast driven by the climate pattern known as the Pacific Decadal Oscillation. Now work led by University of Washington researchers reveals those decadal cycles may overlay even more important, centuries-long ...

Novel radiation therapy QA method: Monte Carlo simulation meets deep learning for fast, accurate epid transmission dose generation

A 100-fold leap into the unknown: a new search for muonium conversion into antimuonium

A new approach to chiral α-amino acid synthesis - photo-driven nitrogen heterocyclic carbene catalyzed highly enantioselective radical α-amino esterification

Physics-defying discovery sheds new light on how cells move

Institute for Data Science in Oncology announces new focus-area lead for advancing data science to reduce public cancer burden

Korea University College of Medicine successfully concludes the 2025 Lee Jong-Wook Fellowship on Infectious Disease Specialists Program

Girls are happiest at school – for good reasons

Researchers from the University of Maryland School of Medicine discover genetic ancestry is a critical component of assessing head and neck cancerous tumors

Comparable patterns of failure between SBRT, lobectomy or pneumonectomy for stage I NSCLC

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: