PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

People with low risk for cocaine dependence have differently shaped brain to those with addiction

Research provides unique insight into the often misunderstood world of addiction

2013-01-17
(Press-News.org) People who take cocaine over many years without becoming addicted have a brain structure which is significantly different from those individuals who developed cocaine-dependence, researchers have discovered. New research from the University of Cambridge has found that recreational drug users who have not developed a dependence have an abnormally large frontal lobe, the section of the brain implicated in self-control. Their research was published in the journal Biological Psychiatry. For the study, led by Dr Karen Ersche, individuals who use cocaine on a regular basis underwent a brain scan and completed a series of personality tests. The majority of the cocaine users were addicted to the drug but some were not (despite having used it for several years).

The scientists discovered that a region in the frontal lobes of the brain, known to be critically implicated in decision-making and self-control, was abnormally bigger in the recreational cocaine users. The Cambridge researchers suggest that this abnormal increase in grey matter volume, which they believe predates drug use, might reflect resilience to the effects of cocaine, and even possibly helps these recreational cocaine users to exert self-control and to make advantageous decisions which minimize the risk of them becoming addicted.

They found that this same region in the frontal lobes of the brain was significantly reduced in size in people with cocaine dependence, confirming earlier research that had found similar results. They believe that at least some of these changes are the result of drug use, which causes drug users to lose grey matter.

They also found that people who use illicit drugs like cocaine exhibit high levels of sensation-seeking personality traits, but only those developing dependence show personality traits of impulsivity and compulsivity.

Dr Ersche, of the Behavioural and Clinical Neuroscience Institute (BCNI) at the University of Cambridge, said: "These findings are important because they show that the use of cocaine does not inevitably lead to addiction in people with good self-control and no familial risk.

"Our findings indicate that preventative strategies might be more effective if they were tailored more closely to those individuals at risk according to their personality profile and brain structure."

The researchers will next explore the basis of the recreational users' apparent resilience to drug dependence.

Dr Ersche added: "Their high level of education, less troubled family background or the beginning of drug-taking only after puberty may all play a role."

### For additional information please contact: Genevieve Maul
Office of Communications
University of Cambridge
Tel: 44-1223-332-300
Mob: 44-7774-017-464
Email: Genevieve.maul@admin.cam.ac.uk

Notes to editors:

1. The paper 'Distinctive Personality Traits and Neural Correlates Associated with Stimulant Drug Use Versus Familial Risk of Stimulant Dependence' was published in Biological Psychiatry.

2. This work was funded by a Medical Research Council (G0701497) and received institutional funds from the Behavioural and Clinical Neuroscience Institute (BCNI), which is jointly funded by the Medical Research Council and the Wellcome Trust. END


ELSE PRESS RELEASES FROM THIS DATE:

Cheating to create the perfect simulation

Cheating to create the perfect simulation
2013-01-17
(Jena) The planet Earth will die – if not before, then when the Sun collapses. This is going to happen in approximately seven billion years. In the universe however the death of suns and planets is an everyday occurance and our solar system partly consists of their remnants. The end of stars – suns – rich in mass is often a neutron star. These "stars' liches" demonstrate a high density, in which atoms are extremely compressed. Such neutron stars are no bigger than a small town, but heavier than our sun, as physicist PD Dr. Axel Maas of the Jena University (Germany) points ...

Dietary shifts driving up phosphorus use

2013-01-17
Dietary changes since the early 1960s have fueled a sharp increase in the amount of mined phosphorus used to produce the food consumed by the average person over the course of a year, according to a new study led by researchers at McGill University. Between 1961 and 2007, rising meat consumption and total calorie intake underpinned a 38% increase in the world's per capita "phosphorus footprint," the researchers conclude in a paper published online in Environmental Research Letters. The findings underscore a significant challenge to efforts to sustainably manage the ...

Viagra converts fat cells

2013-01-17
Researchers from the University of Bonn treated mice with Viagra and made an amazing discovery: The drug converts undesirable white fat cells and could thus potentially melt the unwelcome "spare tire" around the midriff. In addition, the substance also decreases the risk of other complications caused by obesity. The results are now published in "The Journal of the Federation of American Societies for Experimental Biology" (FASEB). Sildenafil – better known as Viagra – is used to treat erectile dysfunction. This substance prevents degradation of cyclic guanosine mono-phosphate ...

Is athleticism linked to brain size?

Is athleticism linked to brain size?
2013-01-17
VIDEO: This movie shows running mice (bred-for-athleticism mouse on the left, regular mouse on the right). Click here for more information. RIVERSIDE, Calif. — Is athleticism linked to brain size? To find out, researchers at the University of California, Riverside performed laboratory experiments on house mice and found that mice that have been bred for dozens of generations to be more exercise-loving have larger midbrains than those that have not been selectively bred ...

Fighting sleep: UGA discovery may lead to new treatments for deadly sleeping sickness

2013-01-17
Athens, Ga. – While its common name may make it sound almost whimsical, sleeping sickness, or African trypanosomiasis, is in reality a potentially fatal parasitic infection that has ravaged populations in sub-Saharan Africa for decades, and it continues to infect thousands of people every year. Few drugs have been developed to treat sleeping sickness since the 1940s, and those still in use are highly toxic, sometimes causing painful side effects and even death. But researchers at the University of Georgia have made a discovery that may soon lead to new therapies for this ...

Critically ill flu patients saved with artificial lung technology treatment

2013-01-17
TORONTO (January 17, 2013 ) - In recent weeks the intensive critical care units at University Health Network's Toronto General Hospital have used Extra Corporeal Lung Support (ECLS) to support five influenza (flu) patients in their recovery from severe respiratory problems. ECLS systems are normally used at the hospital as a bridge to lung transplantation but increasingly, the hospital is using ECLS on patients where the usual breathing machines (ventilators) cannot support the patient whose lungs need time to rest and heal. The ECLS systems are essentially artificial ...

Drug abuse impairs sexual performance in men even after rehabilitation

2013-01-17
Researchers at the University of Granada, Spain, and Santo Tomas University in Colombia have found that drug abuse negatively affects sexual performance in men even after years of abstinence. This finding contradicts other studies reporting that men spontaneously recovered their normal sexual performance at three weeks after quitting substance abuse. The results of this study have been published in the prestigious Journal of Sexual Medicine, the official journal of the International Society for Sexual Medicine. The authors of this paper are Pablo Vallejo Medina –a professor ...

Trading wetlands no longer a deal with the devil

Trading wetlands no longer a deal with the devil
2013-01-17
URBANA – If Faust had been in the business of trading wetlands rather than selling his soul, the devil might be portrayed by the current guidelines for wetland restoration. Research from the University of Illinois recommends a new framework that could make Faustian bargains over wetland restoration sites result in more environmentally positive outcomes. U of I ecologist Jeffrey Matthews explained that under the current policies if a wetland is scheduled for development and a negative impact is unavoidable, the next option is to offset, or compensate, for the destruction ...

UNC researchers use luminescent mice to track cancer and aging in real-time

UNC researchers use luminescent mice to track cancer and aging in real-time
2013-01-17
Chapel Hill, NC – In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth in mice using a gene closely linked to these processes. Researchers have long known that the gene, p16INK4a (p16), plays a role in aging and cancer suppression by activating an important tumor defense mechanism called 'cellular senescence'. The UNC team led by Norman Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Deputy Cancer ...

How are middle-aged women affected by burnout?

How are middle-aged women affected by burnout?
2013-01-17
New Rochelle, NY, January 17, 2013—Emotional exhaustion and physical and cognitive fatigue are signs of burnout, often caused by prolonged exposure to stress. Burnout can cause negative health effects including poor sleep, depression, anxiety, and cardiovascular and immune disorders. The findings of a 9-year study of burnout in middle-aged working women are reported in an article in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website at http://www.liebertpub.com/jwh. In ...

LAST 30 PRESS RELEASES:

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’

New guidelines aim to improve cystic fibrosis screening

Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas

Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition

CCNY physicists uncover electronic interactions mediated via spin waves

Researchers’ 3D-printing formula may transform future of foam

Nurture more important than nature for robotic hand

Drug-delivering aptamers target leukemia stem cells for one-two knockout punch

New study finds that over 95% of sponsored influencer posts on Twitter were not disclosed

New sea grant report helps great lakes fish farmers navigate aquaculture regulations

Strain “trick” improves perovskite solar cells’ efficiency

How GPS helps older drivers stay on the roads

Estrogen and progesterone stimulate the body to make opioids

Dancing with the cells – how acoustically levitating a diamond led to a breakthrough in biotech automation

Machine learning helps construct an evolutionary timeline of bacteria

Cellular regulator of mRNA vaccine revealed... offering new therapeutic options

Animal behavioral diversity at risk in the face of declining biodiversity

Finding their way: GPS ignites independence in older adult drivers

Antibiotic resistance among key bacterial species plateaus over time

‘Some insects are declining but what’s happening to the other 99%?’

Powerful new software platform could reshape biomedical research by making data analysis more accessible

Revealing capillaries and cells in living organs with ultrasound

American College of Physicians awards $260,000 in grants to address equity challenges in obesity care

Researchers from MARE ULisboa discover that the European catfish, an invasive species in Portugal, has a prolonged breeding season, enhancing its invasive potential

Rakesh K. Jain, PhD, FAACR, honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research

Solar cells made of moon dust could power future space exploration

Deporting immigrants may further shrink the health care workforce

Border region emergency medical services in migrant emergency care

Resident physician intentions regarding unionization

[Press-News.org] People with low risk for cocaine dependence have differently shaped brain to those with addiction
Research provides unique insight into the often misunderstood world of addiction