PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Stigma stymies prostate cancer screening, treatment in Ghana

Low screening rates and lack of treatment resulting in late-stage diagnoses, poor outcomes in prostate cancer patients in West African nation

Stigma stymies prostate cancer screening, treatment in Ghana
2013-01-25
(Press-News.org) PHILADELPHIA—Infectious diseases in Ghana tend to capture the most attention, but a quiet crisis may soon take over as the country's most threatening epidemic: cancer.

A new study published in January in the journal BMC Cancer, led by Kosj Yamoah, M.D., Ph.D., a resident in the Department of Radiation Oncology at Thomas Jefferson University and Hospital, takes aim at the issue by investigating prostate cancer diagnoses and treatment delivery in black men living in the West African region, in order to devise research strategies to help improve health outcomes.

Overall, many men are diagnosed at a later stage, with more than half opting out of treatment, they found. The researchers point to stigmas about cancer as a root of the problem.

"Cancer could eclipse infectious diseases as an epidemic if more awareness and intervention doesn't come about," said Dr. Yamoah, who grew up in Ghana until age 20, when he came to the United States. "Cancer can be very hush-hush because of cultural and financial issues and social stigmas associated with the disease. We need to bring awareness and address the needs of the population and barriers to care."

"Cancer is still perceived as a death sentence," he added. "People are scared to go to their doctor to find out if they have it, let alone to follow through with treatment."

In a retrospective analysis of 379 patients referred for treatment at the National Center for Radiotherapy and Nuclear Medicine at the Korle Bu Teaching Hospital (KBTH) from 2003 to 2009, the team found that 33 percent were diagnosed with metastatic disease and 70 percent had a prostate-specific antigen (PSA) score four times higher than men in the United States or Europe at time of diagnosis.

PSA screening rates in Ghana are low, the authors explain, and many men opt out of radiation therapy and other therapies after diagnosis. Out of the 251 patients eligible for radiation therapy, only 141 patients actually received external beam radiation therapy.

Among patients with at least two years of follow up after external beam radiation therapy, three- and five-year PSA-failure free survival was 73.8 percent and 65.1 percent respectively. In the U.S., those percentages are 90 percent and 85 percent, respectively.

Reasons recognized by KBTH clinicians for patients declining radiation therapy included: the prohibitive cost of treatment, fear of radiation, and a state of denial based on their perception of disease originating solely from spiritual causes rather than biologic processes.

The data, which to date provides the largest source of published information on outcomes for prostate cancer treatment in the West African region, is a call to action, according to the authors.

The research team plans to develop treatment regimens tailored to the needs of Ghanaian men, which may differ from guidelines currently utilized in the Unites States and Europe in order to better address the disease burden and improve mortality rates in Ghana. That could mean more frequent PSA screening.

"There is controversy in the United States with PSA testing, but in a country like Ghana, there may be a role for PSA screening, even infrequent screening, because of all the late stage cancers we are finding," said Dr. Yamoah.

The team has established collaboration between two institutions with the hope of improving prostate cancer treatment and plan to start more clinical trials to develop novel, shorter course treatments for locally-advanced prostate cancer.

"Based on these results, our group has proposed a plan for future research aimed at identifying an appropriate role for PSA screening in this population, developing radiation therapy treatment schedules that better fulfill the needs of Ghanaian prostate cancer patients, and contributing to understanding genetic factors associated with prostate cancer risk and treatment response," the authors write.

Sarah E. Hegarty, a statistical analyst in the Department Pharmacology & Experimental Therapeutics at Jefferson, and Terry Hyslop, Ph.D., also of the Department Pharmacology & Experimental Therapeutics at Jefferson, were also part of the study.



INFORMATION:


[Attachments] See images for this press release:
Stigma stymies prostate cancer screening, treatment in Ghana

ELSE PRESS RELEASES FROM THIS DATE:

Study: Store layout an important variable for retailers

Study: Store layout an important variable for retailers
2013-01-25
CHAMPAIGN, Ill. — A retailer's optimal store layout is the result of balancing the interests of two different types of markets – consumers and suppliers, says new research co-written by a University of Illinois business professor. According to Yunchuan "Frank" Liu, a retailer's strategic manipulation of store layout is driven by an incentive to balance the shopping process of "fit-uncertain consumers" and the pricing behavior of upstream suppliers. "Retailers face two different kinds of markets – the consumers who buy goods, and the manufacturers that supply goods," ...

NASA sees Tropical Cyclone Garry continue to intensify

NASA sees Tropical Cyclone Garry continue to intensify
2013-01-25
Tropical Cyclone Garry is in a good environment to intensify and satellite imagery from NOAA's GOES-15 satellite helped confirm that the storm has become more organized. NOAA's GOES-15 satellite captured an infrared image of Tropical Storm Garry when it was located about 330 nautical miles (379.8 miles/ 611.2 km) east of Pago Pago, American Samoa. The image, created by the NASA GOES Project at the NASA Goddard Space Flight Center in Greenbelt, Md., was taken Jan. 24 at 1500 UTC (10 a.m. EST). The image showed a bright white circle of clouds that indicate strong thunderstorms ...

NASA sees remnants of Tropical Storm Oswald still strong

NASA sees remnants of Tropical Storm Oswald still strong
2013-01-25
Infrared imagery from NASA's Aqua satellite revealed that a band of thunderstorms on the eastern side of Tropical Storm Oswald's remnants still contained some punch. Oswald's remnants have triggered severe weather warnings in parts of Queensland, Australia. When NASA's Aqua satellite passed over the eastern side of the remnants of Tropical Cyclone Oswald the Atmospheric Infrared Sounder (AIRS) instrument captured an infrared image of a powerful band of thunderstorms over the Coral Sea. The band of thunderstorms east of Oswald's center showed some strong convection and ...

NASA Super-TIGER balloon shatters flight record

NASA Super-TIGER balloon shatters flight record
2013-01-25
Flying high over Antarctica, a NASA long duration balloon has broken the record for longest flight by a balloon of its size. The record-breaking balloon, carrying the Super Trans-Iron Galactic Element Recorder (Super-TIGER) experiment, has been afloat for 46 days and is on its third orbit around the South Pole. "This is an outstanding achievement for NASA's Astrophysics balloon team," said John Grunsfeld, associate administrator for the Science Mission Directorate at NASA Headquarters in Washington. "Keeping these huge balloons aloft for such long periods lets us do ...

Fetal exposure to tributyltin linked to obesity

2013-01-25
Irvine, Calif. (Corrected version) — Exposing pregnant mice to low doses of the chemical tributyltin (TBT) – which was used in marine antifouling paints and is used as an antifungal agent in some paints, certain plastics and a variety of consumer products – can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found. After exposing pregnant mice to TBT at low concentrations, similar to those found in the environment and in humans, researchers observed increased body fat, liver fat and fat-specific gene expression in liver and ...

Maglev tissues could speed toxicity tests

2013-01-25
In a development that could lead to faster and more effective toxicity tests for airborne chemicals, scientists from Rice University and the Rice spinoff company Nano3D Biosciences have used magnetic levitation to grow some of the most realistic lung tissue ever produced in a laboratory. The research is part of an international trend in biomedical engineering to create laboratory techniques for growing tissues that are virtually identical to those found in people's bodies. In the new study, researchers combined four types of cells to replicate tissue from the wall of ...

Chameleon star baffles astronomers

Chameleon star baffles astronomers
2013-01-25
Pulsars—tiny spinning stars, heavier than the sun and smaller than a city—have puzzled scientists since they were discovered in 1967. Now, new observations by an international team, including University of Vermont astrophysicist Joanna Rankin, make these bizarre stars even more puzzling. The scientists identified a pulsar that is able to dramatically change the way in which it shines. In just a few seconds, the star can quiet its radio waves while at the same time it makes its X-ray emissions much brighter. The research "challenges all proposed pulsar emission theories," ...

Low vitamin D levels linked to high risk of premenopausal breast cancer

2013-01-25
A prospective study led by researchers from the University of California, San Diego School of Medicine has found that low serum vitamin D levels in the months preceding diagnosis may predict a high risk of premenopausal breast cancer. The study of blood levels of 1,200 healthy women found that women whose serum vitamin D level was low during the three-month period just before diagnosis had approximately three times the risk of breast cancer as women in the highest vitamin D group. The study is currently published online in advance of the print edition of the journal ...

Do non-steroidal anti-inflammatory drugs cause kidney failure in children?

2013-01-25
Cincinnati, OH, January 25, 2013 -- Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, are commonly used to treat pain and reduce fever in children. However, the use of NSAIDs has been shown to cause acute kidney injury (AKI) in some children. A new study scheduled for publication in The Journal of Pediatrics reports the findings on the number of children diagnosed with AKI caused by NSAIDs in one hospital over an 11 ½ year span. Dr. Jason Misurac and colleagues from the Indiana University School of Medicine and Butler University retrospectively ...

Frontiers publishes systematic review on the effects of yoga on major psychiatric disorders

2013-01-25
Yoga has positive effects on mild depression and sleep complaints, even in the absence of drug treatments, and improves symptoms associated with schizophrenia and ADHD in patients on medication, according to a systematic review of the exercise on major clinical psychiatric disorders. Published in the open-access journal, Frontiers in Psychiatry, on January 25th, 2013, the review of more than one hundred studies focusing on 16 high-quality controlled studies looked at the effects of yoga on depression, schizophrenia, ADHD, sleep complaints, eating disorders and cognition ...

LAST 30 PRESS RELEASES:

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

Targeting FGFR2 may prevent or delay some KRAS-mutated pancreatic cancers

[Press-News.org] Stigma stymies prostate cancer screening, treatment in Ghana
Low screening rates and lack of treatment resulting in late-stage diagnoses, poor outcomes in prostate cancer patients in West African nation