PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Do non-steroidal anti-inflammatory drugs cause kidney failure in children?

2013-01-25
(Press-News.org) Cincinnati, OH, January 25, 2013 -- Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, are commonly used to treat pain and reduce fever in children. However, the use of NSAIDs has been shown to cause acute kidney injury (AKI) in some children. A new study scheduled for publication in The Journal of Pediatrics reports the findings on the number of children diagnosed with AKI caused by NSAIDs in one hospital over an 11 ½ year span.

Dr. Jason Misurac and colleagues from the Indiana University School of Medicine and Butler University retrospectively screened all patients hospitalized at Riley Hospital for Children at IU Health who were identified with AKI. Out of 1015 patients with AKI, 27 were identified to have NSAID-associated AKI. Seventy-eight percent of the 27 patients had been using NSAIDs for less than 7 days, and 75% took the medication at the correct dosage. In 67% of the cases, the family reported that the child had signs of dehydration. Most of the patients were teens; however, patients who were less than 5 years old were more seriously affected and more likely to need dialysis. Although the reasons for younger children having a more severe disease course are unknown, the authors speculate that it could be due to an increased susceptibility to the toxic effects of NSAIDs. None of the patients died or developed permanent kidney failure, but 30% of the children had evidence of mild chronic kidney damage persisting after recovery from the episode of AKI.

The costs of caring for children with NSAID-associated AKI are significant, especially considering that this is an avoidable condition. Adding to this cost burden is the long-term care needed, because studies show that these patients have an increased risk of progressive chronic kidney disease. In some cases, acetaminophen might be a more appropriate choice for treatment. "This study underscores the importance of understanding the natural history of NSAID-associated AKI, including the potential for development of chronic kidney disease," notes Dr. Misurac. "Providers should continue to provide careful NSAID education to parents and children."

### END


ELSE PRESS RELEASES FROM THIS DATE:

Frontiers publishes systematic review on the effects of yoga on major psychiatric disorders

2013-01-25
Yoga has positive effects on mild depression and sleep complaints, even in the absence of drug treatments, and improves symptoms associated with schizophrenia and ADHD in patients on medication, according to a systematic review of the exercise on major clinical psychiatric disorders. Published in the open-access journal, Frontiers in Psychiatry, on January 25th, 2013, the review of more than one hundred studies focusing on 16 high-quality controlled studies looked at the effects of yoga on depression, schizophrenia, ADHD, sleep complaints, eating disorders and cognition ...

Common anti-fever medications pose kidney injury risk for children

2013-01-25
Sick children, especially those with some dehydration from flu or other illnesses, risk significant kidney injury if given drugs such as ibuprofen and naproxen, Indiana University School of Medicine researchers said Friday. In an article published online Jan. 25 by the Journal of Pediatrics, Jason Misurac, M.D., and colleagues from IU and Butler University reported that nearly 3 percent of cases of pediatric acute kidney injury over a decade could be traced directly to having taken the common nonsteroidal anti-inflammatory drugs, or NSAIDs. Although relatively few ...

Tumor cells engineer acidity to drive cell invasion, Moffitt Cancer Center researchers say

2013-01-25
Researchers at Moffitt Cancer Center and colleagues at Wayne State University School of Medicine investigated the acidity in solid tumors to determine if pH levels play a role in cancer cell invasion in surrounding tissues. They found that an acidic microenvironment can drive cancer cells to spread and propose that neutralizing pH would inhibit further invasion, providing a therapeutic opportunity to slow the progression of cancers. Their study appeared in the Jan. 3 online release of Cancer Research, a publication of the American Association for Cancer Research. According ...

A New Law in California Now Allows Drivers to Send Text Messages with Hands-Free Technology

2013-01-25
A new law in California now allows drivers to send text messages with hands-free technology. As technology continues to advance, lawmakers in California have reconsidered certain distracted driving laws. Recently, a new law was enacted, making the previous texting ban more lenient for California motorists. The new law in California allows drivers to use hands-free technology to send text messages or listen to incoming messages while they are behind the wheel. Previously, motorists in the state had been prohibited from texting altogether, regardless of whether they ...

House-Swapping and Lifetime Gifts as Money-Saving Options

2013-01-25
House-swapping and lifetime gifts as money-saving options In this difficult economic landscape, most families are trying to find ways to save costs in major areas of expenditures such as buying a house or estate taxes. Two possible solutions are house-swapping among family members to avoid realtor's fees and using life-time gifts to children as a means of avoiding overly burdensome estate taxes. House-swapping House swaps are when family members buy each other's homes in order to meet changing needs and to avoid realtors' commissions and other fees. For example, ...

State Police Advise Illinois Motorists to Stay Safe this Winter

2013-01-25
State police advise Illinois motorists to stay safe this winter With the winter driving season in full force, parts of Illinois and the Midwest have already experienced major snowstorms, bringing with it icy and slippery roads. In order to lessen the risk of being involved in a car accident, the Illinois State Police are advising drivers to take proper precautions when driving during adverse weather conditions. State officials encourage Illinois motorists to take extra care when driving on icy or snowy roads and to allow for extra travel time. In addition, winter ...

Getting a Mortgage Loan after Bankruptcy

2013-01-25
Getting a mortgage loan after bankruptcy Even after filing bankruptcy, a person may still be eligible to be approved for a mortgage loan. A record of the bankruptcy can remain on the filer's credit report for up to 10 years. Although many people believe the myth that they will never be able to obtain a mortgage after filing bankruptcy, in reality, filers can be approved for mortgage in as little as one year after a bankruptcy. A mortgage loan can be approved in as little as one year after bankruptcy The amount of time it takes for someone who filed bankruptcy to ...

2013 Brings Sweeping Changes to Florida's PIP Law

2013-01-25
2013 brings sweeping changes to Florida's PIP law In Florida, every driver is required to carry personal injury protection auto insurance, also known as no-fault insurance or PIP coverage. This insurance is designed to cover reasonable medical expenses and wage loss stemming from a car accident injury, regardless of who was at fault in causing the crash. Florida's PIP system has long been the subject of significant controversy. Advocates say that PIP coverage provides an important safety net, and that a generous interpretation of the terms of coverage is necessary ...

Dealing with the Financial Fallout of Childhood Illnesses

2013-01-25
Dealing with the financial fallout of childhood illnesses To a parent, there is nothing more terrifying than learning your child has a serious or life-threatening illness. For nearly every parent, protecting their child's life and health is their most important priority. Parents of sick children often sacrifice everything to help their kids get the treatment they need. Unfortunately, though, treatment for childhood illnesses usually comes at a great expense. When a family's resources are diverted toward paying for a child's medical care, it is not uncommon for the ...

Despite National Decline, California Traffic Deaths on the Rise

2013-01-25
Despite national decline, California traffic deaths on the rise In 2011, the number of fatal collisions nationwide dropped to its lowest point in over 60 years. According to federal transportation data, 32,367 people were killed in traffic accidents in 2011. This figure represents a 1.9 percent decrease from 2010. Although the federal figures are on the decline, not all states are experiencing individual declines. In fact, only 36 states have experienced a decrease in fatal automobile collisions. In addition, despite the national decrease in fatal collisions, pedestrian ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Do non-steroidal anti-inflammatory drugs cause kidney failure in children?