Emotional stress reduces effectiveness of prostate cancer therapies in animal model
Beta-blockers offer some protection
(Press-News.org) WINSTON-SALEM, N.C. – Jan. 25, 2013 – Not surprisingly, a cancer diagnosis creates stress. And patients with prostate cancer show higher levels of anxiety compared to other cancer patients. A new study by researchers at Wake Forest Baptist Medical Center indicates that stress is not just an emotional side effect of the diagnosis; it also can reduce the effectiveness of prostate cancer drugs and accelerate the development of prostate cancer. The findings are published in the February issue of the Journal of Clinical Investigation. The Wake Forest Baptist team, headed by George Kulik, D.V.M., Ph.D., associate professor of cancer biology, tested the effects of behavioral stress in two different mouse models of prostate cancer. One model used mice that were implanted with human prostate cancer cells and treated with a drug that is currently in clinical trial for prostate cancer treatment. When the mice were kept calm and free of stress, the drug destroyed prostate cancer cells and inhibited tumor growth. However, when the mice were stressed, the cancer cells didn't die and the drug did not inhibit tumor growth. In the second model, mice genetically modified to develop prostate cancer were used. When these mice were repeatedly stressed, the size of prostate tumors increased. When the mice were treated with bicalutamide, a drug currently used to treat prostate cancer, their prostate tumors decreased in size. However, if mice were subjected to repeated stress, the prostate tumors didn't respond as well to the drug. After analyzing the data, the Wake Forest Baptist researchers identified the cell signaling pathway by which epinephrine, a hormone also known as adrenaline, sets off the cellular chain reaction that controls cell death. Considering that prostate cancer diagnosis increases stress and anxiety levels, stress-induced activation of the signaling pathway that turns off the cell death process may lead to a vicious cycle of stress and cancer progression, Kulik said. Yet in both models in which the mice were given beta-blocker, stress did not promote prostate tumor growth. Beta-blocker is a drug that inhibits the activation of anti-death signaling by epinephrine. "Providing beta-blockers to prostate cancer patients who had increased epinephrine levels could improve the effectiveness of anti-cancer therapies," Kulik said. "Our findings could be used to indentify prostate cancer patients who will benefit from stress reduction or from pharmacological inhibition of stress-inducing signaling." The researchers now plan to test the same signaling mechanism that was identified in mice to determine if it also works in the same way in human prostates, Kulik said. "We are at the very beginning of understanding complex stress-cancer interactions with multifaceted responses to stress that affect cancer cells, tumor microenvironment, and the organism overall," he said. "We hope that components of this signaling pathway could be used as biomarkers to predict whether and how a given tumor will respond to stress and anti-stress therapies." ### Co-authors of the study are Sazzad Hassan, M.D., Ph.D., Yelena Karpova, B.S., Daniele Baiz, Ph.D., Dana Yancey, Ph.D., Ashok Pullikuth, Ph.D., Anabel Flores, B.S., Thomas Register, Jr., Ph.D., Mark Cline, D.V.M., Ph.D., and Ralph D'Agostino, Ph.D., of Wake Forest Baptist; Nika Danial, Ph.D., of the Dana-Farber Cancer Institute, and Sandeep Robert Datta, M.D., Ph.D., of Harvard Medical School. Funding for the study was provided by the U.S. Department of Defense, grant PC073548, National Cancer Institute, contract R01CA118329, and institutional grants from Wake Forest Baptist.
ELSE PRESS RELEASES FROM THIS DATE:
INRS develops a nanohybrid with remarkable properties using a new laser-plasma process
Montreal, January 25, 2013 – By achieving the synthesis of a novel nanohybrid structure by means of the pulsed laser ablation (PLA) technique, Professor My Ali El Khakani and his team paved the way for a new generation of optoelectronic materials. The combination of carbon nanotubes and lead sulfide (PbS) nanoparticles was performed using an effective and relatively simple process that offers considerable latitude for creating other nanohybrids for a variety of applications. The INRS Énergie Matériaux Télécommunications Research Centre researcher's work, published in the ...
No more 'empty nest:' middle-aged adults face family pressure on both sides
CORVALLIS, Ore. – The "empty nest" of past generations, in which the kids are grown up and middle-aged adults have more time to themselves, has been replaced in the United States by a nest that's full – kids who can't leave, can't find a job and aging parents who need more help than ever before. According to a new study by researchers at Oregon State University, what was once a life stage of new freedoms, options and opportunities has largely disappeared. An economic recession and tough job market has made it hard on young adults to start their careers and families. ...
New tool for mining bacterial genome for novel drugs
Vanderbilt biochemists have discovered that the process bacteria undergo when they become drug resistant can act as a powerful tool for drug discovery. Their findings – reported this week in the Online Early Edition of the Proceedings of the National Academy of Sciences – should give a major boost to natural products drug discovery – the process of finding new drugs from compounds isolated from living organisms – by substantially increasing the number of novel compounds that scientists can extract from individual microorganisms. Bacteria have traditionally been the ...
New suite of chemicals seen causing disease generations later
PULLMAN, Wash.—Washington State University researchers have lengthened their list of environmental toxicants that can negatively affect as many as three generations of an exposed animal's offspring. Writing in the online journal PLOS ONE, scientists led by molecular biologist Michael Skinner document reproductive disease and obesity in the descendants of rats exposed to the plasticizer bisephenol-A, or BPA, as well DEHP and DBP, plastic compounds known as phthalates. In a separate article in the journal Reproductive Toxicology, they report the first observation of cross-generation ...
Breast feeding okay for mothers taking immunosuppressant drug
Highlights The breast milk of mothers taking the immunosuppressant tacrolimus contains only very low levels of the drug. Women taking tacrolimus who wish to breast-feed after appropriate counseling should not be discouraged from doing so. Increasing numbers of pregnant women are taking tacrolimus after organ transplantation and for other conditions. Washington, DC (January 24, 2013) — Women taking the immunosuppressant tacrolimus can rest assured that breast feeding will not elevate their babies' exposure to the drug, according to a study appearing in an upcoming ...
Kidney disease accounts for most of the increased risk of dying early among diabetics
Highlights Among people without diabetes or kidney disease, 10-year mortality was 7.7%. Among individuals with diabetes but without kidney disease, mortality was 11.5%. Among those with both diabetes and kidney disease, mortality was 31.1%. 26 million people in the US and 340 million people in the world have type 2 diabetes. Washington, DC (January 24, 2013) — One in every 10 Americans has diabetes, and a third or more of those with the condition will develop kidney disease. It may be possible to live a long and healthy life with diabetes, but once kidney disease ...
Love triumphs over hate to make exotic new compound
Northwestern University graduate student Jonathan Barnes had a hunch for creating an exotic new chemical compound, and his idea that the force of love is stronger than hate proved correct. He and his colleagues are the first to permanently interlock two identical tetracationic rings that normally are repelled by each other. Many experts had said it couldn't be done. On the surface, the rings hate each other because each carries four positive charges (making them tetracationic). But Barnes discovered by introducing radicals (unpaired electrons) onto the scene, the researchers ...
Science needs a second opinion: Researchers find flaws in study of patients in 'vegetative state'
NEW YORK (Jan. 24, 2013) -- A team of researchers led by Weill Cornell Medical College is calling into question the published statistics, methods and findings of a highly publicized research study that claimed bedside electroencephalography (EEG) identified evidence of awareness in three patients diagnosed to be in a vegetative state. The new reanalysis study led by Weill Cornell neurologists Drs. Andrew Goldfine, Jonathan Victor, and Nicholas Schiff, published in the Jan. 26 issue of the journal Lancet, reports the statistical results and methodology used by a research ...
Chameleon pulsar baffles astronomers
Using a satellite X-ray telescope combined with terrestrial radio telescopes the pulsar was found to flip on a roughly half-hour timescale between two extreme states; one dominated by X-ray pulses, the other by a highly-organised pattern of radio pulses. The research was led by Professor Wim Hermsen from The Netherlands Institute for Space Research and the University of Amsterdam and will appear in the journal Science on the 25th January 2013. Researchers from Jodrell Bank Observatory, as well as institutions around the world, used simultaneous observations with the ...
Genetic landscape of common brain tumors holds key to personalized treatment
Nearly the entire genetic landscape of the most common form of brain tumor can be explained by abnormalities in just five genes, an international team of researchers led by Yale School of Medicine scientists report online in the Jan. 24 edition of the journal Science. Knowledge of the genomic profile of the tumors and their location in the brain make it possible for the first time to develop personalized medical therapies for meningiomas, which currently are only managed surgically. Meningioma tumors affect about 170,000 patients in the United States. They are usually ...
LAST 30 PRESS RELEASES:
American Academy of Arts and Sciences to induct UVA's Garcia-Blanco
Illinois-led team puts cows and microbes to work to reduce greenhouse gases
DOE announces $264 million for basic research in support of Energy Earthshots™
New drug a breakthrough for brain tumor that strikes young people: NEJM editorial
Genome study reveals 30 years of Darwin’s finch evolution
Ghent University’s research team envisions a bright future with active machine learning in chemical engineering
Climate change and carnivores: shifts in the distribution and effectiveness of protected areas in the Amazon
Can ChatGPT help us form personal narratives?
An intelligent control method reduces carbon emissions in energy-intensive equipment
Groundbreaking control method reduces carbon emissions from zinc oxide rotary kilns, boosting profits for zinc smelting industry
Small but mighty new gene editor
Study finds SARS-CoV-2-associated sepsis was more common, deadly than previously thought
Use of electronic clinical data to track incidence and mortality for SARS-CoV-2–associated sepsis
Misinformation, trust, and use of ivermectin and hydroxychloroquine for COVID-19
Neighborhood factors, individual stressors, and cardiovascular health among Black and white adults
New research reveals link between childhood mental health problems and quality of life for young adults
New insights into how the human brain organises language
Visual search: Context facilitates more effective strategies
Malaria: Treatment of Plasmodium falciparum malaria patients under threat in the Horn of Africa
New post-translational modification of the glycolytic enzyme enolase
New frontier in biomedical engineering: Protein coacervates engineered into adhesive for unprecedented skin repair speed
New study unveils insights into ethylene copolymerization with linear and end-cyclized olefins using a metallocene catalyst
Study identifies new pathway to suppressing autoimmunity
Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race
Groundbreaking mathematical proof: new insights into typhoon dynamics unveiled
Teams invent a new metallization method of modified tannic acid photoresist patterning
MoMFs could be central to liver regeneration
A lethal parasite’s secret weapon: Infecting non-immune cells
Ball milling provides high pressure benefits to battery materials
Congenital Heart Surgeons' Society (CHSS) and fourteen professional organizations announce recommendations for performing pediatric heart surgery in US[Press-News.org] Emotional stress reduces effectiveness of prostate cancer therapies in animal model
Beta-blockers offer some protection