PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study reveals superior sedation method for children

2010-10-20
(Press-News.org) Procedural sedation and analgesia is an essential element of care for children requiring painful procedures in the emergency department. The practice of combining ketamine and propofol, two common medications used in emergency departments, has become more popular. However, until recently, it was unclear whether this practice was superior to the use of either agent alone, especially in children.

Research led by Drs. Amit Shah, Gregory Mosdossy and Michael Rieder of the Schulich School of Medicine & Dentistry at The University of Western Ontario and Lawson Health Research Institute provides evidence that when compared to ketamine alone, patients who receive a combination of ketamine and propofol have a slightly faster recovery time and suffer from less severe side effects.

The study, published online in the Annals of Emergency Medicine, included 136 children treated at London Health Sciences Centre's Children's Hospital.

Ketamine is well established as a safe and effective solitary agent for procedural sedation and analgesia. However, it is known to cause adverse side effects, such as vomiting. Propofol is associated with a dose-dependent risk of respiratory depression, but has less severe side effects.

It has been theorized that by combining the two agents, you can decrease the dose requirement of both agents thereby reducing the negative side-effects, but still have a safe and effective analgesia.

This is the first large well-conducted study exploring the use of ketamine-propofol for children in the Paediatric Emergency Department. Previous studies had hinted at its advantage but up until now results were not conclusive.

"Our study found that ketamine-propofol is an effective combination for pediatric procedural sedation, providing a slightly shorter total sedation time than ketamine alone, with less adverse events and higher satisfaction scores," says Dr. Shah. "We believe this study provides evidence for a safe and effective alternative sedation regimen for children in the Emergency Department and may lead to a change in sedation practices in other hospitals."

### END


ELSE PRESS RELEASES FROM THIS DATE:

Iowa State, USDA researchers discover eye test for neurological diseases in livestock

Iowa State, USDA researchers discover eye test for neurological diseases in livestock
2010-10-20
AMES, Iowa – The eyes of sheep infected with scrapie – a neurological disorder similar to mad cow disease – return an intense, almost-white glow when they're hit with blue excitation light, according to a research project led by Iowa State University's Jacob Petrich. The findings suggest technologies and techniques can be developed to quickly and noninvasively test for transmissible spongiform encephalopathies, progressive and fatal neurological diseases such as mad cow disease in cattle and Creutzfeldt-Jakob disease in humans. Petrich, in fact, is working to develop ...

Old logging practices linked to high erosion rates

Old logging practices linked to high erosion rates
2010-10-20
Clear-cut logging and related road-building in the 1950s and 1960s in southern Oregon's Siskiyou Mountains disrupted soil stability and led to unprecedented soil erosion made worse during heavy rainstorms, report University of Oregon researchers. While logging practices have improved dramatically since then, the damaged landscape -- the removal of low vegetation that helps to protect hillsides during fires and rain -- continues to pose a threat into the foreseeable future, said Daniel G. Gavin, professor of geography, and postdoctoral doctoral researcher Daniele Colombaroli. Their ...

The hair brush that reads your mind

2010-10-20
WASHINGTON, Oct. 19 – One of the main techniques for measuring and monitoring mental activity, called functional near infrared spectroscopy (fNIRS), can often be impaired because a person's hair gets in the way. But now, thanks to a team of researchers at the University of Texas at Dallas and the University of Texas at Arlington, a novel device called a "brush optrode" is providing increased sensitivity with fiber tips designed to thread through hair to enhance scalp contact. Details of the device will be presented at the Optical Society's (OSA) 94th annual meeting, ...

Researchers advocate for more education and attention regarding rare breast cancer

2010-10-20
PHILADELPHIA (October 19, 2010)—Inflammatory breast cancer (IBC), an aggressive and rare malignancy, is often initially misdiagnosed as an infection or rash. However, getting the correct diagnosis quickly is critical for patients because the disease spreads beyond the breast in a matter of just days or weeks. With that in mind, leading specialists from The University of Texas MD Anderson Cancer Center and Fox Chase Cancer Center have written a review of the current scientific and medical understanding of IBC, which includes key information on diagnosis, imaging, treatment, ...

ORNL's research reactor revamps veteran neutron scattering tool

2010-10-20
OAK RIDGE, Tenn., Oct. 19, 2010 -- The Cold Triple Axis spectrometer, a new addition to Oak Ridge National Laboratory's High Flux Isotope Reactor and a complementary tool to other neutron scattering instruments at ORNL, has entered its commissioning phase. The CTAX uses "cold" neutrons from the HFIR cold source to study low-energy magnetic excitations in materials. Cold neutrons are slower than their "thermal" neutron counterparts, and thus perfect for probing low-energy dynamics. The instrument, which moves by way of air pads on an epoxy surface known as the "dance ...

Study: Religious diversity increases in America, yet perceptions of Christian nation intensify

2010-10-20
WEST LAFAYETTE, Ind. - While America continues to become more religiously diverse, the belief that America is a Christian nation is growing more intense, according to research from Purdue University. "America is still predominantly Christian, but it is more diverse than ever," said Jeremy Brooke Straughn, an assistant professor of sociology who studies national identity. "At the same time, many people feel even more strongly that America is a Christian country than they did before the turn of the century. This is especially true for Americans who say they are Christians ...

WSU and ASU professors urge one-way Martian colonization missions

2010-10-20
PULLMAN, Wash. - For the chance to watch the sun rise over Olympus Mons, or maybe take a stroll across the vast plains of the Vastitas Borealis, would you sign on for a one-way flight to Mars? It's a question that gives pause to even Dirk Schulze-Makuch, a Washington State University associate professor, who, with colleague Paul Davies, a physicist and cosmologist from Arizona State University, argues for precisely such a one-way manned mission to Mars in an article published this month in the "Journal of Cosmology." In the article, "To Boldly Go: A One-Way Human Mission ...

10-minute plasma treatment improves organic memory performance

2010-10-20
Washington, D.C. (October 19, 2010) -- In its current early stage of development, digital memory circuits that use organic elements instead of silicon or other inorganic materials have a seemingly endless list of variables and options to consider, test, and optimize. While organic electronics are immediately attractive for their potential for extremely low cost and flexible substrates, many design aspects that are now taken for granted in the mature silicon-circuit world must be examined anew from the ground up. A group led by Takhee Lee from Korea's Gwangju Institute ...

Get in synch -- or be enslaved by it

2010-10-20
Washington, D.C. (October 19, 2010) -- We talk about synchronization a lot. We synch up; synch our computers; and get in synch. And synchronous behavior underlies many natural systems, events and phenomena. Understanding conditions that cause oscillators -- which are common electronic components that produce a repetitive electronic signal -- to get in synch or fall out of synch, is necessary to achieve the optimal functioning of oscillator networks that underlie many technologies. The transition from synchronization to desynchronization is the subject of a new investigation ...

Brain might be key to leptin's actions against type 1 diabetes, UT Southwestern researchers find

2010-10-20
DALLAS – Oct. 20, 2010 – New findings by UT Southwestern Medical Center researchers suggest a novel role for the brain in mediating beneficial actions of the hormone leptin in type 1 diabetes. "Our findings really pave the way for understanding the mechanism by which leptin therapy improves type 1 diabetes," said Dr. Roberto Coppari, assistant professor of internal medicine at UT Southwestern and senior author of the study involving laboratory mice. "Understanding the mechanism is important, because if we can determine how leptin drives these benefits, then we may be ...

LAST 30 PRESS RELEASES:

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce

Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes

New research expands laser technology

Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain

A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers

Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes

CTE and normal aging are difficult to distinguish, new study finds

Molecular arms race: How the genome defends itself against internal enemies

Tiny chip speeds up antibody mapping for faster vaccine design

KTU experts reveal why cultural heritage is important for community unity

More misfolded proteins than previously known may contribute to Alzheimer’s and dementia

“Too much going on”: Autistic adults overwhelmed by non-verbal social cues

What’s driving America’s deep freezes in a warming world?

A key role of brain protein in learning and memory is deciphered by scientists

Heart attacks don’t follow a Hollywood script

Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories

Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds

Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%

Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR

New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications

State gun laws and firearm-related homicides and suicides

Use of tobacco and cannabis following state-level cannabis legalization

Long-term obesity and biological aging in young adults

Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement

Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development

A technological breakthrough for ultra-fast and greener AI

Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption

Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications

[Press-News.org] Study reveals superior sedation method for children