PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

5-year follow-up - over half of all ACL reconstructions could be avoided

2013-01-30
(Press-News.org) "We have continued with our study and for the first time are able to present a five-year follow-up on the need for and results of ACL surgery as compared with physiotherapy. The findings have been published in the British Medical Journal and are basically unchanged from 2010. This will no doubt surprise many people, as we have not seen any difference in the incidence of osteoarthritis", says Richard Frobell, one of the researchers behind the study, who is an associate professor at Lund University and a clinician at the orthopaedic department, Helsingborg Hospital. Richard Frobell explains that the research group's results from 2010*, which were published in the New England Journal of Medicine, caused a stir and questions were raised as to whether it was possible to say that an operation would not be needed in the long term. Half of the patients who were randomly assigned not to undergo reconstructive surgery have had an operation in the five years since, after experiencing symptoms of instability. "In this study, there was no increased risk of osteoarthritis or meniscal surgery if the ACL injury was treated with physiotherapy alone compared with if it was treated with surgery. Neither was there any difference in patients' experiences of function, activity level, quality of life, pain, symptoms or general health", says Richard Frobell. "The new report shows that there was no difference in any outcome between those who were operated on straight away, those who were operated on later and those who did not have an operation at all. The message to the medical experts who are treating young, active patients with ACL injuries is that it may be better to start by considering rehabilitation rather than operating straight away." In Sweden, over 5 000 people every year suffer an anterior cruciate ligament injury – mainly young people involved in sport. There are different schools of treatment and Sweden stands out with treatment that is in line with the results of the study. "On an international front, almost all of those with ACL injuries are operated on. In Sweden, just over half are operated on, but in southern Sweden we have been working for many years to use advanced rehabilitation training as the first method of treatment. Our research so far has confirmed that we are right in not choosing to operate on these injuries immediately. Longer-term follow-up is important, however, if we are to look more closely at the development of osteoarthritis in particular", says Richard Frobell. The research group, whose study is called KANON, Knee ACL NON-operative versus operative treatment, is now moving on to the next stage. This year, the third part of the study will begin, following up the patients ten years after anterior cruciate ligament injury. Richard Frobell has also entered into a collaboration with researchers at the School of Economics and Management at Lund University to evaluate the health economics aspects of different treatment methods for ACL injury.

### Publication Title: Treatment for acute anterior cruciate ligament tear: five year outcome of randomised trial BMJ 2013; 346

Authors: Richard Frobell, Harald Roos, Ewa Roos, Frank W Roemer, Jonas Ranstam and Stefan Lohmander

Link to research article in BMJ 2013 http://www.bmj.com/content/346/bmj.f232

*Link to press release from Lund University, 22 July 2010 http://www.lunduniversity.lu.se/o.o.i.s?id=24890&news_item=5367

Contact Richard Frobell, mobile +46 708 507882, +46 42 406 1027



ELSE PRESS RELEASES FROM THIS DATE:

New drug target identified for multiple sclerosis and Alzheimer's disease

2013-01-30
(Boston)–Researchers at Boston University School of Medicine (BUSM) led by Carmela Abraham, PhD, professor of biochemistry, along with Cidi Chen, PhD, and other collaborators, report that the protein Klotho plays an important role in the health of myelin, the insulating material allowing for the rapid communication between nerve cells. These findings, which appear online in Journal of Neuroscience, may lead to new therapies for multiple sclerosis (MS) and Alzheimer's disease (AD), in which white matter abnormalities are also common but have been largely ignored. MS is ...

Female deer take control during the mating season

2013-01-30
A new study provides the first evidence of polyandry – when females choose to mate with more than one male – in female fallow deer. According to a team of scientists from Queen Mary, University of London, UWEHartpury, and University College Dublin, female fallow deer play an active role in selecting their mates, with a consistent proportion (on average 12 per cent) choosing to mate with multiple males each year. "Until now there has been limited understanding of female mate choice during this process, with many people believing that female deer are controlled by males ...

Toward a better cyanide antidote for terrorist attacks and other mass casualty events

2013-01-30
In an advance toward closing a major gap in defenses against terrorist attacks and other mass casualty events, scientists are reporting discovery of a promising substance that could be the basis for development of a better antidote for cyanide poisoning. Their report, which describes a potential antidote that could be self-administered, much like the medication delivered by allergy injection pens, appears in ACS' Journal of Medicinal Chemistry. Steven E. Patterson, Ph.D., and colleagues at the University of Minnesota Center for Drug Design explain that the only existing ...

Why some immigrants get citizenship

2013-01-30
CAMBRIDGE, MA -- For immigrants, the path to citizenship in many countries is filled with hurdles: finding a job, learning the language, passing exams. But for some people, the biggest obstacle of all may be one they cannot help: their country of origin. That's one conclusion of a methodologically innovative study of European immigrants suggesting that, other qualifications being equal, migrants from certain countries may be roughly 40 percent less likely than others to gain citizenship. Even if an immigrant has obtained a good education and job, and solid language ...

First mobile app for green chemistry fosters sustainable manufacturing of medicines

2013-01-30
Mention mobile applications, or mobile apps, and people think of games, email, news, weather, productivity and other software for Apple, Android and other smart phones and tablet computers. But an app with broader impact — the first mobile application to foster wider use of the environmentally friendly and sustainable principles of green chemistry — is the topic of a report in the American Chemical Society's new journal, ACS Sustainable Chemistry & Engineering. Sean Ekins, Alex M. Clark and Antony Williams point out that the companies that manufacture medicines, electronics ...

TV viewing and sedentary lifestyle in teens linked to disease risk in adulthood

2013-01-30
A team of scientists at Umeå University, in collaboration with colleagues in Melbourne, Australia, have found that television viewing and lack of exercise at age 16 is associated with the risk of developing metabolic syndrome at 43 years age. Metabolic syndrome is a name for the disorder of metabolism - a combination of abdominal obesity, elevated blood lipids, hypertension and impaired glucose tolerance - which provides for a significantly increased risk of developing type 2 diabetes, stroke and cardiovascular disease. It has previously been shown that lack of physical ...

Prehistoric humans not wiped out by comet, say researchers

2013-01-30
Comet explosions did not end the prehistoric human culture, known as Clovis, in North America 13,000 years ago, according to research published in the journal Geophysical Monograph Series. Researchers from Royal Holloway university, together with Sandia National Laboratories and 13 other universities across the United States and Europe, have found evidence which rebuts the belief that a large impact or airburst caused a significant and abrupt change to the Earth's climate and terminated the Clovis culture. They argue that other explanations must be found for the apparent ...

Rats, like humans, return to drinking once punishment is removed

2013-01-30
Philadelphia, PA, January 30, 2013 – Once heavy drinking impairs function, a variety of punishment-related threats may motivate people to stop drinking: spouses may threaten divorce, employers may threaten job loss, and courts threaten drunk drivers with losing their driver's license or incarceration. In the face of these threats, many alcohol abusers refrain from drinking, but relapse is very common when the threats of punishment fade, particularly when exposed to alcohol-associated environments (contexts). A new study by researchers at the National Institute on Drug ...

Study reveals significance of second trimester markers for Down's syndrome

2013-01-30
A new analysis has found that some second trimester markers for Down's syndrome that are detected by ultrasound are more telling than others. Published early online in Ultrasound in Obstetrics & Gynecology, the study's results will help adjust pregnant women's risks for having a child with the condition. Screening for Down's syndrome is offered to all pregnant women, who start out with a background risk based on their age. Certain features detected during a second trimester ultrasound exam are potential markers for Down's syndrome, and they include dilated brain ventricles, ...

Mixed forest provides beneficial effects

2013-01-30
Forestry and nature conservation can benefit from promoting more different varieties of trees, according to a new study in which researchers from the University of Gothenburg, Sweden, were involved. Modern forestry is based largely on monocultures – usually pine or spruce trees in Sweden – mainly because this is seen to be more rational. However, a forest also contributes ecosystem services other than just wood production, such as biological diversity, carbon sequestration and berries. A new study by the Swedish University of Agricultural Sciences (SLU) and Future Forests ...

LAST 30 PRESS RELEASES:

Department of Energy announces $179 million for Microelectronics Science Research Centers

Human-related activities continue to threaten global climate and productivity

Public shows greater acceptance of RSV vaccine as vaccine hesitancy appears to have plateaued

Unraveling the power and influence of language

Gene editing tool reduces Alzheimer’s plaque precursor in mice

TNF inhibitors prevent complications in kids with Crohn's disease, recommended as first-line therapies

Twisted Edison: Bright, elliptically polarized incandescent light

Structural cell protein also directly regulates gene transcription

Breaking boundaries: Researchers isolate quantum coherence in classical light systems

Brain map clarifies neuronal connectivity behind motor function

Researchers find compromised indoor air in homes following Marshall Fire

Months after Colorado's Marshall Fire, residents of surviving homes reported health symptoms, poor air quality

Identification of chemical constituents and blood-absorbed components of Shenqi Fuzheng extract based on UPLC-triple-TOF/MS technology

'Glass fences' hinder Japanese female faculty in international research, study finds

Vector winds forecast by numerical weather prediction models still in need of optimization

New research identifies key cellular mechanism driving Alzheimer’s disease

Trends in buprenorphine dispensing among adolescents and young adults in the US

Emergency department physicians vary widely in their likelihood of hospitalizing a patient, even within the same facility

Firearm and motor vehicle pediatric deaths— intersections of age, sex, race, and ethnicity

Association of state cannabis legalization with cannabis use disorder and cannabis poisoning

Gestational hypertension, preeclampsia, and eclampsia and future neurological disorders

Adoption of “hospital-at-home” programs remains concentrated among larger, urban, not-for-profit and academic hospitals

Unlocking the mysteries of the human gut

High-quality nanodiamonds for bioimaging and quantum sensing applications

New clinical practice guideline on the process for diagnosing Alzheimer’s disease or a related form of cognitive impairment or dementia

Evolution of fast-growing fish-eating herring in the Baltic Sea

Cryptographic protocol enables secure data sharing in the floating wind energy sector

Can drinking coffee or tea help prevent head and neck cancer?

Development of a global innovative drug in eye drop form for treating dry age-related macular degeneration

Scientists unlock secrets behind flowering of the king of fruits

[Press-News.org] 5-year follow-up - over half of all ACL reconstructions could be avoided