Stem cell source an important factor, impacting ability to treat myocardial infarction

Different myocardial infarction benefit of ASCs and BMSCs from an 84 year-old male

2013-02-14

(Press-News.org) Putnam Valley, NY. (Feb. 13, 2013) – When a research team from Denmark and Sweden compared the therapeutic capabilities of adipose-derived stem cells (ASCs) versus bone marrow-derived stem cells (BMSCs) obtained from a single 84 year-old male donor with ischemic coronary disease to regeneratively treat myocardial infarction in a rat model, they found that the ASCs preserved more cardiac function in the test rats while neither stem cell type induced myocardial angiogenesis (blood vessel growth.)

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0921rasmussen.

"Treatment of myocardial infarction with bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells has shown promising results," said study co-author Dr. Trine Fink. "The transplantation of MSCs in treating myocardial infarction (MI) has been shown to improve left ventricular function in animal models. In this study, we compared the effects of adipose-derived stem cells and BMSCs from an elderly male suffering from coronary atherosclerosis when the donated cells were transplanted randomly, without the administration of immunosuppressant drugs, into two groups of adult rats modeled with MI."

The researchers noted that the age and health status of cell donors are important factors and that the impact of cell transplantation using cells from elderly patients with cardiac ischemia "needs to be elucidated."

The researchers found that ASCs ameliorated heart failure following MI in the group receiving ASCs while the group receiving the BMSCs received no similar benefit. They found that the BMSCs secreted a significantly larger amount of vascular endothelial growth factor, VEGF, than the ASCs, but that did not result in a better angiogenic response. In addition, the group receiving ASCs had improved left ventricular fraction.

That neither stem cell group induced myocardial angiogenesis raised questions about whether donor age and health have an effect on the efficacy of stem cells used in treating myocardial infarction, said the researchers.

"While this study supported previous findings that ASCs are less prone to diminish in numbers and efficacy with aging when compared to BMSCs, the characteristics of MSCs from elderly patients suffering from coronary atherosclerosis need to be determined," they concluded.

### Contact: Dr. Trine Fink, Laboratory for Stem Cell Research, Aalborg University, Fredrik Bajers Vej 3B, 9220 Aalborg, Denmark
Email trinef@hst.aau.dk
Ph: +45 9940 7550 Citation: : Jeppe Grøndahl Rasmussen, Ole Frøbert, Claus Holst-Hansen, Jens Kastrup, Ulrik Baandrup, Vladimir Zachar, Trine Fink, Ulf Simonsen Comparison Of Human Adipose-Derived Stem Cells And Bone Marrow-Derived Stem Cells In A Myocardial Infarction Model. Cell Transplant. Appeared or available online: December 4, 2012.

The Coeditors-in-chief for CELL TRANSPLANTATION are at the Diabetes Research Institute, University of Miami Miller School of Medicine and Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact, Camillo Ricordi, MD at ricordi@miami.edu or Shinn-Zong Lin, MD, PhD at shinnzong@yahoo.com.tw or David Eve, PhD at celltransplantation@gmail.com

News release by Florida Science Communications www.sciencescribe.net

ELSE PRESS RELEASES FROM THIS DATE:

Impact of stem cell transplantation location in brain a crucial factor for cell survival

2013-02-14

Putnam Valley, NY. (Feb. 13, 2013) – Researchers at the Johns Hopkins University in Baltimore, Md., and the Mossakowski Medical Research Centre in Warsaw, Poland, have found that nonself-donated cells (allografts) better survive implantation into the brains of immunocompetent research mice when the grafts are injected into the striatum (STR) of the brain rather than injected into the forceps minor (FM) region. In their study, all FM grafts were rejected while STR grafts accumulated and survived along the border between the striatum and the corpus callosum. "To the best ...

Drug shown to reverse radioiodine resistance in some advanced thyroid cancers

2013-02-14

NEW YORK, FEBRUARY 13, 2013 – The experimental drug selumetinib may allow some patients with advanced thyroid cancer to overcome resistance to radioiodine (RAI), the most effective therapy for the disease, according to new research from Memorial Sloan-Kettering Cancer Center. Published in the February 14 issue of the New England Journal of Medicine, the study offers new hope for patients with a disease that can have a poor prognosis. An estimated 56,000 new cases of thyroid cancer are diagnosed each year in the United States, and that number is on the rise, according ...

Study suggests link between untreated depression and response to shingles vaccine

2013-02-14

[EMBARGOED FOR FEB. 14, 2013] Results from a new study published in Clinical Infectious Diseases suggest a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine. Older adults are known to be at risk for shingles, a painful condition caused by the reactivation of the varicella-zoster virus, and more than a million new cases occur each year in the U.S. The vaccine boosts cell-mediated immunity to the virus and can decrease the incidence and severity of the condition. In a two-year study, led by Michael ...

A quantum dot energy harvester

2013-02-14

A new type of nanoscale engine has been proposed that would use quantum dots to generate electricity from waste heat, potentially making microcircuits more efficient. "The system is really a simple one, which exploits certain properties of quantum dots to harvest heat," Professor Andrew Jordan of the University of Rochester said. "Despite this simplicity, the power it could generate is still larger than any other nanoengine that has been considered until now." The engines would be microscopic in size, and have no moving parts. Each would only produce a tiny amount of ...

Daniel Brown, Dallas, TX Re-elected to Concierge PA Inc. Executive Board Named Chair of Non-profit, Charitable and Pro Bono Committee

2013-02-14

Concierge PA, Inc., a leading consultancy firm based in Dallas, Texas that specializes in providing cost-contained, top-tier strategic communications and employer/employee solutions to clients throughout North America, announced today that Daniel Brown was unanimously re-elected to its Board of Directors. The corporation also announced that Brown would chair its Non-profit, Charitable and Pro Bono Committee. A native of Louisiana and a long-term resident of Dallas, Mr. Brown brings a wealth of experience to the Executive Board of Concierge PA, Inc. A seasoned operations ...

I am a Visitor in Your World Private Movie Premiere Benefit Event

2013-02-14

The private premiere event of "I am a Visitor in your World", the documentary of a young woman's battle with colon cancer, will take place at Logan Theater, 2646 N Milwaukee Ave, Chicago, IL 60647 March 3rd, 2013. Cocktails and hor d'oeuvres begin at 5pm, show time 6pm. $25 per ticket. Blue tie attire appreciated! The event promises to be a highlight for the 2013 Colon Cancer awareness month. To purchase tickets or for more info please go to http://www.visitormovie.com Contact info: Jennifer Fearon 773-954-7655 jennmf77@aol.com http://www.visitormovie.com ...

Designer to Walk the Runway for New Jean Concept

2013-02-14

As Jurney Jurray, LLC the boutique of handcrafted jewelry and accessories continues to look forward to a fabulous year in fashion, designer Jenee Dionne, who typically works behind the scenes will be working the scene of the upcoming Jeans and Jazz Soiree, Book Signing and Fashion Extravaganza February 16, 2013. In support of the stateside launch of German Chocolate KA2R Jeaxers, which give a "smooth fit for every hip" designed by Vele Keyta Y. Redding and Anette Kilian, Jenee Dionne will be among several models to grace the stage. Jeri Edler of Retail Therapy ...

Kuala Lumpur's Sama-Sama Hotel Completes Renovation with Installation of Bartech Automatic Minibars

2013-02-14

Bartech, a world leader in automatic profit-generating minibar solutions for the hospitality industry, is helping one of the busiest luxury hotels in Asia Pacific, Sama-Sama Hotel Kuala Lumpur International Airport, to boost guestroom revenues while keeping operations running smoothly and efficiently. The newly renovated and rebranded Sama-Sama Hotel, a 5-star hotel formerly under the Pan Pacific flag, has installed Bartech's fully automatic minibars in all 442 guestrooms. The minibars are fitted with custom glass doors and communicate over an Ethernet network. Sama-Sama ...

U.S. Chamber of Commerce Names greeNEWit Amongst the 100 Best in Small Business

2013-02-14

The U.S. Chamber of Commerce recognized greeNEWit, an organization founded to help society build more sustainable communities and better economies through energy efficiency and conserving the use of natural resources, amongst the 100 Blue Ribbon Small Business Award winners, as part of the DREAM BIG Small Business of the Year Award. For the past eight years, the U.S. Chamber of Commerce has been scouting the country for the best in business and honoring leading companies with this prestigious award. The U.S. Chamber of Commerce is honoring greeNEWit for their critical ...

New Music Marketplace, Rock Square, Offers Free Listings Through June 30th, 2013

2013-02-14

Music collectors and enthusiasts anxious for a new selling platform can now take Rock Square for a spin—risk free. Rock Square (www.rocksquare.com) launched late last year and is offering sellers free listings, in auction and fixed-price formats, through June 30th of this year. "Although still in the early stages, Rock Square is growing every day and is primed for early adopters to dominate in their respective categories. Our listing fees are zero right now and our commission fee is very competitive," explains Paul Scharfe, the company's CEO. As a music ...

Stem cell source an important factor, impacting ability to treat myocardial infarction

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: