ESHRE publishes new PGD guidelines
2010-10-22
(Press-News.org) The four guidelines include one outlining the organisation of a PGD centre and three relating to the methods used: amplification-based testing, fluorescence in situ hybridisation (FISH)-based testing and polar body/embryo biopsy.
"The guidelines are a detailed update to the Consortium's initial PGD guidelines, published in the same journal in 2005. They have been developed as a set which, taken together, form a complete best-practice compendium," said Gary Harton, chairman of ESHRE's PGD Consortium and Head of Molecular Genetics at Reprogenetics in Livingston, New Jersey.
The rapid development of new technologies, the evolution of current methods and in light of recent advice from ESHRE on how best practice guidelines should be written, the PGD Consortium believed it necessary to update the existing guidelines.
The first guideline on the organisation of a PGD centre includes the basic requirements of an IVF/PGD centre, transport PGD (when the gametes and embryos to be tested are in a different centre than the patient), inclusion/exclusion criteria for patients, staffing, genetic counseling and accreditation of a centre.
The three more technical guidelines additionally cover laboratory requirements, clinical protocols and follow-up recommendations after diagnosis for each of the PGD methodologies: amplification-based testing, FISH-based testing and polar body/embryo biopsy.
The guidelines on amplification-based and FISH-based testing also outline quality control and quality assurance and the diagnostic confirmation of untransferred embryos. Freezing of embryos after biopsy is covered in the fourth guideline on the use of embryo biopsy in PGD/PGS.
Pre-implantation genetic screening (PGS) has been included in all guidelines. Although current evidence suggests it may be ineffective at the embryo cleavage stage using current technology, PGS may still show improved delivery rates if used at the blastocyst stage or on polar bodies. The ESHRE group decided deliberately to include PGS recommendations to assist every professional in the reproductive field to develop the best laboratory and clinical practice possible.
INFORMATION:
All four papers on this research are published online in Human Reproduction journal today (Friday): doi: 10.1093/humrep/deq265
For more information contact: Hanna Hanssen, Communications Manager ESHRE, Tel: + 32 (0)2 263 64 66,
Mob: +32 (0) 473 35 33 81, hanna@eshre.eu.
ELSE PRESS RELEASES FROM THIS DATE:
2010-10-22
Researchers found that the combination of computed tomography (CT), postmortem CT angiography (CTA) and biopsy can serve as a minimally invasive option for determining natural causes of death such as cardiac arrest, according to a study in the November issue of the American Journal of Roentgenology (www.ajronline.org).
In the last decade, postmortem imaging, especially CT, has gained increasing acceptance in the forensic field. However, CT has certain limitations in the assessment of natural death.
"Vascular and organ pathologic abnormalities, for example, generally ...
2010-10-22
Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain. This is shown in a new study done by researchers at the Hertie Institute of Clinical Brain Research (HIH, University Hospital Tübingen, University of Tübingen) and the German Center for Neurodegenerative Diseases (DZNE), to be published in Science on October 21, 2010.
Alzheimer's disease and a brain vascular ...
2010-10-22
A new type of sound sensor system has been developed to predict the likelihood of a landslide.
Thought to be the first system of its kind in the world, it works by measuring and analysing the acoustic behaviour of soil to establish when a landslide is imminent so preventative action can be taken.
Noise created by movement under the surface builds to a crescendo as the slope becomes unstable and so gauging the increased rate of generated sound enables accurate prediction of a catastrophic soil collapse.
The technique has been developed by researchers at Loughborough ...
2010-10-22
Scientists at The University of Nottingham and the Wellcome Trust Sanger Institute near Cambridge have pin-pointed the 72 molecular switches that control the three key stages in the life cycle of the malaria parasite and have discovered that over a third of these switches can be disrupted in some way.
Their research which has been funded by Wellcome Trust and the Medical Research Council (MRC) is a significant breakthrough in the search for cheap and effective vaccines and drugs to stop the transmission of a disease which kills up to a million children a year.
Until ...
2010-10-22
Power plants that burn fossil fuels remain the main source of electricity generation across the globe. Modern power plants have scrubbers to remove sulfur compounds from their flue gases, which has helped reduce the problem of acid rain. Now, researchers in India have devised a way to convert the waste material produced by the scrubbing process into value-added products. They describe details in the International Journal of Environment and Pollution.
Fossil fuels contain sulfur compounds that are released as sulfur dioxide during combustion. As such, flue gas desulfurisation ...
2010-10-22
Researchers from the University of Valencia (UV) have identified the effects of the way parents bring up their children on social structure in Spain. Their conclusions show that punishment, deprivation and strict rules impact on a family's self esteem.
"The objective was to analyse which style of parental socialisation is ideal in Spain by measuring the psychosocial adjustment of children", Fernando García, co-author of the study and a researcher at the UV, tells SINC.
The study, which has been published in the latest issue of the journal Infancia y Aprendizaje, was ...
2010-10-22
INDIANAPOLIS – A study published earlier this year in the peer reviewed online journal BMC Public Health has found that residing in a neighborhood with adverse living conditions such as low air quality, loud traffic or industrial noise, or poorly maintained streets, sidewalks and yards, makes mobility problems much more likely in late middle-aged African Americans with diabetes.
"We followed a large group of African Americans for 3 years and found an extremely strong correlation between diabetes and adverse neighborhood conditions. The study participants were between ...
2010-10-22
Jena (21 October 2010) Scientists from the Friedrich-Schiller-University Jena (Germany) were successful in improving a fabrication process for Atomic Force Microscopy (AFM) probe tips.
Atomic Force Microscopy is able to scan surfaces so that even tiniest nano structures become visible. Knowledge about these structures is for instance important for the development of new materials and carrier systems for active substances. The size of the probe is highly important for the image quality as it limits the dimensions that can be visualized – the smaller the probe, the smaller ...
2010-10-22
PITTSBURGH—An analysis of plant and petroleum-derived plastics by University of Pittsburgh researchers suggests that biopolymers are not necessarily better for the environment than their petroleum-based relatives, according to a report in Environmental Science & Technology. The Pitt team found that while biopolymers are the more eco-friendly material, traditional plastics can be less environmentally taxing to produce.
Biopolymers trumped the other plastics for biodegradability, low toxicity, and use of renewable resources. Nonetheless, the farming and chemical processing ...
2010-10-22
DURHAM, N.C. -- Being the right size and existing in the limbo between a solid and a liquid state appear to be the secrets to improving the efficiency of chemical catalysts that can create better nanoparticles or more efficient energy sources.
When matter is in this transitional state, a catalyst can achieve its utmost potential with the right combination of catalyst particle size and temperature, according to a pair of Duke University researchers. A catalyst is an agent or chemical that facilitates a chemical reaction. It is estimated that more than 90 percent of chemical ...
LAST 30 PRESS RELEASES:
[Press-News.org] ESHRE publishes new PGD guidelines
