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Better transparency needed on medical journals' competing interests

Press release from PLoS Medicine

2010-10-27
(Press-News.org) Journals need to develop policies to handle the inevitable competing interests that arise when they publish papers that may bring them reprint revenue or increase their impact factors. This is the conclusion of a research article by Andreas Lundh and colleagues from the Nordic Cochrane Centre published in this weeks PLoS Medicine. An accompanying perspective by Harvey Marcovitch, ex-chair of the Committee on Publication Ethics (COPE), and an editorial from the PLoS Medicine Editors discusses this issue further, concluding that journals should apply the same degree of transparency that they require from authors, to themselves.

The article examined randomized clinical trials published in six general medical journals (not including PLoS Medicine but including New England Journal of Medicine (NEJM), the British Medical Journal (BMJ), The Lancet, Annals of Internal Medicine, Archives of Internal Medicine, and JAMA,) over two time periods, 1996� and 2005�, and assessed which of the trials were supported wholly, partly, or not at all by industry. They then used the online academic citation index Web of Science to calculate an approximate impact factor for each journal for 1998 and 2007 and calculated the effect of the published RCTs on the impact factor.

The proportion of RCTs with sole industry support varied between journals. 32% of the RCTs published in the NEJM during both two-year periods had industry support whereas only 7% of the RCTs published in the BMJ in 2005� had industry support. Industry-supported trials were more frequently cited than RCTs with other types of support; omitting industry-supported RCTs from impact factor calculations decreased all the approximate journal impact factors. For example, omitting all RCTs with industry or mixed support decreased the 2007 BMJ and NEJM impact factors by 1% and 15%, respectively.

Finally, the researchers asked the Editor of each journal about journal income from industry sources. For the BMJ and the Lancet, the only journals that provided this information directly, income from reprint sales was 3% and 41%, respectively, of total income in 2005�.

The authors conclude that "journals [should] abide by the same standards related to conflicts of interest, which they rightly require from their authors, and that the sources and the amount of income are disclosed to improve transparency." Commenting on the article, Harvey Marcovitch agrees, saying "Journal editors have expended much time and effort in teasing out how to handle authors' and reviewers' competing interests. They need now to concentrate on their own and those of their employers". In the accompanying editorial "Increased Responsibility and Transparency in an Era of Increased Visibility" the PLoS Medicine Editors, who have posted their own journal's income on the competing interest page of the journal, conclude that "The internet has spurred an intellectual revolution in the dissemination of medical information. Journals have thus far been accepted as one of the most trusted sources of information. It's clear, however, that in order to maintain that trust, journals and editors need to continue to consider all the pressures that can arise in publishing and put in place robust, transparent procedures for handling all the potential conflicts that can arise, whether they are those of authors, editors, or the journals themselves.''

INFORMATION: 'Conflicts of Interest at Medical Journals' by Andreas Lundh and colleagues

Funding: No direct funding was received for this study. The authors were personally salaried by their institutions during the period of writing (though no specific salary was set aside or given for the writing of this paper).

Competing Interests: The authors have declared that no competing interests exist.

Citation: Lundh A, Barbateskovic M, Hrobjartsson A, Gøtzsche PC (2010) Conflicts of Interest at Medical Journals: The Influence of Industry-Supported Randomised Trials on Journal Impact Factors and Revenue – Cohort Study. PLoS Med 7(10): e1000354. doi:10.1371/journal.pmed.1000354

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000354

PRESS-ONLY PREVIEW OF THE ARTICLE: www.plos.org/press/plme-07-10-lundh.pdf

CONTACT: al@cochrane.dk

Related PLoS Medicine Perspective by Harvey Marcovitch:

Funding: No specific funding was received for this paper.

Competing Interests: The author declares no competing financial interests. He is employed by BMJ Publishing Group as a freelance associate editor. He is a director of the Council of Science Editors. The views expressed in this paper are his own.

Citation: Marcovitch H (2010) Editors, Publishers, Impact Factors, and Reprint Income. PLoS Med 7(10):e1000355. doi:10.1371/journal.pmed.1000355

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000355

PRESS-ONLY PREVIEW OF THE ARTICLE: Please contact press@plos.org for a PDF version of the Perspective article.

CONTACT: h.marcovitch@btinternet.com

The PLoS Medicine Editorial: Increased Responsibility and Transparency in an Era of Increased Visibility

Funding: The authors are each paid a salary by the Public Library of Science, and they wrote this editorial during their salaried time.

Competing interests: The authors' individual competing interests are at http://www.plosmedicine.org/static/editorsInterests.action. PLoS Medicine editors are paid a fixed salary (their salary is not linked to the number of papers published in the journal). PLoS Medicine's direct revenue from 2009 is as follows: Total income US$187,640.59 comprises US$ 179,220.00 in author fees, US$ 8339.81 of advertising and other revenue and US$80.78 in reprint revenues. PLoS's overall revenues for 2009 are listed in the 2009 Progress report http://www.plos.org/downloads/progress_update_lo.pdf.

Citation: The PLoS Medicine Editors (2010) Increased Responsibility and Transparency in an Era of Increased Visibility. PLoS Med 7(10): e1000364. doi:10.1371/journal.pmed.1000364

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000364

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-07-10-editorial.pdf

CONTACT: medicine_editors@plos.org


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[Press-News.org] Better transparency needed on medical journals' competing interests
Press release from PLoS Medicine