ANN ARBOR—Caregiving is always tough, but it's that much tougher when caregivers have to rely on family ties that are ambiguous, strained or virtually nonexistent, suggests a University of Michigan study. Published online this month in the Journal of Marriage and Family, the U-M study is one of the first to explore how divorce and remarriage affect wives who are caregivers. The issue affects large numbers of Americans. More than 35 million Americans are remarried, and nearly half a million adults over age 65 remarry every year. At the same time, Americans are living ...

ANN ARBOR, Mich. -- Diet can dramatically lower hypertension and improve heart function in patients with a common type of heart failure, according to research presented at today's Heart Failure Society of America meeting in Orlando, Fla. After 21 days of following a low-sodium Dietary Approaches to Stop Hypertension (DASH) eating plan, patients saw a drop in blood pressure similar to taking anti-hypertension medicine. "Our work suggests diet could play an important role in the progression of heart failure, although patients should always talk to their doctor before ...

An intriguing study led by the University of Colorado Boulder may provide a powerful new tool in the quiver of forensic scientists attempting to determine the time of death in cases involving human corpses: a microbial clock. The clock is essentially the lock-step succession of bacterial changes that occur postmortem as bodies move through the decay process. And while the researchers used mice for the new study, previous studies on the human microbiome – the estimated 100 trillion or so microbes that live on and in each of us – indicate there is good reason to believe ...

COLUMBIA, Mo. – For years, scientists have thought that a continental ice sheet formed during the Late Cretaceous Period more than 90 million years ago when the climate was much warmer than it is today. Now, a University of Missouri researcher has found evidence suggesting that no ice sheet formed at this time. This finding could help environmentalists and scientists predict what the earth's climate will be as carbon dioxide levels continue to rise. "Currently, carbon dioxide levels are just above 400 parts per million (ppm), up approximately 120 ppm in the last ...

COLUMBUS, Ohio – Determining whether a patient's lung cancer has spread to nearby lymph nodes is critical for identifying the most effective therapy, but it usually requires surgery. A new study suggests, however, that measuring levels of a particular molecule in a sample of tumor tissue might accurately answer the question. Researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have discovered that levels of microRNA-31 (miR-31) predict the spread of the most common ...

Australian researchers have demonstrated a strong association between the FTO (fat and obesity) gene and hip fracture in women. While the gene is already well known to affect diabetes and obesity, this is the first study to show that its high-risk variant can increase the risk of hip fracture by as much as 82%. The study, undertaken by Dr Bich Tran and Professor Tuan Nguyen from Sydney's Garvan Institute of Medical Research, examined six gene variants (single nucleotide polymorphisms, or SNPs) of the FTO gene, taken from the DNA of 943 women in the Dubbo Osteoporosis ...

In the already complicated science of what creates – and causes constant change in – two giant doughnuts of radiation surrounding Earth, researchers have added a new piece of information: some of the electrons reach such enormous energies that they are driven by an entirely different set of physical processes. These results were published in a paper in Nature Physics on Sept. 22, 2013. Understanding the nature of these radiation belts and how they swell and shrink over time is an integral part of interpreting, and perhaps someday predicting, the space weather that surrounds ...

CHAPEL HILL, N.C. -- Abiraterone acetate, a recently FDA-approved drug used to treat men with metastatic castration-resistant prostate cancer, significantly delays progression of pain and quality of life deterioration when taken in conjunction with prednisone. The study, published Sept. 24 in Lancet Oncology, was led by Ethan Basch, MD, director of the Cancer Outcomes Research Program at the University of North Carolina Lineberger Comprehensive Cancer Center. Researchers measured the pain and quality of life impact of abiraterone acetate, an orally prescribed treatment ...

"You are not just a ball of cells," says Clifford Tabin, George Jacob and Jacqueline Hazel Leder Professor of Genetics at Harvard Medical School (HMS). The way cells organize within the human body allows us all to function the way we do, but a couple of Harvard professors are concerned as much with that developmental process as with the end result. Tabin shares a common perspective with L. Mahadevan, the Lola England de Valpine Professor of Applied Mathematics at the Harvard School of Engineering and Applied Sciences (SEAS), professor of organismic and evolutionary biology, ...

LEMONT, Ill. – Scientists broke new ground in the study of deep earthquakes, a poorly understood phenomenon that occurs where the oceanic lithosphere, driven by tectonics, plunges under continental plates – examples are off the coasts of the western United States, Russia and Japan. This research is a large step toward replicating the full power of these earthquakes to learn what sets them off and how they unleash their violence. It was made possible only by the construction of a one-of-a-kind X-ray facility that can replicate high-pressure and high-temperature while allowing ...

Patients suffering from early symptoms of Alzheimer's disease who were diagnosed sooner than usual using a brain imaging test received Alzheimer-specific medications earlier than those who did not have the brain imaging results available to their doctors or themselves. These patients also had significantly better clinical outcomes during the subsequent years they were clinically monitored, UCLA researchers have found for the first time. The Metabolic Cerebral Imaging in Incipient Dementia study is an ongoing national clinical trial sponsored by the Centers for Medicare ...

A team from The University of Texas at Arlington has used mathematical modeling to develop a computer simulation they hope will one day improve the treatment of dangerous reactions to medical implants such as stents, catheters and artificial joints. The work resulted from a National Institutes of Health-funded collaboration by research groups headed by Liping Tang, professor of bioengineering in the UT Arlington College of Engineering, and Jianzhong Su, chairman and professor in the UT Arlington College of Science's mathematics department. Results from their computational ...

Adopting proven sustainable land management practices could raise world crop supplies by an estimated 2.3 billion tonnes, worth $1.4 trillion, experts say in a study being released at a major global desertification conference. Conducted by the international Economics of Land Degradation initiative, the scientific interim report says land's economic value "is chronically undervalued and commonly determined by immediate agricultural or forestry market values." "This focus on short-term gain motivates the highest extraction rates possible from land, leading to unsustainable ...

Hereditary spastic paraplegia development associated with changes in endoplasmic reticulum Hereditary spastic paraplegias (HSP) are a group of hereditary diseases that result in progressive loss of motor function in the lower limbs, and mutations in many different genes have been implicated in disease progression. One common feature of HSP is the progressive degradation of the axons of cortical motor neurons; however, it is not fully understood how mutations in is so many different genes result in axonal degradation. In this issue of the Journal of Clinical Investigation, ...

Hereditary spastic paraplegias (HSP) are a group of hereditary diseases that result in progressive loss of motor function in the lower limbs, and mutations in many different genes have been implicated in disease progression. One common feature of HSP is the progressive degradation of the axons of cortical motor neurons; however, it is not fully understood how mutations in is so many different genes result in axonal degradation. In this issue of the Journal of Clinical Investigation, Christian Hübner and colleagues at Jena University develop a mouse model of HSP by introducing ...

Distal renal tubular acidosis (dRTA) develops in response to the loss of acid secretion by α-intercalated cells in the kidney. The inability to remove acid from the body results in low blood potassium levels (hypokalemia), dehydration, and excess calcium in the urine (hypercalcemia), which leads to urinary stone formation. Recently, patients with dRTA have been identified with genetic mutations that lead to the inactivation of proton pumps found in β-intercalated cells, which have been thought to be responsible for base-secretion in the kidney. In this issue ...

Common variable immune deficiency (CVID) is a genetic disease associated with enhanced susceptibility to infection, autoimmunity, and decreased antibody production. Mutations in the tumor necrosis factor receptor superfamily member TACI, are associated with CVID and autoimmunity development. Interestingly, autoimmunity develops in CVID patients with only one mutated copy of TACI, and CVID patients with two mutated TACI alleles do not develop autoimmunity. In this issue of the Journal of Clinical Investigation, Eric Meffre and colleagues at Yale University evaluated B ...

Individuals with a mutation in the gene encoding a zinc transporter, SLC30A8 have an elevated risk of developing type 2 diabetes. Insulin granules that are released from pancreatic β cells contain high levels of zinc; however, it is not clear why individuals with mutations in the SLC30A8 zinc transporter gene are predisposed to type 2 diabetes. In this issue of the Journal of Clinical Investigation, Yoshio Fujitani and colleagues at Juntendo University investigated the role of zinc transport by SLC30A8 in β cells. They found that this zinc transporter is required ...

Moths in northern Finland are less susceptible to rising temperatures than expected, suggesting high latitude moth populations around the world may be partly buffered from the effects of rapid climate warming, according to a new Dartmouth-Finnish study based on the most extensive analyses yet conducted of seasonal patterns in forest animals. The results are important because moths are a key food source for birds, bats and many other predators, and (in their caterpillar stage) are one of the planet's most abundant plant-eating animals and most voracious agricultural pests. ...

Charlottesville, VA (September 24, 2013). Recent scientific findings have raised the fear that young athletes may fare worse after sustaining a sports-related concussion than older athletes. Researchers from Vanderbilt University School of Medicine compared symptoms associated with concussion in middle/high school–age athletes with those in college-age athletes to determine whether age-related differences exist. These researchers found no significant differences between the two age groups in the number or severity of sports-related concussion symptoms or in the amount of ...

Cuckoo finches that lay more than one egg in their victims' nests have a better chance of bamboozling host parents into fostering their parasitic young, a study has found. Dr Martin Stevens from the University of Exeter and Dr Claire Spottiswoode from the University of Cambridge, with Dr Jolyon Troscianko at the University of Exeter, demonstrated that when African cuckoo finch females lay more than one egg in the same nest of their African tawny-flanked prinia hosts, the foster parents find it harder to tell their own eggs from the imposter's. The host is therefore ...

This news release is available in German. Jülich, 24 September 2013 – Magnetic molecules are regarded as promising functional units for the future of information processing. An interdisciplinary team of researchers from Jülich and Aachen were the first to produce particularly robust magnetic molecules that enable a direct electrical readout of magnetic information. This was made possible by selecting the rare earth metal neodymium as the central building block of the molecule. The team's research findings were published online today in the renowned journal Nature ...

Atlanta, September 24, 2013—Early-stage breast cancer patients who receive external beam therapy (XRT) are not at higher risk for serious long-term side effects in the chest area, including increase in deaths from cardiac disease and secondary malignancies, according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting. The study utilized patient information from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database. It evaluated women identified as having primary Stage T1aN0 breast ...

A drug that appears to target specific intestinal bacteria in the guts of mice may create a chain reaction that could eventually lead to new treatments for obesity and diabetes in humans, according to a team of researchers. Mice fed a high-fat diet and provided tempol, an anti-oxidant drug that may help protect people from the effects of radiation, were significantly less obese than those that did not receive the drug, according to Andrew Patterson, assistant professor of molecular toxicology, Penn State, who worked with Frank J. Gonzalez, laboratory metabolism chief, ...

ROCHESTER, Minn. -- Sulfasalazine, a drug commonly prescribed to reduce diarrhea in patients with inflammatory bowel disease, does not reduce diarrhea in patients receiving radiation therapy for cancers in the pelvic area a Mayo Clinic-led study has found. The study also found that the medication may be associated with a higher risk of diarrhea than a placebo when used during radiation therapy to the pelvis. The results were presented today at the American Society of Radiation Oncology's (ASTRO's) 55th Annual Meeting in Atlanta. "Patients receiving radiation therapy ...