A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, reports that donor mortality is about 1 in 500 donors with living donor liver transplantation (LDLT). Research of transplant centers around the world found that those with more experience conducting live donor procedures had lower rates of aborted surgery and life-threatening "near-miss" events. For patients with end-stage liver disease, liver transplantation is their only option to prolong life. However, ...

AUSTIN, Texas — Thanks to a rare bacteria that grows only on rocks in the Swiss Alps, researchers at The University of Texas at Austin and the Pasteur Institute in France have been the first to identify how alcohol might affect key brain proteins. It's a major step on the road to eventually developing drugs that could disrupt the interaction between alcohol and the brain. "Now that we've identified this key brain protein and understand its structure, it's possible to imagine developing a drug that could block the binding site," said Adron Harris, professor of biology ...

MINNEAPOLIS – The teenage years may be a key period of vulnerability related to living in the "stroke belt" when it comes to future stroke risk, according to a new study published in the April 24, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. More people have strokes and die of strokes in the southeastern area known as the stroke belt than in the rest of the United States. So far, research has shown that only part of the difference can be explained by traditional risk factors such as diabetes and high blood pressure. Previous ...

An invisible barrier separates land animals in Australia from those in south-east Asia may also restrict the spillover of animal-borne diseases like avian flu, but researchers have found that fruit bats on either side of this line can carry Nipah virus, a pathogen that causes severe human disease. The findings are published April 24 in the open access journal PLOS ONE by Andrew Breed from the University of Queensland, Australia and colleagues from other institutions. Previous studies have suggested that this biogeographic boundary, named Wallace's line, may have played ...

Deep male voices and high-pitched female voices are perceived as more attractive because listeners gauge the speaker's body size from the frequency of their voice, according to research published April 24 in the open access journal PLOS ONE by Yi Xu from University College London (UK) and colleagues. Studies of animals and birds reveal that listeners can perceive a caller's body size and intension based on the frequency, voice quality and formant spacing of a call. For example, low frequency growls are more likely to indicate larger body size, dominance or a potential ...

Clenching your right hand may help form a stronger memory of an event or action, and clenching your left may help you recollect the memory later, according to research published April 24 in the open access journal PLOS ONE by Ruth Propper and colleagues from Montclair State University. Participants in the research study were split into groups and asked to first memorize, and later recall words from a list of 72 words. There were 4 groups who clenched their hands; One group clenched their right fist for about 90 seconds immediately prior to memorizing the list and then ...

Washington, DC — Stimulating a region of the brain known to be involved in reward decreases binge eating behavior in mice, according to a study published in the April 24 issue of The Journal of Neuroscience. The findings add to a growing body of evidence supporting the role of the brain’s reward system in driving the consumption of palatable food. It could one day pave the way for more effective and lasting treatments for obesity. The numbers of people worldwide living with obesity continues to climb. Recent studies suggest that the consumption of high calorie ...

Lexington, MA, April 24, 2013 (Embargoed until 2:00 PM US Eastern Time) – T2 Biosystems, a company developing direct detection products enabling superior diagnostics, today announced the publication of research supporting the Company's flagship diagnostic test, T2Candida®, in Science Translational Medicine. The research highlights T2Candida as a breakthrough approach to rapid and sensitive identification of species-specific Candida, a sepsis-causing fungus, directly from whole blood in approximately three hours, or up to 25 times faster than the current gold standard of ...

An Autistica consultation published this month found that 24% of children with autism were non-verbal or minimally verbal, and it is known that these problems can persist into adulthood. Professionals have long attempted to support the development of language in these children but with mixed outcomes. An estimated 600,000 people in the UK and 70 million worldwide have autism, a neuro-developmental condition which is life-long. Today, scientists at the University of Birmingham publish a paper in Frontiers in Neuroscience showing that while not all of the current interventions ...

The rediscovery of a mystery animal in a museum's underground storeroom proves that a non-native 'big cat' prowled the British countryside at the turn of the last century. The animal's skeleton and mounted skin was analysed by a multi-disciplinary team of Durham University scientists and fellow researchers at Bristol, Southampton and Aberystwyth universities and found to be a Canadian lynx – a carnivorous predator more than twice the size of a domestic cat. The research, published today in the academic journal Historical Biology, establishes the animal as the earliest ...

MIAMI –– When the eye cancer retinoblastoma is diagnosed in racial and ethnic minority children whose families don't have private health insurance, it often takes a more invasive, potentially life-threatening course than in other children, probably because of delays in diagnosis, Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) researchers will report at the 26th annual meeting of the American Society of Pediatric Hematology Oncology being held in Miami, April 24-27. By analyzing data and tumor samples from 203 children across the United States who had been treated ...

MIAMI--The stem cell transplant regimen that was commonly used in the United States to treat advanced neuroblastoma in children appears to be more toxic than the equally effective regimen employed in Europe and Egypt, according to a new study being presented at the 26th annual meeting of the American Society of Pediatric Hematology Oncology in Miami April 24-27. The U.S. regimen was associated with more acute toxicity to the kidneys and liver. This and other research informed the recent decision of the Children's Oncology Group (COG) to switch to the busulfan-based regimen ...

Chevy Chase, MD—More than a quarter of a century after the Chernobyl nuclear disaster, many children and teenagers who developed thyroid cancer due to radiation are in complete or near remission, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Following the April 26, 1986 explosion and fire at the Chernobyl nuclear plant in the former Soviet Union, the number of children and teenagers diagnosed with differentiated thyroid cancer spiked in Ukraine, Belarus and western areas of Russia. ...

Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur. Their discovery, detailed this week in the open-access journal PLOS ONE, was made in the laboratory fruit fly Drosophila. But the biologists say many of the same genes that regulate biological processes in the hard exoskeleton, or cuticle, of Drosophila also control processes in human skin. That makes them attractive candidates for new kinds of wound-healing drugs or other compounds that could be used ...

Drinking one (or one extra)* 12oz serving size of sugar-sweetened soft drink a day can be enough to increase the risk of developing type 2 diabetes by 22%, a new study suggests. The research is published in Diabetologia (the journal of the European Association for the Study of Diabetes) and comes from data in the InterAct consortium**. The research is by Dr Dora Romaguera, Dr Petra Wark and Dr Teresa Norat, Imperial College London, UK, and colleagues. Since most research in this area has been conducted in North American populations, the authors wanted to establish if ...

Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds research in BioMed Central's open access journal Journal of Therapeutic Ultrasound. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors. High intensity ultrasound is already used to treat solid tumors. Ultrasound can be focused through soft tissue and, because it does not require probes or surgery, is non-invasive. However if the tumor is behind the ribcage ...

Precision agriculture promises to make farming more efficient and should have an important impact on the serious issue of food security, according to a new study published in Significance, the magazine of the Royal Statistical Society and the American Statistical Association. In an article about the study in the magazine's May issue, University of Reading Professor Margaret A. Oliver, BSc, PhD, assesses how there is potential to manage land more effectively to improve the farming economy and crop quality, and to ensure food security. Spatial variation is at the core of ...

Antibiotic resistance is a global problem. The World Health Organisation (WHO) estimates that for tuberculosis alone multi-drug resistance accounts for more than 150,000 deaths each year. WHO warns of "a doomsday scenario of a world without antibiotics," in which antibiotic resistance will turn common infections into incurable killers and make routine surgeries a high-risk gamble. Certain types of bacteria are a scourge of the hospital environment because they are extremely resistant to antibiotics and consequently difficult, if not impossible, to treat. This group of ...

Astronomers have released a new image of the outer atmosphere of Betelgeuse – one of the nearest red supergiants to Earth – revealing the detailed structure of the matter being thrown off the star. The new image, taken by the e-MERLIN radio telescope array operated from the Jodrell Bank Observatory in Cheshire, also shows regions of surprisingly hot gas in the star's outer atmosphere and a cooler arc of gas weighing almost as much as the Earth. Betelgeuse is easily visible to the unaided eye as the bright, red star on the shoulder of Orion the Hunter. The star itself ...

Washington, D.C.— Scientists have long believed that lava erupted from certain oceanic volcanoes contains materials from the early Earth's crust. But decisive evidence for this phenomenon has proven elusive. New research from a team including Carnegie's Erik Hauri demonstrates that oceanic volcanic rocks contain samples of recycled crust dating back to the Archean era 2.5 billion years ago. Their work is published in Nature. Oceanic crust sinks into the Earth's mantle at so-called subduction zones, where two plates come together. Much of what happens to the crust during ...

Prisoners who are psychopaths lack the basic neurophysiological "hardwiring" that enables them to care for others, according to a new study by neuroscientists at the University of Chicago and the University of New Mexico. "A marked lack of empathy is a hallmark characteristic of individuals with psychopathy," said the lead author of the study, Jean Decety, the Irving B. Harris Professor in Psychology and Psychiatry at UChicago. Psychopathy affects approximately 1 percent of the United States general population and 20 percent to 30 percent of the male and female U.S. prison ...

BOSTON (April 24, 2013) – Neurodegenerative and central nervous system (CNS) diseases represent a major public health issue affecting at least 20 million children and adults in the United States alone. Multiple drugs exist to treat and potentially cure these debilitating diseases, but 98 percent of all potential pharmaceutical agents are prevented from reaching the CNS directly due to the blood-brain barrier. Using mucosa, or the lining of the nose, researchers in the department of Otology and Laryngology at the Massachusetts Eye and Ear/Harvard Medical School and the ...

DURHAM, N.C. – The production of a certain kind of brain cell that had been considered an impediment to healing may actually be needed to staunch bleeding and promote repair after a stroke or head trauma, researchers at Duke Medicine report. These cells, known as astrocytes, can be produced from stem cells in the brain after injury. They migrate to the site of damage where they are much more effective in promoting recovery than previously thought. This insight from studies in mice, reported online April 24, 2013, in the journal Nature, may help researchers develop treatments ...

PHILADELPHIA - With a better understanding of underlying mechanisms that cause a rare neurodevelopmental disorder in the Old Order Mennonite population, referred to as Pretzel syndrome, a new study reports that five children were successfully treated with a drug that modifies the disease process, minimizing seizures and improving receptive language. The study, by researchers including experts from the Perelman School of Medicine at the University of Pennsylvania, appears in the journal Science Translational Medicine. The disease - PSME or polyhydramnios, megalencephaly, ...

Boston, Mass.—The higher the percentage of people in a city, town or neighborhood with Facebook interests suggesting a healthy, active lifestyle, the lower that area's obesity rate. At the same time, areas with a large percentage of Facebook users with television-related interests tend to have higher rates of obesity. Such are the conclusions of a study by Boston Children's Hospital researchers comparing geotagged Facebook user data with data from national and New York City-focused health surveys. Together, the conclusions suggest that knowledge of people's online interests ...