The DiMelli (Diabetes Mellitus Incidence Cohort Registry) study examines the frequency and characteristics of diabetes phenotypes in children and young adults below the age of 20. The study was commissioned to investigate the increasing incidence of diabetes mellitus, particularly in childhood and early adulthood. The project is funded by the German Center for Diabetes Research (DZD). Bioprobe measurements were performed centrally by the Central Medical Laboratory (LMZ) at the Helmholtz Zentrum München (HMGU) so as to guarantee the high quality and comparability of laboratory ...

Using large and frequent doses of the pain-killer codeine may actually produce heightened sensitivity to pain, without the same level of relief offered by morphine, according to new research from the University of Adelaide. Researchers in the Discipline of Pharmacology have conducted what is believed to be the world's first experimental study comparing the pain relieving and pain worsening effects of both codeine and morphine. The University's Professor Paul Rolan, who is also a headache specialist at the Royal Adelaide Hospital, says codeine has been widely used as ...

Designers of social robots, take note. Bring your dog to the lab next time you test a prototype, and watch how your pet interacts with it. You might just learn a thing or two that could help you fine-tune future designs. So says Gabriella Lakatos of the Hungarian Academy of Science and Eötvös Loránd University, lead author of a study¹ published in Springer's journal Animal Cognition that found that man's best friend reacts sociably to robots that behave socially towards them, even if the devices look nothing like a human. This animal behavior study tested the reaction ...

Just days before a team of researchers from Woods Hole Oceanographic Institution (WHOI) and National Taiwan University set out to conduct fieldwork in the East China Sea, Typhoon Morakot—one of the most destructive storms ever to hit Taiwan—made landfall on the island, causing widespread damage and drastically altering the flow of water along the nearby continental shelf. The typhoon, which struck in Aug. 2009, caused catastrophic damage in Taiwan, killing several hundred people and dropping up to 2 meters of rain in just 5 days in the mountains. In their work to understand ...

RESEARCH CONCLUSIONS: New genetic research led by the Genographic Project consortium shows a distinctive ancestry for the Uros populations of Peru and Bolivia that predates the arrival of the Spanish conquistadores and may date back to the earliest settlement of the Altiplano, or high plain, of the central Andes some 3,700 years ago. Despite the fact that the Uros today share many lineages with the surrounding Andean populations, they have maintained their own divergent genetic ancestry. WHO ARE THE UROS?: The Uros are a self-identified ethnic group, about 2,000 ...

A study of patients infected with acute hepatitis C virus (HCV) infection found that women had higher rates of spontaneous viral clearance—undetectable levels of the virus without initiating drug therapy. Findings published in Hepatology, a journal of the American Association for the Study of Liver Diseases, indicate that the gene IL28B (rs12979860) and HCV genotype 1 are also independent predictors of spontaneous HCV clearance. In 2011, there were 1,229 cases of acute HCV reported to the Centers for Disease Control and Infection (CDC), which represents a 44% increase ...

PITTSBURGH—Analyses of Twitter feeds have been used to track flu epidemics, predict stock market changes and do political polling, but now that the National Football League season is underway, the natural question is: Can Twitter help beat the spread on NFL games? The answer, say computer scientists at Carnegie Mellon University, is yes. Or, at least it can help a little bit at certain times during the season. They will report their findings Sept. 27 at the Machine Learning and Data Mining for Sports Analytics conference in Prague, Czech Republic. The study began as ...

Hubble previously observed this cluster back in 2002. However, this new image combines visible and infrared data from Hubble's Advanced Camera for Surveys (ACS) to reveal this patch of sky in greater detail than ever before, with a combined total exposure time of over 34 hours. These new, deeper, observations were taken in order to explore the globular clusters within Abell 1689 [1]. This new study has shown that Abell 1689 hosts the largest population of globular clusters ever found. While our galaxy, the Milky Way, is only home to around 150 of these old clumps of stars, ...

If the violins were taken away from the musicians performing Beethoven's 9th symphony, the resulting composition would sound very different. If the violins were left on stage but the violinists were removed, the same mutant version of the symphony would be heard. But what if it ended up sounding like "Hey Jude" instead? This sort of surprise is what scientists from the Virginia Tech Carilion Research Institute had during what they assumed to be a routine experiment in neurodevelopment. Previous studies had shown that the glycoprotein Reelin is crucial to developing ...

ST. PETERSBURG, Fla. (Sept. 12, 2013) — Acidification of the Arctic Ocean is occurring faster than projected according to new findings published in the journal PLoS One. The increase in rate is being blamed on rapidly melting sea ice, a process that may have important consequences for health of the Arctic ecosystem. Ocean acidification is the process by which pH levels of seawater decrease due to greater amounts of carbon dioxide being absorbed by the oceans from the atmosphere. Currently oceans absorb about one-fourth of the greenhouse gas. Lower pH levels make water ...

MANHATTAN, KAN. -- A Kansas State University microbiologist has found a breakthrough herbal medicine treatment for a common human fungal pathogen that lives in almost 80 percent of people. Govindsamy Vediyappan, assistant professor of biology, noticed that diabetic people in developing countries use a medicinal herb called Gymnema slyvestre to help control sugar levels. He decided to study the microbiological use of Gymnema slyvestre -- a tropical vine plant found in India, China and Australia -- to see if it could treat a common human fungal pathogen called Candida albicans. The ...

Philadelphia, PA—One way to study criminal behavior and predict a criminal's next move is by analyzing his or her movement. Several mathematical models have addressed this in detail, in particular, the UCLA "burglary hotspot" model, also the topic of a previous Nugget published by the Society for Industrial and Applied Mathematics (SIAM). In a paper published last month in the SIAM Journal on Applied Mathematics, authors Sorathan Chaturapruek, Jonah Breslau, Daniel Yazdi, Theodore Kolokolnikov, and Scott McCalla propose a mathematical model that analyzes criminal movement ...

CINCINNATI – New research in mouse models suggests that treatment with antioxidants may help reduce behavioral issues linked to the genetic nervous system disorder Neurofibromatosis 1 (NF1) and an associated condition called Costello syndrome. Scientists from Cincinnati Children's Hospital Medical Center report their findings Sept. 12 in Cell Reports. The authors show that defects in the NF1/Ras molecular pathway, which cause the disorders, trigger production of harmful oxidative nitric oxide molecules in the oligodendrocyte glial brain cells of mice. Part of the central ...

The location, widespread nature, and number of fires in this satellite image suggest that these fires were deliberately set to manage land. Farmers often use fire to return nutrients to the soil and to clear the ground of unwanted plants. While fire helps enhance crops and grasses for pasture, the fires also produce smoke that degrades air quality. In Mozambique and Madagascar, the growing season runs from the first rains in October – November. Thus, the clearing of lands in early September heralds the new growing season. Sadly, according to reports in the National Geographic, ...

Gabrielle is a fighter. Tropical Storm Gabrielle regained tropical storm status on Sept. 12 at 11 a.m. EDT after being knocked down to tropical depression status earlier in the day. NASA's GOES Project used NOAA's GOES-East satellite data to create an image that showed wind shear is still having a big effect on Gabrielle, and another low pressure area appears to be organizing in the Gulf of Mexico. At 11 a.m. EDT on Sept. 12, Tropical Depression Gabrielle's center was 200 miles/325 km northwest of Bermuda, and about 530 miles/850 km south-southeast of Nantucket, Mass. ...

The researchers found virulent E. coli bacteria blocked a pathway that would normally protect the gut from infection. These infections are particularly serious in young children and can result in diarrhoea and other complications such as kidney damage. The role of this pathway in fighting gut infection was previously unknown but defects in it are associated with inflammatory bowel disease. The research, published tomorrow in Nature, provides much needed insight into how the gut fights infection. Lead author Professor Elizabeth Hartland from the University's Department ...

Evaluation of the effectiveness of a mass vaccination campaign with a new meningitis serogroup A vaccine, PsA-TT, in sub-Saharan Africa found that it had a dramatic impact on cases of serogroup meningitis and on carriage of the disease-causing bacteria in the throat, according to new research published in The Lancet. Authors from Africa and Europe, led by the London School of Hygiene & Tropical Medicine and Centre de Support en Santé Internationale (CSSI) in Chad, evaluated the effectiveness of a mass vaccination campaign in Chad in 2011 by measuring the incidence of ...

A team of researchers, led by the University of Warwick, have published new data that could prove vital for advances in care for women who suffer from recurrent miscarriage. The recurrent loss of pregnancy through miscarriage causes significant distress to couples, often exacerbated by there being so few treatments available to clinicians. The search for an effective treatment has been the cause of significant controversy in the field of medical research, centering on the role of natural killer cells (or NK cells) and the ability of steroids to prevent miscarriage. Scientists ...

For a long time it was thought that only humans had the ability to anticipate future actions, whereas animals are caught in the here and now. But in recent years, clever experiments with great apes in zoos have shown that they do remember past events and can plan for their future needs. Anthropologists at the University of Zurich have now investigated whether wild apes also have this skill, following them for several years through the dense tropical swamplands of Sumatra. Orangutans communicate their plans Orangutans generally journey through the forest alone, but they ...

Peru's cloud forests are some of the most biologically diverse ecosystems in the world. A profusion of tree and plant species as well as one third of Peru's mammal, bird and frog species make their home in these perennially wet regions, located along the eastern slopes of the Andes Mountains. The high elevation (6,500-11,000 feet), and remote location of these areas makes them some of the hardest to reach and therefore hardest to study ecosystems in the world. To date, scientists only believe a fraction of cloud forest tree and plant species have been discovered. This ...

BUFFALO, N.Y. – The first proteomic analysis of an animal model of a rare, sometimes deadly birth defect, Smith-Lemli-Opitz Syndrome (SLOS), has revealed that the molecular mechanisms that cause it are more complex than previously understood. SLOS involves multiple neurosensory and cognitive abnormalities, mental and physical disabilities, including those affecting vision and in severe cases, death before the age of 10. The research, published by University at Buffalo scientists on Aug. 26 in Molecular and Cellular Proteomics, is the first to demonstrate a broad range ...

A small beach ball-sized satellite designed and built by a team of University of Colorado Boulder students to better understand how atmospheric drag can affect satellite orbits is now slated for launch from Vandenberg Air Force Base in California on Sept. 15. The satellite, known as the Drag and Atmospheric Neutral Density Explorer satellite, or DANDE, is designed to investigate how a layer of Earth's atmosphere known as the thermosphere varies in density at altitudes from about 200 to 300 miles above Earth. There are thousands of satellites orbiting Earth at those altitudes, ...

PORTLAND, Ore. — An HIV/AIDS vaccine candidate developed by researchers at Oregon Health & Science University appears to have the ability to completely clear an AIDS-causing virus from the body. The promising vaccine candidate is being developed at OHSU's Vaccine and Gene Therapy Institute. It is being tested through the use of a non-human primate form of HIV, called simian immunodeficiency virus, or SIV, which causes AIDS in monkeys. Following further development, it is hoped an HIV-form of the vaccine candidate can soon be tested in humans. These research results were ...

A team of researchers at Cincinnati Children's Hospital Medical Center has developed an antibody that could prevent Candida infections that often afflict hospitalized patients who receive central lines. Margaret Hostetter, MD, director of infectious diseases at Cincinnati Children's, and her team developed the antibody, which prevents Candida albicans from binding to heparin, thereby stopping the formation of biofilm in a rat model of catheter-associated infection. A biofilm is a multi-layered buildup of millions of microorganisms that coat the inside of the catheter The ...

DETROIT – Patients with longer-lasting chest pain are more likely having a heart attack than those with pain of a shorter duration, according to a study by researchers at Henry Ford Hospital. The study is published in the September issue of Critical Pathways in Cardiology. Every year, eight to 10 million people in the U.S. go to emergency departments for chest pain. But only 15󈞊 percent of them are having a heart attack. The characteristics of chest pain are important to diagnosing the cause. Researchers studied the relationship between the length of time ...