What effects will the rapidly growing field of synthetic biology have on the conservation of nature? The ecological and ethical challenges stemming from this question will require a new dialogue between members of the synthetic biology and biodiversity conservation communities, say Kent Redford of the Wildlife Conservation Society (WCS) and Archipelago Consulting; Bill Adams of the University of Cambridge; and Georgina Mace of University College London (UCL) in a new paper published 2 April in the open access journal PLOS Biology. The field of synthetic biology—a discipline ...

Among patients with painful chemotherapy-induced peripheral neuropathy, use of the anti-depressant drug duloxetine for 5 weeks resulted in a greater reduction in pain compared with placebo, according to a study in the April 3 issue of JAMA. "Approximately 20 percent to 40 percent of patients with cancer who receive neurotoxic chemotherapy (e.g., taxanes, platinums, vinca alkaloids, bortezomib) will develop painful chemotherapy-induced peripheral neuropathy. Painful chemotherapy-induced neuropathy can persist from months to years beyond chemotherapy completion, causing ...

In an analysis that included data on more than 10 million Medicare beneficiaries admitted to acute care hospitals with a heart attack, congestive heart failure, or pneumonia between 2002 and 2010, 30-day mortality rates for those admitted to critical access hospitals (designated hospitals that provide inpatient care to individuals living in rural communities) increased during this time period compared with patients admitted to other acute care hospitals, according to a study in the April 3 issue of JAMA. "More than 60 million Americans live in rural areas and face challenges ...

With previous evidence suggesting that melatonin may have a role in glucose metabolism, researchers have found an independent association between decreased secretion of melatonin and an increased risk for the development of type 2 diabetes, according to a study in the April 3 issue of JAMA. "Melatonin receptors have been found throughout the body in many tissues including pancreatic islet cells, reflecting the widespread effects of melatonin on physiological functions such as energy metabolism and the regulation of body weight," according to background information in ...

Use of a vaccine to prevent Staphylococcus aureus infections among patients undergoing cardiothoracic surgery did not reduce the rate of serious postoperative S aureus infections compared with placebo and was associated with increased mortality among patients who developed S aureus infections, according to a study in the April 3 issue of JAMA. Infections with S aureus following median sternotomy (incision through the midline of the sternum) cause substantial illness and death. "A safe vaccine that provides protection against a majority of S aureus strains during the ...

Boston – Millions of Americans are diagnosed with type 2 diabetes, yet the exact causes of diabetes still puzzle scientists. Now, new research from Brigham and Women's Hospital (BWH) finds that the amount of melatonin a person secretes during sleep may predict their risk of developing type 2 diabetes. The study appears in the April 3, 2013 issue of JAMA. "This is the first time that an independent association has been established between nocturnal melatonin secretion and type 2 diabetes risk," said Dr. Ciaran McMullan, a researcher in the Renal Division and Kidney ...

Toronto, CANADA – Non-musicians who speak tonal languages may have a better ear for learning musical notes, according to Canadian researchers. Tonal languages, found mainly in Asia, Africa and South America, have an abundance of high and low pitch patterns as part of speech. In these languages, differences in pitch can alter the meaning of a word. Vietnamese, for example, has eleven different vowel sounds and six different tones. Cantonese also has an intricate six-tone system, while English has no tones. Researchers at Baycrest Health Sciences' Rotman Research ...

### About the University of Massachusetts Medical School The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $250 million in research funding annually, 80 percent of which comes from federal funding sources. The mission of the Medical School is to advance the health and well-being of the people of the commonwealth and the world through ...

LAFAYETTE - Tiny sea creatures no bigger than a thumbtack are being credited for playing a key role in helping provide healthy habitats for many kinds of seafood, according to a new study by the Virginia Institute of Marine Science and U.S. Geological Survey. The little crustacean "grazers," some resembling tiny shrimp, are critical in protecting seagrasses from overgrowth by algae, helping keep these aquatic havens healthy for native and economically important species. Crustaceans are tiny to very large shelled animals that include crab, shrimp, and lobster. The ...

PROVIDENCE, R.I. [Brown University] — Despite the unimaginable energy produced during large impacts on the Moon, those impacts may not wipe the mineralogical slate clean, according to new research led by Brown University geoscientists. The researchers have discovered a rock body with a distinct mineralogy snaking for 18 miles across the floor of Copernicus crater, a 60-mile-wide hole on the Moon's near side. The sinuous feature appears to bear the mineralogical signature of rocks that were present before the impact that made the crater. The deposit is interesting because ...

When surveying in the Upper Basin of the Grand Canyon National Park in April 2011, University of Cincinnati faculty and students discovered a previously unknown 17-room subterranean pueblo that likely dates back to the 12th century. For UC anthropology graduate student Ryan Washam, that find – in which he took part – helped spark his current research in how federal agencies are conducting archaeological and environmental protection and preservation efforts in a time of tight budgets. Washam, 23, of Florence, Ky., will present a case study of protection and preservation ...

RESEARCH TRIANGLE PARK, N.C. – Millions of adults are exposed to traumatic events each year. Shortly after exposure many experience symptoms of posttraumatic stress disorder (PTSD) such as flashbacks, emotional numbing and difficulty sleeping. Despite this high rate of exposure, little is known about the effectiveness of treatments aimed at preventing and relieving posttraumatic stress symptoms that adults may experience after such events, according to researchers at the RTI-UNC Evidence-based Practice Center. The article, published online today by the American Journal ...

MADISON — As the shapes of galaxies go, the spiral disk — with its characteristic pinwheel profile — is by far the most pedestrian. Our own Milky Way, astronomers believe, is a spiral. Our solar system and Earth reside somewhere near one of its filamentous, swept-back arms. And nearly 70 percent of the galaxies closest to the Milky Way are spirals, suggesting they have taken the most ordinary of galactic forms in a universe with billions of galaxies. But despite their common morphology, how galaxies like ours get and maintain their characteristic arms has proved to ...

New Rochelle, NY, April 2, 2013—The seizures that affect people with temporal-lobe epilepsy usually start in a region of the brain called the hippocampus. But they are often able to involve other areas outside the temporal lobe, propagating via anatomically and functionally connected networks in the brain. New research findings that link decreased brain cell concentration to altered functional connectivity in temporal-lobe epilepsy are reported in an article in Brain Connectivity, a bimonthly peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article ...

Our emotional responses to the stresses of daily life may predict our long-term mental health, according to a new study published in Psychological Science, a journal of the Association for Psychological Science. Psychological scientist Susan Charles of the University of California, Irvine and colleagues conducted the study in order to answer a long-standing question: Do daily emotional experiences add up to make the straw that breaks the camel's back, or do these experiences make us stronger and provide an inoculation against later distress? Using data from two national ...

ANN ARBOR, Mich. – Everyday, news reports detail the impact of the deficiencies in the nation's mental health care services. Even more startling, a survey from the University of Michigan reveals that many adults across the U.S. believe children and teens have extremely limited or no access to appropriate mental health care services. The W.K. Kellogg Foundation commissioned the National Voices Project to facilitate a five year study to gauge opportunities available for children and teens at the local level in communities across the U.S. Officials at the National Voices ...

PITTSBURGH—Beekeepers and researchers nationally are reporting growing evidence that a powerful new class of pesticides may be killing off bumblebees. Now, research at the University of Pittsburgh points toward another potential cause: metal pollution from aluminum and nickel. Published in the journal Environmental Pollution, the Pitt study finds that bumblebees are at risk of ingesting toxic amounts of metals like aluminum and nickel found in flowers growing in soil that has been contaminated by exhaust from vehicles, industrial machinery, and farming equipment. The ...

Research from the University of Cincinnati shows that perhaps the ancient Puebloans weren't as into the maize craze as once thought. Nikki Berkebile, a graduate student in anthropology in UC's McMicken College of Arts & Sciences, has been studying the subsistence habits of Puebloans, or Anasazi, who lived on the southern rim of the Grand Canyon in the late 11th century. Traditional ethnographic literature indicates these ancient American Indians were heavily dependent on maize as a food source, but Berkebile isn't so sure about that. "I'm trying to assess sustainable ...

CHICAGO --- Lifetime risk for heart failure is similar for blacks and whites and higher than expected for both groups -- ranging from 20 to 45 percent -- according to a new Northwestern Medicine® study. "This is a bad news scenario for both race groups," said Northwestern Medicine researcher Mark Huffman, M.D., the first author of the study. "With lifetime risks this high, heart failure prevention is paramount for all Americans." Huffman is an assistant professor in preventive medicine and medicine-cardiology at Northwestern University Feinberg School of Medicine and ...

The University of Cincinnati's mastery of ancient Maya mysteries continues with new research from professor of biological sciences David Lentz. UC faculty have been involved in multiple research projects concerning ancient Maya culture for more than a decade. This latest Maya study from Lentz focuses on Cerén, a farming village that was smothered under several meters of volcanic ash in the late sixth century. Lentz will present his research, "The Lost World of the Zapotitan Valley: Cerén and its Paleoecological Context," at the 78th annual meeting of the Society for ...

ORLANDO, Fla., April 2, 2013 – Many recent studies have suggested that obesity is associated with chronic inflammation in fat tissues. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered that an imbalance between an enzyme called neutrophil elastase and its inhibitor causes inflammation, obesity, insulin resistance, and fatty liver disease. This enzyme is produced by white blood cells called neutrophils, which play an important role in the body's immune defense against bacteria. The researchers found that obese humans and mice have ...

(SACRAMENTO, Calif.) — A team of UC Davis scientists has found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease. The scientists report their discovery in the Proceedings of the National Academy of Sciences (PNAS). The groundbreaking study was a collaboration among multiple UC Davis laboratories and Harvard University. The metabolite is epoxy docosapentaenoic acid (EDP), an endogenous compound produced by the human body from the omega-3 ...

When we imagine drama playing out between predators and prey, most of us picture stealthy lions and restless gazelle, or a sharp-taloned hawk latched on to an unlucky squirrel. But Ben Baiser, a post-doctoral fellow at the Harvard Forest and lead author of a new study in Oikos, thinks on a more local scale. His inter-species drama plays out in the humble bogs and fens of eastern North America, home to the carnivorous pitcher plant, Sarracenia purpurea. "It's shocking, the complex world you can find inside one little pitcher plant," says Baiser. A pitcher plant's work ...

One often ignored consequence of global climate change is that the Northern Hemisphere is becoming warmer than the Southern Hemisphere, which could significantly alter tropical precipitation patterns, according to a new study by climatologists from the University of California, Berkeley, and the University of Washington, Seattle. Such a shift could increase or decrease seasonal rainfall in areas such as the Amazon, sub-Saharan Africa or East Asia, leaving some areas wetter and some drier than today. "A key finding is a tendency to shift tropical rainfall northward, ...

Irvine, Calif., April 2, 2013 – Our emotional responses to the stresses of daily life may predict our long-term mental health, according to a new study led by a UC Irvine psychologist. The research, which appears online in the journal Psychological Science, suggests that maintaining emotional balance is crucial to avoiding severe mental health problems down the road. Susan Charles, UC Irvine professor of psychology & social behavior, and her colleagues conducted the study in order to answer a long-standing question: Do everyday irritations add up to make the straw that ...