Philadelphia, Pa. (April 2, 2013) – Injuries caused by needles and other sharp instruments are a major occupational hazard for surgeons—with high costs related to the risk of contracting serious infectious diseases, according to a special article in the April issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). ASPS Member Surgeon Dr. Kevin C. Chung and colleagues at The University of Michigan Health System, Ann Arbor, review the risks, health impact and costs of "sharps" injuries for surgeons and ...

Recent efforts by the Canadian government to curb the time allowed for environmental reviews over fears of adverse impact on economic development are misguided and unnecessary, according to research by scientists at the University of Toronto. Instead, the federal government's tinkering will only weaken environmental protection and not expedite economic growth. The researchers found that most environmental regulatory reviews were already being completed within the arbitrary timeframes laid out in the 2012 legislation restricting the reviews of new developments. "Even ...

Increases in ground-level ozone, especially in rural areas, may interfere not only with predator insects finding host plants, but also with pollinators finding flowers, according to researchers from Penn State and the University of Virginia. "Ozone pollution has great potential to perniciously alter key interactions between plants and animals," the researchers said in a recent issue of Environmental Research Letters. The animal tested in this case was the striped cucumber beetle, a predator of cucurbits -- cucumber, squash, pumpkin and melons. These insects dine on ...

Prostate cancer doesn't kill in the prostate – it's only once the disease travels to bone, lung, liver, etc. that it turns fatal. Previous studies have shown that loss of the protein E-Cadherin is essential for this metastasis. A University of Colorado Cancer Center study published this week in the Journal of Biological Chemistry describes for the first time a switch that regulates the production of E-Cadherin: the transcription factor SPDEF turns on and off production, leading to metastasis or stopping it cold in models of prostate cancer. "When E-Cadherin is lost, cells ...

WASHINGTON — A survey of current and former college athletes finds depression levels significantly higher in current athletes, a result that upended the researchers' hypothesis. The finding published in Sports Health suggests the need for more research to understand depression among college athletes. "We expected to see a significant increase in depression once athletes graduated, but by comparison it appears the stress of intercollegiate athletics may be more significant than we and others anticipated," says the study's senior investigator Daniel Merenstein, MD, an associate ...

1. For Greater Weight Loss, a Group Cash Incentive Trumps Individual Rewards A group-based financial incentive leads to greater weight loss than an individual incentive for obese employees. An estimated 67 percent of employers use financial incentives to help their employees adopt healthier behaviors, with the goal of decreasing chronic disease and curbing health care costs. Researchers sought to determine the effectiveness of two financial incentive designs – group-based and individual – for obese employees trying to lose weight. One-hundred-and-four employees with a ...

ANN ARBOR, Mich. — Do cash rewards for healthier habits work? Maybe, says a new study, if you add on one more condition – peer pressure. A growing number of companies are offering employees an opportunity to boost earning power at work via cash incentives to stay healthy. Under the Affordable Care Act, employers will soon be able to offer even larger financial incentives to prod healthy lifestyle behaviors among their workforce, such as quitting smoking and losing weight. But people who are offered money for weight loss may be much more successful when awards are ...

Seeing a doctor within a month of an emergency room visit for chest pain significantly reduced the risk of heart attack or death among high risk patients, according to research published the American Heart Association journal Circulation. Chest pain is the most common reason people go to the emergency room in developed countries and accounts for more than 5 million ER visits each year in the United States. The study is the first to demonstrate the importance of follow-up care for chest pain patients after leaving the ER, researchers said. High risk patients in this study ...

Boston, MA-- Despite their well-documented benefits, statins, drugs used to lower cholesterol, are commonly discontinued in routine care. Statin discontinuation has been linked to increased risk for cardiovascular events and death in patients with coronary artery disease; nevertheless, the reasons for discontinuation are only starting to be explored. In a new study from Brigham and Women's Hospital (BWH), researchers examined the role adverse reactions play in statin discontinuation and found that more than 90 percent of the patients who stopped taking a statin due to an ...

Washington, D.C.—A research team, led by Carnegie's Anna Michalak, has determined that the 2011 record-breaking algal bloom in Lake Erie was triggered by long-term agricultural practices coupled with extreme precipitation, followed by weak lake circulation and warm temperatures. The team also predicts that, unless agricultural policies change, the lake will continue to experience extreme blooms. The research is published in the online early edition of the Proceedings of the National Academy of Sciences the week of April 1, 2013. "The perfect storm of weather events ...

ANN ARBOR—The largest harmful algae bloom in Lake Erie's recorded history was likely caused by the confluence of changing farming practices and weather conditions that are expected to become more common in the future due to climate change. Rather than an isolated, one-time occurrence, Lake Erie's monumental 2011 algae bloom was more likely a harbinger of things to come, according to University of Michigan researchers and colleagues from eight other institutions. The interdisciplinary team explored factors that may have contributed to the event and analyzed the likelihood ...

Coronary heart disease (CHD) increases with BMI, as well as with age, finds an article published in BioMed Central's open access journal BMC Medicine. The research from the Million Women Study indicates that increased weight increases risk of CHD equivalent to that caused by getting older. Researchers from the University of Oxford followed the health of 1.2 million women from England and Scotland for (on average) almost a decade. Analysis of the data showed that the occurrence of CHD increases with BMI so that every 5 unit increase in BMI, calculated as weight/height2, ...

MINNEAPOLIS – Risk prediction tools that estimate future risk of heart disease and stroke may be more useful predictors of future decline in cognitive abilities, or memory and thinking, than a dementia risk score, according to a new study published in the April 2, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology. "This is the first study that compares these risk scores with a dementia risk score to study decline in cognitive abilities 10 years later," said Sara Kaffashian, PhD, with the French National Institute of Health and Medical ...

Boston, MA – Older adults who have higher levels of blood omega-3 levels—fatty acids found almost exclusively in fatty fish and seafood—may be able to lower their overall mortality risk by as much as 27% and their mortality risk from heart disease by about 35%, according to a new study from Harvard School of Public Health (HSPH) and the University of Washington. Researchers found that older adults who had the highest blood levels of the fatty acids found in fish lived, on average, 2.2 years longer than those with lower levels. "Although eating fish has long been considered ...

Highly expressed in various cancers and known for its cytoprotective properties, TRAP1 protein has been identified as a potential target for antitumor treatments. As a result of the research conducted by Len Neckers, from the National Cancer Institute in Bethesda, USA, and Didier Picard, from the University of Geneva (UNIGE), Switzerland, this outlook is now being called into question. The researchers' findings, published in PNAS, describe how TRAP1 disrupts the metabolism of malignant cells, and shows that the quantity of this protein decreases as they progress to a more ...

HOUSTON - (April 1, 2013) – Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers led by those at Baylor College of Medicine in a report that appears online in Proceedings of the National Academy of Sciences. Normally SPOP acts as a tumor suppressor gene by marking SRC-3 for destruction, said Dr. Nicholas Mitsiades, assistant professor of medicine – hematology/oncology and molecular and cellular ...

(TORONTO, Canada – April 1, 2013) – A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant. Resistance to hormone therapy is reported in almost half of ER-positive breast cancer patients and no cure is currently available. The fact that the pathway, called Notch, is a drug target ...

A randomized controlled trial finds that 12 weeks of physical plus mental activity in inactive older adults with cognitive complaints was associated with significant improvement in cognitive function but there was no difference between intervention and control groups, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. An epidemic of dementia worldwide is anticipated during the next 40 years because of longer life expectancies and demographic changes. Behavioral interventions are a potential strategy to prevent or delay ...

The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease appeared mysterious. Researchers at Emory University School of Medicine have demonstrated that this ALS/FTD mutation may be harmful because it creates an "RNA sponge," soaking up an important regulatory protein that binds RNA. The results were published online Monday in the Proceedings of the National Academy of Sciences, Early Edition. "We think ...

Irvine, Calif., April 1, 2013 — California sagebrush in the southern part of the state will adjust better to climate change than sagebrush populations in the north, according to UC Irvine researchers in the Department of Ecology & Evolutionary Biology affiliated with the Center for Environmental Biology. The results of their study, which appears online in Global Change Biology, will assist land management and policy decisions concerning coastal sage scrub restoration. California sagebrush (Artemisia californica), also known as "cowboy cologne," is the fragrant gray-green ...

Boulder, Colo., USA – Two new themes: "Geodynamics and Consequences of Lithospheric Removal in the Sierra Nevada, California" and "The 36-18 Ma southern Great Basin, USA, ignimbrite province and flareup: Swarms of subduction-related supervolcanoes " add new content to Geosphere's already dynamic lineup. Also in the April 2013 issue: themes "ANDRILL McMurdo Ice Shelf (MIS) and Southern McMurdo Sound (SMS) Drilling Projects" and "Exploring the Deep Sea and Beyond," plus three individual articles not associated with a specific theme. 1. Theme introduction; 2. Theme introduction; 3. ...

A California sea lion who bobs her head in time with music has given scientists the first empirical evidence of an animal that is not capable of vocal mimicry but can keep the beat, according to new research published by the American Psychological Association. The study's authors suggest that their findings challenge current scientific theories that an animal's ability to synchronize its movements with sound are associated with the same brain mechanisms that allow for vocal mimicry in humans and some birds such as cockatoos, parrots, and budgerigars. The findings were ...

For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human DNA replication is performed." The results of the research will be published in the journal eLife on 2 April 2013. Part of the DNA replication process -- in humans and in other life forms -- involves loading of molecular structures called ...

As the long-term impact of the Arab Spring continues to take shape, research from political scientists at Princeton University and New York University warns that the protests that swept across the Middle East and North Africa could mark more of an isolated occurrence than a permanent rise of people power in the region. In a paper published online in January by the American Journal of Political Science, "People Power or a One-Shot Deal? A Dynamic Model of Protest," Princeton politics professor Adam Meirowitz and New York University politics Professor Joshua Tucker lay ...

WINSTON-SALEM, N.C. – April 1, 2013 – Using the same strategy that a common virus employs to evade the human immune system, researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine have modified adult stem cells to increase their survival – with the goal of giving the cells time to exert their natural healing abilities. "Basically, we've helped the cells be 'invisible' to the body's natural killer cells, T cells and other aspects of the immune system, so they can survive to promote healing," said Graca Almeida-Porada, M.D., Ph.D., senior ...