COLUMBUS, Ohio – New research suggests that lowering excessive levels of a protein in immune system cells could be a strategy to clear an infection that is deadly to patients with cystic fibrosis (CF). Researchers determined that normalizing levels of the protein, called p62, in cells from mice carrying the most common mutation that causes CF will jump-start a natural cellular process that clears away the offending bacteria. The scientists had previously determined that in cells from mice and humans carrying the CF mutation, the bacteria that cause this infection interfere ...

Plastics have transformed modern society, providing attractive benefits but also befouling waterways and aquifers, depleting petroleum supplies and disrupting human health. Rolf Halden, a researcher at Arizona State University's Biodesign Institute has been following the chemical trail of plastics, quantifying their impact on human health and the environment. In a new overview appearing in the journal Reviews on Environmental Health, Halden and his co-author, ASU student Emily North, detail the risks and societal rewards of plastics and describe strategies to mitigate ...

WORCESTER, MA – A retrovirus called HERV-H, which inserted itself into the human genome millions of years ago, may play an important role in pluripotent stem cells, according to a new study published in the journal Retrovirology by scientists at UMass Medical School. Pluripotent stem cells are capable of generating all tissue types, including blood cells, brain cells and heart cells. The discovery, which may help explain how these cells maintain a state of pluripotency and are able to differentiate into many types of cells, could have profound implications for therapies ...

Researchers participating in the REGICOR Study (Girona Heart Registry), with the participation of IMIM (Hospital del Mar Medical Research Institute) from Barcelona, the Josep Trueta Hospital, the Blanes Hospital and IDIAP Jordi Gol from Girona (Primary Healthcare Research Institute) have carried out a study to assess the impact of the partial smoke-free legislation passed in 2006 on the incidence of acute myocardial infarction in the province of Girona and observed it has dropped 11%. This decrease has been noticed especially among women, population aged between 65 and ...

Stroke, traumatic injury, and metabolic disorder are major causes of brain damage and permanent disabilities, including motor dysfunction, psychological disorders, memory loss, and more. Current therapy and rehab programs aim to help patients heal, but they often have limited success. Now Dr. Shai Efrati of Tel Aviv University's Sackler Faculty of Medicine has found a way to restore a significant amount of neurological function in brain tissue thought to be chronically damaged — even years after initial injury. Theorizing that high levels of oxygen could reinvigorate ...

People with color-grapheme synesthesia experience color when viewing written letters or numerals, usually with a particular color evoked by each grapheme (i.e., the letter 'A' evokes the color red). In a new study, researchers Nathan Witthoft and Jonathan Winawer of Stanford University present data from 11 color grapheme synesthetes who had startlingly similar color-letter pairings that were traceable to childhood toys containing magnetic colored letters. Their findings are published in Psychological Science, a journal of the Association for Psychological Science. Matching ...

ITHACA, N.Y. – Working-class couples that buck convention and live together rather than marry take on traditional roles when it comes to housework, according to a new study by a Cornell University sociologist. Cohabiting women do a disproportionate share of the housework, even when the women work and the men don't – and even when the women want to share the housework more equally, said co-author Sharon Sassler, Cornell professor of policy analysis and management. "When men aren't working, they don't see domestic labor as a means of contributing. In fact, they double ...

WASHINGTON (Jan. 23, 2013) – A study led by Robert G. Hawley, Ph.D., professor and chair of the department of anatomy and regenerative biology at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), may help predict which patients with multiple myeloma will respond better to certain treatments. The study, titled "Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1," was published in the American Journal of Hematology and is available online at: ...

The Sun's visible surface, or photosphere, is 10,000 degrees Fahrenheit. As you move outward from it, you pass through a tenuous layer of hot, ionized gas or plasma called the corona. The corona is familiar to anyone who has seen a total solar eclipse, since it glimmers ghostly white around the hidden Sun. But how can the solar atmosphere get hotter, rather than colder, the farther you go from the Sun's surface? This mystery has puzzled solar astronomers for decades. A suborbital rocket mission that launched in July 2012 has just provided a major piece of the puzzle. The ...

Alexandria, Va., USA – Today, the International and American Associations for Dental Research (IADR/AADR) published a paper titled "ß-catenin is Required in Odontoblasts for Tooth Root Formation." The paper, written by lead authors Tak-Heun Kim and Cheol-Hyeon Bae, Chonbuk National University Korea School of Dentistry, Laboratory for Craniofacial Biology, is published in the IADR/AADR Journal of Dental Research. The tooth root, together with the surrounding periodontium, maintains the tooth in the jaw. The root develops after the crown forms, a process called morphogenesis. ...

As the gun control debate continues, Kevin D. Bradford, an associate professional specialist in marketing at the University of Notre Dame's Mendoza College of Business, says the focus should be on those who distribute guns, not solely on those who buy them. Bradford and a team of researchers conducted a first-of-its-kind study on the ways guns move from legal channels into the hands of criminals. In "Counter-marketing in the Courts: The Case of Marketing Channels and Firearms Diversion, published in the Journal of Public Policy and Marketing, they examined 28 thousand ...

DURHAM, N.C. -- Rising temperatures and shifting rainfall patterns in Madagascar could fuel the spread of lemur parasites and the diseases they carry. By combining data on six parasite species from ongoing surveys of lemur health with weather data and other environmental information for Madagascar as a whole, a team of Duke University researchers has created probability maps of likely parasite distributions throughout the island today. Then, using climate projections for the year 2080, they estimate what parasite distributions might look like in the future. "We ...

AUSTIN, Texas — Rats that are socially isolated during a critical period of adolescence are more vulnerable to addiction to amphetamine and alcohol, found researchers at The University of Texas at Austin. Amphetamine addiction is also harder to extinguish in the socially isolated rats. These effects, which are described this week in the journal Neuron, persist even after the rats are reintroduced into the community of other rats. "Basically the animals become more manipulatable," said Hitoshi Morikawa, associate professor of neurobiology in the College of Natural Sciences. ...

DURHAM, N.C. -- Duke University engineers are layering atom-thick lattices of carbon with polymers to create unique materials with a broad range of applications, including artificial muscles. The lattice, known as graphene, is made of pure carbon and appears under magnification like chicken wire. Because of its unique optical, electrical and mechanical properties, graphene is used in electronics, energy storage, composite materials and biomedicine. However, graphene is extremely difficult to handle in that it easily "crumples." Unfortunately, scientists have been ...

COLUMBUS, Ohio—It weighs half as much as a sports car, and turns on a dime—so its no surprise that the electric car being developed at Ohio State University needs an exceptional traction and motion control system to keep it on the road. With four wheels that turn independently, each with its own built-in electric motor and set of batteries, the experimental car is the only one of its kind outside of commercial carmakers' laboratories. "It is considered one of the promising future vehicle architectures," said Junmin Wang, assistant professor of mechanical engineering ...

New research at the University of Chicago and the University of North Carolina at Chapel Hill shows that children begin to show signs of higher-level thinking skills as young as age 4 ½. Researchers have previously attributed higher-order thinking development to knowledge acquisition and better schooling, but the new longitudinal study shows that other skills, not always connected with knowledge, play a role in the ability of children to reason analytically. The findings, reported in January in the journal Psychological Science, show for the first time that children's ...

(Lebanon, NH)— Dartmouth scientists showed that more than half of all the SNPs associated with breast cancer risk are located in distant regions and bound by FOXA1, a protein required for estrogen receptor-α (ER) function according to a paper published in the journal Nature Genetics in November. Jason Moore, PhD, a Third Century Professor of genetics, director of the Institute for Quantitative Biomedical Sciences, and associate director for bioinformatics at Dartmouth-Hitchcock Norris Cotton Cancer Center, and other researchers used a new methodology that combines ...

Tall, thin women face a greater risk of infection with nontuberculous mycobacteria (NTM), cousins of the organism that causes tuberculosis, according to researchers at National Jewish Health. Women with NTM infections also showed a weakened immune response associated with their fat cells, in a paper published in the Jan. 15, 2013, issue of The American Journal of Respiratory and Critical Care. "Nontuberculous mycobacteria are widespread in the environment, yet only some people develop infections," said Edward Chan, MD, senior author and professor of medicine at National ...

Researchers at Syracuse University's Department of Biomedical and Chemical Engineering at L.C. Smith College of Engineering and Computer Science are studying the toxicity of commonly used nanoparticles, particles up to one million times smaller than a millimeter that could potentially penetrate and damage cell membranes. In a recent article published along with cover art in the leading journal Langmuir entitled "Effects of nanoparticle charge and shape anisotropy on translocation through cell membranes," researchers Shikha Nangia, assistant professor of biomedical and ...

What cancerous conditions lead to what kinds of bacterial infections? If doctors knew, they could predict which patients would likely benefit from pre-treatment with certain kinds of antibiotics. A University of Colorado Cancer Center study published in this month's issue of the International Journal of Infectious Diseases shows the answer: E. coli and Klebsiella pneumoniae are especially prevalent in patients with lung and GI cancers, more so for Klebsiella if these patients have been treated previously with aminopenicillins. "These are really dangerous infections. You ...

COLLEGE PARK, Md. – Filipinos have been an invisible minority in Annapolis, Maryland for more than a century. Now, researchers at the University of Maryland are using oral histories as a way to flesh out their life and times – documenting the incredible challenges they faced – and successes they celebrated. After the Spanish-American War, the Philippines became a U.S. territory. Filipinos were brought to Annapolis – home of the Naval Academy – to serve as desk interns, fire fighters, construction laborers, messmen and stewards. In many cases, the Naval Academy replaced ...

VIDEO: This is a NASA TRMM satellite flyby of Tropical Cyclone Peta in the South Indian Ocean. TRMM revealed that rain was falling at a rate of up to 94 mm... Click here for more information. Infrared data from NASA's Aqua satellite has shown that soon after a low pressure system in northwestern West Australia became Tropical Storm Peta, it made landfall and started to fall apart. Early on Jan. 22, the Joint Typhoon Warning Center (JTWC) gave System 93S a high chance for ...

OAK RIDGE, Tenn., Jan. 23, 2013 -- Looking toward improved batteries for charging electric cars and storing energy from renewable but intermittent solar and wind, scientists at Oak Ridge National Laboratory have developed the first high-performance, nanostructured solid electrolyte for more energy-dense lithium ion batteries. Today's lithium-ion batteries rely on a liquid electrolyte, the material that conducts ions between the negatively charged anode and positive cathode. But liquid electrolytes often entail safety issues because of their flammability, especially as ...

Tropical Storm Oswald's heavy rains have caused flooding in Queensland, Australia and NASA's TRMM satellite measured almost two feet of rain fell in certain areas. Tropical cyclone Oswald's sustained winds have never been greater than 35 knots (~40.2 mph) but the storm's extreme rainfall has resulted in widespread flooding in Australia over northern Queensland. Many roads have been reported flooded resulting in some communities being cut off. NASA's Tropical Rainfall Measuring Mission (TRMM) is a satellite that can measure rainfall from space. TRMM-based satellite precipitation ...

The longstanding ethical framework for protecting human volunteers in medical research needs to be replaced because it is outdated and can impede efforts to improve health care quality, assert leaders in bioethics, medicine, and health policy in two companion articles in a Hastings Center Report special report, "Ethical Oversight of Learning Health Care Systems." One of the authors calling for a new approach is the main architect of the current ethical framework. Seven commentaries in the publication, written by leaders with national responsibility for ethical oversight ...