Bethesda, MD—Physicians may now be better at detecting breast cancer than ever before, but much more work remains to ensure accurate diagnosis is possible and especially to assess future risk. That's why researchers from Germany have been working to develop a new test of gene action to predict cancer risk both at first diagnosis and into the future. In a new research report appearing in the December 2012 issue of The FASEB Journal, researchers show that the various genetic switches, which are turned on and off in the regular development of every cell in the body, can be ...

Climate scientists are still grappling with one of the main questions of modern times: how high will global temperatures rise if the atmospheric concentration of carbon dioxide doubles. Many researchers are turning to the past because it holds clues to how nature reacted to climate change before the anthropogenic impact. The divergent results of this research, however, have made it difficult to make precise predictions about the impact of increased carbon dioxide on future warming. An international team of scientists have evaluated previously published estimates and assigned ...

ATHENS, Ohio (Nov. 29, 2012)—Astronomers were puzzled earlier this year when NASA's Hubble Space Telescope spotted an overabundance of dark matter in the heart of the merging galaxy cluster Abell 520. This observation was surprising because dark matter and galaxies should be anchored together, even during a collision between galaxy clusters. Astronomers have abundant evidence that an as-yet-unidentified form of matter is responsible for 90 percent of the gravity within galaxies and clusters of galaxies. Because it is detected via its gravity and not its light, they call ...

ARLINGTON, Va. —The Office of Naval Research (ONR) is looking to the sun for energy in an effort to help Marines do away with diesel-guzzling generators now used in combat outposts, officials announced Nov. 29. The Renewable Sustainable Expeditionary Power (RSEP) program seeks to create a transportable renewable hybrid system that can provide Marines with electricity for a 15-day mission without relying on fuel resupply convoys that often become targets for adversaries. "This program takes on a number of power-related challenges and ultimately will allow the Marine ...

Bethesda, MD—If you're looking to get some of the benefits of exercise without doing the work, here's some good news. A new research report published online in The FASEB Journal shows that low-intensity vibrations led to improvements in the immune function of obese mice. If the same effect can be found in people, this could have clinical benefits for obese people suffering from a wide range of immune problems related to obesity. "This study demonstrates that mechanical signals can help restore an immune system compromised by obesity," said Clinton Rubin, Ph.D., study ...

Washington, D.C. — Oceanic crust covers two-thirds of the Earth's solid surface, but scientists still don't entirely understand the process by which it is made. Analysis of more than 600 samples of oceanic crust by a team including Carnegie's Frances Jenner reveals a systemic pattern that alters long-held beliefs about how this process works, explaining a crucial step in understanding Earth's geological deep processes. Their work is published in Nature on November 29. Magmas generated by melting of the Earth's mantle rise up below the oceanic crust and erupt on the Earth's ...

Philadelphia, PA, November 29, 2012 – A UK-based study team has determined that there is a correlation between childhood intelligence and chronic widespread pain (CWP) in adulthood, according to a new study published in the December issue of PAIN®. About 10-15 percent of adults report CWP, a common musculoskeletal complaint that tends to occur more frequently among women and those from disadvantaged socioeconomic backgrounds. CWP is a core symptom of fibromyalgia and is one of the most common reasons for consulting a rheumatologist. "One psychological factor that could ...

CALGARY – A three-month-old Winnipeg girl has become the first patient in Canada to receive an experimental and potentially life-saving form of therapy to improve the function of her liver. Physicians at Alberta Children's Hospital, led by medical geneticist Dr. Aneal Khan, successfully completed a series of liver cell transplants earlier this month on patient Nazdana Ali. Nazdana was born last August with a Urea Cycle Disorder (UCD), a genetic disease that causes ammonia to build up in the body that, if untreated, would lead to brain damage and death. Ammonia is ...

This press release is available in Spanish. U.S. Department of Agriculture (USDA) scientists have identified sources of Escherichia coli bacteria that could help restore the reputation of local livestock. Studies by Agricultural Research Service (ARS) scientist Mark Ibekwe suggest that in some parts of California, pathogens in local waterways are more often carried there via runoff from urban areas, not from animal production facilities. ARS is USDA's chief intramural scientific research agency, and this work supports the USDA priority of ensuring food safety. Even ...

A new paradigm for understanding the earliest eras in the history of the universe has been developed by scientists at Penn State University. Using techniques from an area of modern physics called loop quantum cosmology, developed at Penn State, the scientists now have extended analyses that include quantum physics farther back in time than ever before -- all the way to the beginning. The new paradigm of loop quantum origins shows, for the first time, that the large-scale structures we now see in the universe evolved from fundamental fluctuations in the essential quantum ...

CAMBRIDGE, MA -- Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish. The new technique yields tissue constructs that closely mimic the cellular composition of those in the living brain, allowing scientists to study how neurons form connections and to predict how cells from individual patients might respond to different drugs. The work also paves the way for developing bioengineered implants to replace ...

Vigorous exercise is good for health, but only if it's limited to a maximum daily dose of between 30 and 50 minutes, say researchers in an editorial published online in Heart. The idea that more and more high intensity exercise, such as marathons, can only do you good, is a myth say the US cardiologists, and the evidence shows that it's likely to more harm than good to your heart. "If you really want to do a marathon or full distance triathlon, etc, it may be best to do just one or a few and then proceed to safer and healthier exercise patterns," they warn. "A routine ...

New Rochelle, NY, November 29, 2012—Osteoporosis, or reduced bone mineral density that can increase the risk of fractures, may affect as many as 30% of women and 12% of men worldwide. One risk factor for osteoporosis is vitamin D deficiency. A modified form of the vitamin D receptor present in some individuals may lower their risk for developing osteoporosis, according to an article in Genetic Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Genetic Testing and Molecular Biomarkers website. To ...

Following a divorce or separation, many people are encouraged by loved ones or health-care professionals to keep journals about their feelings. But for some, writing in-depth about those feelings immediately after a split may do more harm than good, according to new research. In a study of 90 recently divorced or separated individuals, psychological scientist David Sbarra of the University of Arizona and colleagues found that writing about one's feelings can actually leave some people feeling more emotionally distraught months down the line, particularly those individuals ...

MINNEAPOLIS – A new drug may bring help for people with insomnia, according to a study published in the November 28, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology. The drug, suvorexant, blocks the chemical messengers in the brain called orexins, which regulate wakefulness. Other drugs for insomnia affect different brain receptors. Taking the drug suvorexant increased the amount of time people spent asleep during the night, according to the study. The study involved 254 people ages 18 to 64 who were in good physical and ...

One of the first chemical reactions children learn is the recipe for photosynthesis, combining carbon dioxide, water and solar energy to produce organic compounds. Many of the world's most important photosynthetic eukaryotes such as plants did not develop the ability to combine these ingredients themselves. Rather, they got their light-harnessing organelles -- chloroplasts -- indirectly by stealing them from other organisms. In some instances, this has resulted in algae with multiple, distinct genomes, the evolutionary equivalent of a "turducken*." Chloroplasts originally ...

Judgments made after a moral evaluation are quicker and more extreme than the same judgment based on practical considerations, but morality-based evaluations can be more easily shifted and made with other considerations in mind, according to research published November 28 in the open access journal PLOS ONE by Jay Van Bavel and colleagues from New York University. Previous research has suggested that moral reasoning usually occurs after a person makes a decision, as a post hoc justification of their choice, rather than the basis for the decision itself. This new study ...

When seasonal changes affect food availability, omnivores like blue monkeys adapt by changing their diets, but such nutritional changes may impact female reproduction, according to research published November 28 in the open access journal PLOS ONE by Steffen Foerster from Barnard College, and colleagues from Columbia University and the Smithsonian Institution. The authors found that levels of fecal glucocorticoids (fGC), a stress marker, increased when female monkeys shifted their diet towards lower quality fallback foods, whereas the levels decreased when the monkeys ...

Skeletal remains in an island cave in Favignana, Italy, reveal that modern humans first settled in Sicily around the time of the last ice age and despite living on Mediterranean islands, ate little seafood. The research is published November 28 in the open access journal PLOS ONE by Marcello Mannino and colleagues from the Max Planck Institute for Evolutionary Anthropology, Germany. Genetic analysis of the bones discovered in caves on the Egadi islands provides some of the first mitochondrial DNA data available for early humans from the Mediterranean region, a crucial ...

Scientists have discovered a cognitive biomarker – a biological indicator of a disease – for young adolescents who are at high risk of developing depression and anxiety. Their findings were published today, 28 November, in the journal PLOS ONE. The test for the unique cognitive biomarker, which can be done on a computer, could be used as an inexpensive tool to screen adolescents for common emotional mental illnesses. As the cognitive biomarker may appear prior to the symptoms of depression and anxiety, early intervention (which has proven to be one of the most effective ...

LA JOLLA, CA – Scientists at The Scripps Research Institute (TSRI) have invented a set of chemical tools that is radically simplifying the creation of potential new drug compounds. Pharmaceutical chemists frequently seek to generate dozens or even hundreds of variations of a given compound to see which works best. The new toolkit—described in the November 28, 2012 issue of the journal Nature—makes this process easier and cheaper, enabling previously time- and cost-prohibitive chemical modifications. This fundamental innovation is already being adopted by drug companies ...

Judgments we make with a moral underpinning are made more quickly and are more extreme than those same judgments based on practical considerations, a new set of studies finds. However, the findings, which appear in the journal PLOS ONE, also show that judgments based on morality can be readily shifted and made with other considerations in mind. "Little work has been done on how attaching morality to a particular judgment or decision may affect that outcome," explains Jay Van Bavel, an assistant professor in New York University's Department of Psychology and one of the ...

Researchers report that screening for KRAS and BRAF mutations can reduce the cost of anti-EGFR treatment for metastatic colorectal cancer but with a very small reduction in overall survival according to a new study published on November 28 in the Journal of the National Cancer Institute. Metastatic colorectal cancer patients whose tumors harbor mutations in KRAS (and to a lesser extent, in BRAF) are unlikely to respond to costly anti-EGFR therapies. Screening of patients who are candidates for these therapies for mutations in one of these genes (KRAS) has been recommended, ...

Researchers found that aspirin use is associated with a decreased risk of developing hepatocellular carcinoma and death from chronic liver disease (CLD), according to a study published November 28 in the Journal of the National Cancer Institute. Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, occurs mainly among patients with CLD. Previous reports have linked chronic inflammation due to CLD to cellular processes that could promote carcinogenesis. Because of their anti-inflammatory properties and widespread use to prevent cardiovascular and ...

The combined loss of two tumor suppressor genes, retinoblastoma (RB) and phosphatase and tensin homolog (PTEN) was shown to be strongly associated with progression of DCIS to invasive breast cancer, according to a study published November 28 in the Journal of the National Cancer Institute. Ductal carcinoma in situ (DCIS) is a breast cancer precursor lesion for which there are no established markers defining risk of progression to invasive breast cancer. As a result, the majority of women are treated uniformly with surgery and radiation therapy potentially with additional ...