Many studies have found that problem drinking is related to subsequent unemployment; however, the reverse association is unclear. Some studies have found that unemployment can increase total drinking, alcohol disorders, and/or problem drinking while others have found that unemployment can decrease drinking or have no effect at all. An analysis of binge drinking as either a predictor or outcome of unemployment has found that binge drinking among women seems to have a significant association with long-term unemployment. Results will be published in the November 2012 ...

HOUSTON – (Aug.15, 2012) – A study by a Baylor College of Medicine physician-researcher has shed light on the most effective treatment for adults with Langerhans cell histiocytosis (LCH) in bones. LCH is a disease that can affect the skin, mouth, ears, bones, brain, gastrointestinal system, liver, spleen, or bone marrow. In the study, appearing in the current issue of PLOS ONE, researchers reviewed health records for 58 adults with the disease and compared the effectiveness of three chemotherapy treatments – vinblastine/prednisone, 2-Chlorodeoxyadenosine, and cytosine ...

A paper published 15 August 2012 in Biology of Reproduction's Papers-in-Press reveals that eating 75 grams of walnuts a day improves the vitality, motility, and morphology of sperm in healthy men aged 21 to 35. Approximately 70 million couples experience subfertility or infertility worldwide, with 30 to 50 percent of these cases attributable to the male partner. Some studies have suggested that human semen quality has declined in industrialized nations, possibly due to pollution, poor lifestyle habits, and/or an increasingly Western-style diet. Dr. Wendie Robbins and ...

An investigational drug currently under FDA review for the treatment of rheumatoid arthritis has now shown positive results in patients with moderate-to-severe ulcerative colitis, according to researchers at the University of California San Diego, School of Medicine. The study will appear in the August 16, 2012 issue of the New England Journal of Medicine (NEJM). Results from the phase 2 clinical trial showed the drug Tofacitinib achieved clinical response and remission in certain patients suffering from ulcerative colitis – a chronic inflammatory disease of the colon ...

A previously unrecognized system that drains waste from the brain at a rapid clip has been discovered by neuroscientists at the University of Rochester Medical Center. The findings were published online August 15 in Science Translational Medicine. The highly organized system acts like a series of pipes that piggyback on the brain's blood vessels, sort of a shadow plumbing system that seems to serve much the same function in the brain as the lymph system does in the rest of the body – to drain away waste products. "Waste clearance is of central importance to every organ, ...

CORVALLIS, Ore. – An international group of more than 30 researchers today gave a score to every coastal nation on their contribution to the health of the world's oceans, which showed the United States as being slightly above average, and identified food provision, tourism and recreation as leading concerns. The analysis, published in the journal Nature, scored each nation on a 0-100 scale in 10 separate categories such as clean water, biodiversity, food provision, carbon storage, coastal protection, coastal economies and others. In this "Ocean Health Index," the world ...

A research team from the Peninsula College of Medicine and Dentistry (PCMD), University of Exeter, and University of Cambridge has for the first time established a link between high levels of urinary Bisphenol-A (BPA) and severe coronary artery stenosis (narrowing of the arteries). The study is published in PLoS ONE today, 15th August 2012. The team analysed data from 591 patients who participated in the Metabonomics and Genomics Coronary Artery Disease (MaGiCAD) study in Cambridgeshire, UK. They compared urinary BPA with grades of severity of coronary artery disease ...

Sexual selection in the Forked Fungus Beetle favors larger body and horn size, and a new study investigates the relationship between these traits and the beetles' grip strength, which is crucial for the male to hold on to the female and shield her from other males in an elaborate courtship ritual. The full results are reported on Aug. 15 in the open access journal PLoS ONE. During the courtship ritual, male beetles grab onto the female, sometime for several hours, which would seem to favor males with stronger grip. A video of this behavior is included with the published ...

Given the option to commit spiteful acts, reducing the money payoffs of others at no cost to themselves, many people avoid acting spitefully, but those that do, consistently impose the maximum harm, according to research reported on Aug. 15 in the open access journal PLoS ONE. The authors, Erik Kimbrough of Simon Fraser University in Canada and Philipp Reiss of Maastricht University in the Netherlands, created an artificial auction market scenario, with participants "bidding" for objects and having the opportunity to raise the price paid by others, to test the frequency ...

Specific gut bacteria may be associated with metabolic syndrome traits, as determined by a study of Pennsylvania's Old Order Amish population. The full results are reported on Aug. 15 in the open access journal PLoS ONE. The researchers, led by Claire M. Fraser of the Institute for Genome Sciences at the University of Maryland School of Medicine, chose the Amish as subjects for their study due to their close genetic relationships, similar lifestyles, and low prescription drug usage, among other factors, all of which reduced the number of confounders in the study and helped ...

STANFORD, Calif. — One might expect that ridding a brain cell of damaged proteins would be a universally good thing, and that impairing the cell's ability to do this would allow the faulty proteins to accumulate within the cell, possibly to toxic levels. So a lot of scientific effort has gone into looking for ways to enhance the process by which cells dispose of banged-up proteins. But this thinking may need some revision, according to a new study from the Stanford University School of Medicine. Senior author Thomas Sudhof, MD, professor of molecular and cellular physiology, ...

(Santa Barbara, Calif.) –– Using a new comprehensive index designed to assess the benefits to people of healthy oceans, scientists have evaluated the ecological, social, economic, and political conditions for every coastal country in the world. Their findings, published today in the journal Nature, show that the global ocean scores 60 out of 100 overall on the Ocean Health Index. Individual country scores range widely, from 36 to 86. The highest-scoring locations included densely populated, highly developed nations such as Germany, as well as uninhabited islands, such as ...

Researchers at the University of Maryland School of Medicine have identified 26 species of bacteria in the human gut microbiota that appear to be linked to obesity and related metabolic complications. These include insulin resistance, high blood sugar levels, increased blood pressure and high cholesterol, known collectively as "the metabolic syndrome," which significantly increases an individual's risk of developing diabetes, cardiovascular disease and stroke. The results of the study, which analyzed data from the Old Order Amish in Lancaster County, Pa., are being published ...

PLoS ONE announces the launch of the Synthetic Biology Collection. The new Collection contains an unprecedented number of articles illustrating the many facets of this dynamically evolving research area. The field of synthetic biology interconnects many engineering and scientific disciplines including biology, chemical engineering, chemistry, electrical engineering, and computer science. PLoS ONE has published more than 50 articles covering all aspects of synthetic biology. The journal aims to help increase the visibility of this growing transdisciplinary field by ...

New research has found high rates of sleep apnoea in women, despite the condition usually being regarded as a disorder predominantly of males. The study, published online (16 August 2012) ahead of print today in the European Respiratory Journal, also suggested that women with hypertension and/or obesity were more likely to experience sleep apnoea. Obstructive sleep apnoea is a condition in which there are frequent pauses in breathing during sleep. The incidence of the condition increases with age and it is considered more prevalent in men than in women. In this new ...

The health of the world's oceans received a score of 60 out of 100 from a team of international scientists, including fisheries researchers at the University of British Columbia. The team undertook the first global quantitative assessment of ocean health and created the Ocean Health Index (http://oceanhealthindex.org), published today in the journal Nature. To calculate the overall score, ecological, social, economic, and political conditions were evaluated for every coastal nation in the world. The scores for individual countries ranged widely: from Sierra Leone, ...

In the quest for a universal influenza vaccine—one that elicits broadly neutralizing antibodies that can protect against most or all strains of flu virus—scientists have faced a sobering question: Does pre-existing immunity generated by prior exposure to influenza virus or vaccine hamper production of broadly neutralizing antibodies? If so, then a universal flu vaccine might work best (and perhaps only) in very young children who have had limited exposure to influenza viruses or vaccines. Now, in studies using mice and ferrets, investigators from the Vaccine Research ...

HOUSTON - Genomic deletions promote cancer by carving up or eliminating tumor-suppressor genes, but now scientists report in the journal Nature that the collateral damage they inflict on neighboring genes exposes cancer cells to vulnerabilities and new avenues for attack. Working with cell lines of glioblastoma multiforme, the most lethal type of brain tumor, researchers from the Dana-Farber Cancer Institute at Harvard Medical School, and some now at The University of Texas MD Anderson Cancer Center, found that collateral deletion of a gene vital to tumor metabolism ...

A series of forest searches by dogs specially trained to sniff out northern spotted owl pellets – the undigested bones, fur and other bits regurgitated by owls – improved the probability of finding the owls by nearly 30 percent over a series of traditional vocalization surveys. Since the 1980s scientists and land managers have relied on vocalization surveys that use simulated northern spotted owl calls to elicit owl responses. As forests have been invaded by barred owls, which displace and even kill spotted owls, concerns have grown that spotted owls may be timid about ...

Scientists demonstrate, for the time, a solid-state "MASER" capable of operating at room temperature, paving the way for its widespread adoption – as reported today in the journal Nature. MASER stands for Microwave Amplification by Stimulated Emission of Radiation. Devices based on this process (and known by the same acronym) were developed by scientists more than 50 years ago, before the first LASERs were invented. Instead of creating intense beams of light, as in the case of LASERs, MASERs deliver a concentrated beam of microwaves. Conventional MASER technology works ...

The head of one of the UK's leading cancer research organisations has hailed a golden age in prostate cancer drug discovery as for the fourth time in two years results are published finding a new drug can significantly extend life. A study in the New England Journal of Medicine today shows the drug enzalutamide can significantly extend life and improve quality of life in men with advanced prostate cancer – in findings that could further widen the treatment options for men with the disease. The Institute of Cancer Research, London, and its partner hospital The Royal ...

Neighbourhood income deprivation has a strong negative effect on altruistic behaviour when measured by a 'lost letter' experiment, according to new UCL research published today in PLOS ONE. Researchers from UCL Anthropology used the lost letter technique to measure altruism across 20 London neighbourhoods by dropping 300 letters on the pavement and recording whether they arrived at their destination. The stamped letters were addressed by hand to a study author's home address with a gender neutral name, and were dropped face-up and during rain free weekdays. The results ...

CAMBRIDGE, MA -- By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion. To help speed up the process, MIT researchers have developed RNA-delivering nanoparticles that allow for rapid screening of new drug targets in mice. In their first mouse study, done with researchers at Dana-Farber Cancer Institute and the Broad Institute, they showed that nanoparticles ...

According to a NOAA-led paper published today in the journal Conservation Biology, high levels of background noise, mainly due to ships, have reduced the ability of critically endangered North Atlantic right whales to communicate with each other by about two-thirds. From 2007 until 2010, scientists from Stellwagen Bank National Marine Sanctuary, Cornell Lab of Ornithology, NOAA Fisheries Northeast Fisheries Science Center, and Marine Acoustics Inc. used an array of acoustic recorders to monitor noise levels, measure levels of sound associated with vessels, and to record ...

VIDEO: This video shows the annual cycle of global and Asian fatal landslides (for the full dataset described in the research paper). They have been divided into the 52 weeks... Click here for more information. Landslides kill ten times more people across the world than was previously thought, according to research by Durham University, UK. A new database of hazards shows that 32,300 people died in landslides between 2004 and 2010. Previous estimates ranged from 3,000 ...