In an editorial appearing in the October 25 issue of The New England Journal of Medicine, medical oncologists at Johns Hopkins and Brigham and Women's hospitals provide a four-point plan for integrating palliative care discussions throughout the treatment of patients with terminal illnesses. They write that better planning and communication may improve symptoms, stress, and survival time, as well as lower health care costs at the end of life. The two physicians suggest that their colleagues should discuss palliative care with patients during initial talks about prognosis ...

European countries with gaps in border security surrounding agricultural imports have been invaded by the largest number of exotic insect pests, according to research published Oct 24 in the open access journal PLOS ONE by Steven Bacon and colleagues from the Swiss Federal Research Station Agroscope ART and the University of Fribourg, Switzerland. Invasive agricultural pests pose growing environmental and economic problems, threatening biodiversity and costing billions of dollars in economic losses annually. Large volumes of cross-border trade increase the risks of invasion, ...

PORTLAND, Ore. - Oregon Health & Science University's development of a new gene therapy method to prevent certain inherited diseases has reached a significant milestone. Researchers at the university's Oregon National Primate Research Center and the OHSU Department of Obstetrics & Gynecology have successfully demonstrated their procedure in human cells. It's believed that this research, along with other efforts, will pave the way for future clinical trials in human subjects. The research results are online Wednesday, Oct. 24, in the highly respected journal Nature. Dr. ...

Archer fish knock their insect prey out of overhanging vegetation with a jet of water several times more powerful than the fish's muscles. New research now shows that the fish generate this power externally using water dynamics rather than with any specialized internal organs. The research, published Oct. 24 in the open access journal PLOS ONE by Alberto Vailati and colleagues from the University of Milan, provides the first explanation for how archer fish can generate such powerful jets to capture their prey. Other animals like chameleons and salamanders store energy ...

As we grow older, we are less capable of correctly estimating differences in the weights of objects we lift, according to a study published Oct. 24 in the open access journal PLOS ONE by Jessica Holmin and Farley Norman from North Dakota State University and Western Kentucky University, respectively. Previous studies have shown that aging is frequently associated with a decrease in muscle mass and consequently strength, making it more difficult to lift objects. As a result, older adults often perceive weights they lift as being heavier than they actually are. In the current ...

Analysis of texture differences in satellite images may be an effective way to monitor changes in vegetation, soil and water patterns over time, with potential implications for measuring biodiversity as well, according to new research published Oct. 24 by Matteo Convertino from the University of Florida and colleagues in the open access journal PLOS ONE. The authors designed statistical models to estimate two aspects of biodiversity in satellite images: the number of species in a given region, or 'species richness', and the rate at which species entered or were removed ...

BOSTON—Aspirin therapy can extend the life of colorectal cancer patients whose tumors carry a mutation in a key gene, but has no effect on patients who lack the mutation, Dana-Farber Cancer Institute scientists report in the Oct. 25 issue of the New England Journal of Medicine. In a study involving more than 900 patients with colorectal cancer, the researchers found that, for patients whose tumors harbored a mutation in the gene PIK3CA, aspirin use produced a sharp jump in survival: five years after diagnosis, 97 percent of those taking aspirin were still alive, compared ...

An electronic nose, used to detect the presence of molecules in the breath of a patient, could be used to diagnose obstructive sleep apnoea. A new study, published online today ahead of print (25 October 2012) in the European Respiratory Journal, could make the diagnosis of the condition quick and inexpensive compared to current methods. The gold standard used to identify sleep apnoea is an overnight sleep test. This is technically demanding, time-consuming and cost-intensive. Electronic nose devices have been shown to distinguish between a number of diseases; ...

This press release is available in German. Researchers at Aarhus University, Denmark, made a sensational discovery almost three years ago when they measured electric currents in the seabed. It was unclear as to what was conducting the current, but the researchers imagined the electric currents might run between different bacteria via a joint external wiring network.The researchers have now solved the mystery. It turns out that the whole process takes place inside bacteria that are one centimetre long. They make up a kind of live electric cable that no one had ever imagined ...

We're not used to thinking of ourselves as animals. But as Jason Samson sees it, climate is as important in shaping the distribution and movement of humans as it is in other animals. The McGill-trained ecologist and fellow researchers have been using modeling techniques similar to those used to define the ecological niche for plant and animal species to explore the correlation between climate patterns and population growth in the contiguous United States between 1900-2000. And what they discovered was a pronounced population shift away from areas within the U.S. with cool ...

Could it be that dark matter "halos" — the huge, invisible cocoons of mass that envelop entire galaxies and account for most of the matter in the universe — aren't completely dark after all but contain a small number of stars? Astronomers from UCLA, UC Irvine and elsewhere make a case for that in the Oct. 25 issue of the journal Nature. Astronomers have long disagreed about why they see more light in the universe than it seems they should — that is, why the infrared light they observe exceeds the amount of light emitted from known galaxies. When looking at the cosmos, ...

Just how new species are established is still one of the most central questions in biology. In an article in the leading scientific journal Nature, researchers at Uppsala University in Sweden describe how they mapped the genomes of the European pied flycatcher and the collared flycatcher and found that it is disparate chromosome structures rather than separate adaptations in individual genes that underlies the separation of the species. "We were surprised that such a large part of the genome was nearly identical in the two species," says Hans Ellegren, professor of evolutionary ...

CHICAGO --- In an early-stage breakthrough, a team of Northwestern University scientists has developed a new family of compounds that could slow the progression of Parkinson's disease. Parkinson's, the second most common neurodegenerative disease, is caused by the death of dopamine neurons, resulting in tremors, rigidity and difficulty moving. Current treatments target the symptoms but do not slow the progression of the disease. The new compounds were developed by Richard B. Silverman, the John Evans Professor of Chemistry at the Weinberg College of Arts and Sciences ...

(Garrison, NY) As the presidential candidates clash over the fate of the Affordable Care Act, a set of seven essays by leading legal experts, economists, and scholars examines the implications of the Supreme Court's decision on the ACA and makes it clear that there is no consensus about what is economically or morally just when it comes to health care coverage in this country. The essays appear in the Hastings Center Report. While the essays provide a range of perspectives, a few common themes emerge. Foremost among them is that the individual mandate may not work as ...

A gene known to be involved in cancer and cardiovascular development may be the cause of inflammation in the most common form of aortic aneurysm and may be a key to treatment, according to research from Nationwide Children's Hospital. The study, appearing online in Arteriosclerosis, Thrombosis, and Vascular Biology on October 18, 2012, is the first to show that Notch 1 signaling is activated in abdominal aortic aneurysmal tissue in mice and humans. The aorta is the largest blood vessel in the body. Abdominal aortic aneurysm (AAA) occurs when the weakened aortic wall dilates ...

MIAMI, FL – OCTOBER 24 , 2012 – A study found that a nitinol stent performed better than balloon angioplasty alone in treating blockages of the popliteal artery, which runs through the leg behind the knee. Results of the ETAP trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Due to its location behind the mobile knee joint, it is controversial ...

CHAMPAIGN, Ill. — Scientists report that they can predict who will improve most on an unfamiliar video game by looking at their brain waves. They describe their findings in a paper in the journal Psychophysiology. The researchers used electroencephalography (EEG) to peek at electrical activity in the brains of 39 study subjects before they trained on Space Fortress, a video game developed for cognitive research. The subjects whose brain waves oscillated most powerfully in the alpha spectrum (about 10 times per second, or 10 hertz) when measured at the front of the head ...

MIAMI, FL – OCTOBER 24, 2012 – A study has found that the anti-clotting medication prasugrel reduced cardiovascular events among patients who present with an acute coronary syndrome and are managed medically after an angiogram is performed to determine coronary anatomy. Results of the TRILOGY ACS trial, Angiographic Cohort were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular ...

WASHINGTON — Scaling up the production of biofuels made from algae to meet at least 5 percent -- approximately 39 billion liters -- of U.S. transportation fuel needs would place unsustainable demands on energy, water, and nutrients, says a new report from the National Research Council. However, these concerns are not a definitive barrier for future production, and innovations that would require research and development could help realize algal biofuels' full potential. Biofuels derived from algae and cyanobacteria are possible alternatives to petroleum-based fuels and ...

CHAMPAIGN, Ill. — We humans have a fairly erratic sense of time. We tend to misjudge the duration of events, particularly when they are emotional in nature. Disturbingly negative experiences, for example, seem to last much longer than they actually do. And highly positive experiences seem to pass more quickly than negative ones. Researchers say they have found a way to lessen these emotion-driven time distortions. Having a sense of control over events reduces the influence of emotions on time perception, the researchers report. This is true even for highly reactive emotional ...

MIAMI, FL – OCTOBER 24, 2012 –A strategy of up-front percutaneous coronary intervention (PCI) for lesions confirmed to be obstructive by fractional flow reserve (FFR) was shown to be cost-effective in terms of quality-adjusted life years when compared to medical therapy alone. Results of the Cost-Effectiveness sub study of the FAME 2 trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional ...

MIAMI, FL – OCTOBER 24, 2012 – A study found that transcatheter aortic valve replacement (TAVR) yielded lower mortality rates after three years compared with medical therapy in patients deemed to be ineligible for conventional aortic valve surgery. Results of the PARTNER Cohort B trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. TAVR is the recommended ...

MIAMI, FL – OCTOBER 24, 2012 – A study found that second-generation drug-eluting stents are safe and effective in the treatment of left main coronary artery lesions. Results of the ISAR-LEFT MAIN 2 trial were presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Patients undergoing invasive treatment of unprotected left main coronary artery (uLMCA) lesions are often ...

CHAMPAIGN, Ill. — The bacterium Streptococcus pneumoniae – which can cause pneumonia, meningitis, bacteremia and sepsis – likes to share its antibiotic-defeating weaponry with its neighbors. Individual cells can pass resistance genes to one another through a process called horizontal gene transfer, or by "transformation," the uptake of DNA from the environment. Now researchers report that they can interrupt the cascade of cellular events that allows S. pneumoniae to swap or suck up DNA. The new findings, reported in the journal PLoS ONE, advance the effort to develop ...

TORONTO, Oct. 24, 2012--It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood vessels, they are not responsible for sensing the amount of oxygen that gets to the lungs. That message comes from the endothelial cells – special cells that line the blood vessels – along a "signalling pathway." When a person is low on oxygen, blood vessels throughout the body expand to improve the delivery of this vital molecule ...