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How metastasizing cancer cells enter organs

2012-07-12
This press release is available in German. It is not primary tumors that are responsible for the majority of cancer deaths, but rather their metastases. Physiologists and neuropathologists from the University of Zurich have now identified the origin of metastasis formation, thereby becoming the first to reveal the pathway of metastasizing intestinal cancer cells out of the blood stream. The results allow new approaches in the development of cancer therapies. Every year, over seven million people die of cancer worldwide. Thanks to more effective therapy and better ...

Identifying risky behaviors: The key to HIV prevention

2012-07-12
HIV prevention must be better targeted, according to David Holtgrave from Johns Hopkins Bloomberg School of Public Health in the US, and colleagues. Health care professionals need a more detailed analysis and understanding of the interplay between HIV risk behavior, access to treatment and treatment success among those living with HIV. The authors discuss their proposed framework in a study¹ in a special issue of Springer's journal AIDS and Behavior. The special issue, "Turning the Tide Together: Advances in Behavioral Interventions Research"² is freely available online ...

The more gray matter you have, the more altruistic you are

2012-07-12
This press release is available in German. The volume of a small brain region influences one's predisposition for altruistic behavior. Researchers from the University of Zurich show that people who behave more altruistically than others have more gray matter at the junction between the parietal and temporal lobe, thus showing for the first time that there is a connection between brain anatomy, brain activity and altruistic behavior. Why are some people very selfish and others very altruistic? Previous studies indicated that social categories like gender, income ...

Air in expectant moms' homes contains pesticides, border study finds

2012-07-12
HARLINGEN, Texas (July 11, 2012) — Air samples from homes of Hispanic mothers-to-be along the Texas-Mexico border contained multiple pesticides in a majority of the houses, according to a study conducted by the School of Medicine at The University of Texas Health Science Center San Antonio. All the women were in the third trimester of pregnancy, when the fetal brain undergoes a growth spurt. Several studies have reported that pesticide exposure may adversely affect mental and motor development during infancy and childhood. The new report is in the summer issue of the ...

Down on the cacao farm: Sloths thrive at chocolate's source

2012-07-12
MADISON -- Like many Neotropical fauna, sloths are running out of room to maneuver. As forests in South and Central America are cleared for agriculture and other human uses, populations of these arboreal leaf eaters, which depend on large trees for both food and refuge, can become isolated and at risk. But one type of sustainable agriculture, shade grown cacao plantations, a source of chocolate, could become critical refuges and bridges between intact forests for the iconic animals. In an ongoing study in Costa Rica, wildlife biologists from the University of Wisconsin-Madison ...

Middle-aged women who were child abuse victims at increased risk for heart disease, diabetes

2012-07-12
WASHINGTON – Middle-aged women who report having been physically abused as children are about two times more likely than other women their age to have high blood pressure, high blood sugar, a larger waistline and poor cholesterol levels, according to a new study published by the American Psychological Association. These women are diagnosed as having metabolic syndrome which, according to previous research, places them at an increased risk of developing heart disease and Type 2 diabetes. This link between physical abuse and metabolic syndrome persisted beyond traditional ...

Summer Olympics go for the green as London prepares to host the world

2012-07-12
New Rochelle, NY, July 11, 2012—As athletes from around the world compete for medals at the Summer Olympics in London, the city will be striving to meet Olympic-level sustainability goals. A fascinating first-person view of how these sustainability targets were developed and will be achieved is featured in Sustainability: The Journal of Record, a publication of Mary Ann Liebert, Inc., publishers (www.liebertpub.com) The article is available free online at the Sustainability: The Journal of Record (www.liebertpub.com/sus) website. The central location of the Summer 2012 ...

Cochrane finds no reliable evidence on effectiveness of electric fans in heatwaves

2012-07-12
A new Cochrane systematic review of the effects of electric fans in heatwaves has found no high quality evidence to guide future national and international policies. The review outlines the type of study that would help resolve the uncertainty which is spelt out in a podcast and an editorial all published today in The Cochrane Library. Heatwaves in Europe and the USA have led to increasing interest in health protection measures to reduce the impacts of such extreme weather events on human health. Heatwaves are also an issue for mass gatherings and heatwave planning has ...

ONR opens a gateway to improved network data sharing on Navy ships

2012-07-12
ARLINGTON, Va.—An Office of Naval Research (ONR) universal gateway that gives Sailors access to more accurate, secure, real-time information will be delivered to the fleet in just three years from the project's inception at ONR officials announced July 11. On any Navy destroyer, cruiser or carrier today, there are two networks: one for combat systems (weapons and sensors) and one for command and control, or C2, which also encompasses intelligence, surveillance and reconnaissance. There are some 30 interconnections between the two networks, making it difficult to integrate ...

Got milk? Climate change means stressed cows in southern US may have less

2012-07-12
"Cows are happy in parts of Northern California and not in Florida" is a good way to sum up the findings of new research from the University of Washington, said Yoram Bauman, best known as the "stand-up economist." Bauman and colleagues found that the decline in milk production due to climate change will vary across the U.S., since there are significant differences in humidity and how much the temperature swings between night and day across the country. For instance, the humidity and hot nights make the Southeast the most unfriendly place in the country for dairy cows. Their ...

Ions, not particles, make silver toxic to bacteria

2012-07-12
HOUSTON – (July 11, 2012) – Rice University researchers have settled a long-standing controversy over the mechanism by which silver nanoparticles, the most widely used nanomaterial in the world, kill bacteria. Their work comes with a Nietzsche-esque warning: Use enough. If you don't kill them, you make them stronger. Scientists have long known that silver ions, which flow from nanoparticles when oxidized, are deadly to bacteria. Silver nanoparticles are used just about everywhere, including in cosmetics, socks, food containers, detergents, sprays and a wide range of ...

Strong communication between brain and muscle requires both having the protein LRP4

2012-07-12
AUGUSTA, Ga. – Communication between the brain and muscle must be strong for us to eat, breathe or walk. Now scientists have found that a protein known to be on the surface of muscle cells must be present in both tissues to ensure the conversation is robust. Scientists at the Medical College of Georgia at Georgia Health Sciences University have shown that without LRP4 in muscle cells and neurons, communication between the two cells types is inefficient and short-lived. Problems with the protein appear to contribute to disabling disorders such as myasthenia gravis ...

Making 'renewable' viable

2012-07-12
PHILADELPHIA – In the aftermath of the recent United Nations Rio+20 Conference on Sustainable Development, the focus of many industrialized nations is beginning to shift toward planning for a sustainable future. One of the foremost challenges for sustainability is efficient use of renewable energy resources, a goal that hinges on the ability to store this energy when it is produced and disburse it when it is needed. A team of researchers from Drexel University's College of Engineering have taken up this challenge and has developed a new method for quickly and efficiently ...

Hubble discovers a fifth moon orbiting Pluto

2012-07-12
A team of astronomers using NASA's Hubble Space Telescope is reporting the discovery of another moon orbiting the icy dwarf planet Pluto. The moon is estimated to be irregular in shape and 6 to 15 miles across. It is in a 58,000-mile-diameter circular orbit around Pluto that is assumed to be co-planar with the other satellites in the system. "The moons form a series of neatly nested orbits, a bit like Russian dolls," said team lead Mark Showalter of the SETI Institute in Mountain View, Calif. The discovery increases the number of known moons orbiting Pluto to five. The ...

Hubble discovers new Pluto moon

2012-07-12
Pluto's new-found moon, visible as a speck of light in Hubble images, is estimated to be irregular in shape and between 10 and 25 kilometres across. It is in a 95 000 kilometre-diameter circular orbit around Pluto that is assumed to lie in the same plane as Pluto's other known moons. "The moons form a series of neatly nested orbits, a bit like Russian dolls," said Mark Showalter of the SETI Institute in Mountain View, USA, leader of the scientific team that discovered the new moon. The Pluto team is intrigued that such a small planet can have such a complex collection ...

NASA sees Emilia as a Category 2 hurricane now

2012-07-12
Hurricane Emilia reached peak intensity yesterday, July 10, when its maximum sustained winds hit 140 mph (220 kmh). Today, July 11, Emilia has weakened to a Category 2 hurricane. NASA's Aqua satellite passed over Emilia during its weakening phase. The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument that flies onboard NASA's Aqua satellite captured a visible image of Hurricane Emilia on July 10, 2012 at 2035 UTC / 4:35 p.m. EDT when its winds had weakened down to 125 mph (205 kmh). Emilia continued weakening after Aqua passed by. On July 11 at 5 a.m. ...

Want to get teens interested in math and science? Target their parents

2012-07-12
Increasing the number of students interested in science, technology, engineering, and math – otherwise known as the STEM disciplines – is considered to be vital to national competitiveness in the global economy and to the development of a strong 21st century workforce. But the pipeline leading toward STEM careers begins leaking in high school, when students choose not to take advanced courses in science and math. Experts in research and policy have examined different ways to enhance and promote STEM education, but most of these efforts are focused within the four walls ...

Cleveland Clinic researchers discover molecule that may prevent atherosclerosis

2012-07-12
Wednesday, July 11, 2012, Cleveland: Cleveland Clinic researchers have discovered that a naturally occurring molecule may play a role in preventing plaque buildup inside arteries, possibly leading to new plaque-fighting drugs and improved screening of patients at risk of developing atherosclerosis. Sometimes called hardening or clogging of the arteries, atherosclerosis is the buildup of cholesterol, fatty cells, and inflammatory deposits on the inner walls of the arteries, restricting blood flow to the heart. The disease can affect the arteries in the heart, legs, brain, ...

Scientists first to see trafficking of immune cells in beating heart

2012-07-12
VIDEO: Working in mice, scientists at Washington University School of Medicine in St. Louis have used two‑photon imaging to capture the first images of a beating heart at a resolution so detailed they can... Click here for more information. Blood flow to the heart often is interrupted during a heart attack or cardiac surgery. But when blood flow resumes, the heart may still falter. That's because collateral damage can occur as blood re-enters the heart, potentially ...

Using biomarkers to identify and treat schizophrenia

2012-07-12
In the current online issue of PLoS ONE, researchers at the University of California, San Diego School of Medicine say they have identified a set of laboratory-based biomarkers that can be useful for understanding brain-based abnormalities in schizophrenia. The measurements, known as endophenotypes, could ultimately be a boon to clinicians who sometimes struggle to recognize and treat the complex and confounding mental disorder. "A major problem in psychiatry is that there are currently no laboratory tests that aid in diagnosis, guide treatment decisions or help predict ...

The emotion detectives uncover new ways to fight off youth anxiety and depression

2012-07-12
CORAL GABLES, FL (July 11, 2012)—Emotional problems in childhood are common. Approximately 8 to 22 percent of children suffer from anxiety, often combined with other conditions such as depression. However, most existing therapies are not designed to treat co-existing psychological problems and are therefore not very successful in helping children with complex emotional issues. To develop a more effective treatment for co-occurring youth anxiety and depression, University of Miami (UM) psychologist Jill Ehrenreich-May and her collaborator Emily L. Bilek analyzed the efficacy ...

Transforming cancer treatment

2012-07-12
A Harvard researcher studying the evolution of drug resistance in cancer is predicting that, in a few decades, "many, many cancers could be manageable." Martin Nowak, a Harvard Professor of Mathematics and of Biology and Director of the Program for Evolutionary Dynamics, is one of several co-authors of a paper, published in Nature, that details how resistance to targeted drug therapy emerges in colorectal cancers, and suggests a new, multi-drug approach to treatment could make many cancers manageable, if not curable, illnesses. The key, Nowak's research suggests, ...

Cells derived from debrided burn tissue may be useful for tissue engineering

2012-07-12
Putnam Valley, NY. (July 11, 2012) –A research team in the Netherlands has found that cells from burn eschar, the non-viable tissue remaining after burn injury and normally removed to prevent infection, can be a source of mesenchymal cells that may be used for tissue engineering. Their study compared the efficacy of those cells to adipose (fat)-derived stem cells and dermal fibroblasts in conforming to multipotent mesenchymal stromal cell (MSC) criteria. Their study is published in the current issue of Cell Transplantation (21:5), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/. ...

Retina transplantation improved by manipulating recipient retinal microenvironment

2012-07-12
Putnam Valley, NY. (July 11, 2012) – A research team in the United Kingdom has found that insulin-like growth factor (IGF1) impacts cell transplantation of photoreceptor precursors by manipulating the retinal recipient microenvironment, enabling better migration and integration of the cells into the adult mouse retina. Their study is published in the current issue of Cell Transplantation (21:5), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/. "Photoreceptor death is an irreversible process and represents one of the largest causes of untreatable ...

Toward new drugs for the human and non-human cells in people

2012-07-12
Amid the growing recognition that only a small fraction of the cells and genes in a typical human being are human, scientists are suggesting a revolutionary approach to developing new medicines and treatments to target both the human and non-human components of people. That's the topic of an article, which reviews work relating to this topic from almost 100 studies, in ACS' Journal of Proteome Research. Liping Zhao, Jeremy K. Nicholson and colleagues explain that human beings have been called "superorganisms" because their bodies contain 10 percent human cells and 90 ...
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