Cardiomyopathy comprises a deterioration of the heart muscle that affects the organ's ability to efficiently pump blood through the body. Previously researchers have tied forms of the disease to the alternative splicing of titin, a giant protein that determines the structure and biomechanical properties of the heart, but the molecular mechanism remained unknown. Professor Michael Gotthardt and Professor Norbert Hübner of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, and colleagues have found that the RNA binding motif protein 20 (RBM20), a gene ...

Structural changes in heart muscle cells after heart failure can be reversed by allowing the heart to rest, according to research at Imperial College London. Findings from a study in rats published today in the European Journal of Heart Failure show that the condition's effects on heart muscle cells are not permanent, as has generally been thought. The discovery could open the door to new treatment strategies. Heart failure means that the heart muscle is too weak or stiff to pump blood as effectively as it needs to, and it is commonly the result of a heart attack. Around ...

A century on from the sinking of the Titanic, science writer Richard Corfield takes a look at the cascade of events that led to the demise of the 'unsinkable' ship, taking into account the maths and physics that played a significant part. At 11.40 p.m. on Sunday 14 April 1912 the Titanic, bound from Southampton to New York, struck an iceberg just off the coast of Newfoundland and became fully submerged within three hours, before dropping four kilometres to the bottom of the Atlantic. There have been many stories recounting why the ship struck the iceberg and why two-thirds ...

New research shows it may be no accident when doctors observe how patients suffering from both breast cancer and arthritis seem to have more aggressive cancer. However, the new-found interaction between the two diseases may also suggest a possible treatment. A potential relationship between metastatic breast cancer and autoimmune arthritis, as suggested by past epidemiological studies, has led researchers from the University of North Carolina at Charlotte to perform a series of mouse model experiments that appear to confirm the connection. "Epidemiological studies ...

CHICAGO, IL (April 1, 2012)––Researchers at Fox Chase Cancer Center in Philadelphia have found that a protein associated with other cancers appears to also be important in head and neck cancer, and may consequently serve as a good target for new treatments. The findings will be reported at the AACR Annual Meeting 2012 on Sunday, April 1. The researchers found that patients whose tumors had higher levels of the protein known as Aurora-A had a shorter survival following surgery to remove their tumors than patients whose tumors had normal levels of the protein. "This ...

CHICAGO, IL (April 1, 2012)––Pancreatic cancer kills more than 40,000 people every year, and among cancers it's particularly insidious. For 80 percent of patients, the disease is already so advanced at the time of diagnosis that treatment is unlikely to provide significantly life-extending benefits. For patients diagnosed with localized pancreatic cancer, the five-year survival rate remains barely above 20 percent, according to the National Cancer Institute. New research from scientists at Fox Chase Cancer Center in Philadelphia, which will be presented at the AACR Annual ...

CHICAGO, IL (April 1, 2012)––At the time of diagnosis, the majority of breast cancers are categorized as estrogen-receptor positive, or hormone sensitive, which means their cancerous cells may need estrogen to grow. Patients with this type of cancer often respond favorably to treatments called aromatase inhibitors, like tamoxifen, which cause cell death by preventing estrogen from reaching the cancerous cells. Over time, however, the disease often becomes resistant to estrogen deprivation from the drugs—making treatment options more limited. New findings that will be ...

A new study contrasting ocean temperature readings of the 1870s with temperatures of the modern seas reveals an upward trend of global ocean warming spanning at least 100 years. The research led by Scripps Institution of Oceanography at UC San Diego physical oceanographer Dean Roemmich shows a .33-degree Celsius (.59-degree Fahrenheit) average increase in the upper portions of the ocean to 700 meters (2,300 feet) depth. The increase was largest at the ocean surface, .59-degree Celsius (1.1-degree Fahrenheit), decreasing to .12-degree Celsius (.22-degree Fahrenheit) at ...

In April 1947 the post-war Labour Government raised the school leaving age from 14 to 15 and paved the way for a further increase to 16 in 1972. Now, 65 years later, as the UK prepares to raise the 'education participation age' to 17 in 2013 and to 18 in 2015, new research reveals that the transitions of 1947 and 1972 met with more controversy and difficulty than previously thought. In a study funded by the Economic and Social Research Council, Dr Tom Woodin and Professor Gary McCulloch of the Institute of Education, London, analysed the debate surrounding the implementation ...

WASHINGTON – Fishing for herring, anchovy, and other "forage fish" in general should be cut in half globally to account for their critical role as food for larger species, recommends an expert group of marine scientists in a report released today. The Lenfest Forage Fish Task Force conducted the most comprehensive worldwide analysis of the science and management of forage fish populations to date. Its report, "Little Fish, Big Impact: Managing a crucial link in ocean food webs," concluded that in most ecosystems at least twice as many of these species should be left in ...

Bethesda, MD -- A new discovery in mice may lead to new treatments that could make bone marrow transplants more likely to succeed and to be significantly less dangerous. According to new research findings published in the Journal of Leukocyte Biology (https://www.jleukbio.org) Brazilian scientists may have found a way to prevent the immune system from attacking transplant grafts and damaging the host's own cells after a bone marrow transplant. Specifically, they found that a receptor for a mediator of the inflammatory process, known as platelet activating factor plays ...

CHAPEL HILL, N.C. -- University of North Carolina at Chapel Hill researchers working as part of the International Cystic Fibrosis Consortium have discovered several regions of the genome that may predispose cystic fibrosis (CF) patients to develop an intestinal blockage while still in the uterus. A report of this international study appears online April 1, 2012 in the journal Nature Genetics. It was the work of the North America CF Gene Modifier Consortium, which brought together dozens of investigators from the United States, Canada, and from France, to identify genetic ...

Picky females play a critical role in the survival and diversity of species, according to a Nature study by researchers from the University of British Columbia and the International Institute for Applied Systems Analysis (IIASA) in Austria. To date, biodiversity theories have focused on the role played by adaptations to the environment: the species best equipped to cope with a habitat would win out, while others would gradually go extinct. The new study presents the first theoretical model demonstrating that selective mating alone can promote the long-term coexistence ...

Scientists at Washington University School of Medicine in St. Louis are using powerful DNA sequencing technology not only to identify mutations at the root of a patient's tumor – considered key to personalizing cancer treatment – but to map the genetic evolution of disease and monitor response to treatment. "We're finding clinically relevant information in the tumor samples we're sequencing for discovery-oriented research studies," says Elaine Mardis, PhD, co-director of The Genome Institute at the School of Medicine. "Genome analysis can play a role at multiple time ...

Minor accidents take place every single day in Southern California. These ordeals can often be resolved with the assistance of an insurance company and a fair settlement that is going to quickly pay for injuries, damage to property, or any other associated costs. When drivers are not receiving the financial assistance that they need in order to pay for serious or ongoing medical expenses though, it will not take much for the situation to enhance into a messy legal situation. In order to assist victims, the leading Los Angeles personal injury lawyer, Farhad Hamdam, is now ...

Bethesda, MD—If you're expecting, this might make you feel a little better about reaching for that pint of ice cream: New research published online in the FASEB Journal (http://www.fasebj.org) suggests that twins, and babies of mothers who diet around the time of conception and in early pregnancy, may have an increased risk of obesity and type 2 diabetes throughout their lives. This study provides exciting insights into how behavior can lead to epigenetic changes in offspring related to obesity and disease. "This study may provide a new understanding of why twins can ...

CHICAGO - Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. All of the aberrantly activated translational proteins are regulated by the PI3K/mTOR molecular signaling pathway, which has been implicated in development and progression of several cancers. More recently, mTOR activation has been tied to resistance to standard endocrine therapy in estrogen-receptor positive breast ...

Rutgers scientists think they have found a way to prevent and possibly reverse the most debilitating symptoms of a rare, progressive childhood degenerative disease that leaves children with slurred speech, unable to walk, and in a wheelchair before they reach adolescence. In today's online edition of Nature Medicine, Karl Herrup, chair of the Department of Cell Biology and Neuroscience in the School of Arts and Sciences provides new information on why this genetic disease attacks the cerebellum – a part of the brain that controls movement coordination, equilibrium, and ...

SALT LAKE CITY -- A study led by a University of Utah astrophysicist found a new explanation for the growth of supermassive black holes in the center of most galaxies: they repeatedly capture and swallow single stars from pairs of stars that wander too close. Using new calculations and previous observations of our own Milky Way and other galaxies, "we found black holes grow enormously as a result of sucking in captured binary star partners," says physics and astronomy Professor Ben Bromley, lead author of the study, which is set for online publication April 2 in Astrophysical ...

Tracy Hayward, Founder of The Perfect Puree of Napa Valley, announced today the kick-off of an Enter-to-Win sweepstakes. Entitled "Whisk, Shake & Stir The Perfect Puree," the sweepstakes will offer one lucky winner a week in Napa, California, during the renowned Culinary Institute of America's Worlds of Flavor Conference on November 1 - 3, 2012. The online sweepstakes is open to all and there is no purchase necessary to enter. Entrants simply sign up at the "Whisk, Shake, and Stir" contest page on the Perfect Puree website between April 2 and ...

ROCHESTER, Minn. -- Even as the rates of some cancers are falling, Mayo Clinic is seeing an alarming trend: the dramatic rise of skin cancer, especially among people under 40. According to a study by Mayo Clinic researchers published in the April issue of Mayo Clinic Proceedings, the incidence of melanoma has escalated, and young women are the hardest hit. "We anticipated we'd find rising rates, as other studies are suggesting, but we found an even higher incidence than the National Cancer Institute had reported using the Surveillance, Epidemiology and End Result ...

OAKLAND, Calif., (April 2, 2012) — Vaccines for measles were not associated with an increased risk of febrile seizures among 4-6 year olds during the six weeks after vaccination, according to a study by the Kaiser Permanente Vaccine Study Center that appears in the current issue of Pediatrics. Funded by the U.S. Centers for Disease Control, the study of 86,750 children follows an earlier study published in Pediatrics that showed one particular combination of measles-containing vaccine — the measles, mumps, rubella and chickenpox containing vaccination (or MMRV) — ...

Madeira Optical knows the challenges of 21st century medical practice. When they decided to moved to a new location at 7800 Laurel Ave. Madeira, OH 45243 on March 1st of 2012, Madeira Optical was faced with relocating a complex server and terminal practice management software package. Moving medical equipment and adding a state-of-the art exam lane were also on the agenda. So, Madeira Optical decided to convert from a locally maintained server to the iManaged Solutions virtual hosted environment. When Madeira Optical moved to 7800 Laurel Ave., all they have to do is connect ...

New research confirms that childhood onset temporal lobe epilepsy has a significant impact on brain aging. Study findings published in Epilepsia, a peer-reviewed journal of the International League Against Epilepsy (ILAE), show age-accelerated ventricular expansion outside the normal range in this patient population. According to the Centers for Disease Control and Prevention (CDC), epilepsy affects nearly 2 million Americans. Temporal lobe epilepsy is the most common form of partial epilepsy, with 60% of all patients having this form of the disease. Previous evidence ...

PHILADELPHIA -- Scientists may have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells, according to a study published in Cancer Research, a journal of the American Association for Cancer Research. "This is a major breakthrough in immunotherapy research because we were able to use purified cancer stem cells to generate a vaccine, which strengthened the potency of antibodies and T cells that selectively targeted cancer stem cells," said Qiao Li, Ph.D., a research assistant professor in the department of surgery ...