Imagine millions of cancer cells organized in thousands of small divots. Hit these cells with drugs and when some cells die, you have a candidate for a cancer drug. But a review published this week in the journal Expert Opinion on Drug Discovery argues that these 2D models in fact offer very little information about a potential drug's effects in the body and may often give researchers misleading results. "Up until the 1980s animal models were the standard for cancer drug discovery. However, with the increase in the number of compounds available for testing and the advent ...

The study, published in the journal Stem Cell, adds to our understanding of the role of stem and next stage progenitor cells in tissue regeneration and in the diagnosis and treatment of cancer. While stem cells are known to reside in organs such as the liver and pancreas, they are difficult to isolate. The new findings show that an antibody developed by the team can be used to capture the stem cells. Professor Pera, program leader for Stem Cells Australia and Chair of Stem Cell Sciences at the University of Melbourne, said the antibody was able to detect progenitor cells ...

BEIJING, CHINA (21 JULY 2012)—New research released today by the Rights and Resources Initiative (RRI) shows that despite more understanding, more resources, and policy recommendations, women continue to be largely marginalized and ignored or exploited in resource management processes throughout Asia – to the detriment of global climate and poverty reduction goals. This suite of analyses, released today at the International Workshop on Gender and Forest Tenure in Asia and Collective Forest Tenure Reform in China, demonstrate that exclusion and inequality on gender grounds ...

On the eve of the XIX International AIDS Conference in Washington, DC, the Drugs for Neglected Diseases initiative (DNDi), a not-for-profit research and development (R&D) organization, announces a new collaboration with Indian drug manufacturer Cipla to develop and produce an improved first-line antiretroviral (ARV) combination therapy specifically adapted to meet the treatment needs of infants and toddlers living with HIV/AIDS. Once delivered, this new pediatric ARV combination could help to accelerate the provision of care to the world's youngest children living with ...

Though public participation in scientific research has deep roots in the history of science, in the last few years it has taken off spectacularly from launch pads across the disciplines of science and education, fueled by advances in communications technology and a sea change in a scientific culture now eager to welcome outsiders as collaborators. Citizen science, crowd-sourced science, DIY research, volunteer monitoring, community participatory action research – the variety of banners flying over participatory science projects reflects the diversity of their origins, ...

Scientists at the University of Manchester have uncovered how the internal mechanisms in nerve cells wire the brain. The findings open up new avenues in the investigation of neurodegenerative diseases by analysing the cellular processes underlying these conditions. Dr Andreas Prokop and his team at the Faculty of Life Sciences have been studying the growth of axons, the thin cable-like extensions of nerve cells that wire the brain. If axons don't develop properly this can lead to birth disorders, mental and physical impairments and the gradual decay of brain capacity ...

VIDEO: When food is abundant, it seems that animals do not have to compete but dominant deer hinds still uphold rivalry and select the most nutritious food to maintain their status.... Click here for more information. Deer hinds (Cervus elaphus) have a hierarchical organisation system: the oldest and largest hold the most dominant positions. Therefore, a nutrient rich diet benefits the more dominant hinds, who have preferential access to the best food sources. This allows ...

Innovative research published by the National Physical Laboratory (NPL) and the University of Bradford uses laser microscopes to explore how stone tools were used in prehistory, and the process has helped streamline surface measurement techniques for modern manufacturers. The analysis of stone tools is a key factor in understanding early human life including social organisation and diet. Archaeologists at the University of Bradford hypothesised that reconstructing past activities was the best way to study what each tool was used for. They proposed to measure the surface ...

WASHINGTON -– U.S. Naval Research Laboratory scientists from the Radio Astrophysics and Sensing Section of the Remote Sensing Division in conjunction with radio astronomers and engineers from the National Radio Astronomy Observatory (NRAO), Socorro, N.M., achieve "First Light" image, May 1, 2012, at frequencies below 1-gigahertz (GHz) on the Jansky Very Large Array (JVLA). Through the combined expertise of NRL and NRAO scientists and engineers, a new, modern, wide-band receiver system has been developed and is being deployed onboard the JVLA to enable much more sensitive ...

Charlottesville, VA (July 20, 2012). Surgeons from the Instituto de Patologia da Coluna in Sao Paulo, Brazil have found that an innovative minimally invasive surgical procedure performed to achieve two-level axial lumbar interbody fusion produced immediate successful results, but within 2 years complications set in, making the procedure far less desirable. Findings of this study are reported in the article "Results and complications after 2-level axial lumbar interbody fusion with a minimum 2-year follow-up. Clinical article," by Luis Marchi, Leonardo Oliveira, Etevaldo ...

Philadelphia, PA, July 20, 2012 – A new program that trains emergency medical service technicians (EMS) to read electrocardiograms so that they can evaluate patients with chest pain, and expedite treatment for the severe heart condition known as ST-segment elevation myocardial infarction (STEMI), a serious form of heart attack, has excellent results and should become the standard of care, according to two studies published in the current issue of the Canadian Journal of Cardiology. "It's well established that morbidity and mortality in myocardial infarctions is directly ...

For many years, Titan's thick, methane- and nitrogen-rich atmosphere kept astronomers from seeing what lies beneath. Saturn's largest moon appeared through telescopes as a hazy orange orb, in contrast to other heavily cratered moons in the solar system. In 2004, the Cassini-Huygens spacecraft — a probe that flies by Titan as it orbits Saturn — penetrated Titan's haze, providing scientists with their first detailed images of the surface. Radar images revealed an icy terrain carved out over millions of years by rivers of liquid methane, similar to how rivers of water have ...

The numbers of people in Germany who are blind or visually impaired is going down. Robert P. Finger and his co-authors present their findings in the current edition of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2012; 109[27/28]: 484-9). The aging of the population would lead one to expect an increase in the numbers of blind and visually impaired—for in most cases the main reason for loss of vision is an age-related disease. Rates of macular degeneration, for example, and diabetes-related eye disease both go up with age. At the same time, however, the numbers ...

Researchers at the Institute for Agrobiotechnology (a mixed research centre set up by the Public University of Navarre, the CSIC-National Scientific Research Council, and the Government of Navarre) are designing, by means of laser application, nanostructured reliefs on surfaces so that they acquire antibacterial properties and are more resistant to the formation of bacterial biofilms. The authors of the research say that in the preliminary tests carried out so far with the bacteria Staphylococcus aureus a reduction in the region of 65-70% has been confirmed in the adhesion ...

(Boston) – A research study led by Boston University School of Medicine (BUSM) and the University of Exeter in the United Kingdom, in collaboration with a global consortium, has identified genetic markers that influence a protein involved in regulating estrogen and testosterone levels in the bloodstream. The results, published online in PLoS Genetics, also reveal that some of the genetic markers for this protein are near genes related to liver function, metabolism and type 2 diabetes, demonstrating an important genetic connection between the metabolic and reproductive systems ...

Cambridge, Mass – July 20, 2012 – A team led by Harvard computer scientists, including two undergraduate students, has developed a new tool that could lead to increased security and enhanced performance for commonly used web and mobile applications. Called RockSalt, the clever bit of code can verify that native computer programming languages comply with a particular security policy. Presented at the ACM Conference on Programming Language Design and Implementation (PLDI) in Beijing, in June, RockSalt was created by Greg Morrisett, Allen B. Cutting Professor of Computer ...

A research study led by the Peninsula College of Medicine and Dentistry, University of Exeter, and Boston University School of Medicine, in collaboration with a global consortium, has identified genetic markers that influence a protein involved in regulating oestrogen and testosterone levels in the bloodstream. The results, published online in PLoS Genetics, also reveal that some of the genetic markers for this protein are near genes related to liver function, metabolism and type 2 diabetes, demonstrating an important genetic connection between the metabolic and reproductive ...

A review article appearing in the July 20, 2012, issue of the journal Science describes groundbreaking discoveries that have emerged from the Relativistic Heavy Ion Collider (RHIC) at the U.S. Department of Energy's Brookhaven National Laboratory, synergies with the heavy-ion program at the Large Hadron Collider (LHC) in Europe, and the compelling questions that will drive this research forward on both sides of the Atlantic. With details that help enlighten our understanding of the hot nuclear matter that permeated the early universe, the article is a prelude to the latest ...

MAYWOOD, Ill. - Caregivers of stroke survivors are at risk for developing depression and complications from chronic stress, according to a study published by researchers at the Loyola University Chicago Marcella Niehoff School of Nursing (MNSON) in the latest issue of Biological Research for Nursing. Stroke is one of the leading causes of long-term disability, according to the Centers for Disease Control and Prevention. The National Family Caregiver Association reports that up to 80 percent of stroke survivors are cared for by family members who help them manage their ...

It may pay to invest, but it might be worth more to invest in companies that do not have political ties, says one University of Alberta researcher. Sadok El Ghoul, an associate professor at Campus Saint-Jean, and fellow researchers from the American University of Sharjah and the Olayan School of Business recently presented a paper at the annual conference of the International Journal of Accounting that explored the workings of politically connected firms. In a review of firms from 31 countries, they contend that firms that have some level of political connection, direct ...

UCLA researchers have developed a new transparent solar cell that is an advance toward giving windows in homes and other buildings the ability to generate electricity while still allowing people to see outside. Their study appears in the journal ACS Nano. The UCLA team describes a new kind of polymer solar cell (PSC) that produces energy by absorbing mainly infrared light, not visible light, making the cells nearly 70% transparent to the human eye. They made the device from a photoactive plastic that converts infrared light into an electrical current. "These results ...

Severe influenza doubles the odds that a person will develop Parkinson's disease later in life, according to University of British Columbia researchers. However, the opposite is true for people who contracted a typical case of red measles as children – they are 35 per cent less likely to develop Parkinson's, a nervous system disorder marked by slowness of movement, shaking, stiffness, and in the later stages, loss of balance. The findings by researchers at UBC's School of Population and Public Health and the Pacific Parkinson's Research Centre, published online this ...

A new study shows that a therapeutic intervention called Cognitively-Based Compassion Training (CBCT) appears to improve the mental and physical health of adolescents in foster care. CBCT is a tool that provides strategies for people to develop more compassionate attitudes toward themselves and others. It is well documented that children in foster care have a high prevalence of trauma in their lives. For many, circumstances that bring them into the foster care system are formidable -- sexual abuse, parental neglect, family violence, homelessness, and exposure to drugs. ...

The amount of structural damage that radiation causes in electronic materials at the atomic level may be at least ten times greater than previously thought. That is the surprising result of a new characterization method that uses a combination of lasers and acoustic waves to provide scientists with a capability tantamount to X-ray vision: It allows them to peer through solid materials to pinpoint the size and location of detects buried deep inside with unprecedented precision. The research, which was conducted by post-doctoral fellow Andrew Steigerwald under the supervision ...

NASA's Aqua satellite has been tracking the remnants of Tropical Depression Khanun, and infrared data revealed that it has moved over northeastern China where it is now dissipating. NASA's Aqua satellite passed over Khanun on July 18, 19 and 20 and tracked the northeastern progression of the tropical cyclone after it made landfall. On Wednesday, July 18 at 1659 UTC (12:59 p.m. EDT/U.S.), Tropical Depression Khanun's center was still in the Yellow Sea (west of South Korea). At that time, the Atmospheric Infrared Sounder (AIRS) instrument onboard NASA's Aqua satellite saw ...