The largest-ever study of its type into coronary heart disease, involving scientists from the University of Leicester, has uncovered 13 new genes that increase risk of heart attacks. Professor Nilesh Samani, British Heart Foundation Professor of Cardiology at the University of Leicester, based at Glenfield Hospital, who co-led the international research programme, called CARDIoGRAM, said most of genes identified were not previously known to be involved in the development of coronary heart disease, opening of the possibility of developing new treatments for this common ...

STANFORD, Calif. — Thirteen new gene regions have been convincingly linked to coronary atherosclerosis in a massive, new, international genetics study involving investigators from the Stanford University School of Medicine. The results of the study, to be published online March 6 in Nature Genetics, provide 13 vital new clues on the etiology of this disease, the most common cause of death worldwide. The study doubles the number of gene regions previously known to predispose people to this condition. Coronary atherosclerosis is the process by which plaque builds up in ...

Scientists have identified a single mutated gene that causes Hajdu-Cheney syndrome, a disorder of the bones causing progressive bone loss and osteoporosis (fragile bones). The study, published in Nature Genetics today, gives vital insight into possible causes of osteoporosis and highlights the gene as a potential target for treating the condition. There are only 50 reported cases of Hajdu-Cheney syndrome (HCS), of which severe osteoporosis is a main feature. Osteoporosis is a condition leading to reduction in bone strength and susceptibility to fractures. It is the most ...

Clinical research has greater societal impact over a 15-20 year timescale, while basic research has greater academic impact, according to a new study from RAND Europe and the Health Economics Research Group (HERG) at Brunel University. Project Retrosight was a multinational, four-year study that investigated the translation of basic biomedical and clinical cardiovascular and stroke research, and its impact on future work, policy, products and healthcare. The study was based on a rich source of material taken from 29 carefully selected case studies of grants for research ...

OTTAWA – March 6, 2011 – Insight into the complex biological mechanisms that cause heart disease has taken a major step forward with the discovery of 13 new genes that increase the risk of coronary artery disease (CAD). The influence of the majority of the new genes is independent of other established risk factors, suggesting new, unsuspected causes of CAD. The discovery more than doubles the number of genes known to affect the progression of heart disease. The research also verified the association of 10 previously identified genes to the population at large, meaning ...

Scientists from the Walter and Eliza Hall Institute have identified the key immune cell population responsible for regulating the body's immune response. The finding could have wide-ranging repercussions for the treatment of autoimmune diseases, organ transplantation and cancer, and change how the efficacy of newly developed drugs is measured. The discovery was made by Dr Erika Cretney, Dr Axel Kallies and Dr Stephen Nutt from the institute's Molecular Immunology division. It centred on a population of immune cells called regulatory T cells. Regulatory T cells (T-regs) ...

Japanese researchers have been immersing iron-based compounds in hot alcoholic beverages such as red wine, sake and shochu to induce superconductivity. Scientists from the National Institute for Materials Science, Japan, found that immersing pellets of an iron-based compound in heated alcoholic beverages for 24 hours greatly increase their superconducting ability. Iron-based compounds usually become superconductive after being exposed to air. This process however can take up to several months. This study demonstrated that superconductivity can be induced in just one ...

Microbicides can be used to protect against HIV, and other sexually transmitted diseases, either on their own or with the added protection of a condom. New research published by BioMed Central's open access journal AIDS Research and Therapy has investigated the use of lubricants, originally designed for vaginal application, and has developed and tested new, rectal specific, formulations. Unprotected sex is one of the major ways that HIV spreads through the population. However most research has focused on the production of vaginal microbicides which, due to differences ...

An international research collaboration has identified 13 new gene sites associated with the risk of coronary artery disease and validated 10 sites found in previous studies. Several of the novel sites discovered in the study, which is being published online in Nature Genetics, do not appear to relate to known risk factors, suggesting previously unsuspected mechanisms for cardiovascular disease. "We now have identifed 23 specific genetic 'letters' that appear to confer risk for myocardial infarction and other aspects of coronary artery disease," says Sekar Kathiresan, ...

In an improvement over open-heart surgery, cardiologists now use catheters to eliminate damaged heart tissue in certain patients, such as those with arrhythmias. But this, too, can be a long and painful procedure as many catheters, with different functions, need to be inserted sequentially. Now an interdisciplinary team including researchers from Northwestern University has developed one catheter that can do it all. This tool for cardiac ablation therapy has all necessary medical devices printed on a standard balloon catheter: a device for eliminating damaged tissue using ...

LA JOLLA, CA – "Pluripotent" stem cells—which have the potential to mature into almost any cell in the body—are being widely studied for their role in treating a vast array of human diseases and for generating cells and tissues for transplantation. Now, a team of Scripps Research Institute scientists has created a quality control diagnostic test that will make it much easier for researchers to determine whether their cell lines are normal pluripotent cells. The study was published in an online version of Nature Methods on March 6, 2011. "Many scientists are unhappy ...

(Santa Barbara, Calif.) –– Precision measurement in the world of nanoparticles has now become a possibility, thanks to scientists at UC Santa Barbara. The UCSB research team has developed a new instrument capable of detecting individual nanoparticles with diameters as small as a few tens of nanometers. The study will be published on line this week by Nature Nanotechnology, and appear in the April print issue of the journal. "This device opens up a wide range of potential applications in nanoparticle analysis," said Jean-Luc Fraikin, the lead author on the study. ...

About two-thirds of baby boomers (67%) and generation X'ers (63%) and half of generation Z'ers (50%) and generation Y'ers (49%) watch television every night or almost every night within the hour before going to sleep. "Artificial light exposure between dusk and the time we go to bed at night suppresses release of the sleep-promoting hormone melatonin, enhances alertness and shifts circadian rhythms to a later hour—making it more difficult to fall asleep," says Charles Czeisler, PhD, MD, Harvard Medical School and Brigham and Women's Hospital. "This study reveals that ...

BrianGeary.com will celebrate 'Fat Tuesday' with a 'Phat Newsday' on March 8th, 2011. The tradition of Mardi Gras will be celebrated by allowing clients to fatten their wallets with a 50% savings on news releases. Long-time and first-time clients are invited to take advantage of this savings before it is swept away at midnight (Pacific Standard Time). "It's easy to get so caught up in Carnival," explains spokesman Brian Geary, "that businesses postpone their news announcements until the festivities are over." This often contributes to an anemic pipeline and subsequent ...

For those who are asking for my housing market predictions want me to reassure them that their homes will soon be worth again what they were worth in recent past years. Unfortunately, when it comes to making housing market predictions, what I'm hearing from the National Association of Realtor's is that there are no easy answers Short sales & Loan modifications are still a painful process; Foreclosures are going to continue at these levels for awhile & Unemployment level are still on an average high. Over all this is still the best time to buy if you're able to considering ...

National Juris Solutions has developed state of the art legal software that provides practice management, time/billing, and accounting - all designed specifically for law firms. With one program, you'll meet all your case management, document handling, messaging, time recording, legal billing, and law firm accounting requirements. Duplication of data entry is eliminated and entry errors are significantly reduced, dramatically lowering your malpractice risks and giving you more time to spend on billable tasks. No need for a separate calendaring, contact, case, and legal ...

Like the fast food industry leader posting its 1 millionth hamburger, CrimePAY$ is announcing its 3 millionth publication of Local MugSHOTS sold. The $1 tabloid contains mug shots, wanted fugitives, sex offenders, missing persons and inmate status for criminals in the local territory in which the publication is sold. Each local distributor works closely with law enforcement agencies; the paper targeted to their local area in hopes someone may recognize a face, collect a reward, find a missing person or solve a crime. In 2001 Max Cannon was publishing a free "waiting ...

The Old Schoolhouse Magazine, LLC Boasting an increase of 74 percent since 1999 and now in its fourth decade, the modern homeschooling movement is gaining followers at an astonishing rate. Homeschool, for the most part an unfamiliar term only thirty years ago when the movement began, has become a household word. U.S. educators from both public and private school arenas are very much aware of the movement and its impact, and today popular media frequently make mention of homeschoolers,from characters in CBS's #1 show, NCIS, to homeschool grads who appear as contestants on ...

The Reference Store sells "Virtual" job references to the public. Men and women that face barriers to employment may use a reference service to help minimize or even eliminate these barriers. When its clients apply for jobs, they list one of The Reference Store's "Virtual" companies as their current or former employer. These unsuspecting employers then call these virtual companies and speak to a live virtual human resource manager. http://TheReferenceStore.com There is no clear profile as to who might use a virtual reference service. Clients range from business ...

On this week's episode of parenthood Adam and Kristina (parents) try to explain Asperger's to their son Max. This issue was forced by Max overhearing a conversation recently where it was mentioned that he had Aspergers. According to Dave Angel (founder of The Parenting Aspergers Community) âEURœThis is a very real life situation for many parents, who often struggle to know what to say, how to say it, and when to do so.âEUR What to say - All children with Aspergers need to know of their diagnosis, so they can begin to understand and make sense of the various things ...

PGM announced today their commitment to enhance the quality of medical billing services it provides to clients. A longtime advocate of Remote Access Technologies (point-to-point T1, direct VPN) PGM announced a new strategy with the introduction of several new servers running on Virtual platforms. One of the very best examples of how cloud computing is used to benefit PGM clients is it ability to deliver remote desktops to a large number of users. A desktop delivered from the cloud (as a Service) can provide immediate global network access from the variety of devices being ...

Savvy & Active Sportswear Shoppers can certainly find great deals Ready for this year's Sporting Season activities Popular coupon code site VoucherBuddy.co.uk has released some top deals for the hottest sportswear and equipment from a lot of the country's most recognized retailers. Competitive sports are to be high on the agenda this particular season primarily due to the high profile events on the agenda for next year, the major one indeed being the 2012 Olympic Games together with the recent successes during the Cricket season. Here are several of the prime promotions ...

'Ferry To France' info has recently been added at TravelFranceForFree.com, a website that shows travelers how to travel to France for free. Garry P. Thompson, a member of TravelFranceForFree.com, has shared his wonderful experience of traveling to France. "It was my first day in Paris," says Thompson of TravelFranceForFree.com, a site that helps travelers get 85% discounts on any plane flight to France. "When I arrived in the morning, I immediately grazed on French food. I ate Pims jaffa cakes, baguette with ham and salad, berry tart, rhubard and apple tart, caramel ...

Hulafrog.com, a parent's guide to life with kids in the greater Red Bank area of NJ, is helping local moms find fun, unique and educational summer camps and programs for their kids. Each day in March editors will highlight One Cool Summer Camp in Monmouth County, New Jersey. And Today's Summer Camp Pick is: Silton Swim School's Swim Camp in Manasquan, NJ Silton Swim School If you're looking for a serious swim camp, look no further. Silton Swim runs for two weeks, for three hours a day. ( Kids get three half hour swim lessons interspersed with other activities ...

A family run restaurant, George Tompras and his sister Rnee Bogdanos spend many of their waking hours at Kreis'. Their mother, Angie, also assists in the business, doing much of the office work. "Working together every day is great," says Bogdanos. "We were raised in the business and we care about each other. Never change a winning combination." Tompras learned his craft at the Culinary Institute of America in Hyde Park, N.Y., studying under the finest master chefs in the world. "Cooking is an art; I have to feel it and play with it before I get the finished product," ...