Scientists have confirmed the feasibility of using a new drug delivery system — the basis for a battery-powered skin patch — to administer medication that shows promise for treating peripheral artery disease (PAD) and healing stubborn skin ulcers and burns. The needle-free delivery of the medication, which cannot be given by mouth and can have side effects when injected, is reported in the ACS journal, Molecular Pharmaceutics. Yogeshvar Kalia and colleagues explain that the medication consists of fibroblast growth factors (FGFs), proteins that have shown promise for treating ...

Manufacturers of everything from smart phones to SUVs are starting to design products not just for the customer's use, but also for an often troublesome life after the consumer, according to an article in Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. The cover story by C&EN Senior Editor Melody M. Bomgardner focuses on product stewardship, an increasingly popular approach to environmental protection in which manufacturers, retailers, users, and disposers share responsibility for reducing the environmental impacts of products. That means, for instance, ...

The European Respiratory Journal is today (04 August 2011) publishing the updated guidelines of the World Health Organization (WHO) that aim to help manage drug-resistant tuberculosis (TB). The new document 'The WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update' focuses on priority areas for healthcare professionals in the diagnosis, treatment and care of drug-resistant TB. It also calls for more research to guide the management of the condition. TB is a pandemic that killed 1.7 million people in 2009, excluding those who died ...

U.S. production of ethanol for fuel has been rising quickly, topping 13 billion gallons in 2010. With the usual rail, truck and barge transport methods under potential strain, existing gas pipelines might be an efficient alternative for moving this renewable fuel around the country. But researchers at the National Institute of Standards and Technology (NIST) caution that ethanol, and especially the bacteria sometimes found in it, can dramatically degrade pipelines. At a conference this week,* NIST researchers presented new experimental evidence that bacteria that feed ...

Gram for gram, novel carbon nanofiber-filled coatings devised by researchers from the National Institute of Standards and Technology (NIST) and Texas A&M University outperformed conventional flame retardants used in the polyurethane foam of upholstered furniture and mattresses by at least 160 percent and perhaps by as much as 1,130 percent. The impressive test results, reported in the journal Polymer,* suggest that significant fire-safety advantages can be gained by coating polyurethane foam (PUF) with a club-sandwich-like arrangement of thin layers containing carbon ...

DNA, a molecule famous for storing the genetic blueprints for all living things, can do other things as well. In a new paper,* researchers at the National Institute of Standards and Technology (NIST) describe how tailored single strands of DNA can be used to purify the highly desired "armchair" form of carbon nanotubes. Armchair-form single wall carbon nanotubes are needed to make "quantum wires" for low-loss, long distance electricity transmission and wiring. Single-wall carbon nanotubes are usually about a nanometer in diameter, but they can be millions of nanometers ...

Scheduling umpire crews in Major League Baseball (MLB) can be a daunting task. However, Tallys Yunes, assistant professor of management science at the University of Miami School of Business Administration and his collaborators have created a novel solution. The team developed an efficient method to generate high-quality schedules for the MLB. The study is titled "Scheduling Major League Baseball Umpires and the Traveling Umpire Problem" published online ahead of print by the journal Interfaces, a popular outlet for practitioners in the field of Operations Research. ...

Research led by the Warwick Crop Centre in the School of Life Sciences at the University of Warwick has developed a unique collection of information about the disease resistance of 96 of the world's onion varieties. It will be a crucial resource for commercial growers and seed producers trying to combat one of the most difficult diseases affecting onion crops. This work may also have benefits in terms of and reduced fertiliser consumption and enhanced drought tolerance. The work on onions in this research funded by Defra (The Department for Environment, Food and Rural ...

Researchers at Emory and Georgia Tech have developed a method for predicting which areas of the coronary arteries will develop more atherosclerotic plaque over time, based on intracoronary ultrasound and blood flow measurements. The method could help doctors identify "vulnerable plaque," unstable plaque that is likely to cause a heart attack or stroke. It involves calculating shear stress, or how hard the blood tugs on the walls of the arteries, based on the geometry of the arteries and how fast the blood is moving. The results were posted online this week in the journal ...

New research raises troubling concerns about the use of aggressive drug therapies to treat a wide range of diseases such as MRSA, C. difficile, malaria, and even cancer. "The universally accepted strategy of aggressive medication to kill all targeted disease pathogens has the problematic consequence of giving any drug-resistant disease pathogens that are present the greatest possible evolutionary advantage," says Troy Day, one of the paper's co-authors and Canada Research Chair in Mathematical Biology at Queen's. The researchers note that while the first aim of a drug ...

Measuring the levels of a natural body chemical may allow doctors to reduce the duration of antibiotic use and improve the health outcomes of critically ill patients. "Infection is a common and expensive complication of critical illness and we're trying to find ways to improve the outcomes of sick, elderly patients and, at the same time, reduce health care costs," says Daren Heyland, a professor of Medicine at Queen's, director of the Clinical Evaluation Research Unit at Kingston General Hospital, and scientific director of the Technology Evaluation in the Elderly Network. Prolonged ...

New Rochelle, NY, August 3, 2011—Positive activity interventions (PAIs) offer a safe, low-cost, and self-administered approach to managing depression and may offer hope to individuals with depressive disorders who do not respond or have access to adequate medical therapy, according to a comprehensive review article in The Journal of Alternative and Complementary Medicine, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article, "Delivering Happiness: Translating Positive Psychology Intervention Research for Treating Major and Minor Depressive Disorders" ...

In the months after the April 16, 2007, shootings at Virginia Tech, two professors administered a survey to assess posttraumatic stress among students. The findings have been published in the July 18, 2011 issue of the Journal of Psychological Trauma: Theory, Research, Practice, and Policy, published by the American Psychological Association. According to researchers Michael Hughes, professor of sociology in the College of Liberal Arts and Human Sciences, and Russell T. Jones, professor of psychology in the College of Science, 15.4 percent of Virginia Tech students experienced ...

When we make plans that will change a natural environment — whether it's building a new shopping mall or planting a new forest — surveyors dutifully assess the environmental risks to plant and animal life in the region. But what's environmentally good for one area may be an environmental disaster for an adjacent one, a Tel Aviv University researcher cautions. When displaced by these projects, indigenous species migrate to neighboring habitats, says Guilad Friedemann, a PhD student at TAU's Department of Zoology in the George S. Wise Faculty of Life Sciences. This has ...

People spend 3 billion hours a week playing videogames but little is known scientifically about why they are actually fun in the first place. The vast majority of research into videogames has concentrated on the possible harmful effects of playing videogames, ignoring the simple question of why people actually want to play them. But new research led by scientists at the University of Essex sheds some light on the appeal of videogames and why millions of people around the world find playing them so much fun. The study investigated the idea that many people enjoy playing ...

Many medical devices, ranging from artificial hip joints to dentures and catheters, become sites for unwelcome guests -- complex communities of microbial pathogens called biofilms that are resistant to the human immune system and antibiotics, thus proving a serious threat to human health. However, researchers may have a new way of looking at biofilms, thanks to a study conducted by University of Iowa biologist David Soll and his colleagues published in the Aug. 2 issue of the online, open access journal PLoS Biology. Previously, researchers believed that each pathogen ...

This press release is available in Spanish. Rising carbon dioxide (CO2) levels can reverse the drying effects of predicted higher temperatures on semi-arid rangelands, according to a study published today in the scientific journal Nature by a team of U.S. Department of Agriculture (USDA) and university scientists. Warmer temperatures increase water loss to the atmosphere, leading to drier soils. In contrast, higher CO2 levels cause leaf stomatal pores to partly close, lessening the amount of water vapor that escapes and the amount of water plants draw from soil. ...

JACKSONVILLE, Fla. — A Mayo Clinic orthopedic surgeon suspects that the nagging pain and inflammation that women can experience in their knees may be different from what men encounter, and she has been chosen to lead a novel U.S.-Canadian study to explore the question. The Society for Women's Health Research (SWHR) and its Interdisciplinary Studies in Sex-Differences (ISIS) Network on Musculoskeletal Health has awarded a group of researchers a $127,000 grant to lead a pilot project to understand whether biological differences between men and women affect the incidence and ...

RICHLAND, Wash. – Today, farming often involves transporting crops long distances so consumers from Maine to California can enjoy Midwest corn, Northwest cherries and other produce when they are out of season locally. But it isn't just the fossil fuel needed to move food that contributes to agriculture's carbon footprint. New research published in the journal Biogeosciences provides a detailed account of how carbon naturally flows into and out of crops themselves as they grow, are harvested and are then eaten far from where they're grown. The paper shows how regions that ...

Cambridge, Mass. - August 3, 2011 - Materials scientists and applied physicists collaborating at Harvard's School of Engineering and Applied Sciences (SEAS) have invented a new device that can instantly identify an unknown liquid. The device, which fits in the palm of a hand and requires no power source, exploits the chemical and optical properties of precisely nanostructured materials to distinguish liquids by their surface tension. The finding, published in the Journal of the American Chemical Society (JACS), offers a cheap, fast, and portable way to perform quality ...

Arriving at a rapid and accurate diagnosis is critical during flu outbreaks, but until now, physicians and public health officials have had to choose between a highly accurate yet time-consuming test or a rapid but error-prone test. A new detection method developed at the University of Georgia and detailed in the August edition of the journal Analyst, however, offers the best of both worlds. By coating gold nanoparticles with antibodies that bind to specific strains of the flu virus and then measuring how the particles scatter laser light, the technology can detect influenza ...

New Rochelle, NY, August 3, 2011—A move toward smaller and smaller sample sizes is leading to a new generation of mass spectrometry instrumentation, reports Genetic Engineering & Biotechnology News (GEN). From a specific application point of view, novel nanoflow separation methodologies are ramping up the speed and precision with which scientists are able to validate biomarkers, according to the August issue of GEN (www.genengnews.com/gen-articles/nanoliter-volumes-push-ms-to-new-lows/3741). "Basing biomarker validation on more sophisticated mass spec tools could help ...

RICHMOND, Va. (Aug. 3, 2011) – A single compound with dual function – the ability to deliver a diagnostic and therapeutic agent – may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to findings from Virginia Commonwealth University and Virginia Tech. Glioblastomas are the most common and aggressive brain tumor in humans, with a high rate of relapse. These tumor cells often extend beyond the well-defined tumor margins making it extremely difficult for clinicians and radiologists to visualize with current imaging techniques. Researchers ...

Anyone who follows science has read enthusiastic stories about medical breakthroughs that include the standard disclaimer that the results were obtained in mice and might not carry over to humans. Much later, there might be reports that a drug has been abandoned because clinical trials turned up unforeseen side effects or responses in humans. Given the delay, most readers probably don't connect the initial success and the eventual failure. But Igor Efimov, PhD, a biomedical engineer at Washington University in St. Louis who studies the biophysical and physiological ...

Public awareness about the role and interaction of microbes is essential for promoting human and environmental health, say scientists presenting research at the Ecological Society of America's (ESA) 96th Annual Meeting from August 7-12, 2011. Researchers shed light on the healthy microbes of the human body and other research on microbial and disease ecology to be presented at ESA's 2011 meeting in Austin, Texas. Bellybutton microbiomes Human skin is teeming with microbes—communities of bacteria, many of which are harmless, live alongside the more infamous microbes sometimes ...