Contact Information:

Media Contact

PLOS Medicine press office
medicinepress@plos.org

http://www.plos.org




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Pregnant mothers influence fetal growth through genetics rather than maternal height


2015-08-18
(Press-News.org) Transmitted genes, rather than growth limitations caused by actual differences in maternal height, are the key means by which a mother's height influences her baby's birth weight and length, according to a new study published this week in PLOS Medicine. The report from Ge Zhang and Louis Muglia of Cincinnati Children's Hospital Medical Center and the March of Dimes Prematurity Research Center Ohio Collaborative and colleagues does, however, suggest that maternal height can directly mediate duration of gestation.

Compared to tall mothers, short mothers tend to deliver their babies at earlier gestational ages, with lower birth weights and lengths. To understand whether these associations were causative, Zhang and colleagues analyzed infant size and genetic data, including single nucleotide polymorphisms (SNPs), which mark differences between individuals in genes related to specific characteristics (such as height) obtained from 3,485 Nordic mother/baby pairs. The researchers conducted a type of analysis called Mendelian Randomization, which probed for associations between genetically predicted maternal height and duration of gestation, newborn length, and newborn weight. Birth length and weight were significantly associated with the maternal transmitted height-associated SNPs (p-values 8.08E-05 and 4.02E-12), but the associations with the non-transmitted SNPs were far less significant (p-values 0.0405 and 0.404). However, gestational age was significantly but modestly associated with the maternal non-transmitted SNPs (p-value 0.0424).

The use of the mother's non-transmitted alleles (specific variants of genes) in causal inference is an important advantage of the study. Because non-transmitted alleles will influence fetal growth exclusively via the characteristics of the mother, while transmitted alleles act within both mother and fetus, the study of non-transmitted alleles is central to teasing out the direct role of maternal height in fetal growth. However, confirmation in additional cohorts is warranted, as the study participants here may not have been broadly representative of their populations. Additionally, these findings may not be generalizable to low- and middle- income countries, where nutrition-related factors may substantially restrict growth. The authors state, "[d]isentangling these different mechanisms underlying the association between maternal height and pregnancy outcomes is important, as the knowledge may enhance our understanding of the genetic and environmental etiology of these important pregnancy outcomes and how they impact health."

INFORMATION:

Research Article

Funding: This work was supported by grants from the March of Dimes (22-FY14-470, National Institutes of Health, Cincinnati Children's Hospital Medical Center, Fifth Third Foundation, Norwegian Research Council, Swedish Medical Society, Jane and Dan Olsson Foundations, Swedish Government Grants to Researchers in the Public Health Service, European Community's Seventh Framework Programme, ENGAGE Consortium, the European Research Council, the University of Bergen, Helse Vest, and the KG Jebsen Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

Citation: Zhang G, Bacelis J, Lengyel C, Teramo K, Hallman M, Helgeland Ø, et al. (2015) Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis. PLoS Med 12(8): e1001865. doi:10.1371/journal.pmed.1001865

Author Affiliations:

Human Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States of America Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland PEDEGO Research Center, University of Oulu and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway Department of Pediatrics, Haukeland University Hospital, Bergen, Norway Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001865

Contact:

Dr Ge Zhang: Ge.Zhang@cchmc.org Dr. Louis Muglia: Louis.Muglia@cchmc.orgs


ELSE PRESS RELEASES FROM THIS DATE:

Shorter women have shorter pregnancies

2015-08-18
WHITE PLAINS, N.Y., Aug. 18, 2015 - Shorter mothers have shorter pregnancies, smaller babies, and higher risk for a preterm birth. New research has found that a mother's height directly influences her risk for preterm birth. Investigators at the March of Dimes Prematurity Research Center Ohio Collaborative looked at 3,485 Nordic women and their babies, and found that maternal height, which is determined by genetic factors, helped shape the fetal environment, influencing the length of pregnancy and frequency of prematurity. In contrast, birth length and birth weight ...

Hot chilli may unlock a new treatment for obesity

2015-08-18
University of Adelaide researchers have discovered a high-fat diet may impair important receptors located in the stomach that signal fullness. Published today* in the journal PLOS ONE, researchers from the University's Centre for Nutrition and Gastrointestinal Diseases (based at the South Australian Health and Medical Research Institute) investigated the association between hot chilli pepper receptors (TRPV1) in the stomach and the feeling of fullness, in laboratory studies. "The stomach stretches when it is full, which activates nerves in the stomach to tell the ...

The Tree of Life may be a bush

2015-08-18
New species evolve whenever a lineage splits off into several. Because of this, the kinship between species is often described in terms of a 'tree of life', where every branch constitutes a species. Now, researchers at Uppsala University have found that evolution is more complex than this model would have it, and that the tree is actually more akin to a bush. Less than a year ago, a consortium of some hundred researchers reported that the relationship between all major bird clades had been mapped out by analysing the complete genome of around 50 bird species. This included ...

Complete resection of high-grade brain cancer yields better survival in children -- especially girls

2015-08-18
August 18, 2015 - For children with aggressive brain cancers called high-grade gliomas (HGG), the chances of survival are improved when surgery is successful in eliminating all visible cancer, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Wolters Kluwer. In addition to showing better survival with gross total resection (GTR) for children with HGG, the results suggest that this survival benefit is greater in girls compared to boys with HGG. The study provides "compelling evidence ...

Women choose contraception based on relationships not just pregnancy desires

2015-08-18
Women's contraceptive choices are more often driven by current relationships and sexual activity than by long-term pregnancy intentions, according to Penn State College of Medicine researchers. Cynthia H. Chuang, associate professor of medicine and public health sciences and Carol S. Weisman, Distinguished Professor of Public Health Sciences and Obstetrics and Gynecology and colleagues surveyed nearly 1,000 women in Pennsylvania, all with private health insurance covering prescription contraception, on their contraception use -- including prescription and over-the-counter ...

Cell phones help track of flu on campus

2015-08-18
DURHAM, N.C. -- New methods for analyzing personal health and lifestyle data captured through wearable devices or smartphone apps can help identify college students at risk of catching the flu, say researchers at Duke University and the University of North Carolina-Chapel Hill. With help from a mobile app that monitors who students interact with and when, epidemiologist Allison Aiello of UNC and statistician Katherine Heller of Duke have developed a model that enables them to predict the spread of influenza from one person to the next over time. Unlike most infection ...

Engineers identify how to keep surfaces dry underwater

2015-08-18
Imagine staying dry underwater for months. Now Northwestern University engineers have examined a wide variety of surfaces that can do just that -- and, better yet, they know why. The research team is the first to identify the ideal "roughness" needed in the texture of a surface to keep it dry for a long period of time when submerged in water. The valleys in the surface roughness typically need to be less than one micron in width, the researchers found. That's really small -- less than one millionth of a meter -- but these nanoscopic valleys have macroscopic impact. Understanding ...

UC Davis team finds early inflammatory response paralyzes T cells

2015-08-18
(SACRAMENTO, Calif.) -- In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help orchestrate the body's response to pathogens and other invaders. This mechanism may act as a firewall, shutting down the immune response before it gets out of hand. However, from a clinical standpoint, this discovery could lead to more effective cancer immunotherapies, better drugs for autoimmune conditions and new ways to ...

How an emerging anti-resistance antibiotic targets the bacterial membrane

How an emerging anti-resistance antibiotic targets the bacterial membrane
2015-08-18
Scientists are planning for a future in which superbugs gain the upper hand against our current arsenal of antibiotics. One emerging class of drug candidates, called AMLPs (antimicrobial lipopeptides), shows promise, and an August 18 study in the Biophysical Journal explains why: they selectively kill bacterial cells, while sparing mammalian host cells, by clumping together into microscopic balls that stick to the bacterial membrane--a complex structure that will be slower to mutate and thus resist drugs. "The pressing need for novel antibiotics against resistant strains ...

Cascadia initiative to monitor Northwest Pacific seismic risks

Cascadia initiative to monitor Northwest Pacific seismic risks
2015-08-18
SAN FRANCISCO--Early data coming in from a massive, four-year deployment of seismometers onshore and offshore in the Pacific Northwest are giving scientists a clearer picture of the Cascadia subduction zone, a region with a past and potential future of devastating "megathrust" earthquakes. The preliminary results from the Cascadia Initiative include a report of previously undetected, small earthquakes offshore, and seismic imaging that reveals new offshore structures at the subduction zone. The reports, published as a focus section in the September-October 2015 issue ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Pregnant mothers influence fetal growth through genetics rather than maternal height
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.