PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Paracetamol improves exercise endurance in the heat

2013-09-20
(Press-News.org) Paracetamol has a significant effect on exercise performance and the body's ability to cope with the thermal challenge of exercise in the heat, shows a study published today [20 September] in Experimental Physiology.

The research team have previously shown that paracetamol can improve endurance performance through a reduction in exercise-induced pain. This study suggests, for the first time, that paracetamol can also improve the length of time someone can exercise for in hot conditions. The data suggests that this is achieved by reducing the body's temperature during exercise, which subsequently improves their tolerance to exercise in the heat.

To perform the research, a group of healthy, male participants ingested single doses of paracetamol or a placebo, before cycling at a fixed intensity for as long as they could in hot conditions. During the exercise, measures of core and skin temperature were recorded alongside the participants' perception of the heat.

As the study was performed in humans, with a common over-the counter drug, the implications are far reaching.

Dr Lex Mauger, who led the study at The University of Kent's School of Sport and Exercise Sciences, explains:

"Firstly, consideration by the World Anti-Doping Agency (WADA) and local anti-doping authorities should be made about the use of non-steroidal anti-inflammatory drugs (NSAIDs) in sport – on both health and performance grounds. Secondly, the utility of paracetamol as a first-response drug to exertional heat illness should be investigated."

The research gives a new insight into the effects of paracetamol on endurance exercise, and further studies hope to determine by which mechanisms this takes place.

Dr Mauger says: "Whilst we have found that paracetamol improves the time someone can exercise in the heat, and that this occurs alongside a reduced body temperature, we did not measure the specific mechanisms by which this may have occurred. It is important now to try and isolate how paracetamol reduced participants' body temperature during exercise."

### END


ELSE PRESS RELEASES FROM THIS DATE:

'Cascade of events' caused sudden explosion of animal life

2013-09-20
The explosion of animal life on Earth around 520 million years ago was the result of a combination of interlinked factors rather than a single underlying cause, according to a new study. Dozens of individual theories have been put forward over the past few decades for this rapid diversification of animal species in the early Cambrian period of geological time. But a paper by Professor Paul Smith of Oxford University and Professor David Harper of Durham University suggests a more holistic approach is required to discover the reasons behind what has become known as the ...

UI researchers: Bracing is effective in adolescents with idiopathic scoliosis

2013-09-20
A multi-center study led by University of Iowa researchers to determine whether wearing back braces would prevent the need for spinal correction surgery in children with adolescent idiopathic scoliosis (AIS) was cut short when early results were overwhelmingly in favor of bracing. The study was published in the New England Journal of Medicine today (Sept. 19. 2013). Stuart Weinstein, MD, Ignacio V. Ponseti Chair and Professor of Orthopaedic Surgery and Professor of Pediatrics at University of Iowa Children's Hospital, and Lori Dolan, PhD, a research scientist in The Department ...

New test enables early diagnosis of liver cancer

2013-09-20
Augusta, Ga. – Researchers have found a way to make early liver cancer show its true colors. They have developed a test that will help pathologists clearly distinguish early liver cancer cells from nearly identical normal liver cells by giving them a distinctive red-brown hue. The inability to definitively tell the difference often means the disease is detected late when treatment options are less effective, said Dr. Ravindra Kolhe, pathologist and Medical Director of the Georgia Esoteric, Molecular Labs, LLC, at the Medical College of Georgia at Georgia Regents University. ...

New models of drug-resistant breast cancer hint at better treatments

2013-09-20
Breast cancer that spreads to other organs is extremely difficult to treat. Doctors can buy patients time, but a cure remains elusive. Now, researchers at Washington University School of Medicine in St. Louis have shown that human breast tumors transplanted into mice are excellent models of metastatic cancer and could be valuable tools in the search for better treatments. According to new research published Sept. 19 in Cell Reports, these transplanted tumors maintain the genetic errors that caused the original cancer, even though they are growing in mice. As such, mice ...

Cutting off all points of escape for melanoma cells

2013-09-20
Despite the success of recent approved therapeutics to treat advanced melanoma, metastatic cancer cells inevitably evolve resistance to drugs. In the journal Cell Reports, a team of researchers based at The Wistar Institute, report on the mechanics by which melanoma can evolve resistance to a powerful combination of drugs—BRAF and MEK inhibitors. They found that resistant melanomas acquired a mutation in the MEK2 gene and multiple copies of the mutant BRAF oncogene, simultaneously decreasing the sensitivity to both drug targets. Their findings also uncovered a new potential ...

Protein 'motif' crucial to telomerase activity, Wistar researchers say

2013-09-20
It is difficult to underestimate the importance of telomerase, an enzyme that is the hallmark of both aging and the uncontrolled cell division associated with cancer. In an effort to understand and control telomerase activity, researchers at The Wistar Institute have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase. Altering this motif disrupts telomerase function, they found, a fact that they believe will help them in their efforts to identify inhibitors of telomerase with potential cancer therapeutic properties. Their findings ...

Worm research: Right combination of sugars regulates brain development

2013-09-20
If the development of our nervous system is disturbed, we risk developing serious neurological diseases, impairing our sensory systems, movement control or cognitive functions. This is true for all organisms with a well-developed nervous system, from man to worm. New research from BRIC, University of Copenhagen reveals how a tiny molecule called mir-79 regulates neural development in roundworms. The molecule is required for correct migration of specific nerve cells during development and malfunction causes defects in the nervous system of the worm. The research has just ...

Cleveland Clinic study shows long-term effects of bariatric surgery in patients with Type 2 diabetes

2013-09-20
Thursday, September 19, 2013, Cleveland: Overweight patients with type 2 diabetes continue to experience the benefits of bariatric surgery up to nine years after the procedure, according to new research from Cleveland Clinic's Bariatric & Metabolic Institute, published online today in the journal, Annals of Surgery. Prior research has shown that bariatric surgery effectively treats diabetes and reduces cardiovascular risk factors, but few studies have reported the long-term metabolic effects of bariatric surgery. This trial shows that obese patients with type 2 diabetes ...

Older adults live longer with a few extra pounds -- if they don't add more

2013-09-20
COLUMBUS, Ohio -- Some overweight older adults don't need to lose weight to extend their lives, but they could risk an earlier death if they pack on more pounds. In fact, the nationwide study found that people who were slightly overweight in their 50s but kept their weight relatively stable were the most likely to survive over the next 16 years. They had better survival rates than even normal-weight individuals whose weight increased slightly, but stayed within the normal range. On the other hand, those who started out as very obese in their 50s and whose weight continued ...

Got calcium? Mineral is key to restoring acid rain-damaged forests

2013-09-20
Berkeley — Calcium can do much more than strengthen bones. The mineral is a critical nutrient for healthy tree growth, and new research shows that adding it to the soil helps reverse the decades-long decline of forests ailing from the effects of acid rain. The paper, published today (Thursday, Sept. 19), in the journal Environmental Science and Technology (EST) Letters, and led by John Battles, professor of forest ecology at the University of California, Berkeley, also presents strong evidence that acid rain impairs forest health. The paper reports on 15 years of ...

LAST 30 PRESS RELEASES:

New tablet shows promise for the control and elimination of intestinal worms

Project to redesign clinical trials for neurologic conditions for underserved populations funded with $2.9M grant to UTHealth Houston

Depression – discovering faster which treatment will work best for which individual

Breakthrough study reveals unexpected cause of winter ozone pollution

nTIDE January 2025 Jobs Report: Encouraging signs in disability employment: A slow but positive trajectory

Generative AI: Uncovering its environmental and social costs

Lower access to air conditioning may increase need for emergency care for wildfire smoke exposure

Dangerous bacterial biofilms have a natural enemy

Food study launched examining bone health of women 60 years and older

CDC awards $1.25M to engineers retooling mine production and safety

Using AI to uncover hospital patients’ long COVID care needs

$1.9M NIH grant will allow researchers to explore how copper kills bacteria

New fossil discovery sheds light on the early evolution of animal nervous systems

A battle of rafts: How molecular dynamics in CAR T cells explain their cancer-killing behavior

Study shows how plant roots access deeper soils in search of water

Study reveals cost differences between Medicare Advantage and traditional Medicare patients in cancer drugs

‘What is that?’ UCalgary scientists explain white patch that appears near northern lights

How many children use Tik Tok against the rules? Most, study finds

Scientists find out why aphasia patients lose the ability to talk about the past and future

Tickling the nerves: Why crime content is popular

Intelligent fight: AI enhances cervical cancer detection

Breakthrough study reveals the secrets behind cordierite’s anomalous thermal expansion

Patient-reported influence of sociopolitical issues on post-Dobbs vasectomy decisions

Radon exposure and gestational diabetes

EMBARGOED UNTIL 1600 GMT, FRIDAY 10 JANUARY 2025: Northumbria space physicist honoured by Royal Astronomical Society

Medicare rules may reduce prescription steering

Red light linked to lowered risk of blood clots

Menarini Group and Insilico Medicine enter a second exclusive global license agreement for an AI discovered preclinical asset targeting high unmet needs in oncology

Climate fee on food could effectively cut greenhouse gas emissions in agriculture while ensuring a social balance

Harnessing microwave flow reaction to convert biomass into useful sugars

[Press-News.org] Paracetamol improves exercise endurance in the heat