Delaying gratification, when the reward is under our noses

(Press-News.org) Contact information: PLOS Biology
biologypress@plos.org
Public Library of Science
Delaying gratification, when the reward is under our noses How can some people resist the attraction of immediate pleasures and pursue long-term goals, while others easily succumb and compromise their ultimate expectations? A recent study led by researchers at the Brain and Spine Institute in Paris have found that the brain's memory systems help in resisting temptations. One factor which might explain the difference in people's ability to resist temptation might lie in the activity of a deep brain structure: the hippocampus.

For decades, economists have been interested in the conflict between smaller-sooner and larger-later rewards. Understanding how humans make inter-temporal choices, such as drinking tonight versus good health later, is crucial for designing insurance policies or anti-alcohol campaigns. This issue has recently been analyzed by brain scanners, during which volunteers were asked to make choices between monetary payoffs, for instance $10 now, versus $11 tomorrow. Using this type of paradigm, scientists found that the dorsolateral part of the prefrontal cortex, a region known to implement behavioral control, was crucial for making the choice to wait for higher but delayed payoffs.

"However, these paradigms miss an essential feature of the inter-temporal conflicts we have to face in everyday life", says study leader Mathias Pessiglione: "…immediate rewards can be perceived through our senses, whereas future rewards must be represented in our imagination." To reproduce this situation in the lab, the authors used more natural rewards like food items (for instance, a beer today or a bottle of champagne in a week from now). Volunteers were confronted with choices between immediate rewards presented as pictures, and future rewards presented as text. In this case specifically, the ability to select future rewards was linked to the amount of hippocampus activity. To complete the demonstration, individuals with hippocampus damage due to Alzheimer's disease were tested in the same choice task, as were individuals with a behavioral variant of frontotemporal dementia (bvFTD), arising from prefrontal degeneration. Contrary to individuals with bvFTD, who exhibited excessive impulsivity in all sorts of choices, those with Alzheimer's disease were specifically biased towards immediate rewards when future rewards had to be imagined.

"This is because the hippocampus is necessary for imagining future situations with a richness of details that make them attractive enough" – says Dr Pessiglione. "Indeed, this structure has long been considered as essential for storing past episodes, but scientists have recently discovered that it is also involved in simulating future situations. The consequence is that patients with hippocampus damage suffer not only from memory deficits but also from a difficulty in imagining goals that would counter the attraction of immediate rewards and motivate their actions on the long run."

### Funding: The study was funded by a starting grant from the European Research Council. ML and MB received PhD fellowships from the Ministère de l'Education Nationale and the Délégation Générale des Armées, respectively. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Citation: Lebreton M, Bertoux M, Boutet C, Lehericy S, Dubois B, et al. (2013) A Critical Role for the Hippocampus in the Valuation of Imagined Outcomes. PLoS Biol 11(10): e1001684. doi:10.1371/journal.pbio.1001684