PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Did brain tumor stem cells originate from malignant neural stem cells?

2013-10-29
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Did brain tumor stem cells originate from malignant neural stem cells?

Although it is believed that glioma is derived from brain tumor stem cells, the source and molecular signal pathways of these cells are still unclear. The potential of neural stem cells to transform into brain tumor stem cells has long been considered, but has not been confirmed. A team led by Prof. Yingbin Li from the Second Affiliated Hospital of Nanjing Medical University, China found that doxycycline-induced neural stem cells in the subventricular zone of c-myc+/SV40Tag+/Tet-on+ transgenic mice have increased proliferative activity and inhibitory differentiation similar to tumor stem cells, suggesting that neural stem cells have a tendency for malignant transformation, and could be a source of tumor stem cells. These findings were published in the Neural Regeneration Research (Vol. 8, No. 25, 2013).



INFORMATION:



Article: "Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models" by Guanqun Qiao1, Qingquan Li1, Gang Peng1, Jun Ma1, Hongwei Fan2, Yingbin Li1 (1 Department of Neurosurgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China; 2 Department of Pharmacology, the Third Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China)

Qiao GQ, Li QQ, Peng G, Ma J, Fan HW, Li YB. Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models. Neural Regen Res. 2013;8(25):2360-2369.



ELSE PRESS RELEASES FROM THIS DATE:

Association between glioma susceptibility and XRCC1 Arg399Gln polymorphism

2013-10-29
Association between glioma susceptibility and XRCC1 Arg399Gln polymorphism DNA damage is an important mechanism of glioma. X-ray cross-complementing group 1 (XRCC1) is a DNA repair gene that participates in the base excision repair pathway. To date, many studies ...

A new DNA vaccine induces a Th2 immune response in Alzheimer's disease mice

2013-10-29
A new DNA vaccine induces a Th2 immune response in Alzheimer's disease mice Amyloid-beta (Aβ) active immunization in Alzheimer's disease can increase the rate of Aβ clearance, and delay cognitive dysfunction, but it is easy to induce meningoencephalitis, ...

New drug to help common bowel disease

2013-10-29
New drug to help common bowel disease An international team led by University of Adelaide researchers has identified the mechanism of pain relief of a new drug for treating Irritable Bowel Syndrome with Constipation (IBS-C), based on nonclinical ...

Human immune system shapes skin microbiome

2013-10-29
Human immune system shapes skin microbiome October 29, 2013 -- Our skin plays host to millions of beneficial and potentially disease-causing microorganisms; however, whether our immune system influences these microbial communities to prevent disease is ...

Pregnant rats exposed to obesity hormone lose birth's protective effect on breast cancer

2013-10-29
Pregnant rats exposed to obesity hormone lose birth's protective effect on breast cancer WASHINGTON — Like humans, young rats that give birth have a reduced risk of breast cancer later in life. But a new study shows that this protective effect in animals is negated ...

A potential new class of fast-acting antidepressant

2013-10-29
A potential new class of fast-acting antidepressant More than 1 in 10 Americans take antidepressants, but these medications can take weeks—and for some patients, months—before they begin to alleviate symptoms. Now, scientists from the University ...

Extracting energy from bacteria

2013-10-29
Extracting energy from bacteria Most of us wouldn't consider bacteria a promising energy source of the future. That would be shortsighted, says Leonard Tender, a microbial-electrochemist at the Naval Research Laboratory in Washington, D.C., who believes that ...

New forensic technique for identifying cloth fibers

2013-10-29
New forensic technique for identifying cloth fibers Crime-scene investigators may soon have a new tool to help them catch evildoers. Researchers have demonstrated the proof-of-principle for a new forensic technique to identify individual fibers of cloth, which ...

Scientists reduce behaviors associated with problem gambling in rats

2013-10-29
Scientists reduce behaviors associated with problem gambling in rats With the help of a rat casino, University of British Columbia brain researchers have successfully reduced behaviours in rats that are commonly associated with compulsive gambling in humans. The ...

Child sexual abuse via the Internet on the rise

2013-10-29
Child sexual abuse via the Internet on the rise Sexual abuse of children and adolescents can have serious health consequences for victims. Early studies have revealed that child sexual abuse is associated with an increased risk of later mental and physical ...

LAST 30 PRESS RELEASES:

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce

Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes

New research expands laser technology

Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain

A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers

Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes

CTE and normal aging are difficult to distinguish, new study finds

Molecular arms race: How the genome defends itself against internal enemies

Tiny chip speeds up antibody mapping for faster vaccine design

KTU experts reveal why cultural heritage is important for community unity

More misfolded proteins than previously known may contribute to Alzheimer’s and dementia

“Too much going on”: Autistic adults overwhelmed by non-verbal social cues

What’s driving America’s deep freezes in a warming world?

A key role of brain protein in learning and memory is deciphered by scientists

Heart attacks don’t follow a Hollywood script

Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories

Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds

Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%

Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR

New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications

State gun laws and firearm-related homicides and suicides

Use of tobacco and cannabis following state-level cannabis legalization

Long-term obesity and biological aging in young adults

Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement

Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development

A technological breakthrough for ultra-fast and greener AI

Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption

Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications

[Press-News.org] Did brain tumor stem cells originate from malignant neural stem cells?