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A new treatment for heart attack will soon be available for emergency teams and the emergency ambulance

2013-10-30
(Press-News.org) Contact information: Philippe-Gabriel Steg
gabriel.steg@bch.aphp.fr
33-607-246-224
INSERM (Institut national de la santé et de la recherche médicale)
A new treatment for heart attack will soon be available for emergency teams and the emergency ambulance A new strategy for emergency anticoagulant treatment for patients with acute myocardial infarction has been put in place by a team led by Philippe-Gabriel Steg at Inserm Unit 698 (Haemostasis, Bioengineering, Immunopathology and Cardiovascular Remodelling), at Hôpital Bichat, AP-HP, Université Paris Diderot). These results from the EUROMAX clinical trial are published in The New England Journal of Medicine. Myocardial infarction, commonly called "heart attack," remains the leading cause of death worldwide, and affects nearly 100,000 individuals a year in France. The reference treatment is urgent dilation of the arteries to enable the blood to circulate to the heart (This medical procedure is known as primary angioplasty). Angioplasty requires injectable anticoagulant treatment for which several options are available. An international team led by Philippe-Gabriel Steg at Inserm Unit 698 (Haemostasis, Bioengineering, Immunopathology and Cardiovascular Remodelling), at Hôpital Bichat, AP-HP, Université Paris Diderot) has just reported the results of a large international clinical trial carried out in 9 European countries, on nearly 2,200 patients, testing the administration of anticoagulant treatment prior to arrival in hospital by emergency teams and the emergency ambulance service, and comparing the two strategies, in The New England Journal of Medicine . The first is based on heparin (traditional treatment), the other on a more specific anticoagulant, bivalirudin. One of the main drawbacks of these anticoagulant treatments is the risk of associated haemorrhage. "By dilating the arteries, we also thin the blood, with the risk of uncontrolled bleeding if haemorrhage occurs," explains Philippe-Gabriel Steg. After 30 days of monitoring, bivalirudin reduced the risk of death or serious bleeding by 8.5 to 5.1% and the risk of death, myocardial infarction or major bleed by 9.2 to 6.6%, compared with the strategy using heparin. This benefit was mainly linked to the reduction in serious bleeding, at the cost of an increased risk of stent thrombosis . "The benefits are robust and consistent for all sub-groups tested, and in particular, consistent regardless of the type of oral anti-clotting treatment or route of arterial access used for angioplasty (via the radial or femoral artery)," explains Philippe-Gabriel Steg. These results open up the way to using bivalirudin as an anticoagulant at the pre-hospital phase of myocardial infarction in patients being urgently transferred. They represent progress in the treatment of myocardial infarction that can be immediately used. ### The EUROMAX trial was conducted with the support of The Medicines Company. It is registered in Clinical Trials.gov, under the reference NCT01087723.

Sources Bivalirudin Started During Emergency Transport for Primary PCI
Steg PG, van 't Hof A, Hamm CW, Clemmensen P, Lapostolle F, Coste P, Ten Berg J, Van Grunsven P, Eggink GJ, Nibbe L, Zeymer U, Campo dell' Orto M, Nef H, Steinmetz J, Soulat L, Huber K, Deliargyris EN, Bernstein D, Schuette D, Prats J, Clayton T, Pocock S, Hamon M, Goldstein P, for the EUROMAX Investigators*

The New England Journal of Medicine 30 October 2013

Investigator contact Philippe-Gabriel Steg
Inserm Unit 698, "Haemostasis, Bioengineering, Immunopathology and Cardiovascular Remodelling"
Cardiologie, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, France,
E-mail: gabriel.steg@bch.aphp.fr.
Tel.: +33 1 40 25 86 69 //(0)6 07 24 62 24

Attention overseas investigators (San Francisco – 8-hour time difference) to present the trial results at the TCT conference. If you call at 16:00, Paris time, it will be 8:00 for the investigator. Press contact presse@inserm.fr


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[Press-News.org] A new treatment for heart attack will soon be available for emergency teams and the emergency ambulance