PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Can Aβ worsen cognitive impairment following cerebral ischemia-reperfusion injury?

2013-11-01
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Can Aβ worsen cognitive impairment following cerebral ischemia-reperfusion injury?

Amyloid β-peptide, a major component of senile plaques in Alzheimer's disease, has been impli-cated in neuronal cell death and cognitive impairment. Recently, studies have shown that the pathogenesis of cerebral ischemia is closely linked with Alzheimer's disease. According to a study, administration of amyloid β-peptide could further aggravate impairments to learning and memory and neuronal cell death in the hippocampus of rats subjected to cerebral ischemia-reperfusion injury. The synergistic effect of amyloid β-peptide and cerebral ischemia-reperfusion injury exacerbated nerve damage by inducing glycogen synthase kinase 3β and protein phosphatase 2A activity, which resulted in the phosphorylation of tau protein. This study by Dr. Bo Song and team from Research Center of Stem Cells and Regenerative Medicine, School of Medicine, Tsinghua University, China was published in the Neural Regeneration Research (Vol. 8, No. 26, 2013)



INFORMATION:



Article: " Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury," by Bo Song1, 2, Qiang Ao3, Ying Niu2, Qin Shen1, Huancong Zuo3, Xiufang Zhang2, Yandao Gong2 (1 Research Center of Stem Cells and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China; 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China; 3 Institute of Neurology Disorders, Yuquan Hospital, Tsinghua University, Beijing 100049, China)

Song B, Ao Q, Niu Y, Shen Q, Zuo HC, Zhang XF, Gong YD. Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury. Neural Regen Res. 2013;8(26):2449-2457.



ELSE PRESS RELEASES FROM THIS DATE:

Low-frequency rTMS prevents chronic epileptic seizure

2013-11-01
Low-frequency rTMS prevents chronic epileptic seizure Although increasing evidence indicates that low-frequency repetitive transcranial magnetic stimulation (rTMS), an emerging technology for neural regulation, has antiepileptic effects, the mechanism remains unclear. ...

Exposure to cortisol-like medications before birth may contribute to emotional problems and brain changes

2013-11-01
Exposure to cortisol-like medications before birth may contribute to emotional problems and brain changes Reports new study in Biological Psychiatry Philadelphia, PA, October 31, 2013 – Neonatologists seem to perform miracles in the fight to support the survival of ...

JCI early table of contents for Nov. 1, 2013

2013-11-01
JCI early table of contents for Nov. 1, 2013 Liver tropism is key for B cell deletion immunotherapy Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding ...

Liver tropism is key for B cell deletion immunotherapy

2013-11-01
Liver tropism is key for B cell deletion immunotherapy Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other ...

Dysfunctional chemokine receptor promotes candidiasis

2013-11-01
Dysfunctional chemokine receptor promotes candidiasis Candida albicans is one of the leading causes of hospital-acquired infections in immune compromised patients. The risk of both developing candidiasis and the clinical outcome of infection is variable ...

Home visits lessen emergency care for infants

2013-11-01
Home visits lessen emergency care for infants Nurse home visits lead to dramatic savings in emergency care DURHAM, N.C. -- Home visits from a nurse are a proven, but expensive, way to help newborns get a good start in life. New research from Duke University suggests ...

New study: Rising temperatures challenge Salt Lake City's water supply

2013-11-01
New study: Rising temperatures challenge Salt Lake City's water supply In an example of the challenges water-strapped Western cities will face in a warming world, new research shows that every degree Fahrenheit of warming in the Salt Lake City region ...

Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find

2013-11-01
Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find Researchers at Carnegie Mellon University have found an association between lower socioeconomic status during childhood and adolescence and the length ...

Patients with heart failure need specialist care

2013-11-01
Patients with heart failure need specialist care New research from Karolinska Institutet in Sweden shows that patients with heart failure have high mortality and often are undertreated. According to a study, published in the scientific periodical JACC, many more ...

New IOF review provides guidance on fracture prevention in cancer-associated bone disease

2013-11-01
New IOF review provides guidance on fracture prevention in cancer-associated bone disease International Osteoporosis Foundation Working Group outlines guidelines, treatment options and care pathways to help prevent osteoporosis and fractures in cancer ...

LAST 30 PRESS RELEASES:

Cobalt single atom-phosphate functionalized reduced graphene oxide/perylenetetracarboxylic acid nanosheet heterojunctions for efficiently photocatalytic H2O2 production

World-first study shows Australian marsupials contaminated with harmful ‘forever chemicals’

Unlocking the brain’s hidden drainage system

Enhancing smoking cessation treatment for people living with HIV

Research spotlight: Mapping how gut neurons respond to bacteria, parasites and food allergy

Gordon and Betty Moore Foundation Experimental Physics Investigators awards to UCSB experimentalists opens the door to new insights and innovations

Meerkats get health benefit from mob membership

COVID-19 during pregnancy linked to higher risk of neurodevelopmental disorders in children

How a chorus of synchronized frequencies helps you digest your food

UAlbany researcher partners on $1.2 million NSF grant to explore tropical monsoon rainfall patterns

Checkup time for Fido? Wait might be longer in the country

Genetic variation impact scores: A new tool for earlier heart disease detection

The Lundquist Institute awarded $9 million to launch Community Center of Excellence for Regenerative Medicine

'Really bizarre and exciting': The quantum oscillations are coming from inside

Is AI becoming selfish?

New molten salt method gives old lithium batteries a second life

Leg, foot amputations increased 65% in Illinois hospitals between 2016-2023

Moffitt studies uncover complementary strategies to overcome resistance to KRAS G12Cinhibitors in lung cancer

National summit of experts charts unprecedented roadmap to reduce harms from firearms in new ways

Global environmental DNA (eDNA) surveys significantly expand known geographic and ecological niche ranges of marine fish, highlighting current biases in conservation and ecological modeling

Hundreds of animal studies on brain damage after stroke flagged for problematic images

Prize winner’s research reveals how complex neural circuits are correctly wired during brain development

Supershear rupture sustained in thick fault zone during 2025 Mandalay earthquake, study in research package shows

Study reveals how brain cell networks stabilize memory formation

CTE: More than just head trauma, suggests new study

New psychology study suggests chimpanzees might be rational thinkers

Study links genetic variants to higher 'bad' cholesterol and heart attack risk

Myanmar fault had ideal geometry to produce 2025 supershear earthquake

Breakthrough in BRCA2 research: a novel mechanism behind chemoresistance discovered

New funding for health economics research on substance use disorder treatments

[Press-News.org] Can Aβ worsen cognitive impairment following cerebral ischemia-reperfusion injury?