PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Early data show potential for investigational bioengineered vessel as dialysis graft

2013-11-21
(Press-News.org) Contact information: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Early data show potential for investigational bioengineered vessel as dialysis graft

DURHAM, N.C. – An investigational, man-made blood vessel used in vascular grafts for kidney dialysis patients may potentially show encouraging early results among study patients in Poland, according to preliminary data reported Wednesday by a researcher at Duke Medicine.

Presented at the American Heart Association Scientific Sessions meeting in Dallas, the early findings of this interim patient data track 28 hemodialysis patients who received grafts using the investigational bioengineered vessel during a multi-center study launched in Poland last December.

The investigational bioengineered blood vessel, designed to be the first off-the-shelf product incorporating human tissue in the bioengineering process, provided blood flow in 100 percent of the study patients, reported Jeffrey H. Lawson, M.D., Ph.D., professor of surgery and pathology at Duke University School of Medicine. Eight patients later lost blood flow, but it was restored with interventions in each case.

Lawson said there is a significant need for alternative types of vascular technology. Current synthetic vascular grafts used for hemodialysis access provide initial blood flood in less than 50 percent of patients at six months, and with secondary interventions the success rates rises to 77 percent, Lawson said.

Preliminary interim analysis of the investigational bioengineered vessel currently being used for dialysis among the Polish patients has resulted in no infections to date, no immune reactions and no sign of structural degeneration.

"These early data are very encouraging," said Lawson, who performed the first U.S. implantation of the blood vessel in June in a patient with end-stage kidney disease. "Longer term evaluations in a larger patient population are needed to confirm the early findings, but we are hopeful the technology continues to demonstrate potential benefit to dialysis patients."

The investigational bioengineered blood vessel is manufactured by Humacyte, Inc., a Duke University spin-off company from the lab of Laura Niklason, M.D., Ph.D., who is now vice chair of anesthesia and a professor of biomedical engineering at Yale University. Lawson has collaborated with Niklason and Humacyte for over 15 years to develop the bioengineered vessels.

The technology uses donated human tissue that grows on a biodegradable tubular scaffold, which gradually dissolves as the cells grow. The resulting vessel is then rinsed of its cellular properties, creating a collagen structure that does not appear in preliminary studies to trigger an immune response when implanted in humans. That feature, if established in future studies, could enable it to be mass-produced without tailoring it to individual patients.

The investigational bioengineered vessel is being tested initially as a vascular graft for patients with end-stage kidney disease who need dialysis procedures. An estimated 380,000 people in the United States receive dialysis, and costs associated with vein access complications are significant.

Subject to review and approval from regulatory agencies, subsequent tests of the technology are planned for replacement or bypass of diseased and injured blood vessels.



INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Large dishes increase how much cereal kids request, eat, and waste

2013-11-21
Large dishes increase how much cereal kids request, eat, and waste Big bowls make big appetites Smaller bowl sizes may be the next weapon in the battle against childhood obesity, says a new Cornell study published this week in the Journal of Pediatrics ...

Different types of teacher-child interactions support children's development in different areas

2013-11-21
Different types of teacher-child interactions support children's development in different areas Teachers' daily interactions with children are crucial to making sure they're ready for school. Many state early childhood systems and the federal Office ...

Rotavirus vaccination may also protect children against seizures

2013-11-21
Rotavirus vaccination may also protect children against seizures Findings suggest additional benefit from immunization against common cause of diarrhea [EMBARGOED UNTIL THURSDAY, NOV. 21] A new study suggests an additional—and somewhat surprising—potential ...

For many older adults, vision prescription differs between eyes

2013-11-21
For many older adults, vision prescription differs between eyes Anisometropia found in nearly one-third of people over 75, reports study in Optometry and Vision Science Philadelphia, Pa. (November 21, 2013) - Follow-up in older adults shows a high rate ...

When bye bye becomes buy buy: How homophones affect consumer behavior

2013-11-20
When bye bye becomes buy buy: How homophones affect consumer behavior It is possible to affect how someone will think or act simply by priming that person with just a single word, according to a new study in the Journal of Consumer Research that examines ...

Grieving for Tony Soprano: How the public responds to the death of a brand

2013-11-20
Grieving for Tony Soprano: How the public responds to the death of a brand In a testament to the pervasiveness of consumerism, studies have shown that consumers form subcultures, communities, and tribes around the brands they truly love. While much research ...

Discovery of brain activity in severely brain injured patients who 'wake up' w/ sleep drug

2013-11-20
Discovery of brain activity in severely brain injured patients who 'wake up' w/ sleep drug Pattern of brain activity points to possible neural circuit switched on by drug and may identify other patients who could respond NEW YORK (November 19, 2013) ...

Coffee may help perk up your blood vessels

2013-11-20
Coffee may help perk up your blood vessels Abstract: 12428 (Hall F, Core 7, Poster Board: 7062) The caffeine in a cup of coffee might help your small blood vessels work better, according to research presented at the American Heart Association's Scientific Sessions ...

Smokers who quit cut heart disease risk faster than previous estimates

2013-11-20
Smokers who quit cut heart disease risk faster than previous estimates Abstract: 18709 (Hall F, Core 2, Poster Board: 2006) Cigarette smokers who are over 65 years of age may be able to lower their risk of cardiovascular disease-related deaths to the level of ...

Neurons in brain's 'face recognition center' respond differently in patients with autism

2013-11-20
Neurons in brain's 'face recognition center' respond differently in patients with autism Neuroscientists and neurosurgeons collaborate to determine why patients suffering from autism focus more on the mouth and less on the eyes to collect and process information LOS ...

LAST 30 PRESS RELEASES:

Signs identified that precede sudden arrhythmic death syndrome in young people

Discovery of bacteria's defence against viruses becomes a piece of the puzzle against resistance

Pre-eclampsia is associated with earlier onset and higher incidence of cardiovascular risk factors

Warwick astronomers discover doomed pair of spiralling stars on our cosmic doorstep

Soil conditions significantly increase rainfall in world’s megastorm hotspots

NK cells complexed with bispecific antibody yield high response rates in patients with lymphoma

Planetary health diet and mediterranean diet associated with similar survival and sustainability benefits

Singapore launches national standard to validate antimicrobial disinfectant products

Molecular stool test could improve detection of tuberculosis in adults with HIV

Suspected fibrocartilaginous embolus in Asian small-clawed otter (Aonyx cinereus)

Enhancing heat transfer using the turbulent flow of viscoelastic fluids

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’

New guidelines aim to improve cystic fibrosis screening

Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas

Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition

CCNY physicists uncover electronic interactions mediated via spin waves

Researchers’ 3D-printing formula may transform future of foam

Nurture more important than nature for robotic hand

Drug-delivering aptamers target leukemia stem cells for one-two knockout punch

New study finds that over 95% of sponsored influencer posts on Twitter were not disclosed

New sea grant report helps great lakes fish farmers navigate aquaculture regulations

Strain “trick” improves perovskite solar cells’ efficiency

How GPS helps older drivers stay on the roads

Estrogen and progesterone stimulate the body to make opioids

Dancing with the cells – how acoustically levitating a diamond led to a breakthrough in biotech automation

Machine learning helps construct an evolutionary timeline of bacteria

Cellular regulator of mRNA vaccine revealed... offering new therapeutic options

Animal behavioral diversity at risk in the face of declining biodiversity

Finding their way: GPS ignites independence in older adult drivers

[Press-News.org] Early data show potential for investigational bioengineered vessel as dialysis graft