New report on stem cell research reveals the field is growing twice as fast as the world average

(Press-News.org) Contact information: David Hajime Kornhauser
david@icems.kyoto-u.ac.jp
81-757-539-748
Elsevier
New report on stem cell research reveals the field is growing twice as fast as the world average Presenting positive implications for innovative new treatments and personalized medicine San Diego, December 4, 2013 – Elsevier, EuroStemCell, and Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS), today released "Stem Cell Research report: Trends and Perspectives on the Evolving International Landscape" at the World Stem Cell Summit. This new, comprehensive analysis of the growth and development of the stem cell field as a whole, closely examines the research landscape for embryonic stem (ES) cell, human embryonic stem (hES) cell and induced pluripotent stem (iPS) cell.

In order to provide a broad and transparent data driven view of the field, the study reviewed leading nations' research output, citation impact and collaboration behavior, as well as assessing international differences in focus and growth. The report combines a comprehensive publication analysis from Elsevier's Scopus, the largest scientific abstract and citation database, together with scientists' and other stakeholders' views on current progress and future expectations of the field. Findings will be presented at the World Stem Cell Summit and discussed by Stephen Minger (GE Healthcare), Norio Nakatsuji (Kyoto University iCeMS), Brock C. Reeve (Harvard Stem Cell Institute), Deborah J. Sweet (Cell Press) and Brad Fenwick (Elsevier) on the 6th December.

Highlights and key findings of the report include: Stem cell research is growing twice as fast (7%) as the world average growth in research (2.9%). For the recent area of induced pluripotent stem cells (awarded the Nobel Prize in Physiology or Medicine in 2012), the annual growth rate since 2008 is an astonishing 77%. Stem cell publications are 50% more cited than the world average for all related subject areas, with the following field weighted citation impact (FWCI). ES cell publications maintained a citation impact of above 1.80 (2008-2012), while the hES cell citation impact declined marginally from 2.35 in 2008 to 2.08 in 2012. The emerging field of iPS cell research showed the highest impact within the stem cell field, with a FWCI of 2.93 (2008-2012). Around half of all stem cell papers use keywords related to "drug development" or "regenerative medicine" - Reflecting the field's ongoing development and clinical promise, 47% of stem cell publications used keywords related to regenerative medicine, while 2% used keywords related to drug development. However, iPS cell publications featured drug development more prominently (11% of iPS cell publications), and these papers were also associated with higher citation rates. While Singapore, Italy, the USA, Japan, and Israel show the highest level of activity in stem cell research the US and China show the highest volume.

Stem cell research holds great potential to revolutionize healthcare. Investments into this field strive to deliver new treatments for many serious conditions for which few effective treatments currently exist. Some basic research findings are being translated into new treatments, and with the discovery of induced pluripotent stem cells in 2006, the field has seen a step-change in biological understanding that will affect the way new drugs are identified and tested and, potentially, the way cells can be generated in the lab. While the field has attracted priority status in many countries, it has also been the focus of continuous discussion around ethics and regulation with each nation taking its own policy position, some of which have had a clear effect on the dynamics of the field.

"The challenge for the coming decade is to expand on multi-disciplinary and multi-sector collaboration aimed at large-scale production of high-quality human pluripotent stem cells, and also, robust and reliable production of high-quality differentiated cells", said Professor Norio Nakatsuji, Founding Director of Kyoto University, iCeMS. "In order to provide adequate support to accelerate such research, a nation should take an evidence-based approach with an understanding of the global trend from a multitude of perspectives."

"This report gives us a bird's eye view of the international stem cell field, drawing on advanced bibliometric techniques to identify national and international trends – where is stem cell research strongest, where is the sector developing fastest, are the results of individual funding initiatives translating into high impact publications, and so on," said Professor Clare Blackburn, MRC Centre for Regenerative Medicine, University of Edinburgh and the Project Coordinator of EuroStemCell. "It has been extremely interesting to analyse these data, they contain a lot of provocative information. We hope readers will gain a new understanding of the shape of the field that will stimulate future policy discussions."

Nick Fowler, Managing Director of Academic and Government Institutions for Elsevier, said, "The aim of this report was to support development in stem cell science and policy discussion by bringing together comprehensive analytical overview of the fields together with insights from experts. We are proud we have been able to collaborate with EuroStemCell, Kyoto University, iCeMS and the experts who have provided their valuable input."

### Note to editors The following experts are available for interview concerning this report: Shintaro Sengoku, Associate Professor, Kyoto University, iCeMS, Clare Blackburn, Professor, Tissue Stem Cell Biology, MRC Centre for Regenerative Medicine, University of Edinburgh and Project Coordinator of EuroStemCell, and Anders Karlsson, Vice President, Global Academic Relations, Asia Pacific, Elsevier.

Technical terms and abbreviations used in the report: Pluripotent stem cells can give rise to all of the cell types that make up the body; embryonic stem cells and induced pluripotent stem cells are considered pluripotent. (ES or ESC) Embryonic stem cell (hES or hESC) human embryonic stem cell (iPS or iPSC) induced pluripotent stem cell

About Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) The Institute for Integrated Cell-Material Sciences (iCeMS) at Kyoto University in Japan aims to advance the integration of the cell and material sciences -- both traditionally strong fields for the university -- in a uniquely innovative global research environment. ICeMS combines the biosciences, chemistry, materials science, and physics to create materials for mesoscopic cell control and cell-inspired materials. Such developments hold the promise of significant advances in medicine, pharmaceutical studies, the environment, and industry. http://www.icems.kyoto-u.ac.jp

About EuroStemCell EuroStemCell, launched in March 2010 and funded by the European Commission's Seventh Framework Programme (FP7), unites more than 90 European stem cell and regenerative medicine research labs in a coordinated effort to engage with the public about stem cell science. EuroStemCell is a partnership of scientists, clinicians, ethicists, social scientists and science communicators and works closely with teachers and patient representatives. http://www.eurostemcell.org

About Elsevier Elsevier is a world-leading provider of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include ScienceDirect, Scopus, SciVal, Reaxys, ClinicalKey and Mosby's Suite, which enhance the productivity of science and health professionals, helping research and health care institutions deliver better outcomes more cost-effectively.

A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group PLC, a world leading provider of professional information solutions in the Science, Medical, Legal and Risk and Business sectors, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

Media contact Kyoto University, iCeMS
David Hajime Kornhauser, Manager, Overseas Affairs and
Public Relations
+81-75 753 9748 / 9755
david@icems.kyoto-u.ac.jp

EuroStemCell
Clare Blackburn, Coordinator
Dr. Jan Barfoot, Public Engagement Manager
+44 078 1022-3009
+44 131 651 9506
C.Blackburn@ed.ac.uk J.Barfoot@ed.ac.uk

Elsevier
Ludivine Allagnat
Analyst, Global Academic Relations
+81 3 5561 5620
l.allagnat@elsevier.com