PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Combination of cell transplantation and gene therapy for Alzheimer's disease

2013-12-27
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Combination of cell transplantation and gene therapy for Alzheimer's disease

In a recent study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), Prof. Feng Li and team from Zhongshan School of Medicine, Sun Yat-sen University in China, synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloid beta protein (Aβ) production, and introduced it into the pSilenCircle vector to construct a short hairpin (shRNA) expression plasmid against the BACE1 gene. Researhcers transfected this vector into C17.2 neural stem cells and primary neural stem cells, resulting in downregulation of the BACE1 gene, which in turn induced a considerable reduction in reducing Aβ protein production. This technique combining cell transplantation and gene therapy will open up novel therapeutic avenues for Alzheimer's disease, particularly because it can be used to simultaneously target several pathogenetic changes in the disease.



INFORMATION:

Article: " Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy " by Zhonghua Liu, Shengliang Li, Zibin Liang, Yan Zhao, Yulin Zhang, Yaqi Yang, Minjuan Wang, Feng Li (Department of Neurobiology and Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China)

Liu ZH, Li SL, Liang ZB, Zhao Y, Zhang YL, Yang YQ, Wang MJ, Li F. Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy. Neural Regen Res. 2013;8(33):3095-3106.



ELSE PRESS RELEASES FROM THIS DATE:

Radiotherapy is less often used by breast cancer patients with young children

2013-12-27
Radiotherapy is less often used by breast cancer patients with young children Radiotherapy (RT) after breast conserving surgery (BCS) has been shown to reduce the risk of breast cancer (BC) recurrence. However, although younger women tend ...

Widely-used anti-inflammatory drug shows success in treatment of amyloidosis

2013-12-27
Widely-used anti-inflammatory drug shows success in treatment of amyloidosis (Boston) – A recent study led by researchers from the Amyloidosis Center at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) demonstrates that ...

Multi-component therapy shown beneficial in treating PTSD in adolescent girls

2013-12-27
Multi-component therapy shown beneficial in treating PTSD in adolescent girls Adolescents girls with sexual abuse-related posttraumatic stress disorder (PTSD) experienced greater benefit from prolonged exposure therapy (a type of therapy that has been ...

Adding cognitive behavioral therapy to treatment of pediatric migraine improves relief of symptoms

2013-12-27
Adding cognitive behavioral therapy to treatment of pediatric migraine improves relief of symptoms Among children and adolescents with chronic migraine, the use of cognitive behavioral therapy (CBT) resulted in greater reductions in headache frequency and migraine-related ...

Proportion of opioid treatment programs offering on-site testing for HIV and STIs declines

2013-12-27
Proportion of opioid treatment programs offering on-site testing for HIV and STIs declines A survey of opioid treatment programs finds that the proportion offering on-site testing for human immunodeficiency virus (HIV) and sexually transmitted infections ...

Use of antidepressant does not improve symptoms from stomach disorder

2013-12-27
Use of antidepressant does not improve symptoms from stomach disorder Among patients with idiopathic (of unknown cause) gastroparesis, use of the antidepressant nortriptyline compared with placebo for 15 weeks did not result in improvement in overall ...

Nonsteroidal anti-inflammatory agent slows rate of progression of neurodegenerative disease

2013-12-27
Nonsteroidal anti-inflammatory agent slows rate of progression of neurodegenerative disease Among patients with familial amyloid polyneuropathy, a lethal, genetic neurodegenerative disease, use of the nonsteroidal anti-inflammatory agent diflunisal compared ...

Prolonged exposure therapy found beneficial in treating adolescent girls with PTSD

2013-12-27
Prolonged exposure therapy found beneficial in treating adolescent girls with PTSD (PHILADELPHIA) – Researchers at Penn Medicine report in the December 25 issue of JAMA that a modified form of prolonged exposure therapy ...

Antidepressants for bipolar disorder

2013-12-27
Antidepressants for bipolar disorder The use of antidepressants in the treatment of bipolar disorder remains controversial. Some studies and treatment guidelines suggest that antidepressant treatment for bipolar disorder may have the potential to increase the manic ...

NASA sees the last of Cyclone Bruce in Southern Indian Ocean

2013-12-27
NASA sees the last of Cyclone Bruce in Southern Indian Ocean Tropical Cyclone Bruce is winding down in the Southern Indian Ocean as wind shear and cooler waters affect the storm. NASA's Aqua satellite flew over Bruce on December 24 and showed that wind shear is having ...

LAST 30 PRESS RELEASES:

Fig trees convert atmospheric CO2 to stone

Intra-arterial tenecteplase for acute stroke after successful endovascular therapy

Study reveals beneficial microbes that can sustain yields in unfertilized fields

Robotic probe quickly measures key properties of new materials

Climate change cuts milk production, even when farmers cool their cows

Frozen, but not sealed: Arctic Ocean remained open to life during ice ages

Some like it cold: Cryorhodopsins

Demystifying gut bacteria with AI

Human wellbeing on a finite planet towards 2100: new study shows humanity at a crossroads

Unlocking the hidden biodiversity of Europe’s villages

Planned hydrogen refuelling stations may lead to millions of euros in yearly losses

Planned C-sections increase the risk of certain childhood cancers

Adults who have survived childhood cancer are at increased risk of severe COVID-19

Drones reveal extreme coral mortality after bleaching

New genetic finding uncovers hidden cause of arsenic resistance in acute promyelocytic leukemia

Native habitats hold the key to the much-loved smashed avocado’s future

Using lightning to make ammonia out of thin air

Machine learning potential-driven insights into pH-dependent CO₂ reduction

Physician associates provide safe care for diagnosed patients when directly supervised by a doctor

How game-play with robots can bring out their human side

Asthma: patient expectations influence the course of the disease

UNM physician tests drug that causes nerve tissue to emit light, enabling faster, safer surgery

New study identifies EMP1 as a key driver of pancreatic cancer progression and poor prognosis

XPR1 identified as a key regulator of ovarian cancer growth through autophagy and immune evasion

Flexible, eco-friendly electronic plastic for wearable tech, sensors

Can the Large Hadron Collider snap string theory?

Stuckeman professor’s new book explores ‘socially sustainable’ architecture

Synthetic DNA nanoparticles for gene therapy

New model to find treatments for an aggressive blood cancer

Special issue of Journal of Intensive Medicine analyzes non-invasive respiratory support

[Press-News.org] Combination of cell transplantation and gene therapy for Alzheimer's disease