PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Transient receptor potential channel A1 may contribute to hyperalgesia

2013-12-27
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Transient receptor potential channel A1 may contribute to hyperalgesia

Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents, which may contribute to generation of neurogenic inflammation and hyperalgesia. However, there is no direct evidence that activation of transient receptor potential channel A1 contributes to neuropeptide release from primary afferent neurons. A recent study by Yi Dai and team from Hyogo College of Medicine in Japan demonstrated for the first time that allyl isothiocyanate (AITC; also known as mustard oil) activates transient receptor potential channel A1, resulting in calcitonin gene-related peptide release from the cultured rat dorsal root ganglion neurons. Knockdown of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by allyl isothiocyanate application in cultured dorsal root ganglion neurons. Thus, the researchers concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013).



INFORMATION:

Article: " Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons " by Nobumasa Ushio1, Yi Dai1, 2, 3, Shenglan Wang1, 2, 3, Tetsuo Fukuoka1, Koichi Noguchi1 (1 Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan; 2 Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo 650-8530, Japan; 3 Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine, Kobe, Hyogo 650-8530, Japan)

Ushio N, Dai Y, Wang SL, Fukuoka T, Noguchi K. Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons. Neural Regen Res. 2013;8(32):3013-3019.



ELSE PRESS RELEASES FROM THIS DATE:

An expert consensus on acute thoracolumbar spine and spinal cord injury in China

2013-12-27
An expert consensus on acute thoracolumbar spine and spinal cord injury in China The early management of acute thoracolumbar spine and spinal cord injury is one of the most difficult tasks when treating trauma cases. To standardize the evaluation and treatment of ...

Motor excitability predicts working memory

2013-12-27
Motor excitability predicts working memory Humans with a high motor excitability have a better working memory than humans with a low excitability. This was shown in a study conducted by scientists from the Transfacultary Research Platform at the University of Basel. By measuring ...

Breast cancer patients experience fewer side effects from anticancer drug

2013-12-27
Breast cancer patients experience fewer side effects from anticancer drug A new analysis has found that both real and sham acupuncture treatments may help alleviate side effects of drugs commonly used to treat breast cancer. Published early online in CANCER, a peer-reviewed journal ...

Democracy pays

2013-12-27
Democracy pays Majority wants both punishment for tax evaders and things to go fine for themselves This news release is available in German. In relatively large communities, individuals do not always obey the rules and often exploit the willingness ...

Antibiotics before heart surgery protect against infection

2013-12-27
Antibiotics before heart surgery protect against infection Preoperative antibiotics administered within two hours of operation optimal for protection CHICAGO (December 23, 2013) – A new study found preoperative antibiotic therapy administered within ...

Infectious diarrhea germs stick to healthcare worker hands

2013-12-27
Infectious diarrhea germs stick to healthcare worker hands Study shows healthcare workers' hands contaminated with C. difficile after routine care CHICAGO (December 23, 2013) – A new study finds nearly one in four healthcare workers' hands were ...

Role of chronic medical conditions in readmissions

2013-12-27
Role of chronic medical conditions in readmissions Researchers cite identification and monitoring of known underlying chronic medical conditions as opportunities to reduce readmission rates and improve patient safety Researchers cite identification and ...

Resistance makes waves

2013-12-27
Resistance makes waves There is a growing understanding of the conditions required for superconductivity and how it can be achieved at realistic temperatures This news release is available in German. Even physics can give pointers for energy saving. ...

Cone snails are for life and not just at Christmas

2013-12-27
Cone snails are for life and not just at Christmas Those who fly to tropical shores this Christmas in search of sea and sun may be unaware that an exotic shell picked from the beach could potentially bring relief to many thousands of people suffering life-threatening ...

Slippery bark protects trees from pine beetle attack, according to CU-Boulder study

2013-12-27
Slippery bark protects trees from pine beetle attack, according to CU-Boulder study Trees with smoother bark are better at repelling attacks by mountain pine beetles, which have difficulty gripping the slippery surface, according to a new ...

LAST 30 PRESS RELEASES:

New global burden of disease study: Mortality declines, youth deaths rise, widening health inequities

Chemobiological platform enables renewable conversion of sugars into core aromatic hydrocarbons of petroleum

Individualized perioperative blood pressure management in patients undergoing major abdominal surgery

Proactive vs reactive treatment of hypotension during surgery

Different types of depression linked to different cardiometabolic diseases

Ketogenic diet may protect against stress experienced in the womb

Adults 65 years and older not immune to the opioid epidemic, new study finds

Artificial intelligence emerging as powerful patient safety tool in pediatric anesthesia

Mother’s ZIP code, lack of access to prenatal care can negatively impact baby’s health at birth, new studies show

American Society of Anesthesiologists honors John M. Zerwas, M.D., FASA, with Distinguished Service Award

A centimeter-scale quadruped piezoelectric robot with high integration and strong robustness

Study confirms that people with ADHD can be more creative. The reason may be that they let their mind wander

Research gives insight into effect of neurodegenerative diseases on speech rhythm

Biochar and plants join forces to clean up polluted soils and boost ecosystem recovery

Salk scientist Joseph Ecker awarded McClintock Prize for Plant Genetics and Genome Studies

ADHD: Women are diagnosed five years later than men, despite symptoms appearing at the same age.

Power plants may emit more pollution during government shutdowns

Increasing pressures for conformity de-skilling and demotivating teachers, study warns

Researchers develop smarter menstrual product with potential for wearable health monitoring

Microwaves for energy-efficient chemical reactions

MXene current collectors could reduce size, improve recyclability of Li-ion batteries

Living near toxic sites linked to aggressive breast cancer

New discovery could open door to male birth control

Wirth elected Fellow of American Physical Society

The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: October 10, 2025

Destined to melt

Attitudes, not income, drive energy savings at home

The playbook for perfect polaritons

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

Solar-powered method lights the way to a ‘de-fossilized’ chemical industry

[Press-News.org] Transient receptor potential channel A1 may contribute to hyperalgesia