PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Transient receptor potential channel A1 may contribute to hyperalgesia

2013-12-27
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Transient receptor potential channel A1 may contribute to hyperalgesia

Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents, which may contribute to generation of neurogenic inflammation and hyperalgesia. However, there is no direct evidence that activation of transient receptor potential channel A1 contributes to neuropeptide release from primary afferent neurons. A recent study by Yi Dai and team from Hyogo College of Medicine in Japan demonstrated for the first time that allyl isothiocyanate (AITC; also known as mustard oil) activates transient receptor potential channel A1, resulting in calcitonin gene-related peptide release from the cultured rat dorsal root ganglion neurons. Knockdown of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by allyl isothiocyanate application in cultured dorsal root ganglion neurons. Thus, the researchers concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013).



INFORMATION:

Article: " Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons " by Nobumasa Ushio1, Yi Dai1, 2, 3, Shenglan Wang1, 2, 3, Tetsuo Fukuoka1, Koichi Noguchi1 (1 Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan; 2 Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo 650-8530, Japan; 3 Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine, Kobe, Hyogo 650-8530, Japan)

Ushio N, Dai Y, Wang SL, Fukuoka T, Noguchi K. Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons. Neural Regen Res. 2013;8(32):3013-3019.



ELSE PRESS RELEASES FROM THIS DATE:

An expert consensus on acute thoracolumbar spine and spinal cord injury in China

2013-12-27
An expert consensus on acute thoracolumbar spine and spinal cord injury in China The early management of acute thoracolumbar spine and spinal cord injury is one of the most difficult tasks when treating trauma cases. To standardize the evaluation and treatment of ...

Motor excitability predicts working memory

2013-12-27
Motor excitability predicts working memory Humans with a high motor excitability have a better working memory than humans with a low excitability. This was shown in a study conducted by scientists from the Transfacultary Research Platform at the University of Basel. By measuring ...

Breast cancer patients experience fewer side effects from anticancer drug

2013-12-27
Breast cancer patients experience fewer side effects from anticancer drug A new analysis has found that both real and sham acupuncture treatments may help alleviate side effects of drugs commonly used to treat breast cancer. Published early online in CANCER, a peer-reviewed journal ...

Democracy pays

2013-12-27
Democracy pays Majority wants both punishment for tax evaders and things to go fine for themselves This news release is available in German. In relatively large communities, individuals do not always obey the rules and often exploit the willingness ...

Antibiotics before heart surgery protect against infection

2013-12-27
Antibiotics before heart surgery protect against infection Preoperative antibiotics administered within two hours of operation optimal for protection CHICAGO (December 23, 2013) – A new study found preoperative antibiotic therapy administered within ...

Infectious diarrhea germs stick to healthcare worker hands

2013-12-27
Infectious diarrhea germs stick to healthcare worker hands Study shows healthcare workers' hands contaminated with C. difficile after routine care CHICAGO (December 23, 2013) – A new study finds nearly one in four healthcare workers' hands were ...

Role of chronic medical conditions in readmissions

2013-12-27
Role of chronic medical conditions in readmissions Researchers cite identification and monitoring of known underlying chronic medical conditions as opportunities to reduce readmission rates and improve patient safety Researchers cite identification and ...

Resistance makes waves

2013-12-27
Resistance makes waves There is a growing understanding of the conditions required for superconductivity and how it can be achieved at realistic temperatures This news release is available in German. Even physics can give pointers for energy saving. ...

Cone snails are for life and not just at Christmas

2013-12-27
Cone snails are for life and not just at Christmas Those who fly to tropical shores this Christmas in search of sea and sun may be unaware that an exotic shell picked from the beach could potentially bring relief to many thousands of people suffering life-threatening ...

Slippery bark protects trees from pine beetle attack, according to CU-Boulder study

2013-12-27
Slippery bark protects trees from pine beetle attack, according to CU-Boulder study Trees with smoother bark are better at repelling attacks by mountain pine beetles, which have difficulty gripping the slippery surface, according to a new ...

LAST 30 PRESS RELEASES:

Climate crisis could force wild vanilla plants and pollinating insects apart, threatening global supply

Teens report spending 21% of each driving trip looking at their phone

Study explores the ‘social norms’ of distracted driving among teens

Diver-operated microscope brings hidden coral biology into focus

Enhancing the “feel-good” factor of urban vegetation using AI and street view images

A single genetic mutation may have made humans more vulnerable to cancer than chimpanzees

Innovative nanocomposite hydrogel shows promise for cartilage regeneration in osteoarthritis treatment

2025 Guangci Laboratory Medicine Innovation and Development Conference

LabMed Discovery is included in the ICI World Journals database

LabMed Discovery is included in the China Open Access Journal (COAJ) database

Vaccination support program reduces pneumonia-related mortality by 25 percent among the elderly

Over decades, a healthy lifestyle outperforms metformin in preventing onset of Type 2 diabetes

Mental health disorders, malaria, and heart disease most affected by covid pandemic

Green transition will boost UK productivity

Billions voted in 2024, but major new report exposes cracks in global democracy

Researchers find “forever chemicals” impact the developing male brain

Quantum leap in precision sensing across technologies

Upgrading biocrude oil into sustainable aviation fuel using zeolite-supported iron-molybdenum carbide nanocatalysts

For effective science communication, ‘just the facts’ isn’t good enough

RT-EZ: A golden gate assembly toolkit for streamlined genetic engineering of rhodotorula toruloides

Stem Cell Reports announces five new early career editors

Support networks may be the missing link for college students who seek help for excessive drinking

The New England Journal of Medicine shines spotlight on forensic pathology

Scientists discover protein that helps lung cancer spread to the brain

Perceived social status tied to cardiovascular risks in women but not in men

Brain tumor growth patterns may help inform patient care management

This might be America's first campus tree inventory

Emoji use may impact relationship outcomes

Individual merit, not solidarity, prioritized by early childhood education policies

Preclinical study unlocks a mystery of rapid mouth healing

[Press-News.org] Transient receptor potential channel A1 may contribute to hyperalgesia