PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Transient receptor potential channel A1 may contribute to hyperalgesia

2013-12-27
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Transient receptor potential channel A1 may contribute to hyperalgesia

Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents, which may contribute to generation of neurogenic inflammation and hyperalgesia. However, there is no direct evidence that activation of transient receptor potential channel A1 contributes to neuropeptide release from primary afferent neurons. A recent study by Yi Dai and team from Hyogo College of Medicine in Japan demonstrated for the first time that allyl isothiocyanate (AITC; also known as mustard oil) activates transient receptor potential channel A1, resulting in calcitonin gene-related peptide release from the cultured rat dorsal root ganglion neurons. Knockdown of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by allyl isothiocyanate application in cultured dorsal root ganglion neurons. Thus, the researchers concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013).



INFORMATION:

Article: " Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons " by Nobumasa Ushio1, Yi Dai1, 2, 3, Shenglan Wang1, 2, 3, Tetsuo Fukuoka1, Koichi Noguchi1 (1 Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan; 2 Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo 650-8530, Japan; 3 Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine, Kobe, Hyogo 650-8530, Japan)

Ushio N, Dai Y, Wang SL, Fukuoka T, Noguchi K. Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons. Neural Regen Res. 2013;8(32):3013-3019.



ELSE PRESS RELEASES FROM THIS DATE:

An expert consensus on acute thoracolumbar spine and spinal cord injury in China

2013-12-27
An expert consensus on acute thoracolumbar spine and spinal cord injury in China The early management of acute thoracolumbar spine and spinal cord injury is one of the most difficult tasks when treating trauma cases. To standardize the evaluation and treatment of ...

Motor excitability predicts working memory

2013-12-27
Motor excitability predicts working memory Humans with a high motor excitability have a better working memory than humans with a low excitability. This was shown in a study conducted by scientists from the Transfacultary Research Platform at the University of Basel. By measuring ...

Breast cancer patients experience fewer side effects from anticancer drug

2013-12-27
Breast cancer patients experience fewer side effects from anticancer drug A new analysis has found that both real and sham acupuncture treatments may help alleviate side effects of drugs commonly used to treat breast cancer. Published early online in CANCER, a peer-reviewed journal ...

Democracy pays

2013-12-27
Democracy pays Majority wants both punishment for tax evaders and things to go fine for themselves This news release is available in German. In relatively large communities, individuals do not always obey the rules and often exploit the willingness ...

Antibiotics before heart surgery protect against infection

2013-12-27
Antibiotics before heart surgery protect against infection Preoperative antibiotics administered within two hours of operation optimal for protection CHICAGO (December 23, 2013) – A new study found preoperative antibiotic therapy administered within ...

Infectious diarrhea germs stick to healthcare worker hands

2013-12-27
Infectious diarrhea germs stick to healthcare worker hands Study shows healthcare workers' hands contaminated with C. difficile after routine care CHICAGO (December 23, 2013) – A new study finds nearly one in four healthcare workers' hands were ...

Role of chronic medical conditions in readmissions

2013-12-27
Role of chronic medical conditions in readmissions Researchers cite identification and monitoring of known underlying chronic medical conditions as opportunities to reduce readmission rates and improve patient safety Researchers cite identification and ...

Resistance makes waves

2013-12-27
Resistance makes waves There is a growing understanding of the conditions required for superconductivity and how it can be achieved at realistic temperatures This news release is available in German. Even physics can give pointers for energy saving. ...

Cone snails are for life and not just at Christmas

2013-12-27
Cone snails are for life and not just at Christmas Those who fly to tropical shores this Christmas in search of sea and sun may be unaware that an exotic shell picked from the beach could potentially bring relief to many thousands of people suffering life-threatening ...

Slippery bark protects trees from pine beetle attack, according to CU-Boulder study

2013-12-27
Slippery bark protects trees from pine beetle attack, according to CU-Boulder study Trees with smoother bark are better at repelling attacks by mountain pine beetles, which have difficulty gripping the slippery surface, according to a new ...

LAST 30 PRESS RELEASES:

Mindfulness and cognitive behavioral therapy improve chronic low back pain

Proteins shown to act as ‘guardians’ to keep cells’ energy making mitochondria safe

Letting your mind wander can sometimes improve learning

Exploring how people interact with virtual avatars

Hospital addiction consultation service increases medication treatment for opioid use disorder

Newly discovered PNS microglia found to regulate neuron size

Brain’s own repair mechanism: New neurons may reverse damage in Huntington’s disease

Neighborhood disadvantage, individual experiences of racism, and breast cancer survival

Cardioprotective glucose-lowering agents and dementia risk

Two-thirds of U.S. adolescent minors are impacted by state abortion restrictions

GLP-1RA and SGLT2i medications for type 2 diabetes and Alzheimer disease and related dementias

In the search for life on exoplanets, finding nothing is something too

Molecules that fight infection also act on the brain, inducing anxiety or sociability

Home care cooperatives may be key to addressing the critical shortage of caregivers for the elderly

Researchers have a proven prescription for reducing suicide rates

What if we find nothing in our search for life beyond Earth?

New findings on T cell exhaustion: The body prepares early for mild to severe disease

Howard University football team joins the Nation of Lifesavers

Korea University and Yonsei University's Colleges of Medicine promote a joint research project to train new Korean physician-scientists

Researchers discover way to predict treatment success for parasitic skin disease

Journal of Health Communication publishes inaugural Society for Health Communication special issue

‘Ugh, not that song!’ Background music impacts employees

New study finds that 90 percent of U.S. Christian leaders believe climate change is real

Study finds global downturn in bias against stigmatized groups

Cross-ideological acceptance of illiberal narratives and pro-China propaganda in Japan

AI tool can track effectiveness of multiple sclerosis treatments

The new season of The Last of Us has a spore-ting chance at realism

Alternative approach to Lyme disease vaccine development shows promise in pre-clinical models

Equitable access to digital technologies may help improve cardiovascular health

Is AI in medicine playing fair?

[Press-News.org] Transient receptor potential channel A1 may contribute to hyperalgesia