PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Development of a novel dual JAK/Src kinase inhibitor

2014-01-07
(Press-News.org) Contact information: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Development of a novel dual JAK/Src kinase inhibitor Inhibitors of both JAK and Src kinases represent promising targets for cancer therapeutics because of the central importance of these kinases in tumor cell proliferation and survival. Furthermore, in cancer cells activation of JAK has been reported as a compensatory effect in response to Src inhibitor exposure. This implies simultaneous inhibition of both kinases could have a synergy of anti-cancer effects compared to an agent that inhibits one or the other kinases.

The research article by Liu et al describes MLS-2384 which is a synthetic derivative of amarine natural product, 6-bromoindirubin-3′-oxime. MLS-2384 exhibits a dual JAK/Src kinase inhibitory activity, blocks downstream signaling into the STAT3 pathway, and has anti-cancer activity in various human cancer cell lines. These findings have important clinical implications for understanding the mechanisms of action of bromoindirubin derivatives.

The findings also indicate that this new 6-bromoindirubin derivative, MLS-2384, has potential as an anti-tumor therapeutic agent targeting JAK and Src kinases upstream of STAT3 in a wide variety of human cancer cells.

INFORMATION:

For the full report by Liu et al. in Cancer Biology & Therapy, visit the following link: https://www.landesbioscience.com/journals/cbt/article/26721/

Published by Landes Bioscience since 2002, Cancer Biology & Therapy publishes relevant and high-impact original research with a special focus on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. Established in 2002, Landes Bioscience is an Austin, Texas-based publisher of biology research journals and books. For more information on Landes Bioscience, please visit http://www.landesbioscience.com/.

END



ELSE PRESS RELEASES FROM THIS DATE:

Out-of-pocket costs play major role in treatment adherence for cancer patients

2014-01-07
Out-of-pocket costs play major role in treatment adherence for cancer patients The cost of insurance co-payments for cutting-edge pharmaceuticals can vary widely from patient to patient. When the patient's share of prescription costs becomes ...

NASA's Fermi makes first gamma-ray study of a gravitational lens

2014-01-07
NASA's Fermi makes first gamma-ray study of a gravitational lens

Ear tubes vs. watchful waiting: Tubes do not improve long-term development

2014-01-07
Ear tubes vs. watchful waiting: Tubes do not improve long-term development Watchful waiting or ear tube surgery? It is a decision faced by millions of families of children with recurrent or chronic otitis media with effusion (non-infected ...

Including women on convening committees increases women speakers at scientific meetings

2014-01-07
Including women on convening committees increases women speakers at scientific meetings Women are currently underrepresented among speakers at scientific meetings, both in absolute terms and relative to their representation among attendees, but a new study suggests ...

'Traffic light' food labels, positioning of healthy items produce lasting choice changes

2014-01-07
'Traffic light' food labels, positioning of healthy items produce lasting choice changes The use of color-coded "traffic light" food labels and changes in the way popular items are displayed appear to have produced a long-term increase in the choice ...

Boost careers of female scientists: Make sure women help choose meeting speakers

2014-01-07
Boost careers of female scientists: Make sure women help choose meeting speakers January 7, 2014 — (BRONX, NY) — More women are choosing science careers, yet women are notoriously underrepresented in senior academic positions—often because they ...

Similar characteristics of brain DTI for healthy adult rhesus monkey and young people

2014-01-06
Similar characteristics of brain DTI for healthy adult rhesus monkey and young people Diffusion-tensor imaging can be used to observe the microstructure of brain tissue. Fractional anisotropy reflects the integrity of white matter fibers. Fractional anisotropy of ...

Mannotriose promotes survival of hippocampal neurons

2014-01-06
Mannotriose promotes survival of hippocampal neurons The main component of the Chinese herb Rehmannia, mannotriose, can improve learning and memory. Dr. Lina Zhang and colleagues from Shanghai University of Traditional Chinese Medicine in China used 1 × 10 mol/L ...

Gabapentin inhibits central sensitization during migraine

2014-01-06
Gabapentin inhibits central sensitization during migraine Gabapentin is a gamma-aminobutyric acid derivative, and was approved for the treatment of neuropathic pain by the U.S. Food and Drug Administration in 2002. However, little evidence is available on the effects ...

A single-domain antibody that specifically recognizes amyloid-beta 42 oligomers

2014-01-06
A single-domain antibody that specifically recognizes amyloid-beta 42 oligomers Earlier amyloid-beta assemblies may be one of the most important causes of Alzheimer's disease. Passive immunization of anti-amyloid-beta antibodies can reduce amyloid-beta burden and ...

LAST 30 PRESS RELEASES:

Are lifetimes of big appliances really shrinking?

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

[Press-News.org] Development of a novel dual JAK/Src kinase inhibitor