PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Special focus issue on sepsis

2014-01-08
(Press-News.org) Contact information: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Special focus issue on sepsis A special issue on sepsis has been released by the publisher Landes Bioscience (Austin, TX USA). The articles contained in this special issue of the journal Virulence have been authored by world-class investigators and provide new insights into both the pathogen-related factors and the host defense mechanisms that lead to septic shock and contribute to its resolution or fatal outcome.

Sepsis, or septic shock, is an excessive inflammatory response in answer to a serious infection, most commonly by bacteria, but also fungi, viruses, and parasites. Different microbial components, such as bacterial lipopolysaccharide (LPS), endotoxins, or exotoxins can cause the typical septic inflammatory cascade. The condition can continue even after the infection that caused it is gone. It is a significant cause of morbidity and mortality worldwide. Characteristics of sepsis are massive release of proinflammatory cytokines resulting in tissue damage, an uncontrolled reduction in blood-pressure, multiple organ failure, and death. Sepsis can originate anywhere microbes can gain entry to the body, common sites including the genitourinary tract, the liver and its bile ducts, the gastrointestinal tract, and the lungs. The condition is often life-threatening, especially in people with a weakened immune system or other medical issues.

Dr. Steven Opal from Alpert Medical School of Brown University (Pawtucket, RI USA) has worked with the editorial team of Virulence to organize this special issue on sepsis. Over 20 papers in this issue discuss many different aspects of sepsis and septic shock, such as epidemiology of severe sepsis (Sachin Yende), gender differences in sepsis (Irshad Chaudry), systemic inflammatory response syndrome (Robert Balk), the PIRO model (John Marshall), host innate immune responses to sepsis (Willem Joost Wieringa), the changing immune system in sepsis (Jonathan Boomer), pathogenesis of bacteremia (Eirini Christaki), role of mitochondrial dysfunction in sepsis-induced multi-organ failure (Mervyn Singer), pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock (Daniel De Backer), an alternate pathophysiologic paradigm of sepsis and septic shock—implications for optimizing antimicrobial therapy (Anand Kumar), meningococcal disease and the complement system (Lisa Lewis and Sanjay Ram), contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis (Shiranee Sriskandan), the complex link between influenza and severe sepsis (Diana Florescu), animal models of sepsis (Mitchell Fink), invasive candidiasis as a cause of sepsis (Thierry Calandra), neonatal sepsis (James Padbury), pediatric sepsis (Adrienne Randolph), clinical controversies in the management of patients with severe sepsis (Simon Finfer), clinical impact of multidrug-resistant gram-negative bacilli in the management of septic shock (Aurora Pop-Vicas), bacterial toxins in sepsis (Girish Ramachandran), anti-endotoxin vaccines (Alan Cross), bacteriophage therapy (Xavier Wittebole), rapid diagnosis of sepsis (Konrad Reinhart), and severe sepsis and septic shock—management and performance improvement (Christa Schorr).

In an accompanying editorial, Dr. Opal highlights the importance of this collection of review articles, providing a detailed summary of the current knowledge and science of septic shock research, extending from the molecular to the population level. He writes, "Septic shock continues to pose formidable challenges for emergency room physicians, critical care specialists, surgeons, and infectious disease clinicians alike in caring for these critically ill patients. Early recognition of sepsis and improved therapies to manage the multi-organ dysfunction that frequently follows sepsis pathophysiology remain major unmet medical needs."

INFORMATION:

To view all articles in the special issue, visit the following link: http://www.landesbioscience.com/journals/virulence/toc/volume/5/issue/1/

END



ELSE PRESS RELEASES FROM THIS DATE:

New research may boost drug efficacy in treating pulmonary arterial hypertension

2014-01-08
New research may boost drug efficacy in treating pulmonary arterial hypertension Intravenous/sublingual tissue-penetrating homing peptide enhances activity of other pulmonary drugs, according to new research published in the American Journal of Pathology Philadelphia, ...

8 million lives saved since surgeon general's tobacco warning 50 years ago

2014-01-08
8 million lives saved since surgeon general's tobacco warning 50 years ago Yale study on the impact of anti-smoking measures that began half a century ago A Yale study estimates that 8 million lives have been saved in the United States as a result of anti-smoking measures ...

Sun unleashes first X-class flare of 2014

2014-01-08
Sun unleashes first X-class flare of 2014 The sun emitted a significant solar flare peaking at 1:32 p.m. EST on Jan.7, 2014. This is the first significant flare of 2014, and follows on the heels of mid-level flare earlier in the day. Each flare ...

NASA's SDO sees giant January sunspots

2014-01-08
NASA's SDO sees giant January sunspots An enormous sunspot, labeled AR1944, slipped into view over the sun's left horizon late on Jan. 1, 2014. The sunspot steadily moved toward the right, along with the rotation of the sun, and now sits almost ...

AAS meeting highlights several new Hubble science findings

2014-01-08
AAS meeting highlights several new Hubble science findings NASA's Hubble Space Telescope is providing a new perspective on the remote universe, including new views of young and distant galaxies bursting with stars. Scientists described the findings ...

Nano-capsules show potential for more potent chemoprevention

2014-01-08
Nano-capsules show potential for more potent chemoprevention Researchers at the Winship Cancer Institute of Emory University have discovered a more effective drug delivery system using nanotechnology that could one day significantly affect cancer prevention. The ...

Nutrition guidelines needed for full-service restaurant chains

2014-01-08
Nutrition guidelines needed for full-service restaurant chains According to a new study in the Journal of Nutrition Education and Behavior Philadelphia, PA, January 8, 2014 – Food prepared away from home is typically higher in calories and lower in nutrition than ...

Reactivation of the AKT survival pathway by ERK1/2

2014-01-07
Reactivation of the AKT survival pathway by ERK1/2 Why inhibition of both pathways is important In the study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation ...

Inverse design: New route to design a practical invisibility cloak

2014-01-07
Inverse design: New route to design a practical invisibility cloak With the emergence of metamaterials and transformation optics in the past few years, invisibility has become a scientific possibility that has attracted sustainable research interest. Recently, a review ...

Jumping snails left grounded in future oceans

2014-01-07
Jumping snails left grounded in future oceans Sea snails that leap to escape their predators may soon lose their extraordinary jumping ability because of rising human carbon dioxide emissions, a team of international scientists ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Special focus issue on sepsis